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Prof. Serik MEIRMANOV
Ritsumeikan Asia Pacific University

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Journal article
Published: 13 August 2020 in Social Sciences
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Background: Despite the internationalization of higher education (IoHE) in Kazakhstan and it being among the top 15 countries sending students abroad, the level of student mobility between Kazakhstan and Japan and factors influencing it have not been well analyzed. Aim: The purpose of this study was to explore outgoing student mobility from Kazakhstan to Japan and the reasons underlining this situation. Methods: A descriptive study, involving a literature review and an analysis of data from the two largest universities in Kazakhstan together with those from the Bolashak international scholarship scheme, was performed. Results: The analysis suggested that outgoing student mobility from Kazakhstan to Japan remains at a stable but low level. The mobility of students is mainly a matter of the initiative of universities or the students themselves. The main reasons are the dependence of the policy of the IoHE on the foreign policy of Kazakhstan; the low level of pull factors for students such as affordability, recommendations from acquaintances, or lack of awareness about the country; and absence of a supportive legislative basis for the development of cooperation on higher education between the two countries. Conclusion: Given the areas of common interest economically and politically between Kazakhstan and Japan, there is potential for significantly more student mobility than there is at present.

ACS Style

Aktolkyn Rustemova; Serik Meirmanov; Akito Okada; Zhanar Ashinova; Kamshat Rustem. The Academic Mobility of Students from Kazakhstan to Japan: Problems and Prospects. Social Sciences 2020, 9, 143 .

AMA Style

Aktolkyn Rustemova, Serik Meirmanov, Akito Okada, Zhanar Ashinova, Kamshat Rustem. The Academic Mobility of Students from Kazakhstan to Japan: Problems and Prospects. Social Sciences. 2020; 9 (8):143.

Chicago/Turabian Style

Aktolkyn Rustemova; Serik Meirmanov; Akito Okada; Zhanar Ashinova; Kamshat Rustem. 2020. "The Academic Mobility of Students from Kazakhstan to Japan: Problems and Prospects." Social Sciences 9, no. 8: 143.

Journal article
Published: 28 March 2019 in Sustainability
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Stress and depression can be seen as the major obstacles for sustained education and attainment of foreign students, and in turn, the sustainability of an education system as a whole. However, the mainstream consideration following Berry’s model on acculturation does not take into account whether students of the host countries are immune to these problems. This study aims to examine the prevalence and predictors of help-seeking behaviors among international and domestic students in a multicultural environment by employing ANOVA and polynomial regression. Some significant results from this study are: (1) Informal sources were the most prevalent sources of help-seeking among international and domestic students, while formal help-seeking was not popular; (2) international students were more likely to overcome emotional difficulties alone and seek help on the Internet than domestic students; (3) acculturative stress was a positive predictor of formal, informal, and miscellaneous help-seeking behaviors among international students and informal help-seeking behaviors or among domestic students; and (4) depression was negatively correlated with the willingness of international students to seek help from informal sources. The findings hint at the risk of acculturative stress faced by domestic students in a multicultural environment being overlooked and the lack of help-seeking sources for international students. The study also provides empirical evidence for policy-planners to design a sustainable education system better at supporting students dealing with depression and acculturative stress.

ACS Style

Minh-Hoang Nguyen; Meirmanov Serik; Thu-Trang Vuong; Manh-Tung Ho. Internationalization and Its Discontents: Help-Seeking Behaviors of Students in a Multicultural Environment Regarding Acculturative Stress and Depression. Sustainability 2019, 11, 1865 .

AMA Style

Minh-Hoang Nguyen, Meirmanov Serik, Thu-Trang Vuong, Manh-Tung Ho. Internationalization and Its Discontents: Help-Seeking Behaviors of Students in a Multicultural Environment Regarding Acculturative Stress and Depression. Sustainability. 2019; 11 (7):1865.

Chicago/Turabian Style

Minh-Hoang Nguyen; Meirmanov Serik; Thu-Trang Vuong; Manh-Tung Ho. 2019. "Internationalization and Its Discontents: Help-Seeking Behaviors of Students in a Multicultural Environment Regarding Acculturative Stress and Depression." Sustainability 11, no. 7: 1865.

Journal article
Published: 08 February 2019 in Sustainability
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(1) This study aims to examine the prevalence of depression and its correlation with Acculturative Stress and Social Connectedness among domestic and international students in an international university in Japan. (2) Methods: A Web-based survey was distributed among several classes of students of the university, which yielded 268 responses. On the survey, a nine-item tool from the Patient Health Questionnaire (PHQ-9), the Social Connectedness Scale (SCS) and Acculturative Stress Scale for International Students (ASSIS) were used together with socio-demographic data. (3) Results: The prevalence of depression was higher among international than domestic students (37.81% and 29.85%, respectively). English language proficiency and student age (20 years old) showed a significant correlation with depression among domestic students (β = −1.63, p = 0.038 and β = 2.24, p = 0.048). Stay length (third year) also displayed a significant correlation with depression among international students (β = 1.08, p = 0.032). Among international and domestic students, a statistically significant positive correlation between depression and acculturative stress, and negative associations of social connectedness with depression and acculturative stress were also found. (4) Conclusions: The high prevalence of depression, and its association with Acculturation stress and Social Connectedness, among the students in this study highlight the importance of implementing support programs which consider the role of Acculturation and Social Connectedness.

ACS Style

Minh Hoang Nguyen; Tam Tri Le; Serik Meirmanov. Depression, Acculturative Stress, and Social Connectedness among International University Students in Japan: A Statistical Investigation. Sustainability 2019, 11, 878 .

AMA Style

Minh Hoang Nguyen, Tam Tri Le, Serik Meirmanov. Depression, Acculturative Stress, and Social Connectedness among International University Students in Japan: A Statistical Investigation. Sustainability. 2019; 11 (3):878.

Chicago/Turabian Style

Minh Hoang Nguyen; Tam Tri Le; Serik Meirmanov. 2019. "Depression, Acculturative Stress, and Social Connectedness among International University Students in Japan: A Statistical Investigation." Sustainability 11, no. 3: 878.

Preprint
Published: 24 December 2018
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(1) This study aimed to examine the prevalence of depression and its correlation with acculturative Stress and Social Connectedness among domestic and overseas students in Japan International University. (2) Methods: A Web-based survey was distributed among students of International University, which resulted in 263 responses. On the survey together with socio-demographic data, a nine-item tool from the Patient Health Questionnaire (PHQ-9), was used to measure the prevalence of Depression and its relationship with socio-demographic data, Social Connectedness Scale was used to measure Social Connectedness, and Acculturative Stress Scale for International Students (ASSIS) was used to measured acculturative stress. (3) Results: Depression was significantly high in international and domestic students (37.81% and 29.85% respectively). English language proficiency and students age (20 years old) showed a significant correlation with depression among domestic students (β=-1.63, p=0.038 and β=2.24, p=0.048). Stay length (third year) also displayed a significant correlation with depression among international students (β=1.08, p=0.032). Among international and domestic students statistically significant positive correlation between depression and acculturative stress, negative associations of social connectedness with depression and acculturative stress were also found. Suicidal or self-hurting ideation thoughts are found among around 20% of all students. (4) Conclusions: These findings indicate a relatively high prevalence of depression among students of International University, and overseas students are more affected. Depression, Acculturation stress and Social Connectedness show statistically strong intercorrelation, which highlights the need of host University to recognise the role of Acculturation and Social Connectedness in the development of Depression among students.

ACS Style

Minh Hoang Nguyen; Tam Tri Le; Serik Meirmanov. Depression, Acculturative Stress and Social Connectedness among International University Students in Japan: prevalence and correlation. 2018, 1 .

AMA Style

Minh Hoang Nguyen, Tam Tri Le, Serik Meirmanov. Depression, Acculturative Stress and Social Connectedness among International University Students in Japan: prevalence and correlation. . 2018; ():1.

Chicago/Turabian Style

Minh Hoang Nguyen; Tam Tri Le; Serik Meirmanov. 2018. "Depression, Acculturative Stress and Social Connectedness among International University Students in Japan: prevalence and correlation." , no. : 1.

Journal article
Published: 01 June 2014 in Iranian Journal of Public Health
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Kazakhstan, a developing middle-income country, has the highest road traffic collision (RTC) mortality in the European Region. The aims of this study were to determine main characteristics of road traffic fatalities in Semey region, Kazakhstan and to compare findings with National data and middle-income European countries. This descriptive surveillance study assesses RTC mortality rates and epidemiology in the Semey Region of East Kazakhstan Oblast. Data of all 318 road traffic fatalities form the Semey Regional Center for Forensic Medicine were analyzed for the 5-year period of January 1, 2006 through December 31, 2010. Over the study period, the average road traffic mortality in the Semey Region was 12.1 per 100,000 population with downward trend by 35.1% (p=0.002). The victims mean age was 37.1 (SD=17) years. Males predominated at 74.5%. Vehicle fatality was the most common mode of fatality at 61.3%. The majority of collisions, 53.1%, occurred on highways. Most victims, 67.3%, have died at the scene of collision; in 67.3% of fatalities, autopsies identified multiple injuries as cause of death. The high number of fatal collisions took place in “no snow” season (P<0.001), with an overall 5-years downward dynamic. High proportion of males, pedestrians and car occupants among road traffic fatalities; high proportion of death on scene in case of highway collisions are specifics for Semey region, Kazakhstan. These findings can be used to formulate preventive strategies to reduce fatalities and to improve the medical care system for road traffic fatalities.

ACS Style

Ayan Myssayev; Serik Meirmanov; Tolebay Rakhypbekov; Tolkyn Bulegenov; Yuliya Semenova. The Characteristics of Road Traffic Fatalities in Kazakhstan’s Semey Region, 2006-2010: A Descriptive Retrospective Study. Iranian Journal of Public Health 2014, 43, 760 -768.

AMA Style

Ayan Myssayev, Serik Meirmanov, Tolebay Rakhypbekov, Tolkyn Bulegenov, Yuliya Semenova. The Characteristics of Road Traffic Fatalities in Kazakhstan’s Semey Region, 2006-2010: A Descriptive Retrospective Study. Iranian Journal of Public Health. 2014; 43 (6):760-768.

Chicago/Turabian Style

Ayan Myssayev; Serik Meirmanov; Tolebay Rakhypbekov; Tolkyn Bulegenov; Yuliya Semenova. 2014. "The Characteristics of Road Traffic Fatalities in Kazakhstan’s Semey Region, 2006-2010: A Descriptive Retrospective Study." Iranian Journal of Public Health 43, no. 6: 760-768.

Journal article
Published: 16 March 2011 in The Breast Journal
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ACS Style

Ainur Akilzhanova; Serik Meirmanov; Tamara Zhunussova; Masahiro Nakashima; Noboru Takamura; Zhanay Akanov; Adilzhan Masadykov; Marat Sandybaev; Yerlan Ramankulov; Shunichi Yamashita; Ichiro Sekine. Mutational Screening of the BRCA1 Gene in Sporadic Breast Cancer in Kazakhstan Population. The Breast Journal 2011, 17, 328 -330.

AMA Style

Ainur Akilzhanova, Serik Meirmanov, Tamara Zhunussova, Masahiro Nakashima, Noboru Takamura, Zhanay Akanov, Adilzhan Masadykov, Marat Sandybaev, Yerlan Ramankulov, Shunichi Yamashita, Ichiro Sekine. Mutational Screening of the BRCA1 Gene in Sporadic Breast Cancer in Kazakhstan Population. The Breast Journal. 2011; 17 (3):328-330.

Chicago/Turabian Style

Ainur Akilzhanova; Serik Meirmanov; Tamara Zhunussova; Masahiro Nakashima; Noboru Takamura; Zhanay Akanov; Adilzhan Masadykov; Marat Sandybaev; Yerlan Ramankulov; Shunichi Yamashita; Ichiro Sekine. 2011. "Mutational Screening of the BRCA1 Gene in Sporadic Breast Cancer in Kazakhstan Population." The Breast Journal 17, no. 3: 328-330.

Conference paper
Published: 11 February 2009 in Radiation Health Risk Sciences
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It has been postulated that radiation induces breast cancers in atomic bomb survivors. Oncogene amplification is an important mechanism during breast carcinogenesis and also serves as an indicator of genomic instability (GIN). The aim of this study is to clarify the association of oncogene amplification in breast cancer in atomic bomb survivors with radiation exposure. A total of 593 breast cancers were identifi ed in atomic bomb survivors from 1968 to 1999, and the association between breast cancer incidence and atomic bomb radiation was evaluated. Invasive ductal cancers from 67 survivors and 30 nonsurvivors were analyzed for amplification of the HER2 and c-Myc genes by fl uorescence in situ hybridization and expression of hormone receptors by immunostaining. The incidence rate signifi cantly increased as exposure distance decreased from the hypocenter [hazard ratio (HR) per 1.0-km decrement, 1.47; 95% confi dence interval (CI), 1.30-1.66]. The incidence of HER2 and c-Myc amplification was significantly increased in the order of control, distal, and proximal groups (P=?0.0238 and 0.0128, respectively). Multivariate analyses revealed that distance was a risk factor for co-amplification of HER2 and c-Myc in breast cancer in survivors (odds ratio per 1.0-km increment, 0.17; 95% CI, 0.01-0.63]. The histological grading of breast cancers became signifi cantly higher in the order of control, distal, and proximal groups, and was associated with oncogene amplifications. This study suggested that atomic bomb radiation may affect the development of oncogene amplification by inducing GIN and may be associated with a higher histological grade in breast cancer found in survivors.

ACS Style

Shiro Miura; Masahiro Nakashima; Hisayoshi Kondo; Masahiro Ito; Serik Meirmanov; Tomayoshi Hayashi; Midori Soda; Ichiro Sekine. Significance of Oncogene Amplifications in Breast Cancer in Atomic Bomb Survivors: Associations with Radiation Exposure and Histological Grade. Radiation Health Risk Sciences 2009, 285 -293.

AMA Style

Shiro Miura, Masahiro Nakashima, Hisayoshi Kondo, Masahiro Ito, Serik Meirmanov, Tomayoshi Hayashi, Midori Soda, Ichiro Sekine. Significance of Oncogene Amplifications in Breast Cancer in Atomic Bomb Survivors: Associations with Radiation Exposure and Histological Grade. Radiation Health Risk Sciences. 2009; ():285-293.

Chicago/Turabian Style

Shiro Miura; Masahiro Nakashima; Hisayoshi Kondo; Masahiro Ito; Serik Meirmanov; Tomayoshi Hayashi; Midori Soda; Ichiro Sekine. 2009. "Significance of Oncogene Amplifications in Breast Cancer in Atomic Bomb Survivors: Associations with Radiation Exposure and Histological Grade." Radiation Health Risk Sciences , no. : 285-293.

Conference paper
Published: 11 February 2009 in Radiation Health Risk Sciences
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More than 60 years ago, on August 6 and 9, two atomic bombs destroyed two Japanese cities: Hiroshima and Nagasaki. It was the first time in history that a single weapon caused such enormous casualties in a population. About 120 000 and 75 000 people of Hiroshima and Nagasaki, respectively, most of whom were civilians, died instantaneously. Doctors and scientists had to contend with a new kind of unknown effect: irradiation. The public health system of Japan, as concerns atomic bomb survivors, has passed several stages of development: from individual dose evaluation to well-organized health care. This unique experience may be applied to other areas, such as cancer screening and elderly care. Over 40 years the USSR has tested nuclear bombs more than 450 times at the Semipalatinsk Nuclear Test Site (SNTS), Kazakhstan. There are many villages and larger settlements, including the city of Semey (distance from SNTS, about 150 km) in the vicinity of the test site. It is believed that hundreds of thousands of inhabitants were more or less exposed to long-term radiation fallout. The government of the Republic of Kazakhstan and the international community, including the government of Japan, have implemented several steps toward research on the influence of radioactive fallout and the support of health care of the Semey region inhabitants. However, research and health care concerning the people of the Semey region still needs improvement. For this purpose, the experience of the Japanese public health system may be useful.

ACS Style

Aikan Akanov; Serik Meirmanov; Arslan Indershiev; Aigul Musahanova; Shunichi Yamashita. Nuclear Explosions and Public Health Development. Radiation Health Risk Sciences 2009, 328 -333.

AMA Style

Aikan Akanov, Serik Meirmanov, Arslan Indershiev, Aigul Musahanova, Shunichi Yamashita. Nuclear Explosions and Public Health Development. Radiation Health Risk Sciences. 2009; ():328-333.

Chicago/Turabian Style

Aikan Akanov; Serik Meirmanov; Arslan Indershiev; Aigul Musahanova; Shunichi Yamashita. 2009. "Nuclear Explosions and Public Health Development." Radiation Health Risk Sciences , no. : 328-333.

Original article
Published: 17 March 2008 in Cancer
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BACKGROUND. It has been postulated that radiation induces breast cancers in atomic bomb (A‐bomb) survivors. Oncogene amplification is an important mechanism during breast carcinogenesis and also serves as an indicator of genomic instability (GIN). The objective of this study was to clarify the association of oncogene amplification in breast cancer in A‐bomb survivors with radiation exposure. METHODS. In total, 593 breast cancers were identified in A‐bomb survivors from 1968 to 1999, and the association between breast cancer incidence and A‐bomb radiation exposure was evaluated. Invasive ductal cancers from 67 survivors and 30 nonsurvivors were analyzed for amplification of the HER2 and C‐MYC genes by fluorescence in situ hybridization, and expression levels of hormone receptors were analyzed by immunostaining. RESULTS. The incidence rate increased significantly as exposure distance decreased from the hypocenter (hazard ratio per 1‐km decrement, 1.47; 95% confidence interval [95% CI], 1.30–1.66). The incidence of HER2 and C‐MYC amplification was increased significantly in the order of the control group, the distal group (P = .0238), and the proximal group (P = .0128). Multivariate analyses revealed that distance was a risk factor for the coamplification of C‐MYC and HER2 in breast cancer in survivors (odds ratio per 1‐km increment, 0.17; 95% CI, 0.01–0.63). The histologic grade of breast cancers became significantly higher in the order of the control group, the distal group, and the proximal group and was associated with oncogene amplifications. CONCLUSIONS. The current results suggested that A‐bomb radiation may affect the development of oncogene amplification by inducing GIN and may be associated with a higher histologic grade in breast cancer among A‐bomb survivors. Cancer 2008. © 2008 American Cancer Society.

ACS Style

Shiro Miura; Masahiro Nakashima; Masahiro Ito; Hisayoshi Kondo; Serik Meirmanov; Tomayoshi Hayashi; Midori Soda; Takeshi Matsuo; Ichiro Sekine. Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors. Cancer 2008, 112, 2143 -2151.

AMA Style

Shiro Miura, Masahiro Nakashima, Masahiro Ito, Hisayoshi Kondo, Serik Meirmanov, Tomayoshi Hayashi, Midori Soda, Takeshi Matsuo, Ichiro Sekine. Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors. Cancer. 2008; 112 (10):2143-2151.

Chicago/Turabian Style

Shiro Miura; Masahiro Nakashima; Masahiro Ito; Hisayoshi Kondo; Serik Meirmanov; Tomayoshi Hayashi; Midori Soda; Takeshi Matsuo; Ichiro Sekine. 2008. "Significance of HER2 and C-MYC oncogene amplifications in breast cancer in atomic bomb survivors." Cancer 112, no. 10: 2143-2151.

Early detection and diagnosis
Published: 05 November 2007 in International Journal of Cancer
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Defective DNA damage response (DDR) can result in genomic instability (GIN) and lead to the transformation into cancer. P53‐binding protein 1 (53BP1) belongs to a family of evolutionarily conserved DDR proteins. Because 53BP1 molecules localize at the sites of DNA double strand breaks (DSBs) and rapidly form nuclear foci, the presence of 53BP1 foci can be considered as a cytologic marker for endogenous DSBs reflecting GIN. Although it has been proposed that GIN has a crucial role in the progression of thyroid neoplasms, the significance of GIN during thyroid tumorigenesis remains unclear, particularly in patients. We analyzed, therefore, the level of GIN, as detected with immunofluorescence of 53BP1, in 40 cases of resected thyroid tissues. This study demonstrated a number of nuclear 53BP1 foci in thyroid cancers, suggesting a constitutive activation of DDR in thyroid cancer cells. Because follicular adenoma also showed a few 53BP1 nuclear foci, GIN might be induced at a precancerous stage of thyroid tumorigenesis. Furthermore, high‐grade thyroid cancers prominently exhibited an intense and heterogeneous nuclear staining of 53BP1 immunoreactivity, which was also observed in radiation‐associated cancers and in mouse colonic crypts as a delayed response to a high dose ionizing radiation, suggesting increased GIN with progression of cancer. Thus, the present study demonstrated a difference in the staining pattern of 53BP1 during thyroid carcinogenesis. We propose that immunofluorescence analysis of 53BP1 expression can be a useful tool to estimate the level of GIN and, simultaneously, the malignant potency of human thyroid tumors.

ACS Style

Masahiro Nakashima; Keiji Suzuki; Serik Meirmanov; Yuki Naruke; Mutsumi Matsuu-Matsuyama; Kazuko Shichijo; Vladimir Saenko; Hisayoshi Kondo; Tomayoshi Hayashi; Masahiro Ito; Shunichi Yamashita; Ichiro Sekine. Foci formation of P53-binding protein 1 in thyroid tumors: Activation of genomic instability during thyroid carcinogenesis. International Journal of Cancer 2007, 122, 1082 -1088.

AMA Style

Masahiro Nakashima, Keiji Suzuki, Serik Meirmanov, Yuki Naruke, Mutsumi Matsuu-Matsuyama, Kazuko Shichijo, Vladimir Saenko, Hisayoshi Kondo, Tomayoshi Hayashi, Masahiro Ito, Shunichi Yamashita, Ichiro Sekine. Foci formation of P53-binding protein 1 in thyroid tumors: Activation of genomic instability during thyroid carcinogenesis. International Journal of Cancer. 2007; 122 (5):1082-1088.

Chicago/Turabian Style

Masahiro Nakashima; Keiji Suzuki; Serik Meirmanov; Yuki Naruke; Mutsumi Matsuu-Matsuyama; Kazuko Shichijo; Vladimir Saenko; Hisayoshi Kondo; Tomayoshi Hayashi; Masahiro Ito; Shunichi Yamashita; Ichiro Sekine. 2007. "Foci formation of P53-binding protein 1 in thyroid tumors: Activation of genomic instability during thyroid carcinogenesis." International Journal of Cancer 122, no. 5: 1082-1088.

Article
Published: 08 June 2007 in Endocrine Pathology
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This study addressed the immunohistochemical expression of MUC1 in papillary thyroid carcinoma (PTC) of different histotypes, sizes, and morphological features of aggressiveness, and its correlation with the overexpression of cyclin D1, a target molecule of the Wnt pathway. MUC1 expression was examined in a total of 209 PTCs. Cytoplasmic MUC1 expression was elevated in the tall, columnar cell and oncocytic variants (100%), Warthin-like (78%), and conventional PTCs (61%), and in papillary microcarcinoma (PMC) with the conventional growth pattern (52%). On the contrary, it was low in the follicular variant (27%) of PTC and PMCs with follicular architecture (13%). Cytoplasmic MUC1 accumulation did not associate with any clinicopathological features except peritumoral lymphoid infiltration in PTCs and in PMCs with the conventional growth pattern. MUC1 staining correlated with cyclin D1 overexpression in conventional PTCs and PMCs and PMCs with follicular architecture. The results demonstrate that MUC1 expression varies broadly in different histological variants of PTC, being the lowest in tumors with follicular structure. In general, it does not prove to be a prognosticator of PTC aggressiveness. A high correlation between MUC1 and cyclin D1 implies MUC1 involvement in the Wnt cascade functioning in a large subset of human PTCs and PMCs.

ACS Style

A Abrosimov; Vladimir Saenko; Serik Meirmanov; Masahiro Nakashima; Tatiana Rogounovitch; Olesya Shkurko; Eugeny Lushnikov; Norisato Mitsutake; Hiroyuki Namba; Shunichi Yamashita. The Cytoplasmic Expression of MUC1 in Papillary Thyroid Carcinoma of Different Histological Variants and its Correlation with Cyclin D1 Overexpression. Endocrine Pathology 2007, 18, 68 -75.

AMA Style

A Abrosimov, Vladimir Saenko, Serik Meirmanov, Masahiro Nakashima, Tatiana Rogounovitch, Olesya Shkurko, Eugeny Lushnikov, Norisato Mitsutake, Hiroyuki Namba, Shunichi Yamashita. The Cytoplasmic Expression of MUC1 in Papillary Thyroid Carcinoma of Different Histological Variants and its Correlation with Cyclin D1 Overexpression. Endocrine Pathology. 2007; 18 (2):68-75.

Chicago/Turabian Style

A Abrosimov; Vladimir Saenko; Serik Meirmanov; Masahiro Nakashima; Tatiana Rogounovitch; Olesya Shkurko; Eugeny Lushnikov; Norisato Mitsutake; Hiroyuki Namba; Shunichi Yamashita. 2007. "The Cytoplasmic Expression of MUC1 in Papillary Thyroid Carcinoma of Different Histological Variants and its Correlation with Cyclin D1 Overexpression." Endocrine Pathology 18, no. 2: 68-75.

Journal article
Published: 28 February 2007 in International Congress Series
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ACS Style

Alexander Yu. Abrosimov; Olesya A. Shkurko; Vladimir A. Saenko; Serik Meirmanov; Tatiana I. Rogounovitch; Evgeny F. Lushnikov; Masahiro Nakashima; Hiroyuki Namba; Norisato Mitsutake; Shunichi Yamashita. Immunoexpression of MUC1 in papillary thyroid carcinoma: An association with aberrant expression of β-catenin and cyclin D1 overexpression. International Congress Series 2007, 1299, 263 -270.

AMA Style

Alexander Yu. Abrosimov, Olesya A. Shkurko, Vladimir A. Saenko, Serik Meirmanov, Tatiana I. Rogounovitch, Evgeny F. Lushnikov, Masahiro Nakashima, Hiroyuki Namba, Norisato Mitsutake, Shunichi Yamashita. Immunoexpression of MUC1 in papillary thyroid carcinoma: An association with aberrant expression of β-catenin and cyclin D1 overexpression. International Congress Series. 2007; 1299 ():263-270.

Chicago/Turabian Style

Alexander Yu. Abrosimov; Olesya A. Shkurko; Vladimir A. Saenko; Serik Meirmanov; Tatiana I. Rogounovitch; Evgeny F. Lushnikov; Masahiro Nakashima; Hiroyuki Namba; Norisato Mitsutake; Shunichi Yamashita. 2007. "Immunoexpression of MUC1 in papillary thyroid carcinoma: An association with aberrant expression of β-catenin and cyclin D1 overexpression." International Congress Series 1299, no. : 263-270.

Journal article
Published: 28 February 2007 in International Congress Series
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RET oncogene rearrangement is a well-known molecular alteration observed in papillary thyroid cancer (PTC). RET rearrangement is the commonest oncogenic alterations in Chernobyl-related PTC; nearly all to RET/PTC1 or RET/PTC3, resulting from paracentric inversion of chromosome 10. Other less common variants, usually forming as a result of interchromosomal translocation, occur in an extremely limited number of cases. Most often such translocations have been found in radiation-induced PTC. Here, we report the presence of RET oncogene amplification, a new type of RET cytogenetic alteration, in human thyroid cancers. RET amplification was correlated with radiation-associated, high-grade malignant potency, and p53 overexpression, suggesting genomic instability. We also examined p53-binding protein 1 (53BP1) expressions with immunostaining to clarify the presence of genomic instability in thyroid cancers. In thyroid tumors, the level of 53BP1-focus formation was associated with malignant transformation and high-grade malignant potency as well as RET amplification. RET amplification might be induced by a high level of genomic instability with progression of thyroid carcinogenesis and, subsequently, be associated with radiation-induced and/or high-grade malignant cases.

ACS Style

Masahiro Nakashima; Noboru Takamura; Hiroyuki Namba; Vladimir A. Saenko; Keiji Suzuki; Serik Meirmanov; Tomayoshi Hayashi; Ichiro Sekine. RET oncogene amplification in thyroid cancer: Correlations with radiation-associated, high-grade malignancy, and genomic instability. International Congress Series 2007, 1299, 251 -255.

AMA Style

Masahiro Nakashima, Noboru Takamura, Hiroyuki Namba, Vladimir A. Saenko, Keiji Suzuki, Serik Meirmanov, Tomayoshi Hayashi, Ichiro Sekine. RET oncogene amplification in thyroid cancer: Correlations with radiation-associated, high-grade malignancy, and genomic instability. International Congress Series. 2007; 1299 ():251-255.

Chicago/Turabian Style

Masahiro Nakashima; Noboru Takamura; Hiroyuki Namba; Vladimir A. Saenko; Keiji Suzuki; Serik Meirmanov; Tomayoshi Hayashi; Ichiro Sekine. 2007. "RET oncogene amplification in thyroid cancer: Correlations with radiation-associated, high-grade malignancy, and genomic instability." International Congress Series 1299, no. : 251-255.

Journal article
Published: 31 January 2007 in Human Pathology
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A radiation etiology is well known in thyroid carcinogenesis. RET oncogene rearrangement is the most common oncogenic alteration in Chernobyl-related papillary thyroid cancer (PTC). To find the characteristic alteration associated with RET rearrangements in radiation-induced thyroid cancers, we analyzed the RET oncogene by fluorescence in situ hybridization. The fluorescence in situ hybridization technique has the possibility of detecting RET rearrangements at a single-cell level regardless of the specific fusion partner involved and directly reveals RET copy number on a per-cell basis. Our study demonstrated RET amplification in all 3 cases of radiation-associated thyroid cancers but not in sporadic well-differentiated PTC (n = 11). Furthermore, RET amplification was observed in all 6 cases of sporadic anaplastic thyroid cancers (ATCs). The frequency of RET amplification-positive cells was higher in ATC (7.2%-24.1%) than in PTC (1.5%-2.7%). The highest frequency of RET amplification-positive cells was observed among ATC cases with a strong p53 immunoreactivity. In conclusion, we found RET amplification, which is a rare oncogenic aberration, in thyroid cancer. This report is the first one to suggest the presence of RET amplification in PTC and ATC. RET amplification was correlated with radiation-associated, high-grade malignant potency, and p53 accumulation, suggesting genomic instability. RET amplification might be induced by a high level of genomic instability in connection with progression of thyroid carcinogenesis and, subsequently, be associated with radiation-induced and/or high-grade malignant cases.

ACS Style

Masahiro Nakashima; Noboru Takamura; Hiroyuki Namba; Vladimir Saenko; Serik Meirmanov; Naomichi Matsumoto; Tomayoshi Hayashi; Shigeto Maeda; Ichiro Sekine. RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy. Human Pathology 2007, 38, 621 -628.

AMA Style

Masahiro Nakashima, Noboru Takamura, Hiroyuki Namba, Vladimir Saenko, Serik Meirmanov, Naomichi Matsumoto, Tomayoshi Hayashi, Shigeto Maeda, Ichiro Sekine. RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy. Human Pathology. 2007; 38 (4):621-628.

Chicago/Turabian Style

Masahiro Nakashima; Noboru Takamura; Hiroyuki Namba; Vladimir Saenko; Serik Meirmanov; Naomichi Matsumoto; Tomayoshi Hayashi; Shigeto Maeda; Ichiro Sekine. 2007. "RET oncogene amplification in thyroid cancer: correlations with radiation-associated and high-grade malignancy." Human Pathology 38, no. 4: 621-628.

Evaluation study
Published: 01 January 2007 in Endocrine Journal
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The activating point mutation of the BRAF gene, BRAFT1799A, is the most common and specific genetic alteration in adult papillary thyroid carcinoma (PTC) and a possible marker of malignant potential of PTC. We have applied the PCR-RFLP method using fine-needle aspiration biopsy samples not only to our clinical practice but also to the international medical assistance effort around the Semipalatinsk Nuclear Testing Site in Kazakhstan. Seventy-seven cases (100 nodules) from Japan and 131 cases (137 nodules) from Kazakhstan were examined. There were 14 Japanese and 76 Kazakhstani cases of cytological malignant tumors from the examined samples. We detected 12 (85.7% of PTC) and 19 (25% of PTC) cases with BRAFT1799A among the Japanese and Kazakhstani cases, respectively. Of these cases, we found mutations in one cytologically "suspicious" case and even in two pathologically "benign" cases (after surgery in Kazakhstan). All of the BRAF mutation-positive cases, including those three, were confirmed as PTC by careful pathological examination, including immunohistochemical analysis. In summary, our PCR-RFLP method for BRAFT1799A detection using FNAB samples is useful not only for preoperative diagnosis of PTC but also as a complementary diagnostic tool for accurate pathological diagnosis, even after surgery.

ACS Style

Atsushi Kumagai; Hiroyuki Namba; Zhanay Akanov; Vladimir A. Saenko; Serik Meirmanov; Akira Ohtsuru; Hiroshi Yano; Shigeto Maeda; Masanobu Anami; Tomayoshi Hayashi; Masahiro Ito; Sagadat Sagandikova; Zhanar Eleubaeva; Daniyal Mussinov; Maira Espenbetova; Shunichi Yamashita. Clinical Implications of Pre-Operative Rapid BRAF Analysis for Papillary Thyroid Cancer. Endocrine Journal 2007, 54, 399 -405.

AMA Style

Atsushi Kumagai, Hiroyuki Namba, Zhanay Akanov, Vladimir A. Saenko, Serik Meirmanov, Akira Ohtsuru, Hiroshi Yano, Shigeto Maeda, Masanobu Anami, Tomayoshi Hayashi, Masahiro Ito, Sagadat Sagandikova, Zhanar Eleubaeva, Daniyal Mussinov, Maira Espenbetova, Shunichi Yamashita. Clinical Implications of Pre-Operative Rapid BRAF Analysis for Papillary Thyroid Cancer. Endocrine Journal. 2007; 54 (3):399-405.

Chicago/Turabian Style

Atsushi Kumagai; Hiroyuki Namba; Zhanay Akanov; Vladimir A. Saenko; Serik Meirmanov; Akira Ohtsuru; Hiroshi Yano; Shigeto Maeda; Masanobu Anami; Tomayoshi Hayashi; Masahiro Ito; Sagadat Sagandikova; Zhanar Eleubaeva; Daniyal Mussinov; Maira Espenbetova; Shunichi Yamashita. 2007. "Clinical Implications of Pre-Operative Rapid BRAF Analysis for Papillary Thyroid Cancer." Endocrine Journal 54, no. 3: 399-405.

Journal article
Published: 19 August 2005 in Histopathology
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Aims : Cyclin D1 is a target molecule transcriptionally activated by aberrant β‐catenin in Wnt signalling. Thyroid papillary microcarcinoma (PMC) may be considered a precursor of papillary thyroid cancer (PTC). Ki67 is widely used as a proliferation marker. The aim of this study was to determine whether cyclin D1 overexpression is involved in early thyroid carcinogenesis. Methods and results : Thirty‐five cases of PMC were examined immunohistochemically, including 11 cases less than 5 mm (PMC < 5) and 24 cases more than 5 mm (PMC > 5), and 18 PTC cases (size 11–15 mm). Cyclin D1 expression was significantly lower in PMC < 5 than in PMC > 5, while there was no significant difference between PMC > 5 and PTC. Statistical analysis revealed significant correlations between cyclin D1 labelling index (LI) and Ki67 LI (P = 0.0272)/cytoplasmic β‐catenin expression (P < 0.001) in PMC and PTC. Four of five PMC > 5 cases with lymph node (LN) metastases displayed a high cyclin D1 LI and strong cytoplasmic β‐catenin expression. Conclusions : Cyclin D1 overexpression and correlation with aberrant β‐catenin expression were demonstrated in PMC. Cyclin D1 expression was significantly associated with tumour size and LN metastases in PMC. Cyclin D1 may be up‐regulated at an early stage of thyroid carcinogenesis and promote tumour growth and metastatic potency in PMC through activation of the Wnt/β‐catenin pathway.

ACS Style

D Lantsov; Serik Meirmanov; M Nakashima; H Kondo; V Saenko; Y Naruke; H Namba; M Ito; A Abrosimov; E Lushnikov; I Sekine; Sh Yamashita; Shunichi Yamashita. Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant beta-catenin expression. Histopathology 2005, 47, 248 -256.

AMA Style

D Lantsov, Serik Meirmanov, M Nakashima, H Kondo, V Saenko, Y Naruke, H Namba, M Ito, A Abrosimov, E Lushnikov, I Sekine, Sh Yamashita, Shunichi Yamashita. Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant beta-catenin expression. Histopathology. 2005; 47 (3):248-256.

Chicago/Turabian Style

D Lantsov; Serik Meirmanov; M Nakashima; H Kondo; V Saenko; Y Naruke; H Namba; M Ito; A Abrosimov; E Lushnikov; I Sekine; Sh Yamashita; Shunichi Yamashita. 2005. "Cyclin D1 overexpression in thyroid papillary microcarcinoma: its association with tumour size and aberrant beta-catenin expression." Histopathology 47, no. 3: 248-256.

Case reports
Published: 21 July 2005 in Pathology - Research and Practice
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Primary pulmonary artery sarcomas (PASs) are rare and lethal tumors. They are easily misdiagnosed as chronic pulmonary embolism, mediastinal mass or tumor emboli, which delay a proper treatment. Although the advanced technologies are now increasingly being used, their diagnosis is usually hard to establish preoperatively at the present time. We report here a case of a 68-year-old female with PAS with lung metastases, who firstly presented with symptoms of common cold and anemia. Although a PAS had been suspected, the final diagnosis of pulmonary intimal sarcoma was made only postoperatively by histological and immunohistochemical examination. The patient died 8 months after the operation because of tumor growth progression, despite adjuvant chemotherapy and radiation therapy. Although pulmonary intimal sarcomas are usually of poorly differentiated mesenchymal malignancy, most reported cases are immunohistochemically positive for vimentin, α-smooth muscle actin (SMA), and/or desmin, therefore resembling leiomyosarcomas. However, the diagnosis of leiomyosarcoma should not be made on the basis of immunostains in the absence of typical morphologic features, and PAS, like the present case, should be more appropriately classified as intimal sarcoma according to the new WHO Classification of Tumours of Soft Tissue and Bone published in 2002.

ACS Style

Shiro Miura; Serik Meirmanov; Masahiro Nakashima; Tomayoshi Hayashi; Kuniko Abe; Naoe Tamaru; Yoshiyuki Miyahara; Ichiro Sekine. Intimal sarcoma of the pulmonary artery: Report of an autopsy case. Pathology - Research and Practice 2005, 201, 469 -474.

AMA Style

Shiro Miura, Serik Meirmanov, Masahiro Nakashima, Tomayoshi Hayashi, Kuniko Abe, Naoe Tamaru, Yoshiyuki Miyahara, Ichiro Sekine. Intimal sarcoma of the pulmonary artery: Report of an autopsy case. Pathology - Research and Practice. 2005; 201 (6):469-474.

Chicago/Turabian Style

Shiro Miura; Serik Meirmanov; Masahiro Nakashima; Tomayoshi Hayashi; Kuniko Abe; Naoe Tamaru; Yoshiyuki Miyahara; Ichiro Sekine. 2005. "Intimal sarcoma of the pulmonary artery: Report of an autopsy case." Pathology - Research and Practice 201, no. 6: 469-474.

Journal article
Published: 01 April 2005 in Thyroid
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Premature senescence may play an important role as an acute, drug-, or ionizing radiation (IR)-inducible growth arrest program along with interphase apoptosis and mitotic catastrophe. The aim of the study was to evaluate whether IR can induce senescence-like phenotype (SLP) associated with terminal growth arrest in the thyroid cells, and if so, to evaluate impact of terminal growth arrest associated with SLP in intrinsic radiosensitivity of various thyroid carcinomas. The induction of SLP in thyroid cells were identified by: (1) senescence associated β-galactosidase (SA-β-Gal) staining method, (2) dual-flow cytometric analysis of cell proliferation and side light scatter using vital staining with PKH-2 fluorescent dye, (3) double labeling for 5-bromodeoxyuridine and SA- β-Gal, (4) Staining for SA-β-Gal with consequent antithyroglobulin immunohistochemistry. IR induced SLP associated with terminal growth arrest in four thyroid cancer cells lines and in primary thyrocytes in time- and dose-dependent manner. Analysis of relationship between induction of SLP and radiosensitivity revealed a trend in which more radioresistant cell lines strongly tended to show lower specific SLP yields (r = -0.93, p = 0.068). We find out that SA-β-Gal staining is detectable in irradiated ARO xenotransplants, but not in control tumors. We, therefore, conclude that induction of SLP with terminal growth arrest contribute to the elimination of clonogenic populations after IR.

ACS Style

Alexei Podtcheko; Hiroyuki Namba; Vladimir Saenko; Akira Ohtsuru; Dmitriy Starenki; Serik Meirmanov; Iryna Polona; Tatiana Rogounovitch; Shunichi Yamashita. Radiation-Induced Senescence-Like Terminal Growth Arrest in Thyroid Cells. Thyroid 2005, 15, 306 -313.

AMA Style

Alexei Podtcheko, Hiroyuki Namba, Vladimir Saenko, Akira Ohtsuru, Dmitriy Starenki, Serik Meirmanov, Iryna Polona, Tatiana Rogounovitch, Shunichi Yamashita. Radiation-Induced Senescence-Like Terminal Growth Arrest in Thyroid Cells. Thyroid. 2005; 15 (4):306-313.

Chicago/Turabian Style

Alexei Podtcheko; Hiroyuki Namba; Vladimir Saenko; Akira Ohtsuru; Dmitriy Starenki; Serik Meirmanov; Iryna Polona; Tatiana Rogounovitch; Shunichi Yamashita. 2005. "Radiation-Induced Senescence-Like Terminal Growth Arrest in Thyroid Cells." Thyroid 15, no. 4: 306-313.

Journal article
Published: 01 December 2004 in International Journal of Oncology
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Mutation in exon 15 of the BRAF gene is a characteristic feature of human thyroid papillary carcinoma (PTC). To determine the role of such mutation(s) in the neoplastic progression of thyroid papillary microcarcinoma (PMC), we analyzed 46 cases from 31 Russian and 15 Japanese patients with PMC. Mutated BRAF (the BRAFT1796A transversion in all cases) was detected in 13/46 (28.2%) of the tumors: 9/31 (29.0%) and 4/15 (26.6%) in Russian and Japanese individuals, respectively, displaying no signs of difference in the mutational rates in the PMCs from patients with diverse genetic background seen in PTCs. Occurrence of the BRAF mutation did not significantly correlate with the patients' gender, age at presentation, metastatic indices or with papillary, mixed papillary and follicular, and solid/trabecular PMC histotype. On the contrary, the tumors of follicular morphology significantly associated with the mutation-free genotype (P=0.018), and in the mixed-type tumors characterized by co-occurrence of well-differentiated and less differentiated components, the BRAF mutational frequency was significantly elevated (P=0.020). The results indicate the BRAFT1796A mutation is prevalent in PMCs, and thus these tumors may have a spectrum of genetic events partly overlapping with that of PTCs.

ACS Style

Ilya Sedliarou; Vladimir Saenko; Dmitry Lantsov; Tatiana Rogounovitch; Hiroyuki Namba; Aleksandr Abrosimov; Eugeny Lushnikov; Atsushi Kumagai; Masahiro Nakashima; Serik Meirmanov; Mariko Mine; Tomayoshi Hayashi; Shunichi Yamashita. The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma. International Journal of Oncology 2004, 25, 1729 -1735.

AMA Style

Ilya Sedliarou, Vladimir Saenko, Dmitry Lantsov, Tatiana Rogounovitch, Hiroyuki Namba, Aleksandr Abrosimov, Eugeny Lushnikov, Atsushi Kumagai, Masahiro Nakashima, Serik Meirmanov, Mariko Mine, Tomayoshi Hayashi, Shunichi Yamashita. The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma. International Journal of Oncology. 2004; 25 (6):1729-1735.

Chicago/Turabian Style

Ilya Sedliarou; Vladimir Saenko; Dmitry Lantsov; Tatiana Rogounovitch; Hiroyuki Namba; Aleksandr Abrosimov; Eugeny Lushnikov; Atsushi Kumagai; Masahiro Nakashima; Serik Meirmanov; Mariko Mine; Tomayoshi Hayashi; Shunichi Yamashita. 2004. "The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma." International Journal of Oncology 25, no. 6: 1729-1735.

Original paper
Published: 19 February 2004 in The Journal of Pathology
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Cyclin D1 is a target molecule transcriptionally activated by aberrant β‐catenin in Wnt signalling, while prolyl isomerase Pin1 promotes cyclin D1 overexpression directly or through accumulation of β‐catenin in cancer cells. This study aimed to elucidate whether Pin1 was involved in cyclin D1 overexpression and aberrant β‐catenin in thyroid tumourigenesis by examining 14 follicular adenomas (FAa) and 14 papillary thyroid carcinomas (PTCs). All PTCs displayed cyclin D1 overexpression and strong cytoplasmic β‐catenin and/or decreased membrane β‐catenin expression by immunohistochemistry. Overexpression of cyclin D1 mRNA was observed in 45.5% of FAs and 54.5% of PTCs by TaqMan real‐time PCR. Pin1 expression was observed in PTC by immunostaining and was confirmed by reverse transcriptase‐PCR. There was a strong correlation between cyclin D1 and Pin1/cytoplasmic/membrane β‐catenin expression (p < 0.001), and between Pin1 and cytoplasmic (p < 0.001)/membrane (p = 0.002) β‐catenin expression in thyroid tumours. Mutation of the β‐catenin gene could not be detected in PTC. Western blot analysis demonstrated high levels of cyclin D1 and β‐catenin as well as Pin1 expression in a human PTC cell line possessing wild‐type β‐catenin and APC genes. This study suggests that both cyclin D1 overexpression and aberrant β‐catenin expression are of significance in thyroid tumours. Pin1 expression appears to correlate closely with the level of cyclin D1 and aberrant β‐catenin expression in thyroid tumours such as FA and PTC. Pin1 may be an important factor in regulating cyclin D1 and β‐catenin expression during thyroid carcinogenesis. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

ACS Style

Masahiro Nakashima; Serik Meirmanov; Yuki Naruke; Hisayoshi Kondo; Vladimir Saenko; Tatiana Rogounovitch; Yuki Shimizu-Yoshida; Noboru Takamura; Hiroyuki Namba; Masahiro Ito; Aleksander Abrosimov; Eugeny Lushnikov; Pavel Roumiantsev; Anatoly Tsyb; Shunichi Yamashita; Ichiro Sekine. Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrantβ-catenin expression. The Journal of Pathology 2004, 202, 446 -455.

AMA Style

Masahiro Nakashima, Serik Meirmanov, Yuki Naruke, Hisayoshi Kondo, Vladimir Saenko, Tatiana Rogounovitch, Yuki Shimizu-Yoshida, Noboru Takamura, Hiroyuki Namba, Masahiro Ito, Aleksander Abrosimov, Eugeny Lushnikov, Pavel Roumiantsev, Anatoly Tsyb, Shunichi Yamashita, Ichiro Sekine. Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrantβ-catenin expression. The Journal of Pathology. 2004; 202 (4):446-455.

Chicago/Turabian Style

Masahiro Nakashima; Serik Meirmanov; Yuki Naruke; Hisayoshi Kondo; Vladimir Saenko; Tatiana Rogounovitch; Yuki Shimizu-Yoshida; Noboru Takamura; Hiroyuki Namba; Masahiro Ito; Aleksander Abrosimov; Eugeny Lushnikov; Pavel Roumiantsev; Anatoly Tsyb; Shunichi Yamashita; Ichiro Sekine. 2004. "Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrantβ-catenin expression." The Journal of Pathology 202, no. 4: 446-455.