Richard A. Bunce

Dr. Richard A. Bunce

Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078-3071, USA
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Research Focus & Metrics

Academic Career Length

36Years (1991-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 January 2024 in Pharmaceuticals
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Journal Article
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BNBaskar Nammalwar
Baskar Nammalwar
Richard A. BunceRichard A. Bunce
Richard A. Bunce
Pyrimidines have become an increasingly important core structure in many drug molecules over the past 60 years. This article surveys recent areas in which pyrimidines have had a major impact in drug discovery therapeutics, including anti-infectives, anticancer, immunology, immuno-oncology, neurological disorders, chronic pain, and diabetes mellitus. The article presents the synthesis of the medicinal agents and highlights the role of the biological target with respect to the disease model. Additionally, the biological potency, ADME properties and pharmacokinetics/pharmacodynamics (if available) are discussed. This survey attempts to demonstrate the versatility of pyrimidine-based drugs, not only for their potency and affinity but also for the improved medicinal chemistry properties of pyrimidine as a bioisostere for phenyl and other aromatic π systems. It is hoped that this article will provide insight to researchers considering the pyrimidine scaffold as a chemotype in future drug candidates in order to counteract medical conditions previously deemed untreatable.

24 December 2013 in Molecules
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Journal Article
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BNBaskar Nammalwar
Baskar Nammalwar
Richard A. BunceRichard A. Bunce
Richard A. Bunce
A review of the recent literature is given focusing on synthetic approaches to 1,2,3,4-tetrahydroquinolines, 2,3-dihydro-4(1H)-quinolinones and 4(1H)-quinolinones using domino reactions. These syntheses involve: (1) reduction or oxidation followed by cyclization; (2) SNAr-terminated sequences; (3) acid-catalyzed ring closures or rearrangements; (4) high temperature cyclizations and (5) metal-promoted processes as well as several less thoroughly studied reactions. Each domino method is presented with a brief discussion of mechanism, scope, yields, simplicity and potential utility.

16 March 2001 in The Journal of Organic Chemistry
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Journal Article
Closed access
Richard A. BunceRichard A. Bunce
Richard A. Bunce
DHDerrick M. Herron
Derrick M. Herron
LJLara B. Johnson
Lara B. Johnson
SKSharadsrikar V. Kotturi
Sharadsrikar V. Kotturi

1 July 2006 in Journal of Heterocyclic Chemistry
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Journal Article
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Richard A. BunceRichard A. Bunce
Richard A. Bunce
JSJames E. Schammerhorn
James E. Schammerhorn


1 March 2009 in Journal of Heterocyclic Chemistry
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Journal Article
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Richard A. BunceRichard A. Bunce
Richard A. Bunce
BNBaskar Nammalwar
Baskar Nammalwar