In order to study the inhibition effect of gas–solid two-phase inhibitors on a methane explosion, the influence of these parameters was investigated and compared with that of single-phase inhibitors. The results show that the inhibition effect of gas–solid two-phase inhibitors on a methane explosion is better than the added effect of two single-phase inhibitors, indicating that a synergistic effect can be obtained by gas–solid two-phase inhibitors. The two-phase inhibitors which are composed of NaHCO₃ (BC) powders and inert gas have a better suppressing property than those composed of NH₄H₂PO₄ (ABC) powders and inert gas. The two-phase inhibitors composed of CO₂ and powders have a better suppressing property than those composed of N₂ and powders. The 9.5% premixed methane–air mixture can be completely inhibited by 0.10 g/L BC powders mixed with 8% CO₂. The suppression mechanisms of the gas–solid two-phase inhibitors on the methane explosion were discussed.