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Ms. Ye Zhao
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8Years (2019-Present)
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Representative Publications
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Journal Article
JCjinlong cheng
jinlong chengYZYe Zhao
Ye ZhaoGXGang Xu
Gang XuKZKeran Zhang
Keran ZhangWJWenfeng Jia
Wenfeng JiaZGZhang Guozhong
Zhang Guozhong +4
Some coronaviruses (CoVs) have an extra furin cleavage site (RRKR/S, furin-S2′ site) upstream of the fusion peptide in the spike protein, which plays roles in virion adsorption and fusion. Mutation of the S2′ site of QX genotype (QX-type) infectious bronchitis virus (IBV) spike protein (S) in a recombinant virus background results in higher pathogenicity, pronounced neural symptoms and neurotropism when compared with conditions in wild-type IBV (WT-IBV) infected chickens. In this study, we present evidence suggesting that recombinant IBV with a mutant S2′ site (furin-S2′ site) leads to higher mortality. Infection with mutant IBV induces severe encephalitis and breaks the blood–brain barrier. The results of a neutralization test and immunoprotection experiment show that an original serum and vaccine can still provide effective protection in vivo and in vitro. This is the first demonstration of IBV-induced neural symptoms in chickens with encephalitis and the furin-S2′ site as a determinant of neurotropism.
Journal Article
Infectious bronchitis virus (IBV) is an enveloped and positive-sense single-stranded RNA virus. IBV was the first coronavirus to be discovered and predominantly causes respiratory disease in commercial poultry worldwide. This review summarizes several important aspects of IBV, including epidemiology, genetic diversity, antigenic diversity, and multiple system disease caused by IBV as well as vaccination and antiviral strategies. Understanding these areas will provide insight into the mechanism of pathogenicity and immunoprotection of IBV and may improve prevention and control strategies for the disease.
1 March 2021 in Veterinary Microbiology
Journal Article
GXGang Xu
Gang Xu
SMShuhui Ma
Shuhui Ma
JCJinlong Cheng
Jinlong Cheng
YZYe Zhao
Ye ZhaoZGZhang Guozhong
Zhang Guozhong1 November 2020 in Virology
Journal Article
JZJing Zhao
Jing Zhao
KZKeran Zhang
Keran Zhang
JCJinlong Cheng
Jinlong Cheng
WJWenfeng Jia
Wenfeng Jia
YZYe Zhao
Ye ZhaoZGZhang Guozhong
Zhang GuozhongAbout Me
Ye Zhao, PhD
Assistant Professor of Preventive Veterinary Medicine
Education: 09/2012-06/2018, PhD in Preventive Veterinary Medicine, China Agricultural University; 09/2016-10/2017, Cooperation research in Vetsuisse Faculty, University of Bern; 09/2007-07/2012, B.S. in Veterinary Medicine, China Agricultural University
Training and Professional Experience: 2020-now, Assistant Professor, China Agricultural University College of Veterinary Medicine; 2018-2020, Postdoctoral Fellow, Department of Biochemistry and Molecular Biology, China Agricultural University College of Biological Sciences
Research Interests: Pathogenicity of Nephropathogenic Infectious Bronchitis Virus (IBV); Molecular Biology of IBV; Reverse Genetics System of IBV
Selected Publications
Sun L, Tang XY, Qi JY, Zhang CL, Zhao J, Zhang GZ*, Zhao, Y*. Infect. Genet. Evol, 2021, 94:105006.
Xu G, Ma SH, Cheng JL, Zhao Y*, Zhang GZ*. Veterinary Microbiology. 2021, 254:109014.
Zhao J, Zhang KR, Cheng JL, Jia WF, Zhao Y*, Zhang GZ*. Virology 2020, 550:1-7.
Zhao Y, Cheng JL, Yan SH, Jia WF, Zhang KR, Zhang GZ. Virology 2019, 533: 12-20.
Zhao Y, Xie DQ, Zhang KR, Cheng JL, Xu G, Zhang GZ. Virus Res. 2019, 267: 59-66.
Zhao Y, Cheng JL, Xu G, Thiel V，Zhang GZ. Virus Res 2019, 272.