In this study, we analyzed the temporal-spatial variations of the characteristics of land use change in central Asia over the past two decades. This was conducted using four indicators (change rate, equilibrium extent, dynamic index, and transfer direction) and a multi-scale correlation analysis method, which explained the impact of recent environmental transformations on land use changes. The results indicated that the integrated dynamic degree of land use increased by 2.2% from 1995 to 2015. The areas of cropland, water bodies, and artificial land increased, with rates of 1047 km²/a, 39 km²/a, and 129 km²/a, respectively. On the other hand, the areas of forest, grassland, and unused land decreased, with rates of 54 km²/a, 803 km²/a, and 359 km²/a, respectively. There were significant increases in cropland and water bodies from 1995 to 2005, while the amount of artificial land significantly increased from 2005 to 2015. The increased areas of cropland in Xinjiang were mainly converted from grassland and unused land from 1995 to 2015, while the artificial land increase was mainly a result of the conversion from cropland, grassland, and unused land. The area of cropland rapidly expanded in south Xinjiang, which has led to centroid position to move cropland in Xinjiang in a southwest direction. Economic development and the rapid growth of population size are the main factors responsible for the cropland increases in Xinjiang. Runoff variations have a key impact on cropland changes at the river basin scale, as seen in three typical river basins.