Large Language Models (LLMs) recently demonstrated extraordinary capability, including natural language processing (NLP), language translation, text generation, question answering, etc. Moreover, LLMs are a new and essential part of computerized language processing, having the ability to understand complex verbal patterns and generate coherent and appropriate replies for the situation. Though this success of LLMs has prompted a substantial increase in research contributions, rapid growth has made it difficult to understand the overall impact of these improvements. Since a lot of new research on LLMs is coming out quickly, it is getting tough to get an overview of all of them in a short note. Consequently, the research community would benefit from a short but thorough review of the recent changes in this area. This article thoroughly overviews LLMs, including their history, architectures, transformers, resources, training methods, applications, impacts, challenges, etc. This paper begins by discussing the fundamental concepts of LLMs with its traditional pipeline of the LLMs training phase. It then provides an overview of the existing works, the history of LLMs, their evolution over time, the architecture of transformers in LLMs, the different resources of LLMs, and the different training methods that have been used to train them. It also demonstrated the datasets utilized in the studies. After that, the paper discusses the wide range of applications of LLMs, including biomedical and healthcare, education, social, business, and agriculture. It also illustrates how LLMs create an impact on society and shape the future of AI and how they can be used to solve real-world problems. Then it also explores open issues and challenges to deploying LLMs in real-world scenario. Our review paper aims to help practitioners, researchers, and experts thoroughly understand the evolution of LLMs, pre-trained architectures, applications, challenges, and future goals.

Cardiovascular diseases (CVD) are among the most common serious illnesses affecting human health. CVDs may be prevented or mitigated by early diagnosis, and this may reduce mortality rates. Identifying risk factors using machine learning models is a promising approach. We would like to propose a model that incorporates different methods to achieve effective prediction of heart disease. For our proposed model to be successful, we have used efficient Data Collection, Data Pre-processing and Data Transformation methods to create accurate information for the training model. We have used a combined dataset (Cleveland, Long Beach VA, Switzerland, Hungarian and Stat log). Suitable features are selected by using the Relief, and Least Absolute Shrinkage and Selection Operator (LASSO) techniques. New hybrid classifiers like Decision Tree Bagging Method (DTBM), Random Forest Bagging Method (RFBM), K-Nearest Neighbors Bagging Method (KNNBM), AdaBoost Boosting Method (ABBM), and Gradient Boosting Boosting Method (GBBM) are developed by integrating the traditional classifiers with bagging and boosting methods, which are used in the training process. We have also instrumented some machine learning algorithms to calculate the Accuracy (ACC), Sensitivity (SEN), Error Rate, Precision (PRE) and F1 Score (F1) of our model, along with the Negative Predictive Value (NPR), False Positive Rate (FPR), and False Negative Rate (FNR). The results are shown separately to provide comparisons. Based on the result analysis, we can conclude that our proposed model produced the highest accuracy while using RFBM and Relief feature selection methods (99.05%).

The tremendously growing problem of phishing e-mail, also known as spam including spear phishing or spam borne malware, has demanded a need for reliable intelligent anti-spam e-mail filters. This survey paper describes a focused literature survey of Artificial Intelligence (AI) and Machine Learning (ML) methods for intelligent spam email detection, which we believe can help in developing appropriate countermeasures. In this paper, we considered 4 parts in the email’s structure that can be used for intelligent analysis: (A) Headers Provide Routing Information, contain mail transfer agents (MTA) that provide information like email and IP address of each sender and recipient of where the email originated and what stopovers, and final destination. (B) The SMTP Envelope, containing mail exchangers’ identification, originating source and destination domains\users. (C) First part of SMTP Data, containing information like from, to, date, subject – appearing in most email clients (D) Second part of SMTP Data, containing email body including text content, and attachment. Based on the number the relevance of an emerging intelligent method, papers representing each method were identified, read, and summarized. Insightful findings, challenges and research problems are disclosed in this paper. This comprehensive survey paves the way for future research endeavors addressing theoretical and empirical aspects related to intelligent spam email detection.

Alzheimer’s disease is largely the underlying cause of dementia due to its progressive neurodegenerative nature among the elderly. The disease can be divided into five stages: Subjective Memory Concern (SMC), Mild Cognitive Impairment (MCI), Early MCI (EMCI), Late MCI (LMCI), and Alzheimer’s Disease (AD). Alzheimer’s disease is conventionally diagnosed using an MRI scan of the brain. In this research, we propose a fine-tuned convolutional neural network (CNN) classifier called AlzheimerNet, which can identify all five stages of Alzheimer’s disease and the Normal Control (NC) class. The ADNI database’s MRI scan dataset is obtained for use in training and testing the proposed model. To prepare the raw data for analysis, we applied the CLAHE image enhancement method. Data augmentation was used to remedy the unbalanced nature of the dataset and the resultant dataset consisted of 60000 image data on the 6 classes. Initially, five existing models including VGG16, MobileNetV2, AlexNet, ResNet50 and InceptionV3 were trained and tested to achieve test accuracies of 78.84%, 86.85%, 78.87%, 80.98% and 96.31% respectively. Since InceptionV3 provides the highest accuracy, this model is later modified to design the AlzheimerNet using RMSprop optimizer and learning rate 0.00001 to achieve the highest test accuracy of 98.67%. The five pre-trained models and the proposed fine-tuned model were compared in terms of various performance matrices to demonstrate whether the AlzheimerNet model is in fact performing better in classifying and detecting the six classes. An ablation study shows the hyperparameters used in the experiment. The suggested model outperforms the traditional methods for classifying Alzheimer’s disease stages from brain MRI, as measured by a two-tailed Wilcoxon signed-rank test, with a significance of < 0.05.

In this study, multiple lung diseases are diagnosed with the help of the Neural Network algorithm. Specifically, Emphysema, Infiltration, Mass, Pleural Thickening, Pneumonia, Pneumothorax, Atelectasis, Edema, Effusion, Hernia, Cardiomegaly, Pulmonary Fibrosis, Nodule, and Consolidation, are studied from the ChestX-ray14 dataset. A proposed fine-tuned MobileLungNetV2 model is employed for analysis. Initially, pre-processing is done on the X-ray images from the dataset using CLAHE to increase image contrast. Additionally, a Gaussian Filter, to denoise images, and data augmentation methods are used. The pre-processed images are fed into several transfer learning models; such as InceptionV3, AlexNet, DenseNet121, VGG19, and MobileNetV2. Among these models, MobileNetV2 performed with the highest accuracy of 91.6% in overall classifying lesions on Chest X-ray Images. This model is then fine-tuned to optimise the MobileLungNetV2 model. On the pre-processed data, the fine-tuned model, MobileLungNetV2, achieves an extraordinary classification accuracy of 96.97%. Using a confusion matrix for all the classes, it is determined that the model has an overall high precision, recall, and specificity scores of 96.71%, 96.83% and 99.78% respectively. The study employs the Grad-cam output to determine the heatmap of disease detection. The proposed model shows promising results in classifying multiple lesions on Chest X-ray images.

Identification of brain tumors and accurate grading at an early stage are crucial in cancer diagnosis, as a timely diagnosis can increase the chances of survival. Considering the challenges and risks of tumor biopsies, noninvasive imaging procedures such as Magnetic Resonance Imaging (MRI) are extensively used in analyzing brain tumors. Recent advances in the field of medical imaging with deep learning using three dimensional (3D) MRI is aiding the clinical experts significantly in the diagnosis of brain tumor. In this study, three BraTS MRI datasets named BraTS 2018, BraTS 2019 and BraTS 2020 are employed to classify brain tumor into high-grade glioma (HGG) and low-grade glioma (LGG) where each of the datasets contains four different sequences of 3D MRI brain images named T1-weighted MRI (T1), T1-weighted MRI with contrast enhancement (T1ce), T2-weighted MRI (T2), and Fluid Attenuated Inversion Recovery (FLAIR) for a single patient. This research is composed of two approaches where, in the first part, we propose a hybrid deep learning model named TimeDistributed-CNN-LSTM (TD-CNN-LSTM) combining 3D Convolutional Neural Network (CNN) and Long Short Term Memory (LSTM) where each layer of the architecture is wrapped with a TimeDistributed function. The objective of developing the hybrid model is to consider all the four 3D MRI sequences of each patient as a single input data because every sequence contains necessary information on tumor that can have an impact on improving cancer detection performance. However, interpreting all the MRI sequences together with optimal performance especially in 3D is quite challenging. Therefore, the model is developed with optimal configuration based on highest accuracy performing ablation study for layer architecture and hyper-parameters. In the second part, a 3D CNN model is trained respectively with each of the MRI sequences to compare the performance with TD-CNN-LSTM model. In this regard, for both of the models, BraTS 2018 and BraTS 2019 are combined to increase the number of images and used as train dataset where BraTS 2020 dataset is employed as the test dataset. Moreover, before training the models the datasets is preprocessed to ensure the highest performance. Our results of these two approaches demonstrate that the TD-CNN-LSTM network outperforms 3D CNN achieving the highest test accuracy of 98.90%. Later, to evaluate the performance consistency, the TD-CNN-LSTM model is evaluated with K-fold cross validation using different k values. The approach of putting together all the MRI sequences at a time using hybrid CNN-LSTM approach with good generalization capability to classify brain tumor can be used effectively in future Computer Aided Diagnosis (CAD) based research which can aid radiologists in medical diagnostics.