A network of modular protein complexes inside a cell coordinates many biological processes and is known as protein-protein interaction (PPI) network. APPI network can be modeled as a graph, in which edges represent interactions among proteins, and sub graphs represent protein complexes. Previous methods for protein complex mining from PPI network mainly focused on few topological features like density and degree statistics based on the assumption that proteins inside a complex are highly interactive with each other and thus form dense subgraphs. While this assumption is true for some complexes, it doesn't hold for many others. The important biological information within the protein amino acid sequences, which estimates the interacting property among two proteins for performing a specific biological function is not considered in most of the previous studies. There is a need for algorithms that consider both topological and biological features for correctly identifying protein complexes having varying topological structures and biological patterns inside a PPI network. In this paper, we present an algorithm for detecting protein complexes from interaction graphs. By using graph topological patterns and biological properties as features, we model each complex sub graph by decision tree learners. We use a training set of known complexes to construct decision trees in depth first and BEST FIRST manner using divide and conquer strategy. Splitting criterion, such as information and Gini gain are used in tree expansion process. Training set is divided into subsets and each subset is represented as a branch of tree. Pruning techniques are used to reduce the size of tree. We applied our method to protein interaction data in yeast on two benchmark data sets, i.e., MIPS and CYC2008. According to our results, decision trees achieved a considerable improvement over clique-based algorithms in terms of its ability to recover known complexes by using integrated biological and topological properties.

Sentiment analysis is a widely researched area due to its various applications in customer services, brand monitoring, and market research. Automatic sentiment classification is an important but challenging task. Contrary to the English language, sentiment analysis for low-resource languages like Urdu is an under-explored research area. Most of the work on sentiment analysis in the Urdu language is domain-dependent where models are mostly trained and tested on the same dataset on limited domains. However, sentiments in different domains are expressed differently, and manually annotating the datasets for all possible domains is unfeasible. Training a sentiment classifier using annotated data on one domain and testing it on another domain results in poor performance as the terms appearing in the source domain (training data) might not appear in the target (testing data) domain. In this paper, we present a baseline method for cross-domain sentiment analysis in the Urdu language using two different domains. Feature extraction is performed using n-grams and word embedding techniques. Sentiment classification is performed using machine learning and deep learning classifiers. The proposed method achieves an accuracy, precision, recall, and F1 scores of 0.77, 0.83, 0.68, and 0.75, respectively.

The new COVID-19 emerged in a town in China named Wuhan in December 2019, and since then, this deadly virus has infected 324 million people worldwide and caused 5.53 million deaths by January 2022. Because of the rapid spread of this pandemic, different countries are facing the problem of a shortage of resources, such as medical test kits and ventilators, as the number of cases increased uncontrollably. Therefore, developing a readily available, low-priced, and automated approach for COVID-19 identification is the need of the hour. The proposed study uses chest radiography images (CRIs) such as X-rays and computed tomography (CTs) to detect chest infections, as these modalities contain important information about chest infections. This research introduces a novel hybrid deep learning model named Lightweight ResGRU that uses residual blocks and a bidirectional gated recurrent unit to diagnose non-COVID and COVID-19 infections using pre-processed CRIs. Lightweight ResGRU is used for multi-modal two-class classification (normal and COVID-19), three-class classification (normal, COVID-19, and viral pneumonia), four-class classification (normal, COVID-19, viral pneumonia, and bacterial pneumonia), and COVID-19 severity types’ classification (i.e., atypical appearance, indeterminate appearance, typical appearance, and negative for pneumonia). The proposed architecture achieved f-measure of 99.0%, 98.4%, 91.0%, and 80.5% for two-class, three-class, four-class, and COVID-19 severity level classifications, respectively, on unseen data. A large dataset is created by combining and changing different publicly available datasets. The results prove that radiologists can adopt this method to screen chest infections where test kits are limited.