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Dr. Alessandro Sartorio
Istituto Auxologico Italiano, IRCCS, Experimental Laboratory for Auxo-endocrinological Research, 20145 Milan & Division of Metabolic Diseases and Auxology, 28824 Verbania, Italy

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0 Body Composition
0 Metabolic Syndrome
0 Nutrition
0 Obesity
0 energy expenditure

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Journal article
Published: 25 June 2021 in Journal of Clinical Medicine
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As in adults, obesity also plays a central role in the development of metabolic syndrome (MS) in children. Non-alcoholic fatty liver disease (NAFLD) is considered a manifestation of MS. Not only MS but also NAFLD seem to be inversely associated with serum bilirubin concentrations, an important endogenous tissue protector when only mild elevated. The aim of the study was to evaluate the association between serum bilirubin levels and the prevalence of MS and NAFLD in Italian obese children and adolescents. A retrospective cross-sectional study was performed in 1672 patients aged from 5 to 18 years. Clinical and laboratory parameters were assessed. NAFLD was measured by liver ultrasonography. The study was approved by the Ethical Committee of the Istituto Auxologico Italiano (research project code 1C021_2020, acronym BILOB). MS was present in 24% and fatty liver (FL) in 38% of this population. Bilirubin was not associated with FL and MS as a whole, but it was inversely associated only with selected components of MS, i.e., large WC, high blood pressure and high triglycerides. Our data suggest that bilirubin is not protective against MS and NAFLD in the presence of severe obesity.

ACS Style

Cristina Bellarosa; Giorgio Bedogni; Annalisa Bianco; Sabrina Cicolini; Diana Caroli; Claudio Tiribelli; Alessandro Sartorio. Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children. Journal of Clinical Medicine 2021, 10, 2812 .

AMA Style

Cristina Bellarosa, Giorgio Bedogni, Annalisa Bianco, Sabrina Cicolini, Diana Caroli, Claudio Tiribelli, Alessandro Sartorio. Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children. Journal of Clinical Medicine. 2021; 10 (13):2812.

Chicago/Turabian Style

Cristina Bellarosa; Giorgio Bedogni; Annalisa Bianco; Sabrina Cicolini; Diana Caroli; Claudio Tiribelli; Alessandro Sartorio. 2021. "Association of Serum Bilirubin Level with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study of 1672 Obese Children." Journal of Clinical Medicine 10, no. 13: 2812.

Review
Published: 21 June 2021 in Applied Sciences
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COVID-19 infection frequently leaves the infected subjects with impairments of multi-organs, the so-called post COVID-19 syndrome, which needs to be adequately addressed. The perspective of this narrative review is to verify the possible role of whole-body vibration exercise in the post-COVID-19 rehabilitation of these patients. Publications reporting the use of WBV exercises to counteract fatigue, muscle weakness, neurological manifestations, pain, quality of life, quality of sleep, lung commitments, and mental conditions in different clinical conditions were selected. Considering all the findings described in the current review, it seems that WBV exercise might be potentially useful and effective in the rehabilitation of post COVID-19 syndrome, being able to positively influence fatigue, muscle weakness, and quality of life without any side-effects. Controlled studies are mandatory to define the best protocols to be proposed, which need to be tailored to the individual and clinical characteristics.

ACS Style

Danúbia Sá-Caputo; Ana Coelho-Oliveira; Juliana Pessanha-Freitas; Laisa Paineiras-Domingos; Ana Lacerda; Vanessa Mendonça; Anelise Sonza; Redha Taiar; Alessandro Sartorio; Adérito Seixas; Mario Bernardo-Filho. Whole-Body Vibration Exercise: A Possible Intervention in the Management of Post COVID-19 Complications? Applied Sciences 2021, 11, 5733 .

AMA Style

Danúbia Sá-Caputo, Ana Coelho-Oliveira, Juliana Pessanha-Freitas, Laisa Paineiras-Domingos, Ana Lacerda, Vanessa Mendonça, Anelise Sonza, Redha Taiar, Alessandro Sartorio, Adérito Seixas, Mario Bernardo-Filho. Whole-Body Vibration Exercise: A Possible Intervention in the Management of Post COVID-19 Complications? Applied Sciences. 2021; 11 (12):5733.

Chicago/Turabian Style

Danúbia Sá-Caputo; Ana Coelho-Oliveira; Juliana Pessanha-Freitas; Laisa Paineiras-Domingos; Ana Lacerda; Vanessa Mendonça; Anelise Sonza; Redha Taiar; Alessandro Sartorio; Adérito Seixas; Mario Bernardo-Filho. 2021. "Whole-Body Vibration Exercise: A Possible Intervention in the Management of Post COVID-19 Complications?" Applied Sciences 11, no. 12: 5733.

Protocol
Published: 09 June 2021 in International Journal of Environmental Research and Public Health
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This Randomized Controlled Trial [(RCT) aims to evaluate the effectiveness of a brief Acceptance and Commitment Therapy (ACT)-based intervention combined with treatment as usual (TAU) compared to TAU only in improving psychological conditions in a sample of adolescents with obesity (body mass index, BMI > 97th percentile for age and sex) within the context of a wider multidisciplinary rehabilitation program for weight loss. Fifty consecutive adolescents (12–17 years) of both genders with obesity will be recruited among the patients hospitalized in a clinical center for obesity rehabilitation and randomly allocated into two experimental conditions: ACT + TAU vs. TAU only. Both groups will attend a three-week in-hospital multidisciplinary rehabilitation program for weight loss. The ACT + TAU condition comprises a psychological intervention based on ACT combined with a standard psychological assessment and support to the hospitalization. The TAU comprises the standard psychological assessment and support to the hospitalization. At pre- to post-psychological intervention, participants will complete the Avoidance and Fusion Questionnaire for Youth, the Psychological Well-Being Scale, the Depression Anxiety Stress Scale, the Difficulties in Emotion Regulation Scale, and the Emotional Eating subscale of the Dutch Eating Behavior Questionnaire to assess psychological well-being as the primary outcome and experiential avoidance, psychological distress, emotional dysregulation, and emotional eating as secondary outcomes. Repeated-measures ANOVAs (2 × 2) will be conducted. The study will assess the effectiveness of a brief ACT-based intervention for adolescents with obesity in improving their psychological conditions by targeting specific core processes of the ACT framework (openness, awareness, and engagement). Future directions of the study will assess whether these psychological processes will contribute to addressing long-term weight loss.

ACS Style

Anna Guerrini Usubini; Roberto Cattivelli; Vanessa Bertuzzi; Giorgia Varallo; Alessandro Rossi; Clarissa Volpi; Michela Bottacchi; Sofia Tamini; Alessandra De Col; Giada Pietrabissa; Stefania Mannarini; Gianluca Castelnuovo; Enrico Molinari; Alessandro Sartorio. The ACTyourCHANGE in Teens Study Protocol: An Acceptance and Commitment Therapy-Based Intervention for Adolescents with Obesity: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health 2021, 18, 6225 .

AMA Style

Anna Guerrini Usubini, Roberto Cattivelli, Vanessa Bertuzzi, Giorgia Varallo, Alessandro Rossi, Clarissa Volpi, Michela Bottacchi, Sofia Tamini, Alessandra De Col, Giada Pietrabissa, Stefania Mannarini, Gianluca Castelnuovo, Enrico Molinari, Alessandro Sartorio. The ACTyourCHANGE in Teens Study Protocol: An Acceptance and Commitment Therapy-Based Intervention for Adolescents with Obesity: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health. 2021; 18 (12):6225.

Chicago/Turabian Style

Anna Guerrini Usubini; Roberto Cattivelli; Vanessa Bertuzzi; Giorgia Varallo; Alessandro Rossi; Clarissa Volpi; Michela Bottacchi; Sofia Tamini; Alessandra De Col; Giada Pietrabissa; Stefania Mannarini; Gianluca Castelnuovo; Enrico Molinari; Alessandro Sartorio. 2021. "The ACTyourCHANGE in Teens Study Protocol: An Acceptance and Commitment Therapy-Based Intervention for Adolescents with Obesity: A Randomized Controlled Trial." International Journal of Environmental Research and Public Health 18, no. 12: 6225.

Journal article
Published: 04 May 2021 in Journal of Clinical Medicine
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The aim of this study was to compare the accuracy of different indexes of adiposity and/or body composition in identifying the metabolic syndrome (MetS) in a group of 1528 Caucasian women with obesity: (age ± standard deviation (SD): 50.8 ± 14 years (range 18–83); body mass index (BMI) 43.3 ± 5.9 kg/m2 (30.7–72.9 kg/m2)). The following indexes were assessed in each subject: BMI, fat-free mass index (FFMI), fat mass index (FMI), tri-ponderal mass index (TMI), waist-to-height ratio (WtHR), and the body mass fat index (BMFI). Thereafter, a threshold value adjusted for age, which could identify MetS, was calculated for each index. A significant correlation was found among all indexes (p < 0.0001 for all). However, when the area under the curve (AUC) was compared, WtHR performed significantly better in the whole group and in the different age groups, apart from a lack of statistical difference between WtHR and BMFI in the 45–55 years age group. In conclusion, WtHR seems to be a fair index useful for identifying MetS in women with obesity. The use of thresholds appropriate for age can help further improve its accuracy, thus reinforcing the clinical evaluation for MetS screening.

ACS Style

Giorgio Radetti; Antonio Fanolla; Graziano Grugni; Fiorenzo Lupi; Sofia Tamini; Sabrina Cicolini; Alessandro Sartorio. The Role of Different Indexes of Adiposity and Body Composition for the Identification of Metabolic Syndrome in Women with Obesity. Journal of Clinical Medicine 2021, 10, 1975 .

AMA Style

Giorgio Radetti, Antonio Fanolla, Graziano Grugni, Fiorenzo Lupi, Sofia Tamini, Sabrina Cicolini, Alessandro Sartorio. The Role of Different Indexes of Adiposity and Body Composition for the Identification of Metabolic Syndrome in Women with Obesity. Journal of Clinical Medicine. 2021; 10 (9):1975.

Chicago/Turabian Style

Giorgio Radetti; Antonio Fanolla; Graziano Grugni; Fiorenzo Lupi; Sofia Tamini; Sabrina Cicolini; Alessandro Sartorio. 2021. "The Role of Different Indexes of Adiposity and Body Composition for the Identification of Metabolic Syndrome in Women with Obesity." Journal of Clinical Medicine 10, no. 9: 1975.

Research article
Published: 23 April 2021 in International Journal of Endocrinology
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Background. Metabolic syndrome is a combination of cardiovascular risk factors (i.e., visceral obesity, dyslipidaemia, glucose intolerance, and hypertension), which entails critical issues in terms of medical management and public health. Methods. The aim of the present cross-sectional study was to investigate the age-related changes of the single IDF (International Diabetes Federation) diagnostic criteria for metabolic syndrome (waist circumference, WC; high-density lipoprotein cholesterol, HDL-C; triglycerides; glucose; systolic and diastolic blood pressure, SBP and DBP) in a large population of (Italian) obese women (n = 1.000; body mass index, BMI >30 kg/m2; age: 18–83 yrs), subdivided into two subgroups depending on the presence (n = 630) or absence (n = 370) of metabolic syndrome. Parallelly, the percentages of treatment with hypolipidaemic drugs, hypoglycaemics, and antihypertensives and, among the treated subjects, of control of the underlying condition in accordance with the cut-offs of IDF criteria for dyslipidaemia, hyperglycaemia, and hypertension were determined over six age ranges (i.e., 18–30, 31–40, 41–50, 51–60, 61–70, and > 70 yrs). Results. The prevalence of metabolic syndrome increased with advancing age. In the subgroup with metabolic syndrome, an age-dependent increase in HDL-C, glycaemia, and SBP occurred, while the visceral adiposity was stable. In the same subgroup, triglycerides and DBP decreased age-dependently. In the subgroup without metabolic syndrome, an age-dependent increase in WC, HDL-C, glycaemia, SBP, and DBP was observed. A progressive age-dependent increase in the percentage of patients pharmacologically treated for the cardiometabolic abnormalities was detected in patients with metabolic syndrome, a similar trend being also observed in patients without metabolic syndrome only for the antihypertensives. A clear-cut disproportion between treated versus adequately controlled women (with pharmacotherapy) was detected in the whole population. Conclusions. At least in an Italian context of obese females, the age-dependent worsening of glycaemia and BP exerts a fundamental pathophysiological role in the progressive increase of metabolic syndrome with advancing age, which appears to be not adequately treated in a large part of obese subjects. The results of the present study might be useful for public health decision-makers for programming future more extensive and aggressive non-pharmacological and pharmacological interventions in the obese population.

ACS Style

Antonello E. Rigamonti; Sabrina Cicolini; Sofia Tamini; Diana Caroli; Silvano G. Cella; Alessandro Sartorio. The Age-Dependent Increase of Metabolic Syndrome Requires More Extensive and Aggressive Non-Pharmacological and Pharmacological Interventions: A Cross-Sectional Study in an Italian Cohort of Obese Women. International Journal of Endocrinology 2021, 2021, 1 -10.

AMA Style

Antonello E. Rigamonti, Sabrina Cicolini, Sofia Tamini, Diana Caroli, Silvano G. Cella, Alessandro Sartorio. The Age-Dependent Increase of Metabolic Syndrome Requires More Extensive and Aggressive Non-Pharmacological and Pharmacological Interventions: A Cross-Sectional Study in an Italian Cohort of Obese Women. International Journal of Endocrinology. 2021; 2021 ():1-10.

Chicago/Turabian Style

Antonello E. Rigamonti; Sabrina Cicolini; Sofia Tamini; Diana Caroli; Silvano G. Cella; Alessandro Sartorio. 2021. "The Age-Dependent Increase of Metabolic Syndrome Requires More Extensive and Aggressive Non-Pharmacological and Pharmacological Interventions: A Cross-Sectional Study in an Italian Cohort of Obese Women." International Journal of Endocrinology 2021, no. : 1-10.

Journal article
Published: 06 April 2021 in International Journal of Environmental Research and Public Health
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Objective: To evaluate the impact of the COVID-19 pandemic and the following lockdown on physical exercise (PEx) practice, pain, and psychological well-being. Methods: A cross-sectional multicentric study was performed using a nonrandom convenience sampling from the general population (≥18 years-old) of 6 countries (Brazil, Italy, France, Portugal, Germany, and Spain) adopting social isolation (SI). The validated self-administered online survey (PEF-COVID19) was used. The tests T-test and Chi-square with Bonferroni correction were used for statistical analysis and a multivariate logistic regression model (p ˂ 0.05). Results: We included 3194 replies and ~80% of the respondents were in SI. Brazilian sample was highly influenced by the pandemic considering PEx practice and habits, pain, anxiety, and stress (p ˂ 0.05). Among the European countries, Italy presented the major changes. The model to predict the non-practice of PEx during SI showed that the variables countries, smoking, SI, and PEx level were significant predictors (p ˂ 0.001). Conclusion: The pandemic changed the PEx practice and habits, and the psychological well-being of populations in different manners. Countries, smoking, SI, and PEx level were predictors for the non-practice of PEx. Public health strategies are suggested to avoid sedentary lifestyles and quality of life decrease.

ACS Style

Anelise Sonza; Danúbia Da Cunha De Sá-Caputo; Alessandro Sartorio; Sofia Tamini; Adérito Seixas; Borja Sanudo; Jessica Süßenbach; Marcello Provenza; Vinicius Xavier; Redha Taiar; Mario Bernardo-Filho. COVID-19 Lockdown and the Behavior Change on Physical Exercise, Pain and Psychological Well-Being: An International Multicentric Study. International Journal of Environmental Research and Public Health 2021, 18, 3810 .

AMA Style

Anelise Sonza, Danúbia Da Cunha De Sá-Caputo, Alessandro Sartorio, Sofia Tamini, Adérito Seixas, Borja Sanudo, Jessica Süßenbach, Marcello Provenza, Vinicius Xavier, Redha Taiar, Mario Bernardo-Filho. COVID-19 Lockdown and the Behavior Change on Physical Exercise, Pain and Psychological Well-Being: An International Multicentric Study. International Journal of Environmental Research and Public Health. 2021; 18 (7):3810.

Chicago/Turabian Style

Anelise Sonza; Danúbia Da Cunha De Sá-Caputo; Alessandro Sartorio; Sofia Tamini; Adérito Seixas; Borja Sanudo; Jessica Süßenbach; Marcello Provenza; Vinicius Xavier; Redha Taiar; Mario Bernardo-Filho. 2021. "COVID-19 Lockdown and the Behavior Change on Physical Exercise, Pain and Psychological Well-Being: An International Multicentric Study." International Journal of Environmental Research and Public Health 18, no. 7: 3810.

Journal article
Published: 02 April 2021 in Journal of Clinical Medicine
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To develop predictive models of fatty liver (FL), we performed a cross-sectional retrospective study of 1672 obese children with a median (interquartile range) age of 15 (13–16) years. The outcome variable was FL diagnosed by ultrasonography. The potential predictors were: (1) binary: sex; (2) continuous: age, body mass index (BMI), waist circumference (WC), alanine transaminase (ALT), aspartate transaminase, gamma-glutamyltransferase, glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HDL-cholesterol, LDL-cholesterol, triglycerides, mean arterial pressure, uric acid, and c-reactive protein; (3) ordinal: Pubertal status. Bootstrapped multivariable logistic regression with fractional polynomials was used to develop the models. Two models were developed and internally validated, one using BMI and the other using WC as the anthropometric predictor. Both models included ALT, HOMA-IR, triglycerides, and uric acid as predictors, had similar discrimination (c-statistic = 0.81), and were similarly well calibrated as determined by calibration plots. These models should undergo external validation before being employed in clinical or research practice.

ACS Style

Giorgio Bedogni; Sofia Tamini; Diana Caroli; Sabrina Cicolini; Marco Domenicali; Alessandro Sartorio. Development and Internal Validation of Fatty Liver Prediction Models in Obese Children and Adolescents. Journal of Clinical Medicine 2021, 10, 1470 .

AMA Style

Giorgio Bedogni, Sofia Tamini, Diana Caroli, Sabrina Cicolini, Marco Domenicali, Alessandro Sartorio. Development and Internal Validation of Fatty Liver Prediction Models in Obese Children and Adolescents. Journal of Clinical Medicine. 2021; 10 (7):1470.

Chicago/Turabian Style

Giorgio Bedogni; Sofia Tamini; Diana Caroli; Sabrina Cicolini; Marco Domenicali; Alessandro Sartorio. 2021. "Development and Internal Validation of Fatty Liver Prediction Models in Obese Children and Adolescents." Journal of Clinical Medicine 10, no. 7: 1470.

Original article
Published: 31 March 2021 in Journal for Specialists in Pediatric Nursing
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Purpose Falls are a significant safety risk in hospitalized patients, but little evidence regarding their significance in obese children are available to date. Aim of the study was to determine whether the Pediatric Obesity Fall‐risk Scale (POFS) is able to discriminate between hospitalized obese pediatric patients at high or low risk of falling, to evaluate its sensitivity and specificity and to analyze if the risk factors considered were actually related to the falling event. Design and Methods The sample consisted of 301 children and adolescents hospitalized for a body weight reduction program. In this 12‐month study, 14.6% of patients experienced a fall during hospitalization, the fall rate per 1000 patient days being 5.33 for the first and 4.36 for the second 6‐month of the year. The components of the POFS included chronological age, history of falls, body mass index standard deviation score (BMI‐SDS), and the ability to maintain equilibrium. Results No differences were observed between fallers and nonfallers as far as BMI and BMI‐SDS are concerned. Compared with patients who did not fall, those who fell were significantly younger and shorter and their weights were lower. The POFS identified 85 patients with high and 216 with low falling risk, the two subgroups being comparable for BMI and BMI‐SDS. Compared with patients with low fall‐risk, those with high fall‐risk were significantly younger and shorter and their weights were lower. The sensitivity of the POFS was 61.4%, while the specificity was 77.4%. The positive predictive value of the POFS was 31.8%, while the negative predictive value was 92.1%. The analyses of each POFS component did not show significant differences between fallers and non‐fallers in terms of BMI‐SDS and equilibrium test. Compared with patients who did not fall, those who fell were significantly younger, experienced a fall during the 3 months prior the admission in hospital and their total POFS score was higher. Practice Implications Preventing falls in hospitalized obese pediatric patients is challenging due to the markedly increased risk of this population and specific fall‐risk assessment tools are required to early identify patients who needs more care, attention, and specific nursing/medical interventions.

ACS Style

Sofia Tamini; Sabrina Cicolini; Anna Porcu; Angela Seddone; Nancy Ryan‐Wenger; Alessandro Sartorio. Use of a Pediatric Obesity Fall‐risk Scale (POFS) in 301 hospitalized obese children and adolescents. Journal for Specialists in Pediatric Nursing 2021, e12335 .

AMA Style

Sofia Tamini, Sabrina Cicolini, Anna Porcu, Angela Seddone, Nancy Ryan‐Wenger, Alessandro Sartorio. Use of a Pediatric Obesity Fall‐risk Scale (POFS) in 301 hospitalized obese children and adolescents. Journal for Specialists in Pediatric Nursing. 2021; ():e12335.

Chicago/Turabian Style

Sofia Tamini; Sabrina Cicolini; Anna Porcu; Angela Seddone; Nancy Ryan‐Wenger; Alessandro Sartorio. 2021. "Use of a Pediatric Obesity Fall‐risk Scale (POFS) in 301 hospitalized obese children and adolescents." Journal for Specialists in Pediatric Nursing , no. : e12335.

Journal article
Published: 15 March 2021 in International Journal of Environmental Research and Public Health
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Adolescence is a complex developmental phase, made more complex by obesity and the social isolation imposed by the COVID-19 pandemic. The literature related to the impact of social isolation on obesity self-management in adolescents is scant and inconsistent. This paper describes the phenomenon from the perspectives of a sample of adolescents with obesity enrolled in an inpatients’ multidisciplinary rehabilitation program for weight-loss and their caregivers, and its impact on different life domains. Individual semi-structured ad hoc interviews were conducted with 10 adolescent-caregiver dyads, and narratives were qualitatively investigated using an interpretative phenomenology approach to data. Twenty participants took part in the study. The major themes that emerged from this study fall into five basic categories: (1) COVID-19 as an opportunity to reconsider what makes a good life; (2) Persistence in life; (3) Empowering relationship; (4) Daily routine in quarantine; (5) Lives on hold. Understandings drawn from this study may assist health care professionals in providing holistic support, and guidance to adolescents with weight-related issues and their caregivers who experience social isolation during the COVID-19 pandemic.

ACS Style

Giada Pietrabissa; Clarissa Volpi; Michela Bottacchi; Vanessa Bertuzzi; Anna Guerrini Usubini; Henriette Löffler-Stastka; Tamara Prevendar; Giada Rapelli; Roberto Cattivelli; Gianluca Castelnuovo; Enrico Molinari; Alessandro Sartorio. The Impact of Social Isolation during the COVID-19 Pandemic on Physical and Mental Health: The Lived Experience of Adolescents with Obesity and Their Caregivers. International Journal of Environmental Research and Public Health 2021, 18, 3026 .

AMA Style

Giada Pietrabissa, Clarissa Volpi, Michela Bottacchi, Vanessa Bertuzzi, Anna Guerrini Usubini, Henriette Löffler-Stastka, Tamara Prevendar, Giada Rapelli, Roberto Cattivelli, Gianluca Castelnuovo, Enrico Molinari, Alessandro Sartorio. The Impact of Social Isolation during the COVID-19 Pandemic on Physical and Mental Health: The Lived Experience of Adolescents with Obesity and Their Caregivers. International Journal of Environmental Research and Public Health. 2021; 18 (6):3026.

Chicago/Turabian Style

Giada Pietrabissa; Clarissa Volpi; Michela Bottacchi; Vanessa Bertuzzi; Anna Guerrini Usubini; Henriette Löffler-Stastka; Tamara Prevendar; Giada Rapelli; Roberto Cattivelli; Gianluca Castelnuovo; Enrico Molinari; Alessandro Sartorio. 2021. "The Impact of Social Isolation during the COVID-19 Pandemic on Physical and Mental Health: The Lived Experience of Adolescents with Obesity and Their Caregivers." International Journal of Environmental Research and Public Health 18, no. 6: 3026.

Journal article
Published: 08 November 2020 in Journal of Clinical Medicine
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Few short-term studies of weight loss have been performed in adult patients with Prader–Willi syndrome (PWS) undergoing metabolic rehabilitation. We performed a retrospective cohort study of 45 adult obese PWS patients undergoing a long-term multidisciplinary metabolic rehabilitation program based on diet and physical activity. Body composition was evaluated by dual-energy X-ray absorptiometry in 36 (80%) patients. The mean (95% CI) weight change was −3.6 (−7.6 to 0.4, p = 0.08) kg at 3 years and −4.6 (−8.5 to −0.8, p = 0.02) kg at 6 years, and that of BMI was −1.7 (−3.4 to 0.1, p = 0.06) kg/m2 at 3 years and −2.1 (−3.8 to −0.4, p = 0.02) kg/m2 at 6 years. A decrease of about 2% in fat mass per unit of body mass was observed, which is in line with the expectations for moderate weight loss. A possibly clinically relevant decrease in total and low-density lipoprotein cholesterol was also observed. These long-term results are important for patients with PWS, which is characterized by severe hyperphagia, behavioral disturbances, and cognitive impairment and is generally considered “resistant” to classical weight loss interventions.

ACS Style

Giorgio Bedogni; Graziano Grugni; Sabrina Cicolini; Diana Caroli; Sofia Tamini; Alessandro Sartorio. Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study. Journal of Clinical Medicine 2020, 9, 3596 .

AMA Style

Giorgio Bedogni, Graziano Grugni, Sabrina Cicolini, Diana Caroli, Sofia Tamini, Alessandro Sartorio. Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study. Journal of Clinical Medicine. 2020; 9 (11):3596.

Chicago/Turabian Style

Giorgio Bedogni; Graziano Grugni; Sabrina Cicolini; Diana Caroli; Sofia Tamini; Alessandro Sartorio. 2020. "Changes of Body Weight and Body Composition in Obese Patients with Prader–Willi Syndrome at 3 and 6 Years of Follow-Up: A Retrospective Cohort Study." Journal of Clinical Medicine 9, no. 11: 3596.

Journal article
Published: 05 November 2020 in International Journal of Environmental Research and Public Health
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Type 2 diabetes is increasingly recognized as a spectrum of metabolic disorders sharing chronic hyperglycaemia. In Europe, the continually growing number of migrants from developing countries could affect diabetes phenotypes. We evaluated a population of 426 Italians and 412 undocumented migrants. Using 17 variables (with the exclusion of ethnic origin) we performed a multiple component analysis to detect potential clusters, independently from ethnicity. We also compared the two groups to evaluate potential ethnicity associated differences. We found five clusters of patients with different disease phenotypes. Comparing Italians with undocumented migrants, we noted that the first had more often cardiovascular risk factors and neurologic involvement, while the latter had a higher frequency of diabetic ulcers and renal involvement. Metformin was used in a comparable percentage of patients in all clusters, but other antidiabetic treatments showed some differences. Italians were more often on insulin, due to a larger use of long acting insulin, and received a larger number of oral antidiabetics in combination. Pharmacological treatment of comorbidities showed some differences too. We suggest that type 2 diabetes should be considered as a spectrum of diseases with different phenotypes also in heterogeneous populations, and that this is not due only to ethnic differences.

ACS Style

Gianfrancesco Fiorini; Ivan Cortinovis; Giovanni Corrao; Matteo Franchi; Angela Pincelli; Mario Perotti; Antonello Rigamonti; Alessandro Sartorio; Silvano Cella. Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease? International Journal of Environmental Research and Public Health 2020, 17, 8169 .

AMA Style

Gianfrancesco Fiorini, Ivan Cortinovis, Giovanni Corrao, Matteo Franchi, Angela Pincelli, Mario Perotti, Antonello Rigamonti, Alessandro Sartorio, Silvano Cella. Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease? International Journal of Environmental Research and Public Health. 2020; 17 (21):8169.

Chicago/Turabian Style

Gianfrancesco Fiorini; Ivan Cortinovis; Giovanni Corrao; Matteo Franchi; Angela Pincelli; Mario Perotti; Antonello Rigamonti; Alessandro Sartorio; Silvano Cella. 2020. "Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease?" International Journal of Environmental Research and Public Health 17, no. 21: 8169.

Journal article
Published: 28 October 2020 in Sustainability
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(1) Background: Hypertension is a serious medical condition characterized by a persistent increase in blood pressure (BP), which is prevalent in individuals with knee osteoarthritis (KOA). Pharmacological interventions are normally used to treat both hypertension and KOA; however, a more sustainable form of treatment is desirable for these clinical conditions. Whole-body vibration (WBV) exercise has been proposed as a non-pharmacological therapy for reducing both BP and KOA symptomatology. This study aimed to evaluate the antihypertensive effect of WBV in hypertensive individuals with KOA. (2) Methods: Nineteen hypertensive individuals with KOA were randomly allocated to either a control (CG) (n = 9) or a WBV group (WBVG) (n = 10). Subjects in the WBVG were positioned sitting in a chair in front of a vibrating platform (VP) with the feet on the base (peak-to-peak displacement 2.5, 5.0 and 7.5 mm; frequencies 5 to 14 Hz). In the CG, subjects assumed the same position with the VP turned off. The protocols in the CG and WBVG were performed 2 days/week for a total of 5 weeks. (3) Results: No baseline differences (age, anthropometrics, BP parameters and medications) between the groups were found (p > 0.05). WBV exercise reduced systolic BP (SBP: 126.1 ± 2.7 versus 119.1 ± 3.2 mmHg; p = 0.001; post hoc: p = 0.02; F = 23.97) and mean BP (MBP: 82.6 ± 1.8 versus 78.7 ± 1.8, p = 0.001, post hoc: p = 0.02; F = 23.97), while no significant changes were found in diastolic BP (DBP: 68.5 ± 2.2 versus 64.4 ± 2.3; p = 0.11; F = 2.68). (4) Conclusions: WBV might be considered a sustainable therapy for exerting an antihypertensive effect in medicated hypertensive individuals with KOA. This decline in BP might translate to a reduction in pharmacological need, although further studies are necessary to understand the mechanisms underlying the described effect.

ACS Style

Eloá Moreira-Marconi; Vanessa Caiado; Ygor Teixeira-Silva; Alexandre Meirelles; Marcia Moura-Fernandes; Patrícia Lopes-Souza; Aline Reis-Silva; Danúbia Sá-Caputo; Laisa Paineiras-Domingos; Ana Lacerda; Vanessa Mendonça; Ricardo Cordeiro; Redha Taiar; Alessandro Sartorio; Alexei Wong; Borja Sañudo; Mario Bernardo-Filho. Whole-Body Vibration as Antihypertensive Non-Pharmacological Treatment in Hypertensive Individuals with Knee Osteoarthritis: Randomized Cross-Over Trial. Sustainability 2020, 12, 8944 .

AMA Style

Eloá Moreira-Marconi, Vanessa Caiado, Ygor Teixeira-Silva, Alexandre Meirelles, Marcia Moura-Fernandes, Patrícia Lopes-Souza, Aline Reis-Silva, Danúbia Sá-Caputo, Laisa Paineiras-Domingos, Ana Lacerda, Vanessa Mendonça, Ricardo Cordeiro, Redha Taiar, Alessandro Sartorio, Alexei Wong, Borja Sañudo, Mario Bernardo-Filho. Whole-Body Vibration as Antihypertensive Non-Pharmacological Treatment in Hypertensive Individuals with Knee Osteoarthritis: Randomized Cross-Over Trial. Sustainability. 2020; 12 (21):8944.

Chicago/Turabian Style

Eloá Moreira-Marconi; Vanessa Caiado; Ygor Teixeira-Silva; Alexandre Meirelles; Marcia Moura-Fernandes; Patrícia Lopes-Souza; Aline Reis-Silva; Danúbia Sá-Caputo; Laisa Paineiras-Domingos; Ana Lacerda; Vanessa Mendonça; Ricardo Cordeiro; Redha Taiar; Alessandro Sartorio; Alexei Wong; Borja Sañudo; Mario Bernardo-Filho. 2020. "Whole-Body Vibration as Antihypertensive Non-Pharmacological Treatment in Hypertensive Individuals with Knee Osteoarthritis: Randomized Cross-Over Trial." Sustainability 12, no. 21: 8944.

Journal article
Published: 22 September 2020 in Journal of Clinical Medicine
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Proteins have been demonstrated to reduce food intake in animals and humans via peripheral and central mechanisms. Supplementation of a dietetic regimen with single or mixed amino acids might represent an approach to improve the effectiveness of any body weight reduction program in obese subjects. The aim of the present study was to evaluate the effects of an amino acid mix (L-arginine + L-leucine + L-glutamine + L-tryptophan) on the secretion of some gastrointestinal peptides (i.e., ghrelin and glucagon-like peptide type 1, GLP-1), glucometabolic homeostasis (i.e., glucose, insulin, and glucagon), and appetite (hunger/satiety scored by visual analogue scale, VAS) in obese adolescents (n = 14; 10 females and 4 males; age: 16.6 ± 1.0 years; body mass index (BMI): 36.4 ± 4.6 kg/m²; fat-free mass (FFM): 54.9 ± 4.7%; fat mass (FM): 45.1 ± 4.4%) administered with a fixed-dose (lunch) or ad libitum (dinner) meal. Isocaloric maltodextrins were used as control treatment. During the lunch test, a significant increase in circulating levels of GLP-1, but not of ghrelin, was observed in the amino acid-treated group, which was congruent with significant changes in appetite, i.e., increase in satiety and decrease in hunger. A significant hyperglycemia was found in the maltodextrin-treated group during the prelunch period, without any significant changes in insulin and glucagon between the two groups. During the dinner test, there were no significant differences in appetite (hunger/satiety) and intake of calories. In conclusion, L-arginine, L-leucine, L-glutamine, and L-tryptophan, when administered to obese adolescents with a fixed-dose meal, are capable of evoking an anorexigenic response, which is, at least in part, mediated by an increase in GLP-1 released in circulation by L cells, which are capable of chemosensing specific amino acids present in the intestinal lumen. Further additional studies are requested to understand whether higher doses are necessary to inhibit ad libitum feeding.

ACS Style

Antonello E. Rigamonti; Sofia Tamini; Sabrina Cicolini; Alessandra De Col; Diana Caroli; Stefania Mai; Eugenia Rondinelli; Antonella Saezza; Silvano G. Cella; Alessandro Sartorio. Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal. Journal of Clinical Medicine 2020, 9, 3054 .

AMA Style

Antonello E. Rigamonti, Sofia Tamini, Sabrina Cicolini, Alessandra De Col, Diana Caroli, Stefania Mai, Eugenia Rondinelli, Antonella Saezza, Silvano G. Cella, Alessandro Sartorio. Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal. Journal of Clinical Medicine. 2020; 9 (9):3054.

Chicago/Turabian Style

Antonello E. Rigamonti; Sofia Tamini; Sabrina Cicolini; Alessandra De Col; Diana Caroli; Stefania Mai; Eugenia Rondinelli; Antonella Saezza; Silvano G. Cella; Alessandro Sartorio. 2020. "Evaluation of an Amino Acid Mix on the Secretion of Gastrointestinal Peptides, Glucometabolic Homeostasis, and Appetite in Obese Adolescents Administered with a Fixed-Dose or ad Libitum Meal." Journal of Clinical Medicine 9, no. 9: 3054.

Journal article
Published: 25 August 2020 in Nutrients
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Background: Prader-Willi syndrome (PWS) is conventionally regarded as a model of genetic obesity carrying a metabolically healthier profile and fat compartmentalization than subjects with non-syndromic obesity. Serum uric acid (sUA) is a recognized surrogate marker of metabolic derangement. As no information is currently available on sUA levels in adults with PWS, we aimed to analyze sUA in a large cohort of adult patients with PWS in comparison to a control counterpart; secondly, we aimed to investigate the metabolic and non-metabolic determinants of sUA in PWS. Methods: A cross-sectional study was conducted on 89 consecutive adult patients with genetically confirmed PWS spanning a wide BMI range (17.2–56.7 kg/m2). As controls, 180 age-, sex- and BMI-matched healthy controls were included. sUA levels were analyzed in relation to the PWS status, metabolic variables, hormone status, body composition, and resting energy expenditure (REE). Bivariate correlation and multivariable regression studies were used to test for predictors of sUA in PWS. Results: Despite having similar BMI values, patients with PWS presented with higher FM (p < 0.0001), lower FFM (p < 0.0001) and REE values than controls (p < 0.0001). In PWS, sUA levels were non-significantly different between subjects with and without obesity (5.4 ± 1.3 vs. 4.9 ± 1.1 mg/dL, p = 0.09), and did not vary significantly in relation to genotype, sex steroid or GH replacement, as well as psychiatric treatments. Rates of hyperuricaemia (19.1% vs. 33.7%, p < 0.01) and absolute sUA levels were lower in patients with PWS compared to controls owing to significant differences between subgroups with obesity (5.5 ± 1.4 vs. 6.6 ± 1.6 mg/dL, p < 0.0001). In merged populations, sUA increased in parallel with age, BMI, FM, FFM, REE, glucolipid homeostasis, and inflammatory markers. In a separate analysis in PWS, however, sUA correlations with BMI, FM, and inflammatory markers were null. Stepwise multivariable regression analysis in the PWS group adjusted for karyotype, age, sex, FM, FFM, obesity, triglycerides, and HDL cholesterol, showed that sUA levels were independently associated with FFM (β = 0.35, p < 0.0001) and, albeit less significantly, with triglycerides (β = 0.23, p < 0.05). The introduction of height-normalized FFM (FFM index) in the regression model, however, abrogated the predictive role of FFM on sUA. Conclusions: FFM mass is a strong predictor of sUA. PWS is associated to lower sUA levels than controls likely due to genetic predisposition to different body composition and healthier metabolic phenotype. Further studies are warranted to assess purine metabolism and the clinical significance of the FFM index in PWS.

ACS Style

Paolo Marzullo; Chiara Mele; Alessandro Minocci; Stefania Mai; Massimo Scacchi; Alessandro Sartorio; Gianluca Aimaretti; Graziano Grugni. Fat-Free Mass Is Better Related to Serum Uric Acid Than Metabolic Homeostasis in Prader-Willi Syndrome. Nutrients 2020, 12, 2583 .

AMA Style

Paolo Marzullo, Chiara Mele, Alessandro Minocci, Stefania Mai, Massimo Scacchi, Alessandro Sartorio, Gianluca Aimaretti, Graziano Grugni. Fat-Free Mass Is Better Related to Serum Uric Acid Than Metabolic Homeostasis in Prader-Willi Syndrome. Nutrients. 2020; 12 (9):2583.

Chicago/Turabian Style

Paolo Marzullo; Chiara Mele; Alessandro Minocci; Stefania Mai; Massimo Scacchi; Alessandro Sartorio; Gianluca Aimaretti; Graziano Grugni. 2020. "Fat-Free Mass Is Better Related to Serum Uric Acid Than Metabolic Homeostasis in Prader-Willi Syndrome." Nutrients 12, no. 9: 2583.

Journal article
Published: 30 May 2020 in Journal of Clinical Medicine
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(1) Objective: To compare the accuracy of different indexes of adiposity and/or body composition in identifying metabolic syndrome (MetS) in adult patients suffering from Prader‒Willi syndrome (PWS). (2) Study Design: One hundred and twenty PWS patients (69 females and 51 males), aged 29.1 ± 9.4 years, body mass index (BMI) 36.7 ± 9.9, were evaluated. The following indexes were assessed in each subject: body mass index (BMI), fat-free mass index (FFMI), fat mass index (FMI), tri-ponderal mass index (TMI), waist-to-height ratio (WtHR) and the body mass fat index (BMFI), which adjusts the BMI for the percentage of body fat and waist circumference. Thereafter, a threshold value adjusted for age and sex, which could identify MetS, was calculated for each index. (3) Results: A significant correlation was found among all indexes (p < 0.0001 for all). However, when the area under the curve (AUC) was compared, BMFI performed better than FMI (p < 0.05) and BMI better than TMI (p < 0.05), but only in females. (4) Conclusions: Besides small differences, all the indexes taken into consideration seem to have the same ability to identify MetS in adults with PWS. Consequently, the most easily calculated index, i.e., BMI, should be considered as the best choice. The use of thresholds appropriate for sex and age can further improve its accuracy.

ACS Style

Giorgio Radetti; Antonio Fanolla; Fiorenzo Lupi; Alessandro Sartorio; Graziano Grugni. Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome. Journal of Clinical Medicine 2020, 9, 1646 .

AMA Style

Giorgio Radetti, Antonio Fanolla, Fiorenzo Lupi, Alessandro Sartorio, Graziano Grugni. Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome. Journal of Clinical Medicine. 2020; 9 (6):1646.

Chicago/Turabian Style

Giorgio Radetti; Antonio Fanolla; Fiorenzo Lupi; Alessandro Sartorio; Graziano Grugni. 2020. "Accuracy of Different Indexes of Body Composition and Adiposity in Identifying Metabolic Syndrome in Adult Subjects with Prader-Willi Syndrome." Journal of Clinical Medicine 9, no. 6: 1646.

Review
Published: 22 May 2020 in International Journal of Environmental Research and Public Health
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COVID-19 is a highly infectious respiratory disease which leads to several clinical conditions related to the dysfunction of the respiratory system along with other physical and psychological complaints. Severely affected patients are referred to intensive care units (ICUs), limiting their possibilities for physical exercise. Whole body vibration (WBV) exercise is a non-invasive, physical therapy, that has been suggested as part of the procedures involved with pulmonary rehabilitation, even in ICU settings. Therefore, in the current review, the World Association of Vibration Exercise Experts (WAVEX) reviewed the potential of WBV exercise as a useful and safe intervention for the management of infected individuals with COVID-19 by mitigating the inactivity-related declines in physical condition and reducing the time in ICU. Recommendations regarding the reduction of fatigue and the risk of dyspnea, the improvement of the inflammatory and redox status favoring cellular homeostasis and the overall improvement in the quality of life are provided. Finally, practical applications for the use of this paradigm leading to a better prognosis in bed bound and ICU-bound subjects is proposed.

ACS Style

Borja Sañudo; Adérito Seixas; Rainer Gloeckl; Jörn Rittweger; Rainer Rawer; Redha Taiar; Eddy A. Van Der Zee; Marieke J.G. Van Heuvelen; Ana Cristina Lacerda; Alessandro Sartorio; Michael Bemben; Darryl Cochrane; Trentham Furness; Danúbia De Sá-Caputo; Mario Bernardo-Filho. Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel. International Journal of Environmental Research and Public Health 2020, 17, 3650 .

AMA Style

Borja Sañudo, Adérito Seixas, Rainer Gloeckl, Jörn Rittweger, Rainer Rawer, Redha Taiar, Eddy A. Van Der Zee, Marieke J.G. Van Heuvelen, Ana Cristina Lacerda, Alessandro Sartorio, Michael Bemben, Darryl Cochrane, Trentham Furness, Danúbia De Sá-Caputo, Mario Bernardo-Filho. Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel. International Journal of Environmental Research and Public Health. 2020; 17 (10):3650.

Chicago/Turabian Style

Borja Sañudo; Adérito Seixas; Rainer Gloeckl; Jörn Rittweger; Rainer Rawer; Redha Taiar; Eddy A. Van Der Zee; Marieke J.G. Van Heuvelen; Ana Cristina Lacerda; Alessandro Sartorio; Michael Bemben; Darryl Cochrane; Trentham Furness; Danúbia De Sá-Caputo; Mario Bernardo-Filho. 2020. "Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel." International Journal of Environmental Research and Public Health 17, no. 10: 3650.

Journal article
Published: 21 May 2020 in Nutrients
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Background. In clinical practice, there is the diffuse conviction that obese subjects with metabolic syndrome may be more difficult to treat. Objectives and Methods. The aim of the present study was that to investigate the effectiveness of a 3-week in-hospital body weight reduction program (BWRP) in a large population of obese subjects with and without metabolic syndrome (n = 1922; 222 men and 1700 women, age range 18–83 yr). Outcomes such as body mass index (BMI), total (TOT) and HDL cholesterol, systolic and diastolic blood pressures (SBP and DBP, respectively), coronary heart disease (CHD) score, fatigue severity score (FSS), and stair climbing test (SCT) time were evaluated before and after the intervention (Δ). A sex-, BMI-, and age-related stratification of the obese population with or without metabolic syndrome was applied. Results. When compared to obese subjects without metabolic syndrome, at the basal conditions, obese subjects had a poorer cardiometabolic profile, as demonstrated by higher triglycerides, TOT-cholesterol, DBP, SBP, and CHD score, and a more compromised muscle performance (evaluated by SCT), associated with more perception of fatigue (measured by FSS). Nevertheless, obese subjects with metabolic syndrome obtained more benefits from BWRP than those without metabolic syndrome for some outcomes (i.e., ΔTOT-cholesterol, ΔSBP, and ΔCHD score). Despite these differences, the BWRP-induced weight loss was similar between the two groups (i.e., ΔBMI) as well as the gain of muscle performance (i.e., ΔSCT) and the reduction of fatigue (i.e., ΔFSS). Interestingly, the potentially deleterious fall in HDL-cholesterol levels after BWRP was less evident in obese subjects with metabolic syndrome than those without metabolic syndrome. When pooling all data, the ΔCHD score was associated with age, sex, and metabolic syndrome. The remaining outcomes, such as ΔBMI, ΔFSS, and ΔSCT time, were associated with sex and age but not with metabolic syndrome. Finally, ΔBMI was positively correlated with ΔCHD score, ΔFSS, and ΔSCT time in both obese subjects without metabolic syndrome and obese subjects with metabolic syndrome. Conclusions. When comparing obese subjects undergoing a BWRP, metabolic syndrome is not a negative predictive factor affecting the effectiveness of this intervention in terms of weight loss, muscle performance, and psychological well-being.

ACS Style

Antonello E. Rigamonti; Sabrina Cicolini; Diana Caroli; Alessandra De Col; Massimo Scacchi; Silvano G. Cella; Alessandro Sartorio. Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome. Nutrients 2020, 12, 1495 .

AMA Style

Antonello E. Rigamonti, Sabrina Cicolini, Diana Caroli, Alessandra De Col, Massimo Scacchi, Silvano G. Cella, Alessandro Sartorio. Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome. Nutrients. 2020; 12 (5):1495.

Chicago/Turabian Style

Antonello E. Rigamonti; Sabrina Cicolini; Diana Caroli; Alessandra De Col; Massimo Scacchi; Silvano G. Cella; Alessandro Sartorio. 2020. "Effects of a 3-Week In-Hospital Body Weight Reduction Program on Cardiovascular Risk Factors, Muscle Performance, and Fatigue: A Retrospective Study in a Population of Obese Adults with or without Metabolic Syndrome." Nutrients 12, no. 5: 1495.

Journal article
Published: 14 May 2020 in Nutrients
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We performed an external cross-validation study of 10 equations to estimate resting energy expenditure (REE) in 2037 children with and 389 without obesity. Inclusion criteria were Caucasian ethnicity, age ≤ 18 years, and availability of REE. REE was measured using indirect calorimetry. The correct classification fraction (CCF) of an equation was defined as the fraction of subjects whose estimated REE was within 10% of measured REE. The Molnár equation was the most accurate REE prediction equation with CCFs of 0.70 (95% CI 0.65 to 0.76) in girls without obesity, 0.64 (95% CI 0.61 to 0.66) in girls with obesity, 0.76 (95% CI 0.67 to 0.83) in boys without obesity, and 0.66 (95% CI 0.63 to 0.69) in boys with obesity. The Mifflin equation was the second most accurate equation with CCFs of 0.67 (95% CI 0.61 to 0.73) in girls without obesity, 0.61 (95% CI 0.58 to 0.64) in girls with obesity, 0.75 (95% CI 0.66 to 0.82) in boys without obesity, and 0.66 (95% CI 0.63 to 0.69) in boys with obesity.

ACS Style

Giorgio Bedogni; Simona Bertoli; Ramona De Amicis; Andrea Foppiani; Alessandra De Col; Gabriella Tringali; Nicoletta Marazzi; Valentina De Cosmi; Carlo Agostoni; Alberto Battezzati; Alessandro Sartorio. External Validation of Equations to Estimate Resting Energy Expenditure in 2037 Children and Adolescents with and 389 without Obesity: A Cross-Sectional Study. Nutrients 2020, 12, 1421 .

AMA Style

Giorgio Bedogni, Simona Bertoli, Ramona De Amicis, Andrea Foppiani, Alessandra De Col, Gabriella Tringali, Nicoletta Marazzi, Valentina De Cosmi, Carlo Agostoni, Alberto Battezzati, Alessandro Sartorio. External Validation of Equations to Estimate Resting Energy Expenditure in 2037 Children and Adolescents with and 389 without Obesity: A Cross-Sectional Study. Nutrients. 2020; 12 (5):1421.

Chicago/Turabian Style

Giorgio Bedogni; Simona Bertoli; Ramona De Amicis; Andrea Foppiani; Alessandra De Col; Gabriella Tringali; Nicoletta Marazzi; Valentina De Cosmi; Carlo Agostoni; Alberto Battezzati; Alessandro Sartorio. 2020. "External Validation of Equations to Estimate Resting Energy Expenditure in 2037 Children and Adolescents with and 389 without Obesity: A Cross-Sectional Study." Nutrients 12, no. 5: 1421.

Journal article
Published: 14 April 2020 in Journal of Clinical Medicine
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Background: Prader–Willi syndrome (PWS) is a rare and poorly characterized disease. Recent genomic and transcriptomic studies contributed to elucidate the molecular bases of the syndrome. In this study, we characterized the expression of circulating miRNAs in patients with PWS compared to those with non-syndromic obesity in association with liver steatosis. Methods: MiRNAs were studied by qRT-PCR in serum samples from 30 PWS and 30 non-syndromic obese subjects. Results: MiRNA expression was associated with the presence of the syndrome and to the grade of liver steatosis. MiR-122-5p, miR-151a, miR-92a-3p were up-regulated in obese (4.38-fold, p < 0.01; 2.72-fold, p < 0.05; 1.34-fold p < 0.05, respectively) and were able to differentiate obese from PWS (AUC = 0.81, sens/spec 78/71%). When stratifying groups according to the presence of steatosis, the expression of miR-151a-5p, miR-92a-3p, miR-106b-5p, and miR-93-5p were lower in PWS with steatosis grade 1. Within the group with steatosis grade 1, miR-151a-5p was significantly distinguished PWS from obese (AUC = 0.85, sens/spec 80/85%) and the combination of miR-106b-5p and miR-93-5p showed higher performances in discriminating different grades of steatosis in PWS (AUC = 0.84, sens/spec 93/74%). Conclusions: MiRNAs represent a tool to better classify and characterize PWS, providing new information about the clinical picture and the extent of steatosis.

ACS Style

Muhammad Yogi Pratama; Devis Pascut; Sofia Tamini; Alessandro Minocci; Claudio Tiribelli; Graziano Grugni; Alessandro Sartorio. Circulating microRNA Associated to Different Stages of Liver Steatosis in Prader–Willi Syndrome and Non-Syndromic Obesity. Journal of Clinical Medicine 2020, 9, 1123 .

AMA Style

Muhammad Yogi Pratama, Devis Pascut, Sofia Tamini, Alessandro Minocci, Claudio Tiribelli, Graziano Grugni, Alessandro Sartorio. Circulating microRNA Associated to Different Stages of Liver Steatosis in Prader–Willi Syndrome and Non-Syndromic Obesity. Journal of Clinical Medicine. 2020; 9 (4):1123.

Chicago/Turabian Style

Muhammad Yogi Pratama; Devis Pascut; Sofia Tamini; Alessandro Minocci; Claudio Tiribelli; Graziano Grugni; Alessandro Sartorio. 2020. "Circulating microRNA Associated to Different Stages of Liver Steatosis in Prader–Willi Syndrome and Non-Syndromic Obesity." Journal of Clinical Medicine 9, no. 4: 1123.

Journal article
Published: 01 April 2020 in Journal of Applied Physiology
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Quality of life (QoL) is one of the most important health outcome concepts expressed subjectively. Chronic pain (CP) is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Taking into account the poor QoL and the CP already described in metabolic syndrome (MSy) individuals, this study aimed to evaluate the effects of whole body vibration exercises (WBVE) on these parameters in this population. Thirty-three MSy patients were divided in subgroups A [whole body vibration exercise group (WBVeG), n = 17, 15 females/2 males, 61.1 ± 8.4 yr] and B (control group, n = 16, 14 females/2 males, 58.2 ± 9.1 yr). Subgroup A performed 10 sessions (2 times/wk) of WBVE (18 min/session, with a frequency from 5 up to 14 Hz and a peak-to-peak displacement of 2.5, 5.0, and 7.5 mm) on a side-alternating vibrating platform (VP). Subgroup B did the same protocol, but the VP was turned off. The individuals answered the World Health Organization Quality of Life bref (WHOQoL-bref) questionnaire before the first and after the 10th session. The chronic pain level (CPL) was measured by a numeric rating scale (0–10) before and at the end of each session. Significant improvements were found in physical health ( P = 0.05) and psychological health ( P = 0.04) domains of WHOQoL-bref in WBVeG. A significant acute reduction of the CPL was found in the WBVeG after the protocol, considering the first session and at the last session. WBVE marginally improved physical health and psychological health and decrease the CPL in acute interventions. NEW & NOTEWORTHY Metabolic syndrome patients experience poor quality of life, frequently associated with lack of exercise and bad dietary habits. Additionally, factors such as obesity, neuromusculoskeletal impairment, and peripheral endothelial dysfunction result in a chronic pain level. Whole body vibration exercise might represent a suitable physical therapy, since it is easy to perform, low cost, safe, and capable of promoting an improvement of quality of life and reducing chronic pain level during acute interventions in metabolic syndrome individuals.

ACS Style

Laisa Liane Paineiras-Domingos; Danúbia Da Cunha Sá-Caputo; Arlete Francisca-Santos; Aline Reis-Silva; Rafaelle Pacheco Carvalho-Lima; Mario Fritsch T. Neves; Vinicius Layter Xavier; Hervé Quinart; François Constant Boyer; Alessandro Sartorio; Redha Taiar; Mario Bernardo-Filho. Can whole body vibration exercises promote improvement on quality of life and on chronic pain level of metabolic syndrome patients? A pseudorandomized crossover study. Journal of Applied Physiology 2020, 128, 934 -940.

AMA Style

Laisa Liane Paineiras-Domingos, Danúbia Da Cunha Sá-Caputo, Arlete Francisca-Santos, Aline Reis-Silva, Rafaelle Pacheco Carvalho-Lima, Mario Fritsch T. Neves, Vinicius Layter Xavier, Hervé Quinart, François Constant Boyer, Alessandro Sartorio, Redha Taiar, Mario Bernardo-Filho. Can whole body vibration exercises promote improvement on quality of life and on chronic pain level of metabolic syndrome patients? A pseudorandomized crossover study. Journal of Applied Physiology. 2020; 128 (4):934-940.

Chicago/Turabian Style

Laisa Liane Paineiras-Domingos; Danúbia Da Cunha Sá-Caputo; Arlete Francisca-Santos; Aline Reis-Silva; Rafaelle Pacheco Carvalho-Lima; Mario Fritsch T. Neves; Vinicius Layter Xavier; Hervé Quinart; François Constant Boyer; Alessandro Sartorio; Redha Taiar; Mario Bernardo-Filho. 2020. "Can whole body vibration exercises promote improvement on quality of life and on chronic pain level of metabolic syndrome patients? A pseudorandomized crossover study." Journal of Applied Physiology 128, no. 4: 934-940.