Cathryn Mellersh

Dr. Cathryn Mellersh


Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 September 2006 in Genomics
Verified
Journal Article
Closed access
CMCathryn Mellersh
Cathryn Mellersh
MBM.E.G. Boursnell
M.E.G. Boursnell
LPL. Pettitt
L. Pettitt
EREdward Ryder
Edward Ryder
NHN.G. Holmes
N.G. Holmes
MVM. Vaudin
M. Vaudin

10 April 2019 in National Science Review
Verified
Journal Article
Open access
PDF file
Elaine OstranderElaine Ostrander
Elaine Ostrander
GWGuo-Dong Wang
Guo-Dong Wang
GLGreger Larson
Greger Larson
BVBridgett VonHoldt
Bridgett VonHoldt
BDBrian Davis
Brian Davis
WZWeiwei Zhai
Weiwei Zhai
Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20× whole genomes from 10 000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

3 August 2011 in Veterinary Ophthalmology
Verified
Journal Article
Closed access
PDF file
DGDavid Gould
David Gould
LPLouise Pettitt
Louise Pettitt
BMBryan McLaughlin
Bryan McLaughlin
NHNigel Holmes
Nigel Holmes
OFOliver Forman
Oliver Forman
CMCathryn Mellersh
Cathryn Mellersh

7 June 2019 in Genes
Verified
Journal Article
Open access
PDF file
KBKevin Batcher
Kevin Batcher
PDPeter J. Dickinson
Peter J. Dickinson
MGMichelle Giuffrida
Michelle Giuffrida
BSBeverly Sturges
Beverly Sturges
KVKaren Vernau
Karen Vernau
DBDanika Bannasch
Danika Bannasch
Two FGF4 retrogenes on chromosomes 12 (12-FGF4RG) and 18 (18-FGF4RG) contribute to short-limbed phenotypes in dogs. 12-FGF4RG has also been associated with intervertebral disc disease (IVDD). Both of these retrogenes were found to be widespread among dog breeds with allele frequencies ranging from 0.02 to 1; however, their additive contribution to disease is unknown. Surgical cases of IVDD (n = 569) were evaluated for age of onset, disc calcification, and genotypes for the FGF4 retrogenes. Multivariable linear regression analysis identified the presence of one or two copies of 12-FGF4RG associated with significantly younger age at first surgery in a dominant manner. 18-FGF4RG had only a minor effect in dogs with one copy. Multivariable logistic regression showed that 12-FGF4RG had an additive effect on radiographic disc calcification, while 18-FGF4RG had no effect. Multivariable logistic regression using mixed breed cases and controls identified only 12-FGF4RG as highly associated with disc herniation in a dominant manner (Odds Ratio, OR, 18.42, 95% Confidence Interval (CI) 7.44 to 50.26; p < 0.001). The relative risk for disc surgery associated with 12-FGF4RG varied from 5.5 to 15.1 within segregating breeds and mixed breeds. The FGF4 retrogene on CFA12 acts in a dominant manner to decrease the age of onset and increase the overall risk of disc disease in dogs. Other modifiers of risk may be present within certain breeds, including the FGF4 retrogene on CFA18.

25 August 2006 in Veterinary Ophthalmology
Verified
Journal Article
Closed access
PDF file
CMCathryn Mellersh
Cathryn Mellersh
LPLouise Pettitt
Louise Pettitt
OFOliver P. Forman
Oliver P. Forman
MVMark Vaudin
Mark Vaudin
KBKeith C. Barnett
Keith C. Barnett

1 January 2012 in BMC Genetics
Verified
Journal Article
Open access
PDF file
OFOliver P Forman
Oliver P Forman
LRLuisa De Risio
Luisa De Risio
JSJennifer Stewart
Jennifer Stewart
CMCathryn Mellersh
Cathryn Mellersh
EBElsa Beltran
Elsa Beltran
Neonatal cerebellar cortical degeneration is a neurodegenerative disease described in several canine breeds including the Beagle. Affected Beagles are unable to ambulate normally from the onset of walking and the main pathological findings include Purkinje cell loss with swollen dendritic processes. Previous reports suggest an autosomal recessive mode of inheritance. The development of massively parallel sequencing techniques has presented the opportunity to investigate individual clinical cases using genome-wide sequencing approaches. We used genome-wide mRNA sequencing (mRNA-seq) of cerebellum tissue from a single Beagle with neonatal cerebellar cortical degeneration as a method of candidate gene sequencing, with the aim of identifying the causal mutation.