Green Synthesis of Nanofertilizers and Their Application as a Foliar for Cucurbita pepo L: The implementation of nanofertilizers in agriculture is the purpose in specific to decrease mineral losses in fertilizing and raises the yield during mineral management as well as supporting agriculture development. Hence, this experiment was conducted in Shebin El-Kom, El-Monifia governorate, Egypt, during two seasons 2017 and 2018 to study the effect of micronutrient oxide nanoparticles of zinc, iron, and manganese, as well as combination between these oxides as a foliar application on the growth, yield, and quality of squash plants. The obtained results showed that the spraying of manganese oxide nanoparticles on the plants led to the best vegetative growth characteristics, also, the characteristics of the fruits, yield, and the content of photosynthetic pigments. On the contrary, the content of organic matter, protein, lipids, and energy gave the highest value in squash fruits that have been sprayed with iron oxide nanoparticles.