Konstantinos Palikaras

Prof. Konstantinos Palikaras

Institute of Molecular Biology & Biotechnology, Foundation for Research & Technology - Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece
orcid

Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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11 February 2019 in Nature Neuroscience
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Journal Article
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EFEvandro Fang
Evandro Fang
YHYujun Hou
Yujun Hou
Konstantinos PalikarasKonstantinos Palikaras
Konstantinos Palikaras
BABryan A. Adriaanse
Bryan A. Adriaanse
JKJesse S. Kerr
Jesse S. Kerr
VBVilhelm A. Bohr
Vilhelm A. Bohr

28 August 2018 in Nature Cell Biology
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Konstantinos PalikarasKonstantinos Palikaras
Konstantinos Palikaras
ELEirini Lionaki
Eirini Lionaki
Nektarios TavernarakisNektarios Tavernarakis
Nektarios Tavernarakis

12 August 2021 in Nature Aging
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YAYahyah Aman
Yahyah Aman
TSTomas Schmauck-Medina
Tomas Schmauck-Medina
MHMalene Hansen
Malene Hansen
RMRichard I. Morimoto
Richard I. Morimoto
ASAnna Katharina Simon
Anna Katharina Simon
EFEvandro Fang
Evandro Fang

1 December 2013 in Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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Journal Article
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VNVassiliki Nikoletopoulou
Vassiliki Nikoletopoulou
MMMaria Markaki
Maria Markaki
Konstantinos PalikarasKonstantinos Palikaras
Konstantinos Palikaras
Nektarios TavernarakisNektarios Tavernarakis
Nektarios Tavernarakis

20 April 2015 in Nature
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Journal Article
Closed access
Konstantinos PalikarasKonstantinos Palikaras
Konstantinos Palikaras
ELEirini Lionaki
Eirini Lionaki
Nektarios TavernarakisNektarios Tavernarakis
Nektarios Tavernarakis

14 January 2010 in Cell Death & Disease
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EME Morselli
E Morselli
MMM C Maiuri
M C Maiuri
MMM Markaki
M Markaki
EME Megalou
E Megalou
APA Pasparaki
A Pasparaki
Guido KroemerGuido Kroemer
Guido Kroemer
Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes. In this study, we show that transgenic expression of Sirtuin-1 induces autophagy in human cells in vitro and in Caenorhabditis elegans in vivo. The knockdown or knockout of Sirtuin-1 prevented the induction of autophagy by resveratrol and by nutrient deprivation in human cells as well as by dietary restriction in C. elegans. Conversely, Sirtuin-1 was not required for the induction of autophagy by rapamycin or p53 inhibition, neither in human cells nor in C. elegans. The knockdown or pharmacological inhibition of Sirtuin-1 enhanced the vulnerability of human cells to metabolic stress, unless they were stimulated to undergo autophagy by treatment with rapamycin or p53 inhibition. Along similar lines, resveratrol and dietary restriction only prolonged the lifespan of autophagy-proficient nematodes, whereas these beneficial effects on longevity were abolished by the knockdown of the essential autophagic modulator Beclin-1. We conclude that autophagy is universally required for the lifespan-prolonging effects of caloric restriction and pharmacological Sirtuin-1 activators.