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Several cytokines and adipokines are related to clinical severity and progression in knee osteoarthritis. The aim of this study was to evaluate the associations of IL-8 with clinical severity and with local and systemic adipokines and cytokines. This is a Cross-sectional study including 115 women with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, symptoms duration and body mass index were collected. Radiographic severity was evaluated according to Kellgren–Lawrence. Pain and disability were assessed by Lequesne and Knee injury and Osteoarthritis Outcome Score pain, symptoms and function scales. Three inflammatory markers and five adipokines were measured by ELISA in serum and synovial fluid. Partial correlation coefficient (PCC) and corresponding 95% confidence interval were used to evaluate association. Synovial fluid IL-8 was significantly associated with clinical severity scales. After controlling for potential confounders, associations measured by a Partial Correlation Coefficient (PCC) remained essentially unaltered for Lequesne (PCC = 0.237), KOOS pain (PCC = − 0.201) and KOOS symptoms (PCC = − 0.209), KOOS function (PCC = − 0.185), although the later did not reach statistical significance. Also in synovial fluid samples, associations were found between IL-8 and TNF (PCC = 0.334), IL6 (PCC = 0.461), osteopontin (PCC = 0.575), visfatin (PCC = 0.194) and resistin (PCC = 0.182), although significance was not achieved for the later after statistical control for confounders. None of these associations were detected in serum. In conclusion, IL-8 was associated with clinical severity, inflammatory markers and adipokines in synovial fluid, but not in blood. Although the reported associations are weak to moderate in magnitude, these findings reinforce the notion that local and not systemic inflammation is more relevant to clinical severity in knee OA women with joint effusion.
María García-Manrique; Joan Calvet; Cristóbal Orellana; Antoni Berenguer-Llergo; Silvia Garcia-Cirera; Maria Llop; Néstor Albiñana-Giménez; Carlos Galisteo-Lencastre; Jordi Gratacós. Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion. Scientific Reports 2021, 11, 1 -7.
AMA StyleMaría García-Manrique, Joan Calvet, Cristóbal Orellana, Antoni Berenguer-Llergo, Silvia Garcia-Cirera, Maria Llop, Néstor Albiñana-Giménez, Carlos Galisteo-Lencastre, Jordi Gratacós. Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion. Scientific Reports. 2021; 11 (1):1-7.
Chicago/Turabian StyleMaría García-Manrique; Joan Calvet; Cristóbal Orellana; Antoni Berenguer-Llergo; Silvia Garcia-Cirera; Maria Llop; Néstor Albiñana-Giménez; Carlos Galisteo-Lencastre; Jordi Gratacós. 2021. "Synovial fluid but not plasma interleukin-8 is associated with clinical severity and inflammatory markers in knee osteoarthritis women with joint effusion." Scientific Reports 11, no. 1: 1-7.
Background: COVID-19 pathophysiology and the predictive factors involved are not fully understood, but lymphocytes dysregulation appears to play a role. This paper aims to evaluate lymphocyte subsets in the pathophysiology of COVID-19 and as predictive factors for severe disease. Patient and methods: A prospective cohort study of patients with SARS-CoV-2 bilateral pneumonia recruited at hospital admission. Demographics, medical history, and data regarding SARS-CoV-2 infection were recorded. Patients systematically underwent complete laboratory tests, including parameters related to COVID-19 as well as lymphocyte subsets study at the time of admission. Severe disease criteria were established at admission, and patients were classified on remote follow-up according to disease evolution. Linear regression models were used to assess associations with disease evolution, and Receiver Operating Characteristic (ROC) and the corresponding Area Under the Curve (AUC) were used to evaluate predictive values. Results: Patients with critical COVID-19 showed a decrease in CD3+CD4+ T cells count compared to non-critical (278 (485 IQR) vs. 545 (322 IQR)), a decrease in median CD4+/CD8+ ratio (1.7, (1.7 IQR) vs. 3.1 (2.4 IQR)), and a decrease in median CD4+MFI (21,820 (4491 IQR) vs. 26,259 (3256 IQR)), which persisted after adjustment. CD3+CD8+ T cells count had a high correlation with time to hospital discharge (PC = −0.700 (−0.931, −0.066)). ROC curves for predictive value showed lymphocyte subsets achieving the best performances, specifically CD3+CD4+ T cells (AUC = 0.756), CD4+/CD8+ ratio (AUC = 0.767), and CD4+MFI (AUC = 0.848). Conclusions: A predictive value and treatment considerations for lymphocyte subsets are suggested, especially for CD3CD4+ T cells. Lymphocyte subsets determination at hospital admission is recommended.
Joan Calvet; Jordi Gratacós; María Amengual; Maria Llop; Marta Navarro; Amàlia Moreno; Antoni Berenguer-Llergo; Alejandra Serrano; Cristóbal Orellana; Manel Cervantes. CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective Study. Viruses 2020, 12, 1277 .
AMA StyleJoan Calvet, Jordi Gratacós, María Amengual, Maria Llop, Marta Navarro, Amàlia Moreno, Antoni Berenguer-Llergo, Alejandra Serrano, Cristóbal Orellana, Manel Cervantes. CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective Study. Viruses. 2020; 12 (11):1277.
Chicago/Turabian StyleJoan Calvet; Jordi Gratacós; María Amengual; Maria Llop; Marta Navarro; Amàlia Moreno; Antoni Berenguer-Llergo; Alejandra Serrano; Cristóbal Orellana; Manel Cervantes. 2020. "CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective Study." Viruses 12, no. 11: 1277.
Different adipokines have been reported to play a role in the development, progression, and severity of knee osteoarthritis, but this association may be mediated by obesity. The aim of this study was to evaluate separately the associations of leptin and adiponectin with clinical severity and inflammatory markers in nonobese and obese women with knee osteoarthritis. Cross-sectional study with systematic inclusion of 115 women with symptomatic primary knee osteoarthritis. Age, physical exercise, symptoms duration, and body mass index were collected. Radiographic severity was evaluated according to Kellgren-Lawrence scale. Pain and disability were assessed by WOMAC-total, -pain, -function subscales. Two adipokines (leptin and adiponectin) and 3 inflammatory markers (TNF-α, hsCRP, and IL-6) were measured by ELISA in synovial fluid and serum. Synovial fluid adiponectin was associated with WOMAC pain, function, and total and with synovial fluid IL-6 in nonobese female knee osteoarthritis after controlling by confounders (partial correlation coefficient [PCC] = 0.395, 0.387, 0.427, and 0.649, respectively). Synovial fluid and serum leptin were significantly associated with IL-6 (PCC = 0.354) after controlling by confounders but associations with clinical severity and the rest of inflammatory markers were mitigated after control. Adiponectin in synovial fluid was associated with clinical severity and local inflammatory markers in knee osteoarthritis women, while leptin relation was attenuated when controlled by confounders.
Cristóbal Orellana; Joan Calvet; Antoni Berenguer-Llergo; Néstor Albiñana; María García Manrique; Carlos Galisteo Lencastre; Marta Arévalo; María Llop; Assumpta Caixàs; Jordi Gratacós. Synovial Adiponectin Was More Associated with Clinical Severity than Synovial Leptin in Women with Knee Osteoarthritis. CARTILAGE 2020, 1 .
AMA StyleCristóbal Orellana, Joan Calvet, Antoni Berenguer-Llergo, Néstor Albiñana, María García Manrique, Carlos Galisteo Lencastre, Marta Arévalo, María Llop, Assumpta Caixàs, Jordi Gratacós. Synovial Adiponectin Was More Associated with Clinical Severity than Synovial Leptin in Women with Knee Osteoarthritis. CARTILAGE. 2020; ():1.
Chicago/Turabian StyleCristóbal Orellana; Joan Calvet; Antoni Berenguer-Llergo; Néstor Albiñana; María García Manrique; Carlos Galisteo Lencastre; Marta Arévalo; María Llop; Assumpta Caixàs; Jordi Gratacós. 2020. "Synovial Adiponectin Was More Associated with Clinical Severity than Synovial Leptin in Women with Knee Osteoarthritis." CARTILAGE , no. : 1.
To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)), and radiographic data (Bath Ankylosing Spondylitis Radiology Index (BASRI) score) were compared regarding HLA-B27 status. A univariate and multivariate analysis was performed to identify variables independently related to the presence of HLA-B27. Data from 1235 patients (74.8% male) were analyzed; 1029 were HLA-B27 positive (83%). HLA-B27-positive patients showed higher family aggregation and an earlier onset of disease compared with those who were HLA-B27 negative. HLA-B27-negative patients presented statistically higher BASDAI and BASFI scores and higher prevalence of arthritis, dactylitis, and extra-articular manifestations (psoriasis and inflammatory bowel disease (IBD)) but not anytime uveitis compared with those who were HLA-B27 positive. In the multivariate analysis, family history (odds ratio (OR) 2.10, 95% confidence interval (CI) 1.27–3.49), younger age at diagnosis (OR 0.97, 95% CI 0.96–0.98), presence of peripheral arthritis (OR 0.53, 95% CI 0.32–0.89), dactylitis (OR 0.16, 95% CI 0.05–0.56), psoriasis (OR 0.45, 95% CI 0.26–0.78), and IBD (OR 0.22, 95% CI 0.12–0.40) were the main variables independently related to the presence or not of HLA-B27. In Caucasian AS patients, the presence of HLA-B27 is related to an earlier disease onset and higher family aggregation. Absence of HLA-B27 is related to a higher frequency of peripheral arthritis, dactylitis, and extra-articular manifestations. Being HLAB27 positive is not related to a higher burden of disease or anytime uveitis.
Marta Arévalo; REGISPONSER group; Jordi Gratacós Masmitjà; Mireia Moreno; Joan Calvet; Cristobal Orellana; Desirée Ruiz; Carmen Castro; Pilar Carreto; Marta Larrosa; Eduardo Collantes; Pilar Font. Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database. Arthritis Research & Therapy 2018, 20, 1 -6.
AMA StyleMarta Arévalo, REGISPONSER group, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes, Pilar Font. Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database. Arthritis Research & Therapy. 2018; 20 (1):1-6.
Chicago/Turabian StyleMarta Arévalo; REGISPONSER group; Jordi Gratacós Masmitjà; Mireia Moreno; Joan Calvet; Cristobal Orellana; Desirée Ruiz; Carmen Castro; Pilar Carreto; Marta Larrosa; Eduardo Collantes; Pilar Font. 2018. "Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database." Arthritis Research & Therapy 20, no. 1: 1-6.
Objectives To assess ultrasound (US) abnormalities in patients with clinical and radiographic features of femoracetabular impingement (FAI) without radiologic osteoarthritis. Methods This study included patients aged 50 years or younger with hip pain and clinical and radiographic signs suggestive of FAI but without radiographic hip osteoarthritis. Demographic characteristics, the symptom duration, and the radiologic type of FAI were recorded. Ultrasound examinations assessed for anterior labral abnormalities, osteophytes, bone cortex irregularities, capsular distension, and acetabulofemoral and femoral head‐to‐neck distances. A balanced group of healthy volunteers was used as control participants. Results Forty‐four patients with FAI were evaluated. Ultrasound changes were found in 93.2% of patients, with 63.6% showing some kind of labral abnormality, 40.9% showing articular cartilage abnormalities, 38.6% showing bone contour irregularities, and 29.5% showing osteophytes. The cartilage width and symptom duration were inferior in patients with a damaged articular surface compared with those without (P = .005 and .012, respectively). Patients showing osteophytes on US examinations were slightly older (P = .048). Patients with cam‐type FAI were more frequently male (P = .0001) and younger (P = .022) compared with those who had pincer‐type FAI and also had a shorter symptom duration (P < .05). Patients with symptoms for 2 years or less had a shorter femoral cartilage width (P = .027). Femoral head‐to‐neck distances were shorter in patients compared with controls (P = .0005). Only 1 patient in the control group showed some US abnormality. Conclusions Ultrasound showed detected abnormalities in a significant proportion of patients with symptomatic FAI in early phases of the disease. Additional longitudinal studies are warranted to establish the prognostic importance of these US changes.© 2018 by the American Institute of Ultrasound in Medicine
Cristóbal Orellana; Mireia Moreno; Joan Calvet; Noemí Navarro; María García-Manrique; Jordi Gratacós. Ultrasound Findings in Patients With Femoracetabular Impingement Without Radiographic Osteoarthritis: A Pilot Study. Journal of Ultrasound in Medicine 2018, 38, 895 -901.
AMA StyleCristóbal Orellana, Mireia Moreno, Joan Calvet, Noemí Navarro, María García-Manrique, Jordi Gratacós. Ultrasound Findings in Patients With Femoracetabular Impingement Without Radiographic Osteoarthritis: A Pilot Study. Journal of Ultrasound in Medicine. 2018; 38 (4):895-901.
Chicago/Turabian StyleCristóbal Orellana; Mireia Moreno; Joan Calvet; Noemí Navarro; María García-Manrique; Jordi Gratacós. 2018. "Ultrasound Findings in Patients With Femoracetabular Impingement Without Radiographic Osteoarthritis: A Pilot Study." Journal of Ultrasound in Medicine 38, no. 4: 895-901.
Different patterns of association between synovial fluid adipokines were observed regarding pain and disability in knee osteoarthritis patients. Specifically, adiponectin was associated to pain while resistin and visfatin were mainly related to function.
J. Calvet; C. Orellana; N. Albiñana Giménez; A. Berenguer-Llergo; A. Caixàs; M. García-Manrique; C. Galisteo Lencastre; N. Navarro; M. Larrosa; J. Gratacós. Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study. Osteoarthritis and Cartilage 2018, 26, 276 -284.
AMA StyleJ. Calvet, C. Orellana, N. Albiñana Giménez, A. Berenguer-Llergo, A. Caixàs, M. García-Manrique, C. Galisteo Lencastre, N. Navarro, M. Larrosa, J. Gratacós. Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study. Osteoarthritis and Cartilage. 2018; 26 (2):276-284.
Chicago/Turabian StyleJ. Calvet; C. Orellana; N. Albiñana Giménez; A. Berenguer-Llergo; A. Caixàs; M. García-Manrique; C. Galisteo Lencastre; N. Navarro; M. Larrosa; J. Gratacós. 2018. "Differential involvement of synovial adipokines in pain and physical function in female patients with knee osteoarthritis. A cross-sectional study." Osteoarthritis and Cartilage 26, no. 2: 276-284.
Intraarticular injection is used for pain relief in knee osteoarthritis (OA), but there is not a well defined profile of patient who could get more benefit from it. The purpose of this study was to evaluate the frequency of pain relief at one year after corticosteroids intraarticular injection and to identify clinical factors associated to response in patients with knee osteoarthritis with joint effusion. One-year prospective cohort study of patients with knee OA with joint effusion confirmed by ultrasound. An intraarticular injection was performed following a clinical protocol. Anthropometric measurements, laboratory parameters, clinical severity, ultrasound parameters and radiological severity were collected. Response regarding pain and presence of synovial fluid on ultrasound at one month and at one year were evaluated. Clinical responder were consider in subjects with enough improvement to carry out normal daily activities with pain VAS<40mm. One hundred and thirty-two patients were included.A significant number of patients (61.4%) improved pain at one year following the protocol established in this study. Pain and ultrasound synovial fluid at one month appeared to predict the response at one year. The Lequesne index and the percentage of body fat were independently associated to pain at one year while the Lequesne index and ultrasound synovial hypertrophy were independently related to the presence of synovial fluid at one year. The status regarding pain or ultrasound synovial fluid at one month after an intraarticular joint injection appeared to predict the status at one year in patients with knee osteoarthritis and synovial effusion.
Joan Calvet; Cristobal Orellana; Carlos Galisteo; María García-Manrique; Noemí Navarro; Assumpta Caixàs; Marta Larrosa; Jordi Gratacós. Clinical and ultrasonographic features associated to response to intraarticular corticosteroid injection. A one year follow up prospective cohort study in knee osteoarthritis patient with joint effusion. PLOS ONE 2018, 13, e0191342 .
AMA StyleJoan Calvet, Cristobal Orellana, Carlos Galisteo, María García-Manrique, Noemí Navarro, Assumpta Caixàs, Marta Larrosa, Jordi Gratacós. Clinical and ultrasonographic features associated to response to intraarticular corticosteroid injection. A one year follow up prospective cohort study in knee osteoarthritis patient with joint effusion. PLOS ONE. 2018; 13 (1):e0191342.
Chicago/Turabian StyleJoan Calvet; Cristobal Orellana; Carlos Galisteo; María García-Manrique; Noemí Navarro; Assumpta Caixàs; Marta Larrosa; Jordi Gratacós. 2018. "Clinical and ultrasonographic features associated to response to intraarticular corticosteroid injection. A one year follow up prospective cohort study in knee osteoarthritis patient with joint effusion." PLOS ONE 13, no. 1: e0191342.
Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patients with knee osteoarthritis with joint effusion. Cross-sectional study with systematic inclusion of female patients with symptomatic primary knee osteoarthritis with ultrasound-confirmed joint effusion. Age, physical exercise, knee osteoarthritis symptoms duration, classical cardiovascular risk factors and different anthropometric measurements were collected. Metabolic syndrome was defined in accordance to National Cholesterol Education Program-Adult Treatment Panel III. Radiographic severity was evaluated according to Kellgren-Lawrence scale and Lequesne index was used to assess clinical severity. Seven adipokines (leptin, adiponectin, resistin, visfatin, osteopontin, omentin and chemerin) and three inflammatory markers (tumor necrosis factor α, interleukin 6 and high sensitivity C-reactive protein) were measured by enzyme-linked immunosorbent assay in synovial fluid. Kellgren-Lawrence grade, physical exercise, all anthropometric measurements (especially waist circumference), tumor necrosis factor α, and high levels of leptin, resistin, and ostepontin were related to knee osteoarthritis severity. After adjustment for clinical confounders (age, symptom duration, and radiology), anthropometric measurements, inflammatory markers, and all evaluated adipokines, there were independent associations with clinical severity for resistin (directly associated) and visfatin (inversely associated). No other adipokines or inflammatory markers were independently associated with Lequesne index. The association of radiological parameters, physical exercise, and waist circumference with Lequesne index remained after adjustment. Resistin was directly associated, and visfatin was inversely associated, with clinical severity in female patients with knee osteoarthritis with joint effusion. These associations were more important after adjustment for confounders, especially when all adipokines were evaluated.
Joan Calvet; Cristóbal Orellana; Jordi Gratacós; Antoni Berenguer-Llergo; Assumpta Caixàs; Juan José Chillarón; Juan Pedro-Botet; María García-Manrique; Noemí Navarro; Marta Larrosa. Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion. Arthritis Research & Therapy 2016, 18, 1 -11.
AMA StyleJoan Calvet, Cristóbal Orellana, Jordi Gratacós, Antoni Berenguer-Llergo, Assumpta Caixàs, Juan José Chillarón, Juan Pedro-Botet, María García-Manrique, Noemí Navarro, Marta Larrosa. Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion. Arthritis Research & Therapy. 2016; 18 (1):1-11.
Chicago/Turabian StyleJoan Calvet; Cristóbal Orellana; Jordi Gratacós; Antoni Berenguer-Llergo; Assumpta Caixàs; Juan José Chillarón; Juan Pedro-Botet; María García-Manrique; Noemí Navarro; Marta Larrosa. 2016. "Synovial fluid adipokines are associated with clinical severity in knee osteoarthritis: a cross-sectional study in female patients with joint effusion." Arthritis Research & Therapy 18, no. 1: 1-11.
La relación entre artrosis (OA) y trastornos metabólicos (como hiperglucemia y dislipemia) y comorbilidad cardiovascular, especialmente en el caso de la OA de rodilla, se ha evidenciado claramente en estudios epidemiológicos. Esta asociación no sólo se observa con dichas comorbilidades individuales sino también, por ejemplo, con el síndrome metabólico, claramente implicado en un elevado riesgo de complicaciones cardiovasculares. En gran parte, dicha asociación viene dada por la limitación funcional con relación a la deambulación que presentan los pacientes con enfermedad articular avanzada, así como por la frecuente coexistencia de obesidad, como factor de sobrecarga, y ser una enfermedad más prevalente en personas de edad avanzada. Sin embargo se observa también dicha asociación en grupos de edad más jóvenes y, en concreto, en el caso de OA de manos, lo cual apuntaría a la posible existencia de otros factores, no claramente ligados a la sobrecarga mecánica o a la limitación funcional y el sedentarismo. En este sentido se han implicado factores ligados a mecanismos inflamatorios presentes en la OA y en las comorbilidades cardiovasculares, como la disregulación de la homeostasis lipídica y, en especial, a la acción sistémica de ciertas sustancias, como las adipocitocinas, liberadas predominantemente a partir del tejido adiposo y que tiene una acción sinérgica con ciertas citocinas proinflamatorias, y que aumentan la expresión de mediadores inflamatorios. En el presente trabajo se revisa la evidencia de dichas asociaciones, así como los posibles mecanismos implicados. The relationship between osteoartritis (OA) and metabolic disorders, such as diabetes or dyslipemia, and cardiovascular comorbidity has been well established in epidemiologic studies, especially in the case of knee OA. This association has also been observed between OA and the metabolic syndrome, which is a major risk factor for cardiovascular disease. The functional disability resulting from advanced joint disease as well as Joint overload related to obesity and the the frequent coexistence of cardiovascular morbidity in an aging population were the major factors though to be involved. However, this ssociation has also been found in younger patients and in hand OA, thus pointing to the possible existence of additional factors not related to joint overload, diasbility or age. In recent years several metabolic and inflammatory factors present both in OA and in the different cardiovascular risk factors have been implicated, such as lipid homeostasis dysregulation and especially the activity of adipocytokines, cytokines released from adipose tissue with a synergistic action with proinflammatory cytokines and other inflammatory mediators. The evidence for this associations and the possible mechanisms are reviewed.
Cristóbal Orellana; Joan Calvet. Artrosis y comorbilidad cardiovascular. Seminarios de la Fundación Española de Reumatología 2012, 13, 28 -32.
AMA StyleCristóbal Orellana, Joan Calvet. Artrosis y comorbilidad cardiovascular. Seminarios de la Fundación Española de Reumatología. 2012; 13 ():28-32.
Chicago/Turabian StyleCristóbal Orellana; Joan Calvet. 2012. "Artrosis y comorbilidad cardiovascular." Seminarios de la Fundación Española de Reumatología 13, no. : 28-32.