Indiscriminate discharge of pharmaceutical waste into the aquatic ecosystem may pose serious health challenges to aquatic biota. The effect of acute exposure to ibuprofen was evaluated using changes in behaviour and haematological parameters under static bio-assay method in Clarias gariepinus. Test specimens were exposed to acute concentrations of ibuprofen (0.28, 0.33, 0.38, 0.43 and 0.48 mg l−1) for 24, 48, 72 and 96 h durations respectively. Behavioural and phenotypic changes were observed in surviving fish. There were significant (p < 0.05) concentration and duration-dependent increases in erythrocyte (RBC), haemoglobin (Hb), pack cell volume (PCV) and leukocytes (WBC) in treated fish compared to the control. Insignificant decreases (p > 0.05) in mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were observed in treated fish compared to the control. Ibuprofen elicited dose and duration- dependent decrease in neutrophil counts with t...

Purpose: Plastic particulates and chemicals are emerging environmental pollutants with significant impact on aquatic ecosystems. In this study, the effects of oral uptake of melamine, melamine formaldehyde, and polyvinyl chloride on serum biochemical profiles, antioxidant enzymes activities, lipid peroxidation levels and brain acetyl cholinesterase activities in Clarias gariepinus juveniles were investigated. Methods: Fish specimens were fed diets spiked with melamine, melamine formaldehyde and poly vinyl chloride at 0.3% (3.0 g Kg⁻¹) dietary inclusion for 45 days. Toxicity effect of these plastic chemicals were estimated by assaying relevant biomarkers. Results: After 45 days exposure, Serum glucose was significantly elevated, whereas plasma protein levels were substantially reduced in the exposed fish groups. Serum transaminases were significantly elevated in the exposed groups. Brain acetylcholinesterase and antioxidant enzyme activities declined significantly, while malondialdehyde levels were elevated in the exposed groups. Conclusion: C. gariepinus is an important bioindicator to monitor the ecotoxicological impact of plastic chemicals such as melamine, and polyvinyl chloride.