Infectious diseases pose increasing threats to public health with increasing population density and more and more sophisticated social networks. While efforts continue in studying the large scale dissemination of contagious diseases, individual-based activity and behaviour study benefits not only disease transmission modelling but also the control, containment, and prevention decision making at the local scale. The potential for using tracking technologies to capture detailed space-time trajectories and model individual behaviour is increasing rapidly, as technological advances enable the manufacture of small, lightweight, highly sensitive, and affordable receivers and the routine use of location-aware devices has become widespread (e.g., smart cellular phones). The use of low-cost tracking devices in medical research has also been proved effective by more and more studies. This study describes the use of tracking devices to collect data of space-time trajectories and the spatiotemporal processing of such data to facilitate micro-scale flu transmission study. We also reports preliminary findings on activity patterns related to chances of influenza infection in a pilot study.

Alzheimer’s disease (AD) is a neurodegenerative disease with main symptoms of chronic primary memory loss and cognitive impairment. The study aim was to investigate the correlation between intrahippocampal functional connectivity (FC) and MRI radiomic features in AD. A total of 67 AD patients and 44 normal controls (NCs) were enrolled in this study. Using the seed-based method of resting-state functional MRI (rs-fMRI), the whole-brain FC with bilateral hippocampus as seed was performed, and the FC values were extracted from the bilateral hippocampus. We observed that AD patients demonstrated disruptive FC in some brain regions in the left hippocampal functional network, including right gyrus rectus, right anterior cingulate and paracingulate gyri, bilateral precuneus, bilateral angular gyrus, and bilateral middle occipital gyrus. In addition, decreased FC was detected in some brain regions in the right hippocampal functional network, including bilateral anterior cingulate and paracingulate gyri, right dorsolateral superior frontal gyrus, and right precentral gyrus. Bilateral hippocampal radiomics features were calculated and selected using the A.K. software. Finally, Pearson’s correlation analyses were conducted between these selected features and the bilateral hippocampal FC values. The results suggested that two gray level run-length matrix (RLM) radiomic features and one gray level co-occurrence matrix (GLCM) radiomic feature weakly associated with FC values in the left hippocampus. However, there were no significant correlations between radiomic features and FC values in the right hippocampus. These findings present that the AD group showed abnormalities in the bilateral hippocampal functional network. This is a prospective study that revealed the weak correlation between the MRI radiomic features and the intrahippocampal FC in AD patients.

This study analyzed the changes of land use and land cover (LULC) in New Jersey in the United States from 2007 to 2012. The goal was to identify the driving factors of these changes and to project the five-year trend to 2100. LULC data was obtained from the New Jersey Department of Environmental Protection. The original 86 classes were reclassified to 11 classes. Data analysis and projection were performed using TerrSet 2020. Results from 2007 to 2012 showed that the rate of LULC changes was relatively small. Most changes happened to brush/grasslands, mixed forest lands, farmlands and urban/developed lands. Urban/developed lands and the mixed-forest cover gained while farmlands lost. Using a multi-layer perceptron–Markov chain (MLP–MC) model, we projected the 2015 LULC and validated by actual data to produce a 2100 LULC. Changes from 2012 to 2100 showed that urban/developed lands, as well as brush/grasslands, would continue to gain, while farmlands would lose, although the projected landscape texture would likely be identical to the 2012 landscape. Human and natural factors were discussed. It was concluded that the MLP–MC model could be a useful model to predict short-term LULC change. Unexpected factors are likely to interfere in a long-term projection.

This study examines the accessibility to COVID-19 vaccination resources in two counties surrounding Newark, NJ in the New York Metropolitan Area, United States. The study area represents diverse population makeups. COVID-19 vaccines were made available by different types of vaccination sites including county mass vaccination sites, medical facilities and pharmacies, and a FEMA community vaccination center in spring 2021. We used the two-step floating catchment area method to measure accessibility and calculated the average accessibility scores of different population groups. We examined the patterns and tested the significance of the differences in accessibility across population groups. The results showed clear spatial heterogeneity in the accessibility to vaccine resources with the existing infrastructure (medical/pharmacy vaccine sites). Accessibility patterns changed with the introduction of county mass sites and the FEMA community site. The county mass vaccination sites in one county greatly increased accessibilities for populations of minority and poverty. The FEMA community site in the other county accomplished the same. Both the local health department and the federal government played an important role in mitigating pre-existing inequalities during the vaccination campaign. Our study shows that social determinants of health need to be addressed and taken into explicit consideration when planning resource distribution during the pandemic.

Introduction: Langerhans cell histiocytosis (LCH) is a histiocytic proliferative disease without a well-understood etiology. The aim of our study is to summarize the imaging features of PET/MR in children with LCH and to explore its diagnostic role in LCH. Methods: Retrospective analysis was performed of the pretreatment PET/MR imaging data of 15 children with LCH. Comparison of ADC values was done between lesions and normal tissues. Results: Of the fifteen patients enrolled, five had single-organ or single-system involvement, and ten had multiple-system involvement. Nine patients had varying degrees of bone destruction and increased FDG uptake, whereas thickening and deviation of the pituitary stalk and disappearance of the normal high-signal intensity of T1WI in the neurohypophysis were observed in the pituitary gland in six of them. Splenomegaly with diffuse increased FDG uptake or a normal spleen with increased FDG uptake was found in four cases, liver in three, multiple lymph node enlargement in three, pulmonary lesions in three, and increased metabolism in medullary cavity in two cases. Additionally, two cases involved the skin. Hypermetabolic nodules were detected in muscle in one case, thyroid involvement in one case, and a mediastinal lesion in one case. Conclusion: PET/MR can show well the distribution of the organs, systems, and lesions involved in LCH and is of considerable significance in the systemic evaluation of LCH.