https://www.unipa.it/persone/docenti/l/manuela.labbozzetta Manuela Labbozzetta Date of Birth: 30 August 1977 Place of birth: Palermo, Italy Studies: Degree in Biology, Specialty in Clinical Biochemistry, PhD in Pharmacology and Social-Environmental Toxicology. Current Position: Researcher, Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo (Italy). Teaching Activity: Pharmacology, Pharmacognosy and Toxicology. Main research topics from 2002 to today: Study of the antitumor effects of natural and synthetic compounds in tumor models of innate and acquired multidrug resistance. Analysis of new prognosis factors and possible therapeutic targets in HCC and breast carcinoma. Analysis of genetic polymorphisms of some isozymes of cytochrome P-450 and P-glycoprotein in patients undergoing liver transplantation and kidney, receiving tacrolimus. Analysis of genetic polymorphisms of genes encoding UGT (UDP-glucuronosyltransferase) and DPD (dihydropyrimidine dehydrogenase) metabolites, in subjects with colorectal carcinoma, treated with irinotecan and 5-fluorouracil. Author of more than 35 publications.