Aleksander Popel

Prof. Aleksander Popel

Johns Hopkins University School of Medicine
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orcid

Research Focus & Metrics

Academic Career Length

60Years (1967-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2005 in Annual Review of Fluid Mechanics
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Journal Article
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Aleksander PopelAleksander Popel
Aleksander Popel
PJPaul C. Johnson
Paul C. Johnson
▪ Abstract We review major experimental and theoretical studies on microcirculation and hemorheology, focusing on mechanics of blood flow and the vascular wall. We discuss flow of the blood formed elements [red blood cells (RBCs), white blood cells or leukocytes (WBCs) and platelets] in individual arterioles, capillaries, and venules, and in microvascular networks. We also review mechanical and rheological properties of the formed elements and their interactions with the vascular wall. We discuss short-term and long-term regulation of the microvasculature; the modes of regulation include metabolic, myogenic, and shear-stress-dependent mechanisms as well as vascular adaptation such as angiogenesis and vascular remodeling.

9 July 1998 in Physics of Fluids
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Journal Article
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CEC. D. Eggleton
C. D. Eggleton
Aleksander PopelAleksander Popel
Aleksander Popel
Red blood cells are known to change shape in response to local flow conditions. Deformability affects red blood cell physiological function and the hydrodynamic properties of blood. The immersed boundary method is used to simulate three-dimensional membrane–fluid flow interactions for cells with the same internal and external fluid viscosities. The method has been validated for small deformations of an initially spherical capsule in simple shear flow for both neo-Hookean and the Evans-Skalak membrane models. Initially oblate spheroidal capsules are simulated and it is shown that the red blood cell membrane exhibits asymptotic behavior as the ratio of the dilation modulus to the extensional modulus is increased and a good approximation of local area conservation is obtained. Tank treading behavior is observed and its period calculated.

1 February 2014 in Cytokine & Growth Factor Reviews
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Journal Article
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PVPrakash Vempati
Prakash Vempati
Aleksander PopelAleksander Popel
Aleksander Popel
FGFeilim Mac Gabhann
Feilim Mac Gabhann

1 July 2008 in Antioxidants & Redox Signaling
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Journal Article
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KCKejing Chen
Kejing Chen
RPRoland N. Pittman
Roland N. Pittman
Aleksander PopelAleksander Popel
Aleksander Popel
Nitric oxide (NO) affects two key aspects of O2 supply and demand: It regulates vascular tone and blood flow by activating soluble guanylate cyclase (sGC) in the vascular smooth muscle, and it controls mitochondrial O2 consumption by inhibiting cytochrome c oxidase. However, significant gaps exist in our quantitative understanding of the regulation of NO production in the vascular region. Large apparent discrepancies exist among the published reports that have analyzed the various pathways in terms of the perivascular NO concentration, the efficacy of NO in causing vasodilation (EC50), its efficacy in tissue respiration (IC50), and the paracrine and endocrine NO release. In this study, we review the NO literature, analyzing NO levels on various scales, identifying and analyzing the discrepancies in the reported data, and proposing hypotheses that can potentially reconcile these discrepancies. Resolving these issues is highly relevant to improving our understanding of vascular biology and to developing pharmaceutical agents that target NO pathways, such as vasodilating drugs. Antioxid. Redox Signal. 10, 1185–1198.

2 October 2007 in British Journal of Cancer
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Journal Article
Open access
CKC Kut
C Kut
FGF Mac Gabhann
F Mac Gabhann
Aleksander PopelAleksander Popel
Aleksander Popel
Vascular endothelial growth factor (VEGF) is a major target for the inhibition of tumour vascularisation and the treatment of human cancer. Many tumours produce large quantities of VEGF, and as a result, diagnosis and prognosis of cancer may be predicted by measuring changes in VEGF concentrations in blood. In blood, the VEGF may be located in the plasma, or in the blood-borne cells and formed elements, in particular, platelets and leukocytes. In this study, we collate the measurements of VEGF in platelets, leukocytes, plasma and serum for breast, prostate, colorectal and other cancers. In addition, we analysed the concentration of VEGF in tumour tissue itself, as well as for other tissues in the human body. Although the concentration of VEGF in tumours is high, the size of tumours is small compared to other tissues, in particular, skeletal muscle. Thus, the total quantity of VEGF in tumours and in blood is small compared to the quantity in muscles. This large reservoir of VEGF may have important implications for the treatment of cancer.

20 August 2010 in Microcirculation
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Journal Article
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DFDimitry Fedosov
Dimitry Fedosov
BCBruce Caswell
Bruce Caswell
Aleksander PopelAleksander Popel
Aleksander Popel
GKGeorge Em Karniadakis
George Em Karniadakis