This page has only limited features, please log in for full access.

Unclaimed
Yossi Maatuf
The Institute for Drug Research (IDR), School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Basic Info

Basic Info is private.

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Review
Published: 23 February 2019 in Toxins
Reads 0
Downloads 0

Chronic pain is a major medical issue which reduces the quality of life of millions and inflicts a significant burden on health authorities worldwide. Currently, management of chronic pain includes first-line pharmacological therapies that are inadequately effective, as in just a portion of patients pain relief is obtained. Furthermore, most analgesics in use produce severe or intolerable adverse effects that impose dose restrictions and reduce compliance. As the majority of analgesic agents act on the central nervous system (CNS), it is possible that blocking pain at its source by targeting nociceptors would prove more efficient with minimal CNS-related side effects. The development of such analgesics requires the identification of appropriate molecular targets and thorough understanding of their structural and functional features. To this end, plant and animal toxins can be employed as they affect ion channels with high potency and selectivity. Moreover, elucidation of the toxin-bound ion channel structure could generate pharmacophores for rational drug design while favorable safety and analgesic profiles could highlight toxins as leads or even as valuable therapeutic compounds themselves. Here, we discuss the use of plant and animal toxins in the characterization of peripherally expressed ion channels which are implicated in pain.

ACS Style

Yossi Maatuf; Matan Geron; Avi Priel. The Role of Toxins in the Pursuit for Novel Analgesics. Toxins 2019, 11, 131 .

AMA Style

Yossi Maatuf, Matan Geron, Avi Priel. The Role of Toxins in the Pursuit for Novel Analgesics. Toxins. 2019; 11 (2):131.

Chicago/Turabian Style

Yossi Maatuf; Matan Geron; Avi Priel. 2019. "The Role of Toxins in the Pursuit for Novel Analgesics." Toxins 11, no. 2: 131.