Ten notable meteorological drought indices were compared on tracking the effect of drought on streamflow. A 730-month dataset of precipitation, temperature and evapotranspiration for 88 catchments in Oregon, USA, representing pristine conditions, was used to compute the drought indices. These indices were correlated with the monthly streamflow datasets of the minimum, maximum and mean discharge, and the discharge monthly fluctuation; it was revealed that the 3-month Z-score drought index (Z3) has the best association with the four streamflow variables. The Mann-Kendall trend detection test applied to the latter index time series mainly highlighted a downward trend in the autumn and winter drought magnitude (DM) and an upward trend in the spring and summer DM (p = 0.05). Finally, the Pettitt test indicated an abrupt decline in the annual and autumn DM, which began in 1984 and 1986, respectively.