Co-crystallization of dithiocarbamate complexes [M^II(S₂CNEt₂)₂] (M = Cu 1, Ni 2, Pd 3, Pt 4) and 1,3,5-triiodotrifluorobenzene (FIB) gives an isomorphic series of (1–4)·2FIB co-crystals exhibiting quadruple Cu/Ni/Pd/Pt isostructural exchange. In the structures of (1–4)·2FIB, the halogen-bonded C–I⋯M (Ni, Pd, Pt) and semicoordination M⋯I–C (Cu) metal-involving contacts were identified by X-ray diffractometry and their nature was verified theoretically. The directionality of the I_σ-hole⋯d² _zM^II and M^II⋯I_{electron belt} interactions depends on the identity of a metal center: on going from a rather electrophilic Cu^II to substantially more nucleophilic Ni^II, Pd^II, and Pt^II centers, we observed the electron belt-to-σ-hole switch of a noncovalently bound iodine(I) of FIB and, correspondingly, its shift from semicoordination to halogen bonding. The negative values of the electrostatic potentials (given in parentheses) were estimated for all metal centers and they decrease in the order Cu^II (−8.8) > Ni^II (−24.5) > Pd^II (−28.6) > Pt^II (−33.3 kcal mol⁻¹). Despite the negative potentials at all M^IIs, the semicoordinative contact Cu⋯I was established by the recognition of the LP(I) → LP*(Cu) charge transfer using natural bond orbital (NBO) analysis and the comparison of electron density (ED) and electrostatic potential (ESP) minima positions along the I⋯Cu bond paths. In the case of the rather nucleophilic (although positively charged) Pd^II and Pt^II centers, the contacts C–I⋯d² _z[Pd] and C–I⋯d² _z[Pt] can be attributed to the unconventional metal-involving halogen bonding; these contacts are among the strongest (4.30 and 5.42 kcal mol⁻¹, correspondingly) between any metal center and iodine(I)-based σ-hole donors.

Replacement of amide moiety with the 1,2,4-oxadiazole core in the scaffold of recently reported efflux pump inhibitors afforded a novel series of oxadiazole/2-imidazoline hybrids. The latter compounds exhibited promising antibacterial activity on both Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli, Pseudomonas fluorescens) strains. Furthermore, selected compounds markedly inhibited the growth of certain drug-resistant bacteria. Additionally, the study revealed the antiproliferative activity of several antibacterial frontrunners against pancreas ductal adenocarcinoma (PANC-1) cell line, as well as their type-selective monoamine oxidase (MAO) inhibitory profile.

The {d _{z ²} -M ^II S ₄ } (M = Ni, Pd, Pt) moieties function as integrated five-center acceptors toward a π-hole of an electron-deficient arene furnishing the reverse sandwich structures.