An artificial bee colony (ABC) is a relatively recent swarm intelligence optimization approach. In this paper, we propose the first attempt at applying ABC algorithm in analyzing a microarray gene expression profile. In addition, we propose an innovative feature selection algorithm, minimum redundancy maximum relevance (mRMR), and combine it with an ABC algorithm, mRMR-ABC, to select informative genes from microarray profile. The new approach is based on a support vector machine (SVM) algorithm to measure the classification accuracy for selected genes. We evaluate the performance of the proposed mRMR-ABC algorithm by conducting extensive experiments on six binary and multiclass gene expression microarray datasets. Furthermore, we compare our proposed mRMR-ABC algorithm with previously known techniques. We reimplemented two of these techniques for the sake of a fair comparison using the same parameters. These two techniques are mRMR when combined with a genetic algorithm (mRMR-GA) and mRMR when combined with a particle swarm optimization algorithm (mRMR-PSO). The experimental results prove that the proposed mRMR-ABC algorithm achieves accurate classification performance using small number of predictive genes when tested using both datasets and compared to previously suggested methods. This shows that mRMR-ABC is a promising approach for solving gene selection and cancer classification problems.

In this paper, we propose a new hybrid method based on Correlation-based feature selection method and Artificial Bee Colony algorithm,namely Co-ABC to select a small number of relevant genes for accurate classification of gene expression profile. The Co-ABC consists of three stages which are fully cooperated: The first stage aims to filter noisy and redundant genes in high dimensionality domains by applying Correlation-based feature Selection (CFS) filter method. In the second stage, Artificial Bee Colony (ABC) algorithm is used to select the informative and meaningful genes. In the third stage, we adopt a Support Vector Machine (SVM) algorithm as classifier using the preselected genes form second stage. The overall performance of our proposed Co-ABC algorithm was evaluated using six gene expression profile for binary and multi-class cancer datasets. In addition, in order to proof the efficiency of our proposed Co-ABC algorithm, we compare it with previously known related methods. Two of these methods was re-implemented for the sake of a fair comparison using the same parameters. These two methods are: Co-GA, which is CFS combined with a genetic algorithm GA. The second one named Co-PSO, which is CFS combined with a particle swarm optimization algorithm PSO. The experimental results shows that the proposed Co-ABC algorithm acquire the accurate classification performance using small number of predictive genes. This proofs that Co-ABC is a efficient approach for biomarker gene discovery using cancer gene expression profile.

In the diagnosis and treatment of cancer, cancer classification is a vital issue. Gene selection is much needed to solve the high dimensionality issue in microarray data, small sample size, and noisy. The best way to classify cancer is to select those genes that hold the most informative ones, and this process contributes significantly to the classification performance of microarrays. In this survey, we comprehensively studied hybrid selection methods proposed since 2017, that may be used for comparison to several other algorithms proposed for gene selection in cancer classification in the past and looked to see if there are any challenges future authors that need to be discussed.

Alzheimer’s disease (AD) is a complex genetic disorder that affects the brain and has been the focus of many bioinformatics research studies. The primary objective of these studies is to identify and classify genes involved in the progression of AD and to explore the function of these risk genes in the disease process. The aim of this research is to identify the most effective model for detecting biomarker genes associated with AD using several feature selection methods. We compared the efficiency of feature selection methods with an SVM classifier, including mRMR, CFS, the Chi-Square Test, F-score, and GA. We calculated the accuracy of the SVM classifier using validation methods such as 10-fold cross-validation. We applied these feature selection methods with SVM to a benchmark AD gene expression dataset consisting of 696 samples and 200 genes. The results indicate that the mRMR and F-score feature selection methods with SVM classifier achieved a high accuracy of around 84%, with a number of genes between 20 and 40. Furthermore, the mRMR and F-score feature selection methods with SVM classifier outperformed the GA, Chi-Square Test, and CFS methods. Overall, these findings suggest that the mRMR and F-score feature selection methods with SVM classifier are effective in identifying biomarker genes related to AD and could potentially lead to more accurate diagnosis and treatment of the disease.