Medical microrobotics is an emerging field that aims at non-invasive diagnosis and therapy inside the human body through miniaturized sensors and actuators. Such microrobots can be tethered (e.g., smart microcatheters, microendoscopes) or untethered (e.g., cell-based drug delivery systems). Active motion and multiple functionalities, distinguishing microrobots from mere passive carriers and conventional nanomedicines, can be achieved through external control with physical fields such as magnetism or ultrasound. Here we give an overview of the key challenges in the field of assisted reproduction and how these new technologies could, in the future, enable assisted fertilization in vivo and enhance embryo implantation. As a case study, we describe a potential intervention in the case of recurrent embryo implantation failure, which involves the non-invasive delivery of an early embryo back to the fertilization site using magnetically-controlled microrobots. As the embryo will be in contact with the secretory oviduct fluid, it can develop under natural conditions and in synchrony with the endometrium preparation. We discuss the potential microrobot designs, including a proper selection of materials and processes, envisioning their translation from bench to animal studies and human medicine. Finally, we highlight regulatory and ethical considerations for bringing this technology to the clinic.

Controllable magnetic fields can be used to optimize flows in technical and industrial processes involving liquid metals in order to improve quality and yield. However, experimental studies in magnetohydrodynamics often involve complex, turbulent flows and require planar, two-component (2c) velocity measurements through only one acoustical access. We present the phased array ultrasound Doppler velocimeter as a modular research platform for flow mapping in liquid metals. It combines the pulse wave Doppler method with the phased array technique to adaptively focus the ultrasound beam. This makes it possible to resolve smaller flow structures in planar measurements compared with fixed-beam sensors and enables 2c flow mapping with only one acoustical access via the cross beam technique. From simultaneously measured 2-D velocity fields, quantities for turbulence characterization can be derived. The capabilities of this measurement system are demonstrated through measurements in the alloy gallium-indium-tin at room temperature. The 2-D, 2c velocity measurements of a flow in a cubic vessel driven by a rotating magnetic field (RMF) with a spatial resolution of up to 2.2 mm are presented. The measurement results are in good agreement with a semianalytical simulation. As a highlight, two-point correlation functions of the velocity field for different magnitudes of the RMF are presented.

Zinc-air flow batteries provide a scalable and cost-efficient energy storage solution. However, the achieved power density depends on the local flow conditions of the zinc particle suspension in the electrochemical cell. Numerical modeling is challenging due to the complex multiphase fluid and the interaction of flow and electrochemistry. Hence, performing experiments is crucial to investigate the influence of the flow conditions on the electrical performance, which requires flow instrumentation for the opaque suspension. To resolve the flow field across the 2.6-mm-wide flow channel of the investigated zinc-air flow battery (ZAB), a spatial resolution below 100 μm has to be typically achieved. Using ultrasound techniques, the achieved spatial resolution is limited by the trade-off between ultrasound frequency and imaging depth. This trade-off is even more critical for suspensions due to the scattering of the ultrasound, which increases strongly with frequency. We propose super-resolution particle tracking velocimetry (SRPTV) to overcome this limitation by achieving the required spatial resolution at a low ultrasound frequency. SRPTV is based on the super-resolution technique ultrasound localization microscopy, which is adapted to strongly scattering suspensions by using a dual-frequency-phased array and applying a coherence weighting beamformer to suppress speckles, which result from the scattering at the zinc particles of the suspension. The spatial resolution and the velocity uncertainty are characterized through calibration measurement and numerical simulation. A spatial resolution of 66 μm at an excitation wavelength of 330 μm was achieved, which is sufficient for performing flow investigation in an operational ZAB. The measured flow profile reveals shear-thinning properties and wall slip and therefore differs significantly-from a parabolic flow profile of a Newtonian fluid. The presented technique offers potential for performing flow investigations of suspensions in small geometries with a spatial resolution beyond the diffraction limit.