Limited information on the potential toxicity of ionic liquids (ILs) becomes the bottleneck that creates a barrier in their large-scale application. In this work, two quantitative structure-activity relationships (QSAR) models were used to evaluate the toxicity of ILs toward the acetylcholinesterase enzyme using multiple linear regression (MLR) and extreme learning machine (ELM) algorithms. The structures of 57 cations and 21 anions were optimized using quantum chemistry calculations. The electrostatic potential surface area (S_EP) and the screening charge density distribution area (S_σ) descriptors were calculated and used for prediction of IL toxicity. Performance and predictive aptitude between MLR and ELM models were analyzed. Highest squared correlation coefficient (R²), and also lowest average absolute relative deviation (AARD%) and root-mean-square error (RMSE) were observed for training set, test set, and total set for the ELM model. These findings validated the superior performance of ELM over the MLR toxicity prediction model.