Alterations of water flows resulting from the manifestation of powerful hydro–social imaginaries often produce an uneven distribution of burdens and benefits for different social groups or regions, reflecting their social and political power. Marginalized regions can suffer manufactured territorialized water scarcity, which disturbs the natural, economic and socio-political order of water users, and as this article shows, inevitably affects their psychological wellbeing. Set in the context of the surroundings of Lake Urmia in Iran, once one of the largest hypersaline lakes in the world and now a severely degraded ecosystem mainly as a result of water overuse in its watershed, this article explores how and through which pathways this manufactured water scarcity impacted the mental health of the water users in the region. The research findings reveal that alterations in this local hydro–social territory and the resulting biophysical, financial and social changes, as well as impacts on physical health of water users, relate to chronic psychological stress, social isolation, intra-community conflicts, despair, hopelessness, depression and anxiety.

Background: Benzalkonium chloride (BAC) is one of the most common ingredients of the disinfectants. It is commonly detected in surface and wastewaters where it can interact with the residues of pharmaceuticals that are also common wastewater pollutants. Among the latter, the residues of antineoplastic drugs are of particular concern as recent studies showed that they can induce adverse effect in aquatic organisms at environmentally relevant concentrations.Methods: Ecotoxicity of BAC as an individual compound and in a binary mixture with an antineoplastic drug 5-fluorouracil (5-FU) was determined towards algaPseudokirchneriella subcapitata,a representative of primary producers.The toxicity of the BAC+5-FU binary mixture was predicted by the two basic models: concentration addition (CA) and independent action (IA), and compared to the experimentally determined toxicity. Additionally combination index (CI) was calculated to determine the type of interaction.Results: After 72 h exposure to BAC a concentration dependent growth inhibition ofP. subcapitatawas observed with an EC₅₀0.255 mg/L. Comparing the predicted no effect concentration to the measured concentrations in the surface waters indicate that BAC at current applications and occurrence in aquatic environment may affect algal populations. The measured toxicity of the mixture was higher from the predicted and calculated CI confirmed synergistic effect on the inhibition of algal growth, at least at EC₅₀concentration. The observed synergism may have impact on the overall toxicity of wastewaters, whereas it is less likely for general environments because the concentrations of 5-FU are several orders of magnitude lower from its predicted no effect concentration.Discussion: These results indicate that combined effects of mixtures of disinfectants and antineoplastic drugs should be considered in particular when dealing with environmental risk assessment as well as the management of municipal and hospital wastewaters.

The unequal vulnerability of Kurdish and Azeri minorities in the case of the degradation of Lake Urmia, Iran