I gained extensive experience in precise genome editing in eukaryotic cellular systems. At my start in Frankfurt, I developed a novel conditional gene trapping approach based on site-specific recombinases that paved the way towards national and international large-scale conditional mouse mutagenesis programs. At that time, I was responsible for vector development within the German Gene Trap Consortium (GGTC) and the European Conditional Mouse Mutagenesis (EUCOMM) program, to which I contributed a large variety of different gene-driven mutagenesis strategies. I was trained as a biochemist, a molecular biologist, and a cellular biologist. My current research focus lies in the influence of the microenvironment on leukemic cell behavior, gene editing, and genome-wide genetic screens, as well as in the development of techniques for the gene therapy of monogenic diseases using CRISPR/Cas9 technology.