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Background and aim: Over the last decades, the incidence of melanoma has been steadily growing, with 4.2% of the population worldwide affected by cutaneous melanoma (CM) in 2020 and with a higher incidence and mortality in men than in women. We investigated both the risk factors for CM development and the prognostic and predictive factors for survival, stratifying for both sex and gender. Methods: We conducted a systematic review of studies indexed in PUB-MED, EMBASE, and Scopus until 4 February 2021. We included reviews, meta-analyses, and pooled analyses investigating differences between women and men in CM risk factors and in prognostic and predictive factors for CM survival. Data synthesis: Twenty-four studies were included, and relevant data extracted. Of these, 13 studies concerned potential risk factors, six concerned predictive factors, and five addressed prognostic factors of melanoma. Discussion: The systematic review revealed no significant differences in genetic predisposition to CM between males and females, while there appear to be several gender disparities regarding CM risk factors, partly attributable to different lifestyles and behavioral habits between men and women. There is currently no clear evidence of whether the mutational landscapes of CM differ by sex/gender. Prognosis is justified by a complex combination of phenotypes and immune functions, while reported differences between genders in predicting the effectiveness of new treatments are inconsistent. Overall, the results emerging from the literature reveal the importance of considering the sex/gender variable in all studies and pave the way for including it towards precision medicine. Conclusions: Men and women differ genetically, biologically, and by social construct. Our systematic review shows that, although fundamental, the variable sex/gender is not among the ones collected and analyzed.
Oriana D’Ecclesiis; Saverio Caini; Chiara Martinoli; Sara Raimondi; Camilla Gaiaschi; Giulio Tosti; Paola Queirolo; Camilla Veneri; Calogero Saieva; Sara Gandini; Susanna Chiocca. Gender-Dependent Specificities in Cutaneous Melanoma Predisposition, Risk Factors, Somatic Mutations, Prognostic and Predictive Factors: A Systematic Review. International Journal of Environmental Research and Public Health 2021, 18, 7945 .
AMA StyleOriana D’Ecclesiis, Saverio Caini, Chiara Martinoli, Sara Raimondi, Camilla Gaiaschi, Giulio Tosti, Paola Queirolo, Camilla Veneri, Calogero Saieva, Sara Gandini, Susanna Chiocca. Gender-Dependent Specificities in Cutaneous Melanoma Predisposition, Risk Factors, Somatic Mutations, Prognostic and Predictive Factors: A Systematic Review. International Journal of Environmental Research and Public Health. 2021; 18 (15):7945.
Chicago/Turabian StyleOriana D’Ecclesiis; Saverio Caini; Chiara Martinoli; Sara Raimondi; Camilla Gaiaschi; Giulio Tosti; Paola Queirolo; Camilla Veneri; Calogero Saieva; Sara Gandini; Susanna Chiocca. 2021. "Gender-Dependent Specificities in Cutaneous Melanoma Predisposition, Risk Factors, Somatic Mutations, Prognostic and Predictive Factors: A Systematic Review." International Journal of Environmental Research and Public Health 18, no. 15: 7945.
Background Respiratory syncytial virus (RSV) infections are one of the leading causes of lower respiratory tract infections and have a major burden on society. For prevention and control to be deployed effectively, an improved understanding of the seasonality of RSV is necessary. Objectives The main objective of this study was to contribute to a better understanding of RSV seasonality by examining the GERi multi-country surveillance dataset. Methods RSV seasons were included in the analysis if they contained ≥100 cases. Seasonality was determined using the “average annual percentage” method. Analyses were performed at a subnational level for the United States and Brazil. Results We included 601 425 RSV cases from 12 countries. Most temperate countries experienced RSV epidemics in the winter, with a median duration of 10–21 weeks. Not all epidemics fit this pattern in a consistent manner, with some occurring later or in an irregular manner. More variation in timing was observed in (sub)tropical countries, and we found substantial differences in seasonality at a subnational level. No association was found between the timing of the epidemic and the dominant RSV subtype. Conclusions Our findings suggest that geographical location or climatic characteristics cannot be used as a definitive predictor for the timing of RSV epidemics and highlight the need for (sub)national data collection and analysis.
Lisa Staadegaard; Saverio Caini; Sonam Wangchuk; Binay Thapa; Walquiria Aparecida Ferreira de Almeida; Felipe Cotrim de Carvalho; Rodrigo A. Fasce; Patricia Bustos; Jan Kyncl; Ludmila Novakova; Alfredo Bruno Caicedo; Domenica Joseth de Mora Coloma; Adam Meijer; Mariëtte Hooiveld; Q. Sue Huang; Tim Wood; Raquel Guiomar; Ana Paula Rodrigues; Vernon Jian Ming Lee; Li Wei Ang; Cheryl Cohen; Jocelyn Moyes; Amparo Larrauri; Concepción Delgado‐Sanz; Clarisse Demont; Mathieu Bangert; Michel Dückers; Jojanneke van Summeren; John Paget. Defining the seasonality of respiratory syncytial virus around the world: National and subnational surveillance data from 12 countries. Influenza and Other Respiratory Viruses 2021, 1 .
AMA StyleLisa Staadegaard, Saverio Caini, Sonam Wangchuk, Binay Thapa, Walquiria Aparecida Ferreira de Almeida, Felipe Cotrim de Carvalho, Rodrigo A. Fasce, Patricia Bustos, Jan Kyncl, Ludmila Novakova, Alfredo Bruno Caicedo, Domenica Joseth de Mora Coloma, Adam Meijer, Mariëtte Hooiveld, Q. Sue Huang, Tim Wood, Raquel Guiomar, Ana Paula Rodrigues, Vernon Jian Ming Lee, Li Wei Ang, Cheryl Cohen, Jocelyn Moyes, Amparo Larrauri, Concepción Delgado‐Sanz, Clarisse Demont, Mathieu Bangert, Michel Dückers, Jojanneke van Summeren, John Paget. Defining the seasonality of respiratory syncytial virus around the world: National and subnational surveillance data from 12 countries. Influenza and Other Respiratory Viruses. 2021; ():1.
Chicago/Turabian StyleLisa Staadegaard; Saverio Caini; Sonam Wangchuk; Binay Thapa; Walquiria Aparecida Ferreira de Almeida; Felipe Cotrim de Carvalho; Rodrigo A. Fasce; Patricia Bustos; Jan Kyncl; Ludmila Novakova; Alfredo Bruno Caicedo; Domenica Joseth de Mora Coloma; Adam Meijer; Mariëtte Hooiveld; Q. Sue Huang; Tim Wood; Raquel Guiomar; Ana Paula Rodrigues; Vernon Jian Ming Lee; Li Wei Ang; Cheryl Cohen; Jocelyn Moyes; Amparo Larrauri; Concepción Delgado‐Sanz; Clarisse Demont; Mathieu Bangert; Michel Dückers; Jojanneke van Summeren; John Paget. 2021. "Defining the seasonality of respiratory syncytial virus around the world: National and subnational surveillance data from 12 countries." Influenza and Other Respiratory Viruses , no. : 1.
Purpose: Anorexia nervosa (AN) is an eating disorder (ED) that is divided in a restrictive (R-AN) and atypical (A-AN) form depending on the body mass index (BMI). In 100 adolescents with AN, we reviewed the diagnosis (R-AN and A-AN) in relation to different diagnostic criteria (absolute BMI, DSM-5 criteria, European Guidelines and Cacciari percentile curves) and we studied the prevalence of suicidality (suicidal thoughts and behaviours). We also observed the association between suicidality and severity of AN symptoms and psychiatric comorbidities.Methods: We subdivided AN in R-AN and A-AN, considering the four diagnostic criteria previously described. We used the Fisher’s exact test and the Mann-Whitney test for categorical and continuous variables, and we applied multivariate analysis of variance and covariance. Results: Thirty-one % of patients changed diagnosis from R-AN to A-AN depending on which diagnostic criteria was used. Twenty-seven % of patients presented suicidality and they showed greater severity of specific AN psychopathology.Conclusions: Categorization of the AN in childhood can change depending on the diagnostic criteria used. Suicidality is independent from BMI, and seems to be related to specific ED psychopathology and psychiatric comorbidity. These data confirm the need to conceptualize the pathology in a different way and improve the therapeutic intervention. Our findings also highlight the importance of screening for suicidality among children and adolescents at onset of AN to prevent suicide.Level of evidence: level IV
Alberta Mereu; Teresa Fantoni; Saverio Caini; Francesca Monzali; Elena Roselli; Silvia Taddei; Stefano Lucarelli; Tiziana Pisano. Suicidality in Adolescents With Onset of Anorexia Nervosa: From the Conceptualization of the Symptom to Clinical Practice. 2021, 1 .
AMA StyleAlberta Mereu, Teresa Fantoni, Saverio Caini, Francesca Monzali, Elena Roselli, Silvia Taddei, Stefano Lucarelli, Tiziana Pisano. Suicidality in Adolescents With Onset of Anorexia Nervosa: From the Conceptualization of the Symptom to Clinical Practice. . 2021; ():1.
Chicago/Turabian StyleAlberta Mereu; Teresa Fantoni; Saverio Caini; Francesca Monzali; Elena Roselli; Silvia Taddei; Stefano Lucarelli; Tiziana Pisano. 2021. "Suicidality in Adolescents With Onset of Anorexia Nervosa: From the Conceptualization of the Symptom to Clinical Practice." , no. : 1.
Luca Giovanni Locatello; Benedetta Trotta; Chiara Bruno; Michele Trotta; Giandomenico Maggiore; Laura Rasero; Saverio Caini; Oreste Gallo. Systemic steroids may enhance recovery from loss of smell and taste in hospitalized coronavirus disease 2019 (COVID‐19) patients: an observational study. International Forum of Allergy & Rhinology 2021, 1 .
AMA StyleLuca Giovanni Locatello, Benedetta Trotta, Chiara Bruno, Michele Trotta, Giandomenico Maggiore, Laura Rasero, Saverio Caini, Oreste Gallo. Systemic steroids may enhance recovery from loss of smell and taste in hospitalized coronavirus disease 2019 (COVID‐19) patients: an observational study. International Forum of Allergy & Rhinology. 2021; ():1.
Chicago/Turabian StyleLuca Giovanni Locatello; Benedetta Trotta; Chiara Bruno; Michele Trotta; Giandomenico Maggiore; Laura Rasero; Saverio Caini; Oreste Gallo. 2021. "Systemic steroids may enhance recovery from loss of smell and taste in hospitalized coronavirus disease 2019 (COVID‐19) patients: an observational study." International Forum of Allergy & Rhinology , no. : 1.
Non-melanoma skin cancers (NMSC) are more frequent among men, but women (especially those aged < 40 years) have experienced steeper growth in their incidence rates in recent years. Hormonal factors were hypothesized to be playing a role in modulating NMSC risk, but the studies published to date provided conflicting results. We systematically reviewed and meta-analysed the studies focusing on the association between hormone-related characteristics (use of exogenous sex hormones, and aspects of menstrual and reproductive history) and the risk of NMSC among women. We included observational and experimental studies published in PubMed and EMBASE until February 2020. We calculated summary relative risk (SRR) and 95% confidence intervals (CI) by applying random effects models with maximum likelihood estimation, and used the I2 statistics to quantify the degree of heterogeneity of risk estimates across studies. Eleven independent studies encompassing a total of over 30,000 NMSC cases were included in quantitative analyses. No evidence of an increased NMSC risk emerged among ever vs. never users of oral contraceptives (SRR 1.13, 95% CI 0.88–1.45) or hormones for menopause (SRR 1.09, 95% CI 0.87–1.37). Likewise, age at menarche or at menopause and parity were not associated with NMSC risk. Heterogeneity across studies was low, and pooled results were comparable between NMSC subtypes. We found no evidence that hormonal factors play a role in the pathogenesis of NMSC among women.
Saverio Caini; Simone Pietro De Angelis; Federica Corso; Carolina Fantini; Sara Raimondi; Laura Pala; Ignazio Stanganelli; Vincenzo de Giorgi; Sara Gandini. Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis. Scientific Reports 2021, 11, 1 -8.
AMA StyleSaverio Caini, Simone Pietro De Angelis, Federica Corso, Carolina Fantini, Sara Raimondi, Laura Pala, Ignazio Stanganelli, Vincenzo de Giorgi, Sara Gandini. Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis. Scientific Reports. 2021; 11 (1):1-8.
Chicago/Turabian StyleSaverio Caini; Simone Pietro De Angelis; Federica Corso; Carolina Fantini; Sara Raimondi; Laura Pala; Ignazio Stanganelli; Vincenzo de Giorgi; Sara Gandini. 2021. "Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis." Scientific Reports 11, no. 1: 1-8.
We conducted a systematic review and meta-analysis of the association between somatic mutations of the TERT gene promoter and melanoma survival. Data from nineteen independent studies (>2,500 melanoma overall) were pooled using random effects meta-analysis models. TERT-mutated melanoma patients had a significantly worse overall survival (OS) (summary hazard ratio 1.43, 95 % confidence intervals (CI) 1.05–1.95) compared to wild-type ones. The association became stronger when combining risk estimates for overall and melanoma-specific survival (MSS) (1.52, 95 % CI 1.14–2.02), and when restricting the analysis to studies mostly based on invasive non-acral cutaneous melanomas (1.77, 95 % CI 1.00–3.15). Limited, yet suggestive evidence of a detrimental effect of TERT promoter mutations on melanoma prognosis emerged also for other survival measures (e.g. disease-free and distant metastasis-free survival). We found suggestive evidence of a detrimental effect of TERT mutations on melanoma patients’ survival.
Sara Gandini; Ines Zanna; Simone De Angelis; Domenico Palli; Sara Raimondi; Simone Ribero; Giovanna Masala; Mariano Suppa; Federica Bellerba; Federica Corso; Luigi Nezi; Eduardo Nagore; Saverio Caini. TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis. Critical Reviews in Oncology/Hematology 2021, 160, 103288 .
AMA StyleSara Gandini, Ines Zanna, Simone De Angelis, Domenico Palli, Sara Raimondi, Simone Ribero, Giovanna Masala, Mariano Suppa, Federica Bellerba, Federica Corso, Luigi Nezi, Eduardo Nagore, Saverio Caini. TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis. Critical Reviews in Oncology/Hematology. 2021; 160 ():103288.
Chicago/Turabian StyleSara Gandini; Ines Zanna; Simone De Angelis; Domenico Palli; Sara Raimondi; Simone Ribero; Giovanna Masala; Mariano Suppa; Federica Bellerba; Federica Corso; Luigi Nezi; Eduardo Nagore; Saverio Caini. 2021. "TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis." Critical Reviews in Oncology/Hematology 160, no. : 103288.
To conduct a systematic review and meta-analysis of the role of SBRTdrug combination in patients affected by mRCC and associated oncologic outcomes and toxicity profiles. We performed a critical review of the Pubmed, Medline, and Embase databases from January 1, 2000 through April 30, 2020 according to the Preferred Reporting Items and Meta-Analyses statement. To assess the overall quality of the literature reviewed, we used a modified Delphi tool. A total of 6 studies were included, corresponding to a cohort of 216 patients. Tyrosine Kinases Inhibitors were the most widely used drugs in combination with SBRT, being administered in 93% patients. No study reported an increase of radiation-induced toxicity. SBRT resulted to be safe, without increase in terms of drugs-related adverse events in this setting. Moreover, this approach showed promising clinical outcomes in terms of LC and OS
Gianluca Ingrosso; Carlotta Becherini; Giulio Francolini; Andrea Lancia; Emanuele Alì; Saverio Caini; Maria Ausilia Teriaca; Alessandro Marchionni; Andrea Riccardo Filippi; Lorenzo Livi; Giuseppe Sanguineti; Cynthia Aristei; Beatrice Detti. Stereotactic body radiotherapy (SBRT) in combination with drugs in metastatic kidney cancer: A systematic review. Critical Reviews in Oncology/Hematology 2021, 159, 103242 .
AMA StyleGianluca Ingrosso, Carlotta Becherini, Giulio Francolini, Andrea Lancia, Emanuele Alì, Saverio Caini, Maria Ausilia Teriaca, Alessandro Marchionni, Andrea Riccardo Filippi, Lorenzo Livi, Giuseppe Sanguineti, Cynthia Aristei, Beatrice Detti. Stereotactic body radiotherapy (SBRT) in combination with drugs in metastatic kidney cancer: A systematic review. Critical Reviews in Oncology/Hematology. 2021; 159 ():103242.
Chicago/Turabian StyleGianluca Ingrosso; Carlotta Becherini; Giulio Francolini; Andrea Lancia; Emanuele Alì; Saverio Caini; Maria Ausilia Teriaca; Alessandro Marchionni; Andrea Riccardo Filippi; Lorenzo Livi; Giuseppe Sanguineti; Cynthia Aristei; Beatrice Detti. 2021. "Stereotactic body radiotherapy (SBRT) in combination with drugs in metastatic kidney cancer: A systematic review." Critical Reviews in Oncology/Hematology 159, no. : 103242.
Germline variants of the melanocortin‐1‐receptor (MC1R) gene are the most common genetic trait predisposing to cutaneous melanoma (CM). Here, we performed a literature review and meta‐analysis of the association between MC1R gene variants and the frequency of somatic mutations of the BRAF, NRAS, and TERT genes in CM patients. We included studies published until January 2020 in MEDLINE, EMBASE, Ovid Medline, and two grey literature databases. Random effect models were used to pool study‐specific estimates into summary odds ratio (SOR) and 95% confidence intervals (CIs). Subgroup and sensitivity analyses were conducted to identify potential sources of heterogeneity and assess the robustness of pooled estimates. Twelve studies published between 2006 and 2018 (encompassing 3566 CM, mostly on nonacral sites) were included. MC1R gene variants were not significantly associated with the frequency of somatic mutations of the BRAF and NRAS genes. Only three studies focused on somatic mutations of the TERT gene promoter, all of which reported moderate‐to‐strong positive associations with MC1R germline variants. MC1R gene variants appear to make only moderate changes, if any, to the risk of BRAF‐ or NRAS‐mutant CM. The association with TERT promoter mutations is suggestive, yet it warrants confirmation as it is based on a still limited number of studies
Ines Zanna; Saverio Caini; Sara Raimondi; Calogero Saieva; Giovanna Masala; Daniela Massi; Emilia Cocorocchio; Paola Queirolo; Ignazio Stanganelli; Sara Gandini. Germline MC1R variants and frequency of somatic BRAF, NRAS , and TERT mutations in melanoma: Literature review and meta‐analysis. Molecular Carcinogenesis 2021, 60, 167 -171.
AMA StyleInes Zanna, Saverio Caini, Sara Raimondi, Calogero Saieva, Giovanna Masala, Daniela Massi, Emilia Cocorocchio, Paola Queirolo, Ignazio Stanganelli, Sara Gandini. Germline MC1R variants and frequency of somatic BRAF, NRAS , and TERT mutations in melanoma: Literature review and meta‐analysis. Molecular Carcinogenesis. 2021; 60 (3):167-171.
Chicago/Turabian StyleInes Zanna; Saverio Caini; Sara Raimondi; Calogero Saieva; Giovanna Masala; Daniela Massi; Emilia Cocorocchio; Paola Queirolo; Ignazio Stanganelli; Sara Gandini. 2021. "Germline MC1R variants and frequency of somatic BRAF, NRAS , and TERT mutations in melanoma: Literature review and meta‐analysis." Molecular Carcinogenesis 60, no. 3: 167-171.
We reviewed and meta-analysed the available evidence (until December 2019) about circulating tumour DNA (ctDNA) levels and melanoma patients survival. We included twenty-six studies (>2,000 patients overall), which included mostly stage III-IV cutaneous melanoma patients and differed widely in terms of systemic therapy received and somatic mutations that were searched. Patients with detectable ctDNA before treatment had worse progression-free survival (PFS) (summary hazard ratio (SHR) 2.47, 95% confidence intervals (CI) 1.85-3.29) and overall survival (OS) (SHR 2.98, 95% CI 2.26-3.92), with no difference by tumour stage. ctDNA detectability during follow-up was associated with poorer PFS (SHR 4.27, 95%CI 2.75-6.63) and OS (SHR 3.91, 95%CI 1.97-7.78); in the latter case, the association was stronger (p = 0.01) for stage IV vs. III melanomas. Between-estimates heterogeneity was low for all pooled estimates. ctDNA is a strong prognostic biomarker for advanced-stage melanoma patients, robust across tumour (e.g. genomic profile) and patients (e.g. systemic therapy) characteristics.
Sara Gandini; Ines Zanna; Simone Pietro De Angelis; Emilia Cocorocchio; Paola Queirolo; Jenny H Lee; Matteo S Carlino; Luca Mazzarella; Bruno Achutti Duso; Domenico Palli; Sara Raimondi; Saverio Caini. Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis. Critical Reviews in Oncology/Hematology 2020, 157, 103187 .
AMA StyleSara Gandini, Ines Zanna, Simone Pietro De Angelis, Emilia Cocorocchio, Paola Queirolo, Jenny H Lee, Matteo S Carlino, Luca Mazzarella, Bruno Achutti Duso, Domenico Palli, Sara Raimondi, Saverio Caini. Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis. Critical Reviews in Oncology/Hematology. 2020; 157 ():103187.
Chicago/Turabian StyleSara Gandini; Ines Zanna; Simone Pietro De Angelis; Emilia Cocorocchio; Paola Queirolo; Jenny H Lee; Matteo S Carlino; Luca Mazzarella; Bruno Achutti Duso; Domenico Palli; Sara Raimondi; Saverio Caini. 2020. "Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis." Critical Reviews in Oncology/Hematology 157, no. : 103187.
We studied the determinants of motivation among post-menopausal women enrolled in a two-year diet and physical activity primary prevention randomized trial. Participants were requested to grade the importance attached to changing their lifestyle, their confidence about being able to implement the change, and their willingness to be involved in studies focusing on lifestyle. We used multi-adjusted regression to investigate the association between individual characteristics, study arm, and individual motivation at study entry and end. Participants (n = 234) were highly motivated both at entry and throughout the study. Women with pre-existing healthier eating habits and lifestyles (e.g., high consumption of fruit and vegetables, low red meat consumption, and physically active) were more motivated at entry and over the course of the study. Women assigned to any intervention arm were more motivated than those in the control arm. These findings may help enhance adherence to recommendations and improve effectiveness of community-based health promotion campaigns.
Saverio Caini; Melania Assedi; Elisa Grechi; Ilaria Ermini; Donatella Zagni; Daniela Occhini; Maria Castaldo; Benedetta Bendinelli; Domenico Palli; Giovanna Masala. Time Course and Determinants of Individual Motivation among Women Enrolled in a Diet and Physical Activity Primary Prevention Trial. International Journal of Environmental Research and Public Health 2020, 17, 8589 .
AMA StyleSaverio Caini, Melania Assedi, Elisa Grechi, Ilaria Ermini, Donatella Zagni, Daniela Occhini, Maria Castaldo, Benedetta Bendinelli, Domenico Palli, Giovanna Masala. Time Course and Determinants of Individual Motivation among Women Enrolled in a Diet and Physical Activity Primary Prevention Trial. International Journal of Environmental Research and Public Health. 2020; 17 (22):8589.
Chicago/Turabian StyleSaverio Caini; Melania Assedi; Elisa Grechi; Ilaria Ermini; Donatella Zagni; Daniela Occhini; Maria Castaldo; Benedetta Bendinelli; Domenico Palli; Giovanna Masala. 2020. "Time Course and Determinants of Individual Motivation among Women Enrolled in a Diet and Physical Activity Primary Prevention Trial." International Journal of Environmental Research and Public Health 17, no. 22: 8589.
We reviewed the association between seasonal influenza vaccination and the risk of SARS-CoV-2 infection or complicated illness or poor outcome (e.g., severe disease, need for hospitalization or ventilatory support, or death) among COVID-19 patients. None of the studies that were reviewed (n = 12) found a significant increase in the risk of infection or in the illness severity or lethality, and some reported significantly inverse associations. Our findings support measures aimed at raising influenza vaccination coverage in the coming months.
Marco Del Riccio; Chiara Lorini; Guglielmo Bonaccorsi; John Paget; Saverio Caini. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature. International Journal of Environmental Research and Public Health 2020, 17, 7870 .
AMA StyleMarco Del Riccio, Chiara Lorini, Guglielmo Bonaccorsi, John Paget, Saverio Caini. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature. International Journal of Environmental Research and Public Health. 2020; 17 (21):7870.
Chicago/Turabian StyleMarco Del Riccio; Chiara Lorini; Guglielmo Bonaccorsi; John Paget; Saverio Caini. 2020. "The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature." International Journal of Environmental Research and Public Health 17, no. 21: 7870.
We reviewed the association between seasonal influenza vaccination and the risk of SARS-CoV-2 infection or complicated illness or poor outcome (e.g. severe disease, need for hospitalization or ventilatory support, or death) among COVID-19 patients. None of the studies that were reviewed (n=12) found a significant increase in the risk of infection or in the illness severity or lethality, while some reported significantly inverse associations. Our findings support measures aimed at raising influenza vaccination coverage in the coming months.
Marco Del Riccio; Chiara Lorini; Guglielmo Bonaccorsi; John Paget; Saverio Caini. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature. 2020, 1 .
AMA StyleMarco Del Riccio, Chiara Lorini, Guglielmo Bonaccorsi, John Paget, Saverio Caini. The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature. . 2020; ():1.
Chicago/Turabian StyleMarco Del Riccio; Chiara Lorini; Guglielmo Bonaccorsi; John Paget; Saverio Caini. 2020. "The Association between Influenza Vaccination and the Risk of SARS-CoV-2 Infection, Severe Illness, and Death: A Systematic Review of the Literature." , no. : 1.
We reviewed the association between seasonal influenza vaccination and the risk of SARS-CoV-2 infection or complicated illness or poor outcome (e.g. severe disease, need for hospitalization or ventilatory support, or death) among COVID-19 patients. None of the studies that were reviewed (n=12) found a significant increase in the risk of infection or in the illness severity or lethality, while some reported significantly inverse associations. Our findings support measures aimed at raising influenza vaccination coverage in the coming months.
Marco Del Riccio; Chiara Lorini; Guglielmo Bonaccorsi; John Paget; Saverio Caini. The association between influenza vaccination and the risk of SARS-CoV-2 infection, severe illness, and death: a systematic review of the literature. 2020, 1 .
AMA StyleMarco Del Riccio, Chiara Lorini, Guglielmo Bonaccorsi, John Paget, Saverio Caini. The association between influenza vaccination and the risk of SARS-CoV-2 infection, severe illness, and death: a systematic review of the literature. . 2020; ():1.
Chicago/Turabian StyleMarco Del Riccio; Chiara Lorini; Guglielmo Bonaccorsi; John Paget; Saverio Caini. 2020. "The association between influenza vaccination and the risk of SARS-CoV-2 infection, severe illness, and death: a systematic review of the literature." , no. : 1.
John Paget; Saverio Caini; Ben Cowling; Susanna Esposito; Ann R. Falsey; Angela Gentile; Jan Kyncl; C. MacIntyre; Richard Pitman; Bruno Lina. The impact of influenza vaccination on the COVID-19 pandemic? Evidence and lessons for public health policies. Vaccine 2020, 38, 6485 -6486.
AMA StyleJohn Paget, Saverio Caini, Ben Cowling, Susanna Esposito, Ann R. Falsey, Angela Gentile, Jan Kyncl, C. MacIntyre, Richard Pitman, Bruno Lina. The impact of influenza vaccination on the COVID-19 pandemic? Evidence and lessons for public health policies. Vaccine. 2020; 38 (42):6485-6486.
Chicago/Turabian StyleJohn Paget; Saverio Caini; Ben Cowling; Susanna Esposito; Ann R. Falsey; Angela Gentile; Jan Kyncl; C. MacIntyre; Richard Pitman; Bruno Lina. 2020. "The impact of influenza vaccination on the COVID-19 pandemic? Evidence and lessons for public health policies." Vaccine 38, no. 42: 6485-6486.
Local failure (LF) following stereotactic radiosurgery (SRS) of brain metastases (BM) may be treated with a second course of SRS (SRS2), though this procedure may increase the risk of symptomatic radionecrosis (RN) A literature search was conducted according to PRISMA to identify studies reporting LF, overall survival (OS) and RN rates following SRS2. Meta-analysis was performed to identify predictors of RN. Analysis included 11 studies (335 patients,389 metastases). Pooled 1-year LF was 24%(CI95% 19-30%): heterogeneity was acceptable(I2 = 21.4%).Median pooled OS was 14 months (Confidence Interval 95%, CI95% 8.8-22.0 months).Cumulative crude RN rate was 13% (95%CI 8%-19%), with acceptable heterogeneity (I2 = 40.3%). Subgroup analysis showed higher RN incidence in studies with median patient age ≥59 years (13% [95%CI 8%-19%] vs 7%[95%CI 3%-12%], p = 0.004) and lower incidence following prior Whole Brain Radiotherapy (WBRT,19%[95%CI 13%-25%] vs 7%[95%CI 3%-13%],p = 0.004). SRS2 is an effective strategy for in-site recurrence of BM previously treated with SRS.
Mauro Loi; Saverio Caini; Silvia Scoccianti; Pierluigi Bonomo; Kim De Vries; Giulio Francolini; Gabriele Simontacchi; Daniela Greto; Isacco Desideri; Icro Meattini; Joost Nuyttens; Lorenzo Livi. Stereotactic reirradiation for local failure of brain metastases following previous radiosurgery: Systematic review and meta-analysis. Critical Reviews in Oncology/Hematology 2020, 153, 103043 .
AMA StyleMauro Loi, Saverio Caini, Silvia Scoccianti, Pierluigi Bonomo, Kim De Vries, Giulio Francolini, Gabriele Simontacchi, Daniela Greto, Isacco Desideri, Icro Meattini, Joost Nuyttens, Lorenzo Livi. Stereotactic reirradiation for local failure of brain metastases following previous radiosurgery: Systematic review and meta-analysis. Critical Reviews in Oncology/Hematology. 2020; 153 ():103043.
Chicago/Turabian StyleMauro Loi; Saverio Caini; Silvia Scoccianti; Pierluigi Bonomo; Kim De Vries; Giulio Francolini; Gabriele Simontacchi; Daniela Greto; Isacco Desideri; Icro Meattini; Joost Nuyttens; Lorenzo Livi. 2020. "Stereotactic reirradiation for local failure of brain metastases following previous radiosurgery: Systematic review and meta-analysis." Critical Reviews in Oncology/Hematology 153, no. : 103043.
We reviewed the diagnostic accuracy of SARS-CoV-2 serological tests. Random-effects models yielded a summary sensitivity of 82% for IgM, and 85% for IgG and total antibodies. For specificity, the pooled estimate were 98% for IgM and 99% for IgG and total antibodies. In populations with ≤ 5% of seroconverted individuals, unless the assays have perfect (i.e. 100%) specificity, the positive predictive value would be ≤ 88%. Serological tests should be used for prevalence surveys only in hard-hit areas.
Saverio Caini; Federica Bellerba; Federica Corso; Angélica Díaz-Basabe; Gioacchino Natoli; John Paget; Federica Facciotti; Simone Pietro De Angelis; Sara Raimondi; Domenico Palli; Luca Mazzarella; Pier Giuseppe Pelicci; Paolo Vineis; Sara Gandini. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. Eurosurveillance 2020, 25, 2000980 .
AMA StyleSaverio Caini, Federica Bellerba, Federica Corso, Angélica Díaz-Basabe, Gioacchino Natoli, John Paget, Federica Facciotti, Simone Pietro De Angelis, Sara Raimondi, Domenico Palli, Luca Mazzarella, Pier Giuseppe Pelicci, Paolo Vineis, Sara Gandini. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications. Eurosurveillance. 2020; 25 (23):2000980.
Chicago/Turabian StyleSaverio Caini; Federica Bellerba; Federica Corso; Angélica Díaz-Basabe; Gioacchino Natoli; John Paget; Federica Facciotti; Simone Pietro De Angelis; Sara Raimondi; Domenico Palli; Luca Mazzarella; Pier Giuseppe Pelicci; Paolo Vineis; Sara Gandini. 2020. "Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies up to 25 April 2020 and public health implications." Eurosurveillance 25, no. 23: 2000980.
Serology-based tests have become a key public health element in the COVID-19 pandemic to assess the degree of herd immunity that has been achieved in the population. These tests differ between one another in several ways. Here, we conducted a systematic review and meta-analysis of the diagnostic accuracy of currently available SARS-CoV-2 serological tests, and assessed their real-world performance under scenarios of varying proportion of infected individuals. We included independent studies that specified the antigen used for antibody detection and used quantitative methods. We identified nine independent studies, of which six were based on commercial ELISA or CMIA/CLIA assays, and three on in-house tests. Test sensitivity ranged from 68% to 93% for IgM, from 65% to 100% for IgG, and from 83% to 98% for total antibodies. Random-effects models yielded a summary sensitivity of 82% (95%CI 75-88%) for IgM, and 85% for both IgG (95%CI 73-93%) and total antibodies (95%CI 74-94%). Specificity was very high for most tests, and its pooled estimate was 98% (95%CI 92-100%) for IgM and 99% (95%CI 98-100%) for both IgG and total antibodies. The heterogeneity of sensitivity and specificity across tests was generally high (I2≤50%). In populations with a low prevalence (≤5%) of seroconverted individuals, the positive predictive value would be ≤88% for most assays, except those reporting perfect specificity. Our data suggest that the use of serological tests for large-scale prevalence surveys (or to grant "immunity passports") are currently only justified in hard-hit regions, while they should be used with caution elsewhere.
Saverio Caini; Federica Bellerba; Federica Corso; Angelica Diaz-Basabe; Gioacchino Natoli; John Paget; Federica Facciotti; Sara Raimondi; Domenico Palli; Luca Mazzarella; Pier Giuseppe Pelicci; Paolo Vineis; Sara Gandini. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies and public health implications. 2020, 1 .
AMA StyleSaverio Caini, Federica Bellerba, Federica Corso, Angelica Diaz-Basabe, Gioacchino Natoli, John Paget, Federica Facciotti, Sara Raimondi, Domenico Palli, Luca Mazzarella, Pier Giuseppe Pelicci, Paolo Vineis, Sara Gandini. Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies and public health implications. . 2020; ():1.
Chicago/Turabian StyleSaverio Caini; Federica Bellerba; Federica Corso; Angelica Diaz-Basabe; Gioacchino Natoli; John Paget; Federica Facciotti; Sara Raimondi; Domenico Palli; Luca Mazzarella; Pier Giuseppe Pelicci; Paolo Vineis; Sara Gandini. 2020. "Meta-analysis of diagnostic performance of serological tests for SARS-CoV-2 antibodies and public health implications." , no. : 1.
Health literacy (HL) is an individual ability as well as a distributed resource available within an individual’s social network. We performed an explorative study assessing the role of HL as the country-level ecological variable in predicting the health disparities among immigrants. Country-level HL data were obtained from the publicly available first European Health Literacy Survey reports. Individual-level data on citizenship, perceived health status, body mass index, smoking habits, physical activity and attendance at breast and cervical cancer screening were extracted from the European Health Interview Survey of Eurostat. Data from both sources were obtained for Austria, Bulgaria, Greece, Poland and Spain. The country-specific odds ratio (OR) for the association between the participants’ citizenship and other individual health-relevant characteristics was pooled into summary OR using random-effects models. Meta-regression was used to explore whether the HL of a country could explain part of the between-countries heterogeneity. Results: For the perceived health status, nutritional status and attendance at cervical cancer screening, the lower was the country-level HL (as ecological variable), the higher were the health inequalities relating to citizenship. The results of our exploratory research suggest that improving the population HL may help mitigate health inequalities between residents and migrants.
Chiara Lorini; Saverio Caini; Francesca Ierardi; Letizia Bachini; Fabrizio Gemmi; Guglielmo Bonaccorsi. Health Literacy as a Shared Capacity: Does the Health Literacy of a Country Influence the Health Disparities among Immigrants? International Journal of Environmental Research and Public Health 2020, 17, 1149 .
AMA StyleChiara Lorini, Saverio Caini, Francesca Ierardi, Letizia Bachini, Fabrizio Gemmi, Guglielmo Bonaccorsi. Health Literacy as a Shared Capacity: Does the Health Literacy of a Country Influence the Health Disparities among Immigrants? International Journal of Environmental Research and Public Health. 2020; 17 (4):1149.
Chicago/Turabian StyleChiara Lorini; Saverio Caini; Francesca Ierardi; Letizia Bachini; Fabrizio Gemmi; Guglielmo Bonaccorsi. 2020. "Health Literacy as a Shared Capacity: Does the Health Literacy of a Country Influence the Health Disparities among Immigrants?" International Journal of Environmental Research and Public Health 17, no. 4: 1149.
OBJECTIVEThree to five days of external lumbar drainage (ELD) of CSF is a test for ventriculoperitoneal shunt (VPS) selection in idiopathic normal pressure hydrocephalus (iNPH). The accuracy and complication rates of a shorter (1-day) ELD procedure were analyzed.METHODSData of patients with iNPH who underwent 1-day ELD to be selected to undergo VPS placement with a programmable valve in the period from 2005 to 2015 were reviewed. Patients experiencing VPS complications, valve malfunctioning, or with less than 1 year of follow-up were excluded. The ability of 1-day ELD to predict VPS outcome at 1- and 12-month follow-up was assessed by calculating sensitivity, specificity, and positive and negative predictive values.RESULTSOf 93 patients who underwent 1-day ELD, 3 did not complete the procedure. Of the remaining 90 patients, 2 experienced transient nerve root irritation. Twenty-four patients had negative test outcomes and 66 had positive test outcomes. Nine negative-outcome patients had intraprocedural headache, which showed 37.5% sensitivity (95% confidence interval [CI] 19.5%–59.2%) and 100% specificity (95% CI 93.1%–100%) as predictors of negative 1-day ELD outcome. Sixty-eight patients (6 with negative and 62 with positive outcomes) underwent VPS insertion, which was successful in 0 and 58 patients, respectively, at 1-month follow-up. Test sensitivity and specificity in predicting surgical outcome at 1-month follow-up were 100% (95% CI 92.3%–100%) and 60% (95% CI 27.4%–86.3%), respectively, with 94.1% accuracy (95% CI 85.6–98.4%). Among the 1-day ELD–positive patients, 2 showed no clinical benefit at 12 months follow-up. Test sensitivity and specificity in predicting surgical outcome at 12-month follow-up was 100% (95% CI 92.5%–100%) and 75.0% (95% CI 35.6%–95.5%), respectively, with 97.1% (95% CI 89.8%–99.6%) accuracy.CONCLUSIONSOne-day ELD is a reliable tool in iNPH management, with low complication risk and short trial duration. The test is very consistent in predicting who will have a positive outcome with VPS placement, given the high chance of successful outcome at 1- and 12-month follow-up; negative-outcome patients have a high risk of unsuccessful surgery. Intraprocedural headache is prognostic of 1-day ELD negative outcome.
Pasquale Gallina; Giancarlo Lastrucci; Saverio Caini; Nicola Di Lorenzo; Berardino Porfirio; Antonio Scollato. Accuracy and safety of 1-day external lumbar drainage of CSF for shunt selection in patients with idiopathic normal pressure hydrocephalus. Journal of Neurosurgery 2019, 131, 1011 -1017.
AMA StylePasquale Gallina, Giancarlo Lastrucci, Saverio Caini, Nicola Di Lorenzo, Berardino Porfirio, Antonio Scollato. Accuracy and safety of 1-day external lumbar drainage of CSF for shunt selection in patients with idiopathic normal pressure hydrocephalus. Journal of Neurosurgery. 2019; 131 (4):1011-1017.
Chicago/Turabian StylePasquale Gallina; Giancarlo Lastrucci; Saverio Caini; Nicola Di Lorenzo; Berardino Porfirio; Antonio Scollato. 2019. "Accuracy and safety of 1-day external lumbar drainage of CSF for shunt selection in patients with idiopathic normal pressure hydrocephalus." Journal of Neurosurgery 131, no. 4: 1011-1017.
We describe the epidemiological characteristics, pattern of circulation, and geographical distribution of influenza B viruses and its lineages using data from the Global Influenza B Study. We included over 1.8 million influenza cases occurred in thirty-one countries during 2000–2018. We calculated the proportion of cases caused by influenza B and its lineages; determined the timing of influenza A and B epidemics; compared the age distribution of B/Victoria and B/Yamagata cases; and evaluated the frequency of lineage-level mismatch for the trivalent vaccine. The median proportion of influenza cases caused by influenza B virus was 23.4%, with a tendency (borderline statistical significance, p = 0.060) to be higher in tropical vs. temperate countries. Influenza B was the dominant virus type in about one every seven seasons. In temperate countries, influenza B epidemics occurred on average three weeks later than influenza A epidemics; no consistent pattern emerged in the tropics. The two B lineages caused a comparable proportion of influenza B cases globally, however the B/Yamagata was more frequent in temperate countries, and the B/Victoria in the tropics (p = 0.048). B/Yamagata patients were significantly older than B/Victoria patients in almost all countries. A lineage-level vaccine mismatch was observed in over 40% of seasons in temperate countries and in 30% of seasons in the tropics. The type B virus caused a substantial proportion of influenza infections globally in the 21st century, and its two virus lineages differed in terms of age and geographical distribution of patients. These findings will help inform health policy decisions aiming to reduce disease burden associated with seasonal influenza.
Saverio Caini; Gabriela Kusznierz; Verònica Vera Garate; Sonam Wangchuk; Binay Thapa; Francisco José De Paula Júnior; Walquiria Aparecida Ferreira De Almeida; Richard Njouom; Rodrigo A. Fasce; Patricia Bustos; Luzhao Feng; Zhibin Peng; Jenny Lara Araya; Alfredo Bruno; Doménica De Mora; Mónica Jeannette Barahona De Gámez; Richard Pebody; Maria Zambon; Rocio Higueros; Rudevelinda Rivera; Herman Kosasih; Maria Rita Castrucci; Antonino Bella; Hervé A. Kadjo; Coulibaly Daouda; Ainash Makusheva; Olga Bessonova; Sandra S. Chaves; Gideon O. Emukule; Jean-Michel Heraud; Norosoa H. Razanajatovo; Amal Barakat; Fatima El Falaki; Adam Meijer; Gé A. Donker; Q. Sue Huang; Tim Wood; Angel Balmaseda; Rakhee Palekar; Brechla Moreno Arévalo; Ana Paula Rodrigues; Raquel Guiomar; Vernon Jian Ming Lee; Li Wei Ang; Cheryl Cohen; Florette Treurnicht; Alla Mironenko; Olha Holubka; Joseph Bresee; Lynnette Brammer; Mai T. Q. Le; Phuong V. M. Hoang; Clotilde El Guerche-Séblain; John Paget; the Global Influenza B Study team. The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century. PLOS ONE 2019, 14, e0222381 .
AMA StyleSaverio Caini, Gabriela Kusznierz, Verònica Vera Garate, Sonam Wangchuk, Binay Thapa, Francisco José De Paula Júnior, Walquiria Aparecida Ferreira De Almeida, Richard Njouom, Rodrigo A. Fasce, Patricia Bustos, Luzhao Feng, Zhibin Peng, Jenny Lara Araya, Alfredo Bruno, Doménica De Mora, Mónica Jeannette Barahona De Gámez, Richard Pebody, Maria Zambon, Rocio Higueros, Rudevelinda Rivera, Herman Kosasih, Maria Rita Castrucci, Antonino Bella, Hervé A. Kadjo, Coulibaly Daouda, Ainash Makusheva, Olga Bessonova, Sandra S. Chaves, Gideon O. Emukule, Jean-Michel Heraud, Norosoa H. Razanajatovo, Amal Barakat, Fatima El Falaki, Adam Meijer, Gé A. Donker, Q. Sue Huang, Tim Wood, Angel Balmaseda, Rakhee Palekar, Brechla Moreno Arévalo, Ana Paula Rodrigues, Raquel Guiomar, Vernon Jian Ming Lee, Li Wei Ang, Cheryl Cohen, Florette Treurnicht, Alla Mironenko, Olha Holubka, Joseph Bresee, Lynnette Brammer, Mai T. Q. Le, Phuong V. M. Hoang, Clotilde El Guerche-Séblain, John Paget, the Global Influenza B Study team. The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century. PLOS ONE. 2019; 14 (9):e0222381.
Chicago/Turabian StyleSaverio Caini; Gabriela Kusznierz; Verònica Vera Garate; Sonam Wangchuk; Binay Thapa; Francisco José De Paula Júnior; Walquiria Aparecida Ferreira De Almeida; Richard Njouom; Rodrigo A. Fasce; Patricia Bustos; Luzhao Feng; Zhibin Peng; Jenny Lara Araya; Alfredo Bruno; Doménica De Mora; Mónica Jeannette Barahona De Gámez; Richard Pebody; Maria Zambon; Rocio Higueros; Rudevelinda Rivera; Herman Kosasih; Maria Rita Castrucci; Antonino Bella; Hervé A. Kadjo; Coulibaly Daouda; Ainash Makusheva; Olga Bessonova; Sandra S. Chaves; Gideon O. Emukule; Jean-Michel Heraud; Norosoa H. Razanajatovo; Amal Barakat; Fatima El Falaki; Adam Meijer; Gé A. Donker; Q. Sue Huang; Tim Wood; Angel Balmaseda; Rakhee Palekar; Brechla Moreno Arévalo; Ana Paula Rodrigues; Raquel Guiomar; Vernon Jian Ming Lee; Li Wei Ang; Cheryl Cohen; Florette Treurnicht; Alla Mironenko; Olha Holubka; Joseph Bresee; Lynnette Brammer; Mai T. Q. Le; Phuong V. M. Hoang; Clotilde El Guerche-Séblain; John Paget; the Global Influenza B Study team. 2019. "The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century." PLOS ONE 14, no. 9: e0222381.