Prof. Dr. Alessandro Poggi has been working on cellular and tumor immunology for more than 40 years. He is the author of over 240 original articles published in indexed journals, and he is a reviewer of several scientific journals. Starting from his first doctoral degree in Biological Sciences (1982), he worked on functional characteristics of leukocyte subsets. After his Post-Doctoral Fellow training at the Ludwig Cancer Institute in Lausanne, Switzerland (1985–1987), he was appointed as an Assistant Member at the IST (Immunopathology Unit) in Genoa studying natural killer cell development and function, as well as γδT cells, molecular aspects of survival of subsets of leukocytes and the role of mesenchymal stromal cells in tumor microenvironments. In 2000, he took his second doctoral degree in Medicine and Surgery, and from July 2009, he has been a director of the Molecular Oncology and Angiogenesis Unit at the IRCCS Ospedale Policlinico San Martino in Genoa. In the last 10 years, his research has been more focused on 3D culture systems such as spheroid and organoids in static and dynamic conditions, digital pathology, digital image analysis, conventional and advanced microscopy, drug nanoformulation and antibody drug conjugates for triggering targeted antitumor immune response.