Nitinol (NiTi), an alloy of nickel and titanium, wires are an important biomedical material that has been used in catheter tubes, guidewires, stents, and other surgical instruments. As such wires are temporarily or permanently inserted inside the human body, their surfaces need to be smoothed and cleaned in order to prevent wear, friction, and adhesion of bacteria. In this study, NiTi wire samples of micro-scale diameters (i.e., Ø 200 μm and Ø 400 μm) were polished by an advanced magnetic abrasive finishing (MAF) process using a nanoscale polishing method. Furthermore, bacterial adhesion (i.e., Escherichia coli (E. coli), and Staphylococcus aureus (S. aureus)) to the initial and final surfaces of NiTi wires were investigated and compared in order to assess the impact of surface roughness on bacterial adhesion to the surfaces of NiTi wires. The finding revealed that the surfaces of NiTi wires were clean and smooth with a lack of particle impurities and toxic components on the final surface polished using the advanced MAF process. The surface roughness Ra values of the Ø 200 μm and Ø 400 μm NiTi wires were smoothly enhanced to 20 nm and 30 nm from the 140 nm and 280 nm initial surface roughness values. Importantly, polishing the surfaces of a biomedical material such as NiTi wire to nano-level roughness can significantly reduce bacterial adhesion on the surface by more than 83.48% in the case of S. aureus, while in the case of E. coli was more than 70.67%.

Phenolics from plant materials have garnered attention in nanomedicine research, due to their various medicinal properties. Caffeic acid, a phenolic compound that is abundant in coffee beans, has been proven to have anticancer effects, due to its reactive oxygen species (ROS)-inducing properties. Here, a supramolecular nanomedicine was designed using caffeic acid molecule and the synthetic anticancer drug bortezomib, via catechol–boronic acid conjugation and Fe(III) ion crosslinking. Bortezomib is a proteasome-inhibiting drug and its boronic acid functional group can bind to caffeic acid’s catechol moiety. By having a nanoparticle formulation that can deliver bortezomib via intracellular endocytosis, the catechol–boronic acid conjugation can be dissociated, which liberates the boronic acid functional group to bind to the 26S proteasome of the cell. The ROS-inducing property of caffeic acid also complements the bortezomib payload, as the latter suppresses the survival mechanism of the cell through NF-κB inhibition.

Flexible and stretchable structural systems require geometries capable of maintaining mechanical stability under repeated deformation while minimizing localized stress concentration. In this study, a beetle elytra-inspired flexible architecture based on the interdigitated suture geometry of the diabolical ironclad beetle was developed and compared with conventional Peano curve-based structures. The proposed geometry incorporated elongated elliptical motifs designed to enhance tensile deformability and promote stress redistribution during loading. Finite element analysis demonstrated that the beetle-inspired structures exhibited more uniform strain propagation and lower local stress concentration than conventional structures, particularly in the horizontal configuration. Uniaxial tensile testing further confirmed enhanced deformation sustainability and delayed structural failure in the beetle-inspired architectures. In addition, comparative simulations of deformable sensor-interconnect systems revealed reduced peak stress accumulation near rigid island regions. Overall, the present study demonstrates that beetle-inspired interdigitated geometries can effectively enhance flexibility and mechanical stability in stretchable systems, suggesting their strong potential for future flexible and deformable devices requiring high durability under repeated mechanical deformation.