Varun Kushwah

Dr. Varun Kushwah

Research Center for Pharmaceutical Engineering (RCPE), Graz, Austria
orcid

Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 December 2016 in Expert Opinion on Drug Delivery
Verified
Journal Article
Closed access
RARhythm Arora
Rhythm Arora
SKSameer S. Katiyar
Sameer S. Katiyar
VKVarun Kushwah
Varun Kushwah
SJSanyog Jain
Sanyog Jain
Background: The present work focuses on the development of ultra-small solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) encapsulating cyclosporine and calcipotriol, further incorporated into gel, increasing their penetration through the skin. Research design and methods: Developed SLN and NLC were characterized regarding particle size, zeta potential, %entrapment efficiency and dispersed into carbopol 934P-NF gel. Gel was further characterized for rheological behavior and spreadability. Ex vivo dermatokinetic by tape stripping method, in vitro efficacy on HaCaT cell lines and in vivo efficacy on imiquimod induced psoriatic model in mice were evaluated. Results: Ultra-small (size<100 nm) particles were formed with high entrapment efficiency and spherical morphology. Ex vivo dermatokinetic studies revealed deeper and confined drug penetration of lipid formulation gel in epidermal layers as compared to free drug. In vitro study on HaCaT cell lines depicted higher uptake and high efficacy owing to decrease in cell viability for NLC. The anti-psoriatic efficacy in BALB/c mice (evaluated on basis of cytokine levels and skin morphology) highlighted potential of drug-loaded NLC significantly higher as compared to drug loaded SLN and marketed formulation Betagel. Conclusions: The study demonstrated that NLC gel had higher efficacy in psoriatic management and hold promise for further exploration.

1 February 2016 in Carbohydrate Polymers
Verified
Journal Article
Closed access
CDChander Parkash Dora
Chander Parkash Dora
FTFrancesco Trotta
Francesco Trotta
VKVarun Kushwah
Varun Kushwah
NDNaresh Devasari
Naresh Devasari
CSCharan Singh
Charan Singh
SJSanyog Jain
Sanyog Jain

1 May 2017 in Nanomedicine: Nanotechnology, Biology and Medicine
Verified
Journal Article
Closed access
AKAmanpreet Kaur
Amanpreet Kaur
SKSameer S. Katiyar
Sameer S. Katiyar
VKVarun Kushwah
Varun Kushwah
SJSanyog Jain
Sanyog Jain

1 February 2016 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
NGNeeraj K. Garg
Neeraj K. Garg
RTRajeev K. Tyagi
Rajeev K. Tyagi
BSBhupinder Singh
Bhupinder Singh
GSGajanand Sharma
Gajanand Sharma
PNPradip Nirbhavane
Pradip Nirbhavane
OKOP Katare
OP Katare

1 October 2016 in Colloids and Surfaces B: Biointerfaces
Verified
Journal Article
Closed access
NGNeeraj K. Garg
Neeraj K. Garg
BSBhupinder Singh
Bhupinder Singh
AJAshay Jain
Ashay Jain
PNPradip Nirbhavane
Pradip Nirbhavane
RSRajeev Sharma
Rajeev Sharma
OKOP Katare
OP Katare

1 February 2019 in Colloids and Surfaces B: Biointerfaces
Verified
Journal Article
Closed access
PSPrashant Sahu
Prashant Sahu
SKSushil Kashaw
Sushil Kashaw
SSSamaresh Sau
Samaresh Sau
VKVarun Kushwah
Varun Kushwah
SJSanyog Jain
Sanyog Jain
Arun K. IyerArun K. Iyer
Arun K. Iyer