Three well-known natural diosgenyl glycosides which have the same sugar chains but different sequence, ophipogonin C′, polyphillin C and prosapogenin B, were synthesised by a facile approach. A method using the levulinyl group as a protecting group to selectively mask the C3–OH of diosgenyl 4,6-O-benzylidene-β-d-glucopyranoside is described.
31 May 2012 in European Journal of Medicinal Chemistry