Layered materials with intracrystalline reactivity undergo intercalation and pillaring reactions to produce materials with useful properties for catalysis, electrodes for Li batteries and adsorbents. New possibilities for the use of layered inorganic solids came out from the layered structures capable of delamination. The exfoliated particles are considered a new class of nanomaterial based on single crystal nanosheets. Due to their unique morphological features and properties, these nanosheets can be used as building blocks for nanomaterials with innovative properties. In this feature article we describe the aspects related to layered niobate exfoliation and the new possibilities that arises from the use of niobate nanosheets in the manufacturing of thin films, layer-by-layer (LbL) assemblies, hybrid structures, sensors and other materials.