Adalberto Merighi

Prof. Adalberto Merighi

Department of Veterinary Sciences, University of Turin - Turin - Italy
orcid

Research Focus & Metrics

Academic Career Length

42Years (1985-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2008 in Progress in Neurobiology
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Journal Article
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AMAdalberto Merighi
Adalberto Merighi
CSChiara Salio
Chiara Salio
AGA Ghirri
A Ghirri
LLL Lossi
L Lossi
FFFrancesco Ferrini
Francesco Ferrini
RBRita Bardoni
Rita Bardoni

18 June 2016 in Molecules
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Journal Article
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BFBárbara Frias
Bárbara Frias
AMAdalberto Merighi
Adalberto Merighi
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved in somatic and visceral peripheral inflammation, in the modulation of nociceptive inputs to spinal cord and brain stem centers, as well as the integration of diverse painful stimuli. In this review, we first describe the chemical and pharmacological properties of capsaicin and its derivatives in relation to their analgesic properties. We then consider the biochemical and functional characteristics of TRPV1, focusing on its distribution and biological effects within the somatosensory and viscerosensory nociceptive systems. Finally, we discuss the use of capsaicin as an agonist of TRPV1 to model acute inflammation in slices and other ex vivo preparations.

1 January 1997 in Brain Research Bulletin
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Journal Article
Closed access
PPPaolo Peretto
Paolo Peretto
AMAdalberto Merighi
Adalberto Merighi
AFAldo Fasolo
Aldo Fasolo
LBLuca Bonfanti
Luca Bonfanti

1 August 1986 in Journal of Neurocytology
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Journal Article
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SGS. Gulbenkian
S. Gulbenkian
AMAdalberto Merighi
Adalberto Merighi
JWJ. Wharton
J. Wharton
IVI. M. Varndell
I. M. Varndell
JPJ. M. Polak
J. M. Polak

1 July 1999 in Brain Research Bulletin
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Journal Article
Closed access
PPPaolo Peretto
Paolo Peretto
AMAdalberto Merighi
Adalberto Merighi
AFAldo Fasolo
Aldo Fasolo
LBLuca Bonfanti
Luca Bonfanti

Verified
Journal Article
Open access
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LLLaura Lossi
Laura Lossi
CCClaudia Castagna
Claudia Castagna
AMAdalberto Merighi
Adalberto Merighi
Caspase-3, onto which there is a convergence of the intrinsic and extrinsic apoptotic pathways, is the main executioner of apoptosis. We here review the current literature on the intervention of the protease in the execution of naturally occurring neuronal death (NOND) during cerebellar development. We will consider data on the most common altricial species (rat, mouse and rabbit), as well as humans. Among the different types of neurons and glia in cerebellum, there is ample evidence for an intervention of caspase-3 in the regulation of NOND of the post-mitotic cerebellar granule cells (CGCs) and Purkinje neurons, as a consequence of failure to establish proper synaptic contacts with target (secondary cell death). It seems possible that the GABAergic interneurons also undergo a similar type of secondary cell death, but the intervention of caspase-3 in this case still remains to be clarified in full. Remarkably, CGCs also undergo primary cell death at the precursor/pre-migratory stage of differentiation, in this instance without the intervention of caspase-3. Glial cells, as well, undergo a process of regulated cell death, but it seems possible that expression of caspase-3, at least in the Bergmann glia, is related to differentiation rather than death.