Dr. Michael Van Dyke has had a lifetime interest in the study of ligand-nucleic acid interactions and associated methods development. Spans forty years of small molecule-DNA interactions, general eukaryotic transcription mechanisms, immobilized metal affinity chromatography, G*G multiplex nucleic acids, combinatorial selection methods, lysine deacetylase regulation by inflammation, and ribosome homeostasis under nutritional stress conditions. His most recent work includes a reverse-genetic approach towards understanding potential biological functions of putative transcriptional regulatory proteins in the model organisms Escherichia coli and Thermus thermophilus and examining refractory cleavage sequences for type IIS restriction endonucleases.