The availability and sustainability of suitable and good quality drinking water is a global concern. Such uncertainties threaten livestock production with an attendant ripple effect on food security. Small ruminants, including sheep and goats, appear to be promising to smallholder farmers in solving this problem because of their ability to survive in water-limited areas and harsh environment when compared with large ruminants. Their small body size is also seen as an advantage, because less water will be required for proper digestion and feed utilization. Therefore, this review will provide information regarding the adaptive responses of small ruminants on thermoregulation, blood metabolites, immune status, drug pharmacokinetics, reproduction and hormonal indices during the period of water stress. Adaptable and indigenous breeds are known to be more tolerant to water stress than selected breeds. A drop in feed intake and weight reduced respiratory rate and increased concentration of blood metabolites are the general effects and/or observations that are encountered by small ruminants during the period of water stress. The concept of water tolerance either as deprivation and/or restriction of indigenous and adaptable breeds of small ruminants is gaining ground in research studies around the world. However, more research, however, seeking to explore water tolerance capacity of adaptable breeds especially in arid and water limiting areas are still needed.

Mycotoxins are toxic secondary metabolites produced by various fungi that contaminate livestock feed, posing serious threats to animal health, productivity, and food safety. Although historical research has often examined individual mycotoxins in isolation, real-world conditions typically involve the simultaneous presence of multiple mycotoxins, resulting in additive or synergistic toxic effects that are often more severe than those observed with single toxin exposures. This review comprehensively synthesizes recent findings on multi-mycotoxin contamination in livestock feed, highlighting their physiological effects, mechanisms of action, and implications for regulatory frameworks. Multi-mycotoxin interactions exacerbate oxidative stress, immune suppression, impaired reproduction, and organ damage across species, leading to reduced growth performance, decreased milk and egg production, compromised carcass and wool quality, and increased mortality rates. A major concern is that current international regulatory standards mainly address individual mycotoxins, overlooking the compounded risks of co-occurrence. Global surveillance studies consistently reveal high prevalence rates of mycotoxin mixtures in feedstuffs, especially combinations involving DON, ZEN, AFB₁, FB₁, and OTA. Understanding these interactions and their underlying cellular mechanisms is critical for improving risk assessment models, formulating integrated mitigation strategies, and safeguarding both livestock productivity and human food security.

Water restriction in small ruminants is usually accompanied by a drop in feed intake, body weight, and disturbances in the normal internal milieu. However, attempts to lessen the burden of water stress with vitamin C (VC) supplementation have been greeted with conflicting reports. Therefore, this experiment was conducted to evaluate the effect of single and/or multiple VC supplementations in water-restricted Xhosa goats by evaluating their performance, heat tolerance, and blood metabolites. In total, 42 does, 12 mo old and with an average weight of 15.92 ± 2.12 kg were evaluated for 75 d. The does were distributed according to a complete randomized design into seven groups of six comparable animals: W0, without water restriction (control); W70, water restriction of 70% of ad libitum water intake (WI); W50, water restriction of 50% ad libitum WI; W70⁺, water restriction of 70% of ad libitum WI plus 3 g VC daily; W50⁺, water restriction 50% of ad libitum WI plus 3 g VC daily; W70⁺⁺, water restriction of 70% of ad libitum WI plus 3 g VC and extra 5 g VC given every eighth day; and W50⁺⁺, water restriction of 50% of ad libitum WI plus 3 g VC and extra 5 g VC given every eighth day. Goats under the W50 group were the most affected (P < 0.05) and the effect was more pronounced in their body condition scores (BCs). Weight loss due to water restriction was reduced by VC supplementation in treated groups. Changes in body thermal gradient, rectal temperature, cholesterol, and bilirubin were similar (P > 0.05) across the various experimental groups. The attenuation effect of VC was significant (P < 0.05) in responses to respiratory rate, Na⁺, K⁺, Mg²⁺, Cl⁻, Ca²⁺, and urea. Supplementation of VC (either single or multiple) did not significantly (P > 0.05) improve the effect of water restriction on BCs, FAMACHA, glucose, globulin, alanine aminotransferase, and high-density lipoprotein. The additive effect of multiple VC significantly influenced (P < 0.05) Na⁺ and Mg²⁺. Limited WI affects growth and other physiological parameters in Xhosa goats. However, supplementation of VC may be beneficial at modulating the stressful stimuli imposed by water stress.

The abundance of fruit waste from the food industry and wineries, particularly peels, seeds, and other fruit pomace throughout the year, could lead to health and environmental hazards if not channelled into productive areas. Improving or transforming these waste products for better use in other vital sectors could be achieved via solid-state fermentation (SSF) since most waste products are solid. One such productive and important area is the feeding of livestock, which will guarantee millennium food security goals for many nations of the world. The nutritional and antioxidant composition of abundantly available fruit pomace and agro-industrial byproducts could be improved via solid-state fermentation for overall livestock productivity. They contain substantial dietary fibre, protein, and phenolic compounds; hence, improving them via fermentation could serve the livestock industry in dual capacities, including nutraceutical and conventional feedstuff. This review seeks to provide reinforcing evidence on the applicability and impact of fruit pomaces on livestock nutrition. The significant nutrient improvements, beneficial outcomes in feeding trials, and inconsistencies or areas of research gap were also explored.

Probiotics have emerged as gut modulators, capable of restructuring microbial communities to enhance animal health and performance. This review synthesizes peer-reviewed studies published between 2015 and 2025, retrieved from Scopus, Web of Science, and Google Scholar. It encompasses both ruminant and monogastric species to evaluate the effects of probiotic supplementation under diverse production environments. Evidence indicates that diet, age, host genetics, and management practices strongly influence gut microbiome composition and function, explaining the context-dependent nature of probiotic efficacy. These interventions improve growth performance, feed efficiency, gut morphology, pathogen resistance, and systemic immune parameters, supporting their potential as sustainable alternatives to antibiotic growth promoters. However, responses vary and are context-dependent, based on differences in strain specificity, dosage, host physiology, and environmental stress. By explaining how probiotic-mediated modulation translates into improved productivity, reduced antimicrobial dependence, and greater resilience in real-world farming systems, this review highlights their practical value for modern livestock production. Future research should focus on field-based validation, multi-omics approaches to resolve host–microbiota–probiotic interactions, and long-term assessments of animal health, productivity, and environmental impacts. Strategic deployment of probiotics, combined with scalable delivery technologies and regulatory alignment, can enhance resilience, sustainability, and efficiency in livestock production systems.