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Prof. Aleksandar Ž. Kostić
University of Belgrade, Faculty of Agriculture, Chair of Chemistry and Biochemistry

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0 Antioxidants
0 Food Chemistry
0 pollen
0 phytochemical analysis
0 bioactive compounds

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pollen
Antioxidants
bioactive compounds
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phytochemical analysis

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Short Biography

Dr Aleksandar Ž. Kostić is Assistant professor at Chair of Chemistry and Biochemistry, Faculty of Agriculture, University of Belgrade, teaching in different Chemistry courses. His research area is focused on phytochemistry (with special emphasis on pollen chemistry and nutrition and bioactive compounds in plant materials), food chemistry, water chemistry, health risk assessment for human expressed through food and water consummation and polyacrylic hydrogels. Until now, he is author and co-author of more than seventy scientific papers in total (twenty five peer-reviewed articles), two university textbooks and two student handbooks. His articles have been cited more than 300 times, h-index is 12 (Google Scholar). He is a reviewer for top International Journals such as Trends in Analytical Chemistry, Biomolecules, Phytochemistry, Phytochemical Analysis, Food Chemistry, Food Hydrocolloids, Talanta, International Journal of Molecular Sciences, Journal of the Science of Food and Agriculture, Biomolecules, Journal of Functional Foods, Molecules, Foods, Journal of Food Composition and Analysis, Plant Physiology and Biochemistry, Toxins, Polymers, Pharmaceutics, LWT-Food Science and Technology, Chemistry & Biodiversity, etc. He is a member of Serbian Chemical Society, International Bee Research Association (IBRA), IHC (International Honey Comission) expertise group for pollen, Society for Medicinal Plant and Natural Product Research.

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Journal article
Published: 29 July 2021 in Theory and practice of meat processing
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The objective of this study was to determine whether the addition of different pollen powder concentrations (0.5; 1.0 and 1.5 g/100 g) had an influence on techno-functional, textural and sensorial traits of frankfurters. Examining the techno-functional characteristics of pollen, a conclusion was reached that the higher the concentration, the higher the emulsification and better techno-functional properties. Also, FTIR-ATR analysis has shown that specific pollen molecules provided good emulsifying properties of sausages. On the other hand, sensory analysis showed that sausages with the addition of 1.0% and 1.5% of pollen powder have a more pronounced floral odor. Warner-Bratzler shear force test has shown that the incorporation of pollen caused a more stable product throughout sixty days of storage than the control sample. It could be explained by the formation of more protein-protein interactions due to the addition of non-meat proteins in the formulation of frankfurters and obtaining a more stable product than the control one. All things considered, it can be concluded that pollen exhibits good techno-functional properties and could be utilized in the formulation of frankfurters with improved and steady techno-functional properties during two months of refrigerated storage.

ACS Style

S. M. Novakovic; I. V. Djekic; M. B. Pesic; A. Z. Kostic; D. D. Milincic; I. В. Tomasevic. Techno-functional, textural and sensorial properties of frankfurters as affected by the addition of bee pollen powder. Theory and practice of meat processing 2021, 6, 135-140 .

AMA Style

S. M. Novakovic, I. V. Djekic, M. B. Pesic, A. Z. Kostic, D. D. Milincic, I. В. Tomasevic. Techno-functional, textural and sensorial properties of frankfurters as affected by the addition of bee pollen powder. Theory and practice of meat processing. 2021; 6 (2):135-140.

Chicago/Turabian Style

S. M. Novakovic; I. V. Djekic; M. B. Pesic; A. Z. Kostic; D. D. Milincic; I. В. Tomasevic. 2021. "Techno-functional, textural and sensorial properties of frankfurters as affected by the addition of bee pollen powder." Theory and practice of meat processing 6, no. 2: 135-140.

Journal article
Published: 07 July 2021 in Antioxidants
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The current study intended to determine, for the first time, phenolic and fatty acid profile, antioxidant and certain nutritional properties of monofloral bee-collected artichoke (Cynara scolymus) pollen. Based on UHPLC-DAD MS-MS analysis the main phenolics in extractable fraction were different flavonol glycosides (in particular Isorhamnetin-3-O-glucoside, 49.2 mg/kg of dry weight) while ferulic acid was the predominant phenolic compound (39.4 mg/kg of dry weight) in the alkaline hydrolyzable fraction. Among fatty acids (FAs), results of GC-FID analysis revealed prevalence of unsaturated FAs with cis-5,8,11,14,17-eicosapentaenoic acid (EPA) and oleic acid as the main ones- 28.4% and 24.9%, respectively. Based on the FA composition, nutritional analysis proved that artichoke bee-collected pollen had balanced ω-6 and ω-3 FAs content. To determine the antioxidant properties of pollen, five different assays were applied. It was proved that bioactive compounds in artichoke pollen possessed significant ability to quench DPPH radical as well as ABTS radical cation. In addition, in vitro phosphomolybdenum assay confirmed that artichoke pollen is an excellent source of different antioxidants. Pollen extracts exhibited moderate ferric reducing power as well as low ferrous chelating ability. Some further antioxidant studies (preferably in vivo) should be performed to confirm the observed results.

ACS Style

Aleksandar Kostić; Danijel Milinčić; Nebojša Nedić; Uroš Gašić; Bojana Špirović Trifunović; Denis Vojt; Živoslav Tešić; Mirjana Pešić. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara scolymus) Pollen. Antioxidants 2021, 10, 1091 .

AMA Style

Aleksandar Kostić, Danijel Milinčić, Nebojša Nedić, Uroš Gašić, Bojana Špirović Trifunović, Denis Vojt, Živoslav Tešić, Mirjana Pešić. Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara scolymus) Pollen. Antioxidants. 2021; 10 (7):1091.

Chicago/Turabian Style

Aleksandar Kostić; Danijel Milinčić; Nebojša Nedić; Uroš Gašić; Bojana Špirović Trifunović; Denis Vojt; Živoslav Tešić; Mirjana Pešić. 2021. "Phytochemical Profile and Antioxidant Properties of Bee-Collected Artichoke (Cynara scolymus) Pollen." Antioxidants 10, no. 7: 1091.

Journal article
Published: 30 June 2021 in Biomolecules
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The aim of this research was phenolics and protein characterization and antioxidant properties evaluation of skimmed thermally treated goat’s milk powder enriched with different concentration of grape pomace seed extract (SE). The dominant phenolics in SE were phenolic acids, flavan–3-ols and procyanidins. Different electrophoretic techniques together with UHPLC-MS/MS analysis revealed the presence of phenolics-protein interactions in the samples, mainly procyanidins with whey protein/caseins complexes. Addition of SE into thermally treated goat’s milk significantly improved antioxidant properties of goat’s milk such as TAC, FRP, DPPH and ABTS•+ scavenging activity. Gallic acid, catechin, and procyanidins mostly contributed to these activities. The schematic representation of phenolics–casein micelles interactions in thermally treated goat’s milk enriched with SE was given. The addition of SE into thermally treated goat’s milk can be a promising strategy in food waste recovery and to enhance the beneficial health effects of goat’s milk-based functional foods.

ACS Style

Danijel Milinčić; Aleksandar Kostić; Uroš Gašić; Steva Lević; Slađana Stanojević; Miroljub Barać; Živoslav Tešić; Viktor Nedović; Mirjana Pešić. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules 2021, 11, 965 .

AMA Style

Danijel Milinčić, Aleksandar Kostić, Uroš Gašić, Steva Lević, Slađana Stanojević, Miroljub Barać, Živoslav Tešić, Viktor Nedović, Mirjana Pešić. Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties. Biomolecules. 2021; 11 (7):965.

Chicago/Turabian Style

Danijel Milinčić; Aleksandar Kostić; Uroš Gašić; Steva Lević; Slađana Stanojević; Miroljub Barać; Živoslav Tešić; Viktor Nedović; Mirjana Pešić. 2021. "Skimmed Goat’s Milk Powder Enriched with Grape Pomace Seed Extract: Phenolics and Protein Characterization and Antioxidant Properties." Biomolecules 11, no. 7: 965.

Article
Published: 01 March 2021 in Biological Trace Element Research
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Vegetables are important contributors to a healthy diet, and their adequate daily intake can help prevent some of the major illnesses. The aim of the study was to examine the content of the major and trace elements in selected organically grown (OG) and conventionally grown (CG) vegetables (cabbage, kohlrabi, Brussels sprout, beetroot, carrot, potato, and onion), taken from city green markets. Multi-elemental analysis was carried out by inductively coupled plasma method with optical emission spectrometry (ICP-OES). Nutritional quality evaluation in comparison to nutritional reference values was done. In studied vegetables, Al, Ca, K, Fe (with the exception of organic kohlrabi), Mg, Na, P, S, and Zn were quantified in all samples, whereas As, Cd, Co, Hg, Se, and V were below the limit of detection for these elements. Macroelements and trace elements were found at higher concentrations in OG and CG vegetables, respectively. Differences in concentrations of studied elements between the same vegetable species produced in two agricultural systems were significant, except for beetroot (p ≤ 0.05). Principal component analysis and hierarchical cluster analysis results showed that the botanical origin had higher influence on sample differentiation than the agronomic practice, which was in accordance with the results obtained by Mann-Whitney U test. Good quality of both OG and CG vegetables in respect of nutritionally beneficial elements was observed.

ACS Style

Jelena B. Popović-Djordjević; Aleksandar Ž. Kostić; Miloš B. Rajković; Irena Miljković; Đurđa Krstić; Gianluca Caruso; Sina Siavash Moghaddam; Ilija Brčeski. Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation. Biological Trace Element Research 2021, 1 -11.

AMA Style

Jelena B. Popović-Djordjević, Aleksandar Ž. Kostić, Miloš B. Rajković, Irena Miljković, Đurđa Krstić, Gianluca Caruso, Sina Siavash Moghaddam, Ilija Brčeski. Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation. Biological Trace Element Research. 2021; ():1-11.

Chicago/Turabian Style

Jelena B. Popović-Djordjević; Aleksandar Ž. Kostić; Miloš B. Rajković; Irena Miljković; Đurđa Krstić; Gianluca Caruso; Sina Siavash Moghaddam; Ilija Brčeski. 2021. "Organically vs. Conventionally Grown Vegetables: Multi-elemental Analysis and Nutritional Evaluation." Biological Trace Element Research , no. : 1-11.

Journal article
Published: 18 February 2021 in Food Chemistry
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The aim of research was to determine polyphenols bioaccessibility and antioxidant properties of thermally-treated skimmed goat milk enriched with sunflower bee-collected pollen through in vitro digestion. HPLC analysis confirmed that pollen-enriched milk contained flavonols as the main phenolic fraction (80.7–76.2%) followed by phenolic acids (14.2–17.4%). Among individual compounds quercetin-3-O-glucoside (155.1–197.2 μg/L) and p-coumaric acid (29.5–30.7 μg/L) were the main quantified flavonols and phenolic acids, respectively. After digestion of milk/pollen sample, total polyphenols recovery was 30.71% with higher phenolic acids recovery (40.1%) compared to flavonols (28.3%) indicating strong interactions between caprine milk casein micelles and pollen polyphenols. Applied antioxidant assays (phosphomolybdenum, ABTS•+scavenging activity and ferrous-ion-chelating capacity) have confirmed complexity of prepared product- it had high ability to quench ABTS•+ radicals and to form chelating complexes with Fe2+ ions. Digestion provoked 20% reduction in total antioxidant capacity compared to the initial sample. TTSG milk/pollen powder could be good functional ingredient.

ACS Style

Aleksandar Ž. Kostić; Danijel D. Milinčić; Nemanja S. Stanisavljević; Uroš M. Gašić; Steva Lević; Milan O. Kojić; Živoslav Lj. Tešić; Viktor Nedović; Miroljub B. Barać; Mirjana B. Pešić. Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen. Food Chemistry 2021, 351, 129310 .

AMA Style

Aleksandar Ž. Kostić, Danijel D. Milinčić, Nemanja S. Stanisavljević, Uroš M. Gašić, Steva Lević, Milan O. Kojić, Živoslav Lj. Tešić, Viktor Nedović, Miroljub B. Barać, Mirjana B. Pešić. Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen. Food Chemistry. 2021; 351 ():129310.

Chicago/Turabian Style

Aleksandar Ž. Kostić; Danijel D. Milinčić; Nemanja S. Stanisavljević; Uroš M. Gašić; Steva Lević; Milan O. Kojić; Živoslav Lj. Tešić; Viktor Nedović; Miroljub B. Barać; Mirjana B. Pešić. 2021. "Polyphenol bioaccessibility and antioxidant properties of in vitro digested spray-dried thermally-treated skimmed goat milk enriched with pollen." Food Chemistry 351, no. : 129310.

Journal article
Published: 11 February 2021 in Zemdirbyste-Agriculture
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ACS Style

Jelena M. Golijan; Danijel D. Milinčić; Radivoj B. Petronijević; Mirjana B. Pešić; Sladjana P. Stanojević; Miroljub B. Barać; Slavoljub Lekić; Aleksandar Ž. Kostić. Comparison of sugars, lipids and phenolics content in the grains of organically and conventionally grown soybean in Serbia. Zemdirbyste-Agriculture 2021, 108, 51 -56.

AMA Style

Jelena M. Golijan, Danijel D. Milinčić, Radivoj B. Petronijević, Mirjana B. Pešić, Sladjana P. Stanojević, Miroljub B. Barać, Slavoljub Lekić, Aleksandar Ž. Kostić. Comparison of sugars, lipids and phenolics content in the grains of organically and conventionally grown soybean in Serbia. Zemdirbyste-Agriculture. 2021; 108 (1):51-56.

Chicago/Turabian Style

Jelena M. Golijan; Danijel D. Milinčić; Radivoj B. Petronijević; Mirjana B. Pešić; Sladjana P. Stanojević; Miroljub B. Barać; Slavoljub Lekić; Aleksandar Ž. Kostić. 2021. "Comparison of sugars, lipids and phenolics content in the grains of organically and conventionally grown soybean in Serbia." Zemdirbyste-Agriculture 108, no. 1: 51-56.

Research article
Published: 01 February 2021 in Journal of Environmental Science and Health, Part B
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Soybean soaking water whey (SWW) is obtained as the waste of soy milk production and mostly represents an environmental problem. The aim of this study was to assess the content of proteins and content and activity of trypsin inhibitors of fresh SWW, obtained during soy milk production. Two zones of Bowman-Birk trypsin inhibitors (BBI) were detected. One was identified as a monomeric form of BBI (0.61-2.93%) and the other one was identified as a polymeric form of BBI (0.45-3.33%). The degree of BBI extraction (1.88-5.49%) was influenced by the soybean genotype and the grain size, i.e. it increased with increasing grain size. Kunitz trypsin inhibitor was not detected. Total proteins were found in traces in SWW (0.03-0.06%). Low residual trypsin inhibitor activity (0.32-0.55%) suggested that SWW can potentially be applied for preparing food or feed. In that case it will not be waste but a cheap functional supplement with BBI as a biologically active component.

ACS Style

Sladjana P. Stanojevic; Miroljub B. Barać; Aleksandar Ž. Kostić; Mirjana B. Pešić. Trypsin inhibitor content and activity of soaking water whey as waste in soy milk processing. Journal of Environmental Science and Health, Part B 2021, 56, 292 -296.

AMA Style

Sladjana P. Stanojevic, Miroljub B. Barać, Aleksandar Ž. Kostić, Mirjana B. Pešić. Trypsin inhibitor content and activity of soaking water whey as waste in soy milk processing. Journal of Environmental Science and Health, Part B. 2021; 56 (3):292-296.

Chicago/Turabian Style

Sladjana P. Stanojevic; Miroljub B. Barać; Aleksandar Ž. Kostić; Mirjana B. Pešić. 2021. "Trypsin inhibitor content and activity of soaking water whey as waste in soy milk processing." Journal of Environmental Science and Health, Part B 56, no. 3: 292-296.

Journal article
Published: 21 January 2021 in Arabian Journal of Chemistry
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In this study, the chemical profile of bee pollen (BP) and bee bread (BB) samples collected from the same beehive were analyzed by LC–MS/MS (liquid chromatography technique coupled with tandem mass spectrometry), providing the identification of 23 phenolic compounds and 42 free amino acids (FAAs). Rutin was the phenolic compound with the highest rate of occurrence in both BP and BB samples. However, concentrations of protocatechuic acid, 2,5-dihydroxybenzoic acid and kaempferol compounds were significantly higher in BB samples than in BP samples from the same hive probably as result of microbial activity and glycosides degradation. The obtained data revealed that the phenolic profiles of the samples differ not only by the type of a product but also by region. Among FAAs proline was the predominant compound in all the analyzed BP and BB samples followed by l-asparagine (BP samples) and l-aspartic acid (BP and BB samples). A high content of proline can be used as a parameter of sample freshness. Also, Principal Component Analysis (PCA) and Cluster analysis proved the possibility of using phlorizin as a chemotaxonomic marker for Rosaceae (Malus or Prunus genus) pollen presence in BP1 sample. In addition, amino acid profile had higher impact on BP and BB sample differentiation due to lower FAAs content in BB samples probably caused by microbial activity. To the best of our knowledge, this study is the first to compare the individual phenolic compounds and free amino acids of bee pollen and bee bread samples with the same botanical origin (predominantly originated from plants belonging to the following families: Asteraceae, Fabaceae, Plantaginaceae and Rosaceae).

ACS Style

Nesrin Ecem Bayram; Yusuf Can Gercek; Saffet Çelik; Nazlı Mayda; Aleksandar Ž. Kostić; Aleksandra M. Dramićanin; Aslı Özkök. Phenolic and free amino acid profiles of bee bread and bee pollen with the same botanical origin – similarities and differences. Arabian Journal of Chemistry 2021, 14, 103004 .

AMA Style

Nesrin Ecem Bayram, Yusuf Can Gercek, Saffet Çelik, Nazlı Mayda, Aleksandar Ž. Kostić, Aleksandra M. Dramićanin, Aslı Özkök. Phenolic and free amino acid profiles of bee bread and bee pollen with the same botanical origin – similarities and differences. Arabian Journal of Chemistry. 2021; 14 (3):103004.

Chicago/Turabian Style

Nesrin Ecem Bayram; Yusuf Can Gercek; Saffet Çelik; Nazlı Mayda; Aleksandar Ž. Kostić; Aleksandra M. Dramićanin; Aslı Özkök. 2021. "Phenolic and free amino acid profiles of bee bread and bee pollen with the same botanical origin – similarities and differences." Arabian Journal of Chemistry 14, no. 3: 103004.

Journal article
Published: 01 January 2021 in Phyton
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ACS Style

Stefan M. Kolašinac; Zora P. Dajić Stevanović; Sofija N. Kilibarda; Aleksandar Ž. Kostić. Carotenoids: New Applications of “Old” Pigments. Phyton 2021, 90, 1041 -1062.

AMA Style

Stefan M. Kolašinac, Zora P. Dajić Stevanović, Sofija N. Kilibarda, Aleksandar Ž. Kostić. Carotenoids: New Applications of “Old” Pigments. Phyton. 2021; 90 (4):1041-1062.

Chicago/Turabian Style

Stefan M. Kolašinac; Zora P. Dajić Stevanović; Sofija N. Kilibarda; Aleksandar Ž. Kostić. 2021. "Carotenoids: New Applications of “Old” Pigments." Phyton 90, no. 4: 1041-1062.

Journal article
Published: 11 December 2020 in LWT
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Phenolic compounds and biopotential (antioxidant, cellular antioxidant and cytotoxic activity) of grape pomace (GP) skin, seed, stem and whole GP originating from indigenous red grape variety Prokupac were evaluated. The UHPLC-Orbitrap MS4 analysis showed the presence of 75 phenolic compounds (57 non-anthocyanins and 18 anthocyanins), among which considerable content of ethyl gallate was observed and malvidin-3-O-hexoside-(8,8)-methylmethyne-(epi)catechin was identified. The stem had significant content of stilbenoids. The GP seed and the whole GP showed the highest antioxidant activity estimated by ABTS•+ DPPH• and H2O2 scavenging assays that were strongly correlated with the presence of flavan-3-ols, phenolic acids and ethyl gallate. The GP skin exerted cellular antioxidant activity on adenocarcinoma cells (EC50 = 56.4 mg TPCs/mL) which was strongly correlated with the presence of flavonols and anthocyanins. These by-products of Prokupac red grape variety are a notable source of phenolic compounds with good antioxidant activity that can be extensively used in food and pharmaceutical industry.

ACS Style

Danijel D. Milinčić; Nemanja S. Stanisavljević; Aleksandar Ž. Kostić; Svetlana Soković Bajić; Milan O. Kojić; Uroš M. Gašić; Miroljub B. Barać; Sladjana P. Stanojević; Živoslav Lj Tešić; Mirjana B. Pešić. Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety. LWT 2020, 138, 110739 .

AMA Style

Danijel D. Milinčić, Nemanja S. Stanisavljević, Aleksandar Ž. Kostić, Svetlana Soković Bajić, Milan O. Kojić, Uroš M. Gašić, Miroljub B. Barać, Sladjana P. Stanojević, Živoslav Lj Tešić, Mirjana B. Pešić. Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety. LWT. 2020; 138 ():110739.

Chicago/Turabian Style

Danijel D. Milinčić; Nemanja S. Stanisavljević; Aleksandar Ž. Kostić; Svetlana Soković Bajić; Milan O. Kojić; Uroš M. Gašić; Miroljub B. Barać; Sladjana P. Stanojević; Živoslav Lj Tešić; Mirjana B. Pešić. 2020. "Phenolic compounds and biopotential of grape pomace extracts from Prokupac red grape variety." LWT 138, no. : 110739.

Book chapter
Published: 20 November 2020 in Saffron
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Crocus sativus is a plant from Iridaceae family that blooms in the autumn and does not grow in the wild. The plant is mostly cultivated because of red flower stigmas that after drying make the highly valued saffron spice with the unique organoleptic attributes, also named as “red gold.” As the synthetic antioxidants became a matter of safety concern for usage in the food industry, the attention of scientists was drawn to further exploration of the antioxidant power and health benefits of antioxidants from herbs and spices. The chemical composition of stigmas, related to primary and secondary metabolites, make saffron a rich source of distinct bioactive compounds with pronounced antioxidant properties. Among them, crocin, crocetin, picrocrocin, and safranal are the most important ones that contribute to sensory properties of saffron. Literature data suggest that stigmas (saffron spice) posses a great antioxidant potential expressed through in vitro and in vivo assays. On the other hand, there is an increasing number of studies showing that saffron processing waste and plant “specific parts” may be a rich source of bioactive compounds with significant antioxidant activity. The significance of valorization of the waste material originated from the saffron crop is especially relevant in the terms of the agri-food sector and environmental pollution reduction.

ACS Style

Jelena B. Popović-Djordjević; Aleksandar Ž. Kostić; Mustafa Kiralan. Antioxidant activities of bioactive compounds and various extracts obtained from saffron. Saffron 2020, 41 -97.

AMA Style

Jelena B. Popović-Djordjević, Aleksandar Ž. Kostić, Mustafa Kiralan. Antioxidant activities of bioactive compounds and various extracts obtained from saffron. Saffron. 2020; ():41-97.

Chicago/Turabian Style

Jelena B. Popović-Djordjević; Aleksandar Ž. Kostić; Mustafa Kiralan. 2020. "Antioxidant activities of bioactive compounds and various extracts obtained from saffron." Saffron , no. : 41-97.

Review
Published: 03 April 2020 in Chemistry & Biodiversity
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Herbal drugs are a useful source of different bioactive compounds. Asteraceae species, as the most widespread vascular plants can be used both as food and as medicine due to the great diversity of recorded chemical components - different phenolic compounds, terpenes, carotenoids, vitamins, alkaloids, etc. The Balkan Peninsula is characterized by great diversity of plants from Asteraceae family, including presence of rare and endemic species. In this review, results of the survey of chemical composition and biological activity, mainly focusing on antioxidant, antimicrobial and anticancer effects of selected Balkans' Asteraceae species were provided. In addition, information on edible plants from Asteraceae family is presented, due to growing interest for the so-called "healthy diet" and possible application of Balkans' Asteraceae species as food of high nutritional value or as a source of functional food ingredients.

ACS Style

Aleksandar Ž. Kostić; Peđa Janaćković; Stefan M. Kolašinac; Zora P. Dajić Stevanović. Balkans’ Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry. Chemistry & Biodiversity 2020, 17, 1 .

AMA Style

Aleksandar Ž. Kostić, Peđa Janaćković, Stefan M. Kolašinac, Zora P. Dajić Stevanović. Balkans’ Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry. Chemistry & Biodiversity. 2020; 17 (6):1.

Chicago/Turabian Style

Aleksandar Ž. Kostić; Peđa Janaćković; Stefan M. Kolašinac; Zora P. Dajić Stevanović. 2020. "Balkans’ Asteraceae Species as a Source of Biologically Active Compounds for the Pharmaceutical and Food Industry." Chemistry & Biodiversity 17, no. 6: 1.

Journal article
Published: 19 March 2020 in Chemosphere
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The aim of this study was to investigate the bioaccessibility of pesticide residues in blueberries (commercial and sample from controlled field trial) from Serbia, involving the presence of a complex food matrix and to assess the potential risk to human health. The presence of nine active substances (azoxystrobin, boscalid, fludioxonil, cyprodinil, pyrimethanil, pyridaben, pyriproxyfen, acetamiprid and thiametoxam) in initial blueberry samples was determined in concentration range from 5.15 μg/kg for thiametoxam to 187 μg/kg for azoxystrobin. Clothianidin, metabolite of thiametoxam, was not detected in any blueberry sample. However, after in vitro digestion, the content of initially detected pesticides residues was significantly decreased or it was below limit of quantification resulting in the total bioaccessibility of about 15%. Azoxystrobin, pyrimethanil and fludioxonil was quantified in digestive juice at concentrations which were about 81%, 37% and 10% less than the inital concentration, respectively. The presence of food matrix during digestion of blueberries even more severely reduced concentration of pesticide residues (total bioaccessibility was about 7%) compared to digestion without the food matrix. Only azoxystrobin was quantified after digestion with food matrix in concentration of 27 μg/kg in sample from controlled field trial and detected in two commercial samples but below the limit of quantification. Furthermore, chronic risk assessment indicated that risk is acceptable for the health of different human subpopulation groups. The current study on pesticides residues, most commonly applied on blueberries, provides for the first time an insight into their bioaccessibility under conditions that mimic physiological environment of human digestive tract.

ACS Style

Danijel D. Milinčić; Uroš D. Vojinović; Aleksandar Ž. Kostić; Mirjana Pešić; Bojana D. Špirović Trifunović; Dragica V. Brkić; Milan Ž. Stević; Milan Kojic; Nemanja S. Stanisavljević. In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix. Chemosphere 2020, 252, 126568 .

AMA Style

Danijel D. Milinčić, Uroš D. Vojinović, Aleksandar Ž. Kostić, Mirjana Pešić, Bojana D. Špirović Trifunović, Dragica V. Brkić, Milan Ž. Stević, Milan Kojic, Nemanja S. Stanisavljević. In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix. Chemosphere. 2020; 252 ():126568.

Chicago/Turabian Style

Danijel D. Milinčić; Uroš D. Vojinović; Aleksandar Ž. Kostić; Mirjana Pešić; Bojana D. Špirović Trifunović; Dragica V. Brkić; Milan Ž. Stević; Milan Kojic; Nemanja S. Stanisavljević. 2020. "In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix." Chemosphere 252, no. : 126568.

Research
Published: 13 March 2020 in Cereal Chemistry
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Background and objectives Quinoa is considered to be a “natural functional food” due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health‐promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings 13 phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration, and time‐dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT‐116, as well as the presence of 7 new phenolic and flavonoid compounds.

ACS Style

Radmila I. Stikić; Danijel Milinčić; Aleksandar Ž. Kostić; Zorica B. Jovanović; Uroš Gašić; Živoslav Lj. Tešić; Nataša Z. Djordjević; Sladjana K. Savić; Borisz G. Czekus; Mirjana Pešić. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. Cereal Chemistry 2020, 97, 626 -633.

AMA Style

Radmila I. Stikić, Danijel Milinčić, Aleksandar Ž. Kostić, Zorica B. Jovanović, Uroš Gašić, Živoslav Lj. Tešić, Nataša Z. Djordjević, Sladjana K. Savić, Borisz G. Czekus, Mirjana Pešić. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. Cereal Chemistry. 2020; 97 (3):626-633.

Chicago/Turabian Style

Radmila I. Stikić; Danijel Milinčić; Aleksandar Ž. Kostić; Zorica B. Jovanović; Uroš Gašić; Živoslav Lj. Tešić; Nataša Z. Djordjević; Sladjana K. Savić; Borisz G. Czekus; Mirjana Pešić. 2020. "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars." Cereal Chemistry 97, no. 3: 626-633.

Conference paper
Published: 04 February 2020 in 8th European Medical and Biological Engineering Conference
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Vegetables play an important role in human nutrition and their importance in diet is determined by its chemical composition. Numerous studies indicate a high degree of contamination of soil and plants produced in certain agro-ecological conditions, especially near urban and industrial areas. Accordingly, toxic and potentially toxic elements (aluminum, chromium, copper, manganese, nickel, lead and zinc) were quantified in edible parts of four vegetable species (potato, cabbage, carrot and broccoli) by means of inductively coupled plasma–optical emission spectrometry (ICP–OES). In addition, health risk assessment was done and expressed through estimated weekly intake of elements (EWI) and hazard quotient (HQ). Samples of each species originating from different localities were collected from three green markets in the city of Belgrade (Serbia). The content of studied elements ranged from 1.32 to 4.00, 0.31 to 5.77, 3.50 to 23.11, 1.82 to 11.17 and 2.11 to 10.62 mg/kg for aluminum, cooper, manganese, nickel and zinc, respectively. Chromium was detected in carrot sample (1.76 mg/kg), whereas concentration of lead in two samples of broccoli exceeded the maximum allowed concentration (>0.3 mg/kg) set by the national regulations. The average estimated weekly intakes for Al, Cu, and Zn were within the safe limits set by FAO/WHO, while for Ni and Pb in some vegetables were considerably higher than proposed values. In respect to the obtained results, a great weekly health risk was indicated for chromium, nickel and lead with the highest HQ values: 2.44, 10.32 and 2.02, respectively. The results of the study impose the necessity for continuous monitoring of harmful elements content in individual vegetable crops as well as strict regulative guide-lines in order to diminish possibility of contamination.

ACS Style

Irena Miljković; Jelena Popović-Djordjević; Miloš B. Rajković; Aleksandar Ž. Kostić; Blaženka Popović; Ilija Brčeski. Quantification of Selected Toxic and Potentially Toxic Elements in Vegetables, and Health Risk Assessment. 8th European Medical and Biological Engineering Conference 2020, 229 -236.

AMA Style

Irena Miljković, Jelena Popović-Djordjević, Miloš B. Rajković, Aleksandar Ž. Kostić, Blaženka Popović, Ilija Brčeski. Quantification of Selected Toxic and Potentially Toxic Elements in Vegetables, and Health Risk Assessment. 8th European Medical and Biological Engineering Conference. 2020; ():229-236.

Chicago/Turabian Style

Irena Miljković; Jelena Popović-Djordjević; Miloš B. Rajković; Aleksandar Ž. Kostić; Blaženka Popović; Ilija Brčeski. 2020. "Quantification of Selected Toxic and Potentially Toxic Elements in Vegetables, and Health Risk Assessment." 8th European Medical and Biological Engineering Conference , no. : 229-236.

Conference paper
Published: 04 February 2020 in 8th European Medical and Biological Engineering Conference
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Pollen (floral or bee-collected) can be used as a good source of different nutrients including several important biogenic elements (minerals). The aim of this study was to determine content of selected biogenic elements (phosphorous, potassium, sulphur, calcium, magnesium, iron and zinc) in monofloral bee-collected pollen originated from sunflower (Helianthus annuus L.) plants grown in Serbia and to estimate its nutritional value regarding to elements content. In that purpose ICP-OES analytical method was applied. According to obtained results the examined pollen sample contains above mentioned elements in following quantities: P – 3523.98 mg/kg; K – 2869.13 mg/kg; S – 1951.74 mg/kg; Ca – 1919.20 mg/kg; Mg – 654.36 mg/kg; Fe –83.55 mg/kg; Zn – 45.92 mg/kg of dry weight. Based on recommended daily intakes for iron, phosphorus and zinc application of pollen, as food or food ingredient, will cover meaningful part of human needs for these three important elements.

ACS Style

Aleksandar Ž. Kostić; Biljana P. Dojčinović; Nebojša Nedić; Danijel Milinčić; Nebojša Đ. Pantelić; Sladjana P. Stanojević; Miroljub B. Barać; Živoslav Lj. Tešić; Mirjana Pešić. Content and Nutritional Value of Selected Biogenic Elements in Monofloral Sunflower Bee-Collected Pollen from Serbia. 8th European Medical and Biological Engineering Conference 2020, 211 -217.

AMA Style

Aleksandar Ž. Kostić, Biljana P. Dojčinović, Nebojša Nedić, Danijel Milinčić, Nebojša Đ. Pantelić, Sladjana P. Stanojević, Miroljub B. Barać, Živoslav Lj. Tešić, Mirjana Pešić. Content and Nutritional Value of Selected Biogenic Elements in Monofloral Sunflower Bee-Collected Pollen from Serbia. 8th European Medical and Biological Engineering Conference. 2020; ():211-217.

Chicago/Turabian Style

Aleksandar Ž. Kostić; Biljana P. Dojčinović; Nebojša Nedić; Danijel Milinčić; Nebojša Đ. Pantelić; Sladjana P. Stanojević; Miroljub B. Barać; Živoslav Lj. Tešić; Mirjana Pešić. 2020. "Content and Nutritional Value of Selected Biogenic Elements in Monofloral Sunflower Bee-Collected Pollen from Serbia." 8th European Medical and Biological Engineering Conference , no. : 211-217.

Review
Published: 05 January 2020 in Biomolecules
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Pollen is recognized as an excellent dietary supplement for human nutrition, which is why it can be found in different forms on the market (granules, capsules, tablets, pellets, and powders). But, the digestibility of pollen’s nutrients is strongly affected by the presence of a pollen shell, which can decrease the bioavailability of nutrients by 50% and more. Since consumers have become more aware of the benefits of a healthy diet and the necessity to improve pollen digestibility, different pollen-based functional food products have been developed and extensive studies were done to estimate the beneficial effects of pollen-based feed on animal growth, health, and rigor mortise stage. Considering the positive effects of pollen nutrients and phytometabolites on human and animal health, the aim of this paper was to give an overview of recent achievements in the application of pollen in the formulation of functional food and animal diets. Special attention was paid to the effects of pollen’s addition on the nutritional, functional, techno-functional, and sensory properties of the new formulated food products. Anti-nutritional properties of pollen were also discussed. This review points out the benefits of pollen addition to food and feed and the possible directions in the further development of functional food and feed for the wellbeing of everyone.

ACS Style

Aleksandar Ž. Kostić; Danijel D. Milinčić; Miroljub B. Barać; Mohammad Ali Shariati; Živoslav Lj. Tešić; Mirjana B. Pešić. The Application of Pollen as a Functional Food and Feed Ingredient—The Present and Perspectives. Biomolecules 2020, 10, 84 .

AMA Style

Aleksandar Ž. Kostić, Danijel D. Milinčić, Miroljub B. Barać, Mohammad Ali Shariati, Živoslav Lj. Tešić, Mirjana B. Pešić. The Application of Pollen as a Functional Food and Feed Ingredient—The Present and Perspectives. Biomolecules. 2020; 10 (1):84.

Chicago/Turabian Style

Aleksandar Ž. Kostić; Danijel D. Milinčić; Miroljub B. Barać; Mohammad Ali Shariati; Živoslav Lj. Tešić; Mirjana B. Pešić. 2020. "The Application of Pollen as a Functional Food and Feed Ingredient—The Present and Perspectives." Biomolecules 10, no. 1: 84.

Journal article
Published: 01 January 2020 in Journal of the Serbian Chemical Society
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The aim of this study was to determine fatty acid and soluble sugar profiles of the grape seed flour originated from non-fermented dried pomace of international and autochthonous grape varieties in order to estimate their potential nutritional value. The grape seed flours were obtained from the grapes harvested in technological maturity. It has been shown that grape seed flours contained significant quantities of unsaturated fatty acids (UFAs), especially linoleic fatty acids, whose content ranged from 61.15 - 83.47 %. Oleic acid mostly contributed to the content of monounsaturated fatty acids, while the stearic acid was the most abundant saturated fatty acid (SFA). Among polyunsaturated fatty acids, mainly ?-6 FAs, were the most represented. The tested grape seed flours had the high UFA/SFA ratio (3.63- 11.09), low atherogenicity (0.04-0.13) and thrombogenicity (0.16-0.47) indices. Fifteen different sugars were found in analysed samples with the total concentration ranging from 40588 to 91319 mg/kg seed with fructose and glucose as the most abundant. Principal component analysis based on the content of FAs and soluble sugars revealed unique composition of the seed flour of Prokupac variety. These findings indicate that the tested grape seed flours is a good source of nutritionally valuable FAs and sugars that can play an important role in the formulation of a new functional food products.

ACS Style

Danijel Milinčić; Aleksandar Ž. Kostić; Bojana D. Špirović-Trifunović; Živoslav Lj. Tešić; Tomislav B. Tosti; Aleksandra M. Dramićanin; Miroljub B. Barać; Mirjana B. Pešić. Grape seed flour of different grape pomaces: Fatty acid profile, soluble sugar profile and nutritional value. Journal of the Serbian Chemical Society 2020, 85, 305 -319.

AMA Style

Danijel Milinčić, Aleksandar Ž. Kostić, Bojana D. Špirović-Trifunović, Živoslav Lj. Tešić, Tomislav B. Tosti, Aleksandra M. Dramićanin, Miroljub B. Barać, Mirjana B. Pešić. Grape seed flour of different grape pomaces: Fatty acid profile, soluble sugar profile and nutritional value. Journal of the Serbian Chemical Society. 2020; 85 (3):305-319.

Chicago/Turabian Style

Danijel Milinčić; Aleksandar Ž. Kostić; Bojana D. Špirović-Trifunović; Živoslav Lj. Tešić; Tomislav B. Tosti; Aleksandra M. Dramićanin; Miroljub B. Barać; Mirjana B. Pešić. 2020. "Grape seed flour of different grape pomaces: Fatty acid profile, soluble sugar profile and nutritional value." Journal of the Serbian Chemical Society 85, no. 3: 305-319.

Journal article
Published: 27 December 2019 in Food Technology and Biotechnology
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The aim of this paper is to determine nutritive, functional, microbiological and sensory properties of probiotic beverages produced from different volume ratios of cow's milk and soy beverage (25:75, 50:50 and 75:25). Pure cow’s milk and soy beverage served as control samples. Fermentation was performed at 43 °C by a combined culture consisting of the probiotic strain Lactobacillus acidophilus La5 and yoghurt culture. Viable counts of La5 strain in the produced beverages ranged from 7.52 to 8.20 log CFU/mL, which is above the probiotic minimum (106 CFU/mL). Lactic acid was the most prevalent organic acid in all samples (660.1 to 1003.0 mg/100 mL). The fatty acid profiles of fermented beverages were as follows: the mass fraction of saturated fatty acids was 22.2–82.7 %, of unsaturated fatty acids 22.3–77.8 % and of polyunsaturated fatty acids 15.5–65.9 %. The main soy sugars were transformed well (80 % stachyose and 50 % raffinose conversion) into lactic acid during fermentation. Functional probiotic beverages were successfully produced from different volume ratios of cow's milk and soy beverage by L. acidophilus La5 and yoghurt culture. Mixing cow's milk with soy beverage significantly improved the sensory properties of the product, especially its smell, taste and colour. The acceptability test showed good acceptance by potential consumers of all fermented beverage samples except for the sample made from 100 % soy beverage. In the end, the obtained results represent a good basis for optimisation of the ideal volume ratios of cow's milk and soy beverage for production of fermented beverages characterised by good viability of probiotic bacteria as well as by good functional, nutritive and sensory characteristics.

ACS Style

Edina Šertović; Zlatan Sarić; Miroljub Barać; Irena Barukčić; Aleksandar Kostić; Rajka Božanić. Physical, Chemical, Microbiological and Sensory Characteristics of a Probiotic Beverage Produced from Different Mixtures of Cow's Milk and Soy Beverage by Lactobacillus acidophilus La5 and Yoghurt Culture. Food Technology and Biotechnology 2019, 57, 461 -467.

AMA Style

Edina Šertović, Zlatan Sarić, Miroljub Barać, Irena Barukčić, Aleksandar Kostić, Rajka Božanić. Physical, Chemical, Microbiological and Sensory Characteristics of a Probiotic Beverage Produced from Different Mixtures of Cow's Milk and Soy Beverage by Lactobacillus acidophilus La5 and Yoghurt Culture. Food Technology and Biotechnology. 2019; 57 (4):461-467.

Chicago/Turabian Style

Edina Šertović; Zlatan Sarić; Miroljub Barać; Irena Barukčić; Aleksandar Kostić; Rajka Božanić. 2019. "Physical, Chemical, Microbiological and Sensory Characteristics of a Probiotic Beverage Produced from Different Mixtures of Cow's Milk and Soy Beverage by Lactobacillus acidophilus La5 and Yoghurt Culture." Food Technology and Biotechnology 57, no. 4: 461-467.

Review
Published: 25 November 2019 in Biomolecules
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Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

ACS Style

Javad Sharifi-Rad; Farzad Kobarfard; Athar Ata; Seyed Abdulmajid Ayatollahi; Nafiseh Khosravi-Dehaghi; Arun Kumar Jugran; Merve Tomas; Esra Capanoglu; Karl R. Matthews; Jelena Popović-Djordjević; Aleksandar Kostić; Senem Kamiloglu; Farukh Sharopov; Muhammad Iqbal Choudhary; Natália Martins. Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence. Biomolecules 2019, 9, 777 .

AMA Style

Javad Sharifi-Rad, Farzad Kobarfard, Athar Ata, Seyed Abdulmajid Ayatollahi, Nafiseh Khosravi-Dehaghi, Arun Kumar Jugran, Merve Tomas, Esra Capanoglu, Karl R. Matthews, Jelena Popović-Djordjević, Aleksandar Kostić, Senem Kamiloglu, Farukh Sharopov, Muhammad Iqbal Choudhary, Natália Martins. Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence. Biomolecules. 2019; 9 (12):777.

Chicago/Turabian Style

Javad Sharifi-Rad; Farzad Kobarfard; Athar Ata; Seyed Abdulmajid Ayatollahi; Nafiseh Khosravi-Dehaghi; Arun Kumar Jugran; Merve Tomas; Esra Capanoglu; Karl R. Matthews; Jelena Popović-Djordjević; Aleksandar Kostić; Senem Kamiloglu; Farukh Sharopov; Muhammad Iqbal Choudhary; Natália Martins. 2019. "Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence." Biomolecules 9, no. 12: 777.