Water recycling is becoming progressively more important as the need for Integrated Urban Water Management (IUWM) is increasing to ensure a transition towards a more sustainable use for water. Perceptions and public acceptance of water reuse are recognised as paramount factors for the successful introduction of wastewater reuse projects, regardless of the strength of scientific evidence in their favour. This article analyses perceptions of risks and benefits of using treated wastewater for irrigation purposes in agriculture when dealing with different crops. Data from an original farmer survey are analysed through descriptive statistics and a classification tree approach. The study reveals limited knowledge of wastewater treatment, yet a good level of openness towards the reuse of wastewater for irrigation. A lower risk perception and a higher acceptance level are mainly explained by positive expectations with regard to the environmental characteristics of effluent water, higher education, and specific cropping choices. Enhancing information availability is also found to positively affect social acceptance. The ease of converting current water-management practices to the new water source explains the perceived benefits of reusing water.