This paper aims to investigate the robust and distinguishable pattern of heart rate variability (HRV) signals, acquired from wearable electrocardiogram (ECG) or photoplethysmogram (PPG) sensors, for driver drowsiness detection. As wearable sensors are so vulnerable to slight movement, they often produce more noise in signals. Thus, from noisy HRV signals, we need to find good traits that differentiate well between drowsy and awake states. To this end, we explored three types of recurrence plots (RPs) generated from the R–R intervals (RRIs) of heartbeats: Bin-RP, Cont-RP, and ReLU-RP. Here Bin-RP is a binary recurrence plot, Cont-RP is a continuous recurrence plot, and ReLU-RP is a thresholded recurrence plot obtained by filtering Cont-RP with a modified rectified linear unit (ReLU) function. By utilizing each of these RPs as input features to a convolutional neural network (CNN), we examined their usefulness for drowsy/awake classification. For experiments, we collected RRIs at drowsy and awake conditions with an ECG sensor of the Polar H7 strap and a PPG sensor of the Microsoft (MS) band 2 in a virtual driving environment. The results showed that ReLU-RP is the most distinct and reliable pattern for drowsiness detection, regardless of sensor types (i.e., ECG or PPG). In particular, the ReLU-RP based CNN models showed their superiority to other conventional models, providing approximately 6–17% better accuracy for ECG and 4–14% for PPG in drowsy/awake classification.

Mental stress can lead to traffic accidents by reducing a driver’s concentration or increasing fatigue while driving. In recent years, demand for methods to detect drivers’ stress in advance to prevent dangerous situations increased. Thus, we propose a novel method for detecting driving stress using nonlinear representations of short-term (30 s or less) physiological signals for multimodal convolutional neural networks (CNNs). Specifically, from hand/foot galvanic skin response (HGSR, FGSR) and heart rate (HR) short-term input signals, first, we generate corresponding two-dimensional nonlinear representations called continuous recurrence plots (Cont-RPs). Second, from the Cont-RPs, we use multimodal CNNs to automatically extract FGSR, HGSR, and HR signal representative features that can effectively differentiate between stressed and relaxed states. Lastly, we concatenate the three extracted features into one integrated representation vector, which we feed to a fully connected layer to perform classification. For the evaluation, we use a public stress dataset collected from actual driving environments. Experimental results show that the proposed method demonstrates superior performance for 30-s signals, with an overall accuracy of 95.67%, an approximately 2.5–3% improvement compared with that of previous works. Additionally, for 10-s signals, the proposed method achieves 92.33% classification accuracy, which is similar to or better than the performance of other methods using long-term signals (over 100 s).

Drug repositioning offers new clinical indications for old drugs. Recently, many computational approaches have been developed to repurpose marketed drugs in human diseases by mining various of biological data including disease expression profiles, pathways, drug phenotype expression profiles, and chemical structure data. However, despite encouraging results, a comprehensive and efficient computational drug repositioning approach is needed that includes the high-level integration of available resources. In this study, we propose a systematic framework employing experimental genomic knowledge and pharmaceutical knowledge to reposition drugs for a specific disease. Specifically, we first obtain experimental genomic knowledge from disease gene expression profiles and pharmaceutical knowledge from drug phenotype expression profiles and construct a pathway-drug network representing a priori known associations between drugs and pathways. To discover promising candidates for drug repositioning, we initialize node labels for the pathway-drug network using identified disease pathways and known drugs associated with the phenotype of interest and perform network propagation in a semisupervised manner. To evaluate our method, we conducted some experiments to reposition 1309 drugs based on four different breast cancer datasets and verified the results of promising candidate drugs for breast cancer by a two-step validation procedure. Consequently, our experimental results showed that the proposed framework is quite useful approach to discover promising candidates for breast cancer treatment.

Automatic detection of abnormal heart rhythms, including atrial fibrillation (AF), using signals obtained from a single-lead wearable electrocardiogram (ECG) device, is useful for daily cardiac health monitoring. In this study, we propose a novel image-based deep learning framework to classify single-lead ECG recordings of short variable length into several different rhythms associated with arrhythmias. By transforming variable-length 1D ECG signals into fixed-size 2D time-morphology representations and feeding them to the beat–interval–texture convolutional neural network (BIT-CNN) model, we aimed to learn the comprehensible characteristics of beat shape and inter-beat patterns over time for arrhythmia classification. The proposed approach allows feature embedding vectors to provide interpretable time-morphology patterns focused at each step of the learning process. In addition, this method reduces the number of model parameters needed to be trained and aids visual interpretation, while maintaining similar performance to other CNN-based approaches to arrhythmia classification. For experiments, we used the PhysioNet/CinC Challenge 2017 dataset and achieved an overall F_{1_NAO} of 81.75% and F_{1_NAOP} of 76.87%, which are comparable to those of the state-of-the-art methods for variable-length ECGs.

This study aims to utilize heart rate variability (HRV) signals obtained with a wearable sensor for driver drowsiness detection. To this end, we investigated respiration characteristics derived from HRV signals based on the known fact that respiratory activity can be estimated from the high frequency (HF) band of HRV signals. For drowsiness detection, many earlier works commonly used dominant respiration (DR) characteristics. However, in some situations where emphasized power in a power spectrum of HRV occurs at multi sub-frequency, the DR measures may possibly fail to capture overall respiration characteristics. To handle this problem, we propose two spectral indices, the weighted mean (WM) and the weighted standard deviation (WSD) of the HF band in the power spectrum. These indices are used to properly capture the overall shape of the respiratory activity shown through the HF band of the HRV power spectrum as an alternative to the DR measures. For experiments, we collected HRV data with an electrocardiogram device worn on the body under a virtual driving environment. The proposed indices somewhat clearly showed the tendency that respiratory frequency decreases and respiration regularity increases in drowsy states of all subjects, while existing DR measures hardly showed this. In addition, when the proposed indices are used alone or together with conventional HRV-related measures as input features for classification models, they showed the best performance in distinguishing drowsiness from wakefulness.

In practice, some drugs produce a number of negative biological effects that can mitigate their effectiveness as a remedy. To address this issue, several studies have been performed for the prediction of drug-induced toxicity from gene-expression data, and a significant amount of work has been done on predicting limited drug-induced symptoms or single-organ toxicity. Since drugs often lead to some injuries in several organs like liver or kidney, however, it would be very useful to forecast the drug-induced injuries for multiple organs. Therefore, in this work, our aim was to develop a multi-organ toxicity prediction model using an integrative model of gene-expression data. To train our integrative model, we used 3708 in-vivo samples of gene-expression profiles exposed to one of 41 drugs related to 21 distinct physiological changes divided between liver and kidney (liver 11, kidney 10). Specifically, we used the gene-expression profiles to learn an ensemble classifier for each of 21 pathology prediction models. Subsequently, these classifiers were combined with weights to generate an integrative model for each pathological finding. The integrative model outputs the likeliness of presenting the trained pathology in a given test sample of gene-expression profile, called an integrative prediction score (IPS). For the evaluation of an integrative model, we estimated the prediction performance with the k-fold cross-validation. Our results demonstrate that the proposed integrative model is superior to individual pathology prediction models in predicting multi-organ drug-induced toxicities over all the targeted pathological findings. On average, the AUC of the integrative models was 88% while the AUC of individual pathology prediction models was 68%. Not only does this integrative model produce comparable prediction performance to existing approaches, but also it produces very stable performance overall. In addition, our approach is easily expandable to a variety of other multi-organ toxicology applications.