During last 5 years, Dr. Cho has tried to walk one step more advance his research goal beyond phosphorylation. Dr. Cho has settled-up his laboratories with modernized and advanced experimental instruments. Dr. Cho introduced F-box proteins to screen and identify novel signaling pathways involved in cancer development and chemoresistance. By mammalian-two hybrid assay, Dr. Cho and his colleagues have found some F-box proteins can specifically interact with a member of STAT family proteins. A juicy fruit from the research was harvested to publish the research results to PNAS in 2020. By signaling network analysis, Dr. Cho and his colleagues also found that the chemoresistance in ovarian and prostate cancers is caused by novel cross-talking in signaling networks between MAPK and PKB signaling pathways. We strongly convince that the novel signaling pathways might harbor the physiological relevance with cancer development and chemoresistance in human.
Research Keywords & Expertise
Carcinogenesis
protein stability
signaling mechanisms
Molecular targeting
Chemoprevention and tu...
Fingerprints
13%
Carcinogenesis
5%
protein stability
5%
signaling mechanisms
5%
Molecular targeting
Short Biography
During last 5 years, Dr. Cho has tried to walk one step more advance his research goal beyond phosphorylation. Dr. Cho has settled-up his laboratories with modernized and advanced experimental instruments. Dr. Cho introduced F-box proteins to screen and identify novel signaling pathways involved in cancer development and chemoresistance. By mammalian-two hybrid assay, Dr. Cho and his colleagues have found some F-box proteins can specifically interact with a member of STAT family proteins. A juicy fruit from the research was harvested to publish the research results to PNAS in 2020. By signaling network analysis, Dr. Cho and his colleagues also found that the chemoresistance in ovarian and prostate cancers is caused by novel cross-talking in signaling networks between MAPK and PKB signaling pathways. We strongly convince that the novel signaling pathways might harbor the physiological relevance with cancer development and chemoresistance in human.
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