Huajun Zhao

Dr. Huajun Zhao

Professor

Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 February 2023 in Phytomedicine
Verified
Journal Article
Closed access
MNMaowei Ni
Maowei Ni
JZJie Zhou
Jie Zhou
ZZZhihui Zhu
Zhihui Zhu
QXQiang Xu
Qiang Xu
ZYZhuomin Yin
Zhuomin Yin
HZHuajun Zhao
Huajun Zhao

3 May 2022 in Phytomedicine
Verified
Journal Article
Closed access
HHHuanwu Hong
Huanwu Hong
SLSiyue Lou
Siyue Lou
FZFanli Zheng
Fanli Zheng
HGHang Gao
Hang Gao
NWNina Wang
Nina Wang
HZHuajun Zhao
Huajun Zhao

1 February 2019 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
YWYi-Qi Wang
Yi-Qi Wang
JMJin-Bo Mao
Jin-Bo Mao
MZMing-Qian Zhou
Ming-Qian Zhou
YJYa-Wei Jin
Ya-Wei Jin
CLCheng-Hua Lou
Cheng-Hua Lou
CWCheng-Ping Wen
Cheng-Ping Wen

22 April 2022 in European Journal of Pharmacology
Verified
Journal Article
Closed access
YWYingying Wei
Yingying Wei
ZZZhihui Zhu
Zhihui Zhu
HHHongtao Hu
Hongtao Hu
JGJiaqi Guan
Jiaqi Guan
BYBo Yang
Bo Yang
HZHuajun Zhao
Huajun Zhao

31 October 2017 in Natural Product Research
Verified
Journal Article
Closed access
BYBo Yang
Bo Yang
JSJia Wei Shen
Jia Wei Shen
DZDong Heng Zhou
Dong Heng Zhou
YZYa Ping Zhao
Ya Ping Zhao
WWWei Qian Wang
Wei Qian Wang
HZHuajun Zhao
Huajun Zhao
Michael reaction acceptors (MRAs) are a class of active compounds. There is a great prospect to screen STAT3 inhibitors from Eupatorium lindleyanum, furthermore, to discover lead compounds for anti-triple-negative breast cancer (TNBC). In this study, glutathione (GSH) was employed, and a UPLC-MS screening method was developed to discover MRAs. We screened MRAs which can inhibit STAT3 using a STAT3-dependent reporter system. Six sesquiterpene lactones, including a new compound Eupalinolide O (1), together with five known compounds, Eupalinolide I (2), Eupalinolide K (3), Eupalinolide H (4), Eupalinolide J (5) and Eupalinolide G (6) were isolated. Eupalinolide J was identified as MRA that decreased luciferase activity of STAT3. Preliminary activity assessment showed that Eupalinolide J could inhibit the viability of TNBC cell lines. We demonstrated that Eupalinolide J, which is a natural typical MRA, has a notable inhibition of STAT3 activity and a potential cytotoxic activity against TNBC cell lines.

1 November 2024 in Genes & Diseases
Verified
Journal Article
Open access
CJChenying Jiang
Chenying Jiang
CSChenjun Shen
Chenjun Shen
MNMaowei Ni
Maowei Ni
LHLili Huang
Lili Huang
HHHongtao Hu
Hongtao Hu
ZZzhihui zhu
zhihui zhu
Ovarian cancer is one of the most common malignant tumors of the female reproductive system. The majority of patients with advanced ovarian cancer are mainly treated with cisplatin-based chemotherapy. As the most widely used first-line anti-neoplastic drug, cisplatin produces therapeutic effects through multiple mechanisms. However, during clinical treatment, cisplatin resistance has gradually emerged, representing a challenge for patient outcome improvement. The mechanism of cisplatin resistance, while known to be complex and involve many processes, remains unclear. We hope to provide a new direction for pre-clinical and clinical studies through this review on the mechanism of ovarian cancer cisplatin resistance and methods to overcome drug resistance.