Biomechanical studies are expanding across a variety of fields, from biomedicine to biomedical engineering. From the molecular to the system level, mechanical stimuli are crucial regulators of the development of organs and tissues, their growth and related processes such as remodelling, regeneration or disease. When dealing with cell mechanics, various experimental techniques have been developed to analyse the passive response of cells; however, cell variability and the extraction process, complex experimental procedures and different models and assumptions may affect the resulting mechanical properties. For these purposes, this review was aimed at collecting the available literature focused on experimental chondrocyte and chondron biomechanics with direct connection to their biochemical functions and activities, in order to point out important information regarding the planning of an experimental test or a comparison with the available results. In particular, this review highlighted (i) the most common experimental techniques used, (ii) the results and models adopted by different authors, (iii) a critical perspective on features that could affect the results and finally (iv) the quantification of structural and mechanical changes due to a degenerative pathology such as osteoarthritis.

The paper aims to investigate the natural frequencies of sandwich plates by means of a Finite Element (FE) formulation based on the Reissner-Mindlin Zig-zag (RMZ) theory. The structures are made of a damaged isotropic soft-core and two external stiffer orthotropic face-sheets. These skins are strengthened at the nanoscale level by randomly oriented Carbon nanotubes (CNTs) and are reinforced at the microscale stage by oriented straight fibers. These reinforcing phases are included in a polymer matrix and a three-phase approach based on the Eshelby-Mori-Tanaka scheme and on the Halpin-Tsai approach, which is developed to compute the overall mechanical properties of the composite material. A non-uniform distribution of the reinforcing fibers is assumed along the thickness of the skin and is modeled analytically by means of peculiar expressions given as a function of the thickness coordinate. Several parametric analyses are carried out to investigate the mechanical behavior of these multi-layered structures depending on the damage features, through-the-thickness distribution of the straight fibers, stacking sequence, and mass fraction of the constituents. Some final remarks are presented to provide useful observations and design criteria.

Purpose: Knowledge of the behavior of concrete at mesoscale level requires, as a fundamental aspect, to characterize aggregates and specifically, their thermal properties if fire hazards (e.g. spalling) are accounted for. The assessment of aggregates performance (and, correspondingly, concrete materials made of aggregates, cement paste and ITZ – interfacial transition zone) is crucial for defining a realistic structural response as well as damage scenarios.Design/methodology/approach: It is here assumed that concrete creep is associated to cement paste only and that creep obeys to the B3 model proposed by Bažant and Baweja since it shows good compatibility with experimental results and it is properly justified theoretically.Findings: First, the three‐dimensionality of the geometric description of concrete at the meso‐level can be appreciated; then, creep of cement paste and ITZ allows to incorporate in the model the complex reality of creep, which is not only a matter of fluid flow and pressure dissipation but also the result of chemical‐physical reactions; again, the description of concrete as a composite material, in connection with porous media analysis, allows for understanding the hygro‐thermal and mechanical response of concrete, e.g. hygral barriers due to the presence of aggregates can be seen only at this modelling level. Finally, from the mechanical viewpoint, the remarkable damage peak effect arising from the inclusion of ITZ, if compared with the less pronounced peak when ITZ is disregarded from the analysis, is reported.Originality/value: The fully coupled 3D F.E. code NEWCON3D has been adopted to perform fully coupled thermo‐hygro‐mechanical meso‐scale analyses of concrete characterized by aggregates of various types and various thermal properties. The 3D approach allows for differentiating each constituent (cement paste, aggregate and ITZ), even from the point of view of their rheologic behaviour. Additionally, model B3 has been upgraded by the calculation of the effective humidity state when evaluating drying creep, instead than using approximate expressions. Damage maps allows for defining an appropriate concrete mixture to withstand spalling and to characterize the coupled behaviour of ITZ as well.