Professor Chang is the Bingei and L & T Charitable Foundation Professor in Dementia Research and the Lab Chief for the Laboratory of Neurodegenerative Diseases in the School of Biomedical Sciences. He was also the Founder and Secretary of HKU Alzheimer’s Disease Research Network. He organized International Alzheimer’s Disease Conference every year from 2000 to 2019. Professor Chang received his undergraduate training in Biochemistry in Hong Kong learning neurochemistry. He then learnt neuroimmunology, neuroanatomy and neurochemistry for his MPhil study. He moved to University of Munich (Ludwig-Maximiliam University of Munich, LMU), Institute for Surgical Research in Germany for his PhD working on clinical neuroscience and neurophysiology. Afterwards, he moved to National Institutes of Health for his postdoctoral training working on molecular neuroscience and neuropharmacology. Professor Chang’s research interest is pathophysiological changes of Alzheimer’s disease (AD) and the risk factors (depression, cigarette smoking, systemic inflammation, and environmental toxins) leading to AD. His recent focus is on how body immune responses modulate neuroimmune responses and progression of neurodegeneration and dementia. He has published over 202 peer-reviewed papers, 15 book chapters and edited 4 books in these areas. He has been listed as Top 1% Scholar by Clarivate Analytics since 2018. Professor Chang is in the International Advisory Board of International AD/PD Symposium.