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Sung Won Kim
Department of Otolaryngology-Head and Neck Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

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Review article
Published: 15 August 2021 in The American Journal of Surgery
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Background Early diagnosis of vocal cord iatrogenic injury is crucial, as is perioperative vocal cord evaluation. Methods Vocal cord mobility detected via transcutaneous laryngeal ultrasonography was compared with that detected via laryngoscopy (the reference). The vocal cord visualization rate of ultrasonography for evaluation of mobility was explored. Results The diagnostic odds ratio of transcutaneous laryngeal ultrasonography was 303.2212 (95% CI, [86.7944; 1059.3198]). The area under the summary receiver operating characteristic curve was 0.944. The sensitivity, specificity, and negative predictive value were 0.9154 [0.8471; 0.9548], 0.9771 [0.9541; 0.9887], and 0.9915 [0.9868; 0.9946], respectively. The vocal cord visualization of ultrasonography used to evaluate vocal cord mobility was high (0.9572 [0.9091; 0.9804]). Conclusions Since transcutaneous laryngeal ultrasonography has the advantage in vocal cord visualization, it can be considered when laryngoscopy is unavailable or patients refuse laryngoscopy. Also, it is diagnostically accurate regardless of the used landmarks, VCP definition, and timing for application.

ACS Style

Do Hyun Kim; Jaeyoon Lee; Youngjun Seo; Sung Won Kim; Se Hwan Hwang. Perioperative transcutaneous laryngeal ultrasonography to assess vocal cord function in thyroid surgery. The American Journal of Surgery 2021, 1 .

AMA Style

Do Hyun Kim, Jaeyoon Lee, Youngjun Seo, Sung Won Kim, Se Hwan Hwang. Perioperative transcutaneous laryngeal ultrasonography to assess vocal cord function in thyroid surgery. The American Journal of Surgery. 2021; ():1.

Chicago/Turabian Style

Do Hyun Kim; Jaeyoon Lee; Youngjun Seo; Sung Won Kim; Se Hwan Hwang. 2021. "Perioperative transcutaneous laryngeal ultrasonography to assess vocal cord function in thyroid surgery." The American Journal of Surgery , no. : 1.

Review
Published: 01 August 2021 in Clinical and Experimental Otorhinolaryngology
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Objectives. This study evaluated the diagnostic value of various symptoms of coronavirus disease 2019 (COVID-19) in screening for this disease.Methods. Two authors (working independently) comprehensively reviewed six databases (PubMed, Cochrane Database, Embase, Web of Science, Scopus, and Google Scholar) from their dates of inception until November 2020. The predictive value of patient-reported symptoms, including otolaryngologic and general symptoms, was evaluated in adults who underwent testing for COVID-19. True-positive, true-negative, false-positive, and false-negative data were extracted from each study. The methodological quality of the included studies was evaluated using the quality assessment of diagnostic accuracy studies tool (ver. 2).Results. Twenty-eight prospective and retrospective studies were included in the meta-analysis. The diagnostic odds ratio (DOR) of a change in olfaction and/or taste was 10.20 (95% confidence interval [CI], 8.43–12.34). The area under the summary receiver operating characteristic curve was 0.8. Olfactory and/or taste changes had a low sensitivity (0.57; 95% CI, 0.47–0.66) but moderate negative (0.78; 95% CI, 0.69–0.85] and positive (0.78; 95% CI, 0.66–0.87) predictive values and a high specificity (0.91; 95% CI, 0.83–0.96). Olfactory and/or taste changes had a higher diagnostic value than the other otolaryngologic symptoms, a higher DOR and specificity, and a similar or higher diagnostic value than the other general symptoms.Conclusion. Among otolaryngologic symptoms, olfactory and/or taste dysfunction was the most closely associated with COVID-19 and its general symptoms, and should therefore be considered when screening for the disease.

ACS Style

Do Hyun Kim; Sung Won Kim; Gulnaz Stybayeva; So Yun Lim; Se Hwan Hwang. Predictive Value of Olfactory and Taste Symptoms in the Diagnosis of COVID-19: A Systematic Review and Meta-Analysis. Clinical and Experimental Otorhinolaryngology 2021, 14, 312 -320.

AMA Style

Do Hyun Kim, Sung Won Kim, Gulnaz Stybayeva, So Yun Lim, Se Hwan Hwang. Predictive Value of Olfactory and Taste Symptoms in the Diagnosis of COVID-19: A Systematic Review and Meta-Analysis. Clinical and Experimental Otorhinolaryngology. 2021; 14 (3):312-320.

Chicago/Turabian Style

Do Hyun Kim; Sung Won Kim; Gulnaz Stybayeva; So Yun Lim; Se Hwan Hwang. 2021. "Predictive Value of Olfactory and Taste Symptoms in the Diagnosis of COVID-19: A Systematic Review and Meta-Analysis." Clinical and Experimental Otorhinolaryngology 14, no. 3: 312-320.

Research
Published: 13 July 2021 in Stem Cell Research & Therapy
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Background Stem cell transplantation is a fascinating therapeutic approach for the treatment of many neurodegenerative disorders; however, clinical trials using stem cells have not been as effective as expected based on preclinical studies. The aim of this study is to validate the hypothesis that human neural crest-derived nasal turbinate stem cells (hNTSCs) are a clinically promising therapeutic source of adult stem cells for the treatment of Alzheimer’s disease (AD). Methods hNTSCs were evaluated in comparison with human bone marrow-derived mesenchymal stem cells (hBM-MSCs) according to the effect of transplantation on AD pathology, including PET/CT neuroimaging, immune status indicated by microglial numbers and autophagic capacity, neuronal survival, and cognition, in a 5 × FAD transgenic mouse model of AD. Results We demonstrated that hNTSCs showed a high proliferative capacity and great neurogenic properties in vitro. Compared with hBM-MSC transplantation, hNTSC transplantation markedly reduced Aβ42 levels and plaque formation in the brains of the 5 × FAD transgenic AD mice on neuroimaging, concomitant with increased survival of hippocampal and cortex neurons. Moreover, hNTSCs strongly modulated immune status by reducing the number of microglia and the expression of the inflammatory cytokine IL-6 and upregulating autophagic capacity at 7 weeks after transplantation in AD models. Notably, compared with transplantation of hBM-MSCs, transplantation of hNTSCs significantly enhanced performance on the Morris water maze, with an increased level of TIMP2, which is necessary for spatial memory in young mice and neurons; this difference could be explained by the high engraftment of hNTSCs after transplantation. Conclusion The reliable evidence provided by these findings reveals a promising therapeutic effect of hNTSCs and indicates a step forward the clinical application of hNTSCs in patients with AD.

ACS Style

Jung Yeon Lim; Sang In Park; Soon A. Park; Jung Ho Jeon; Ho Yong Jung; Jung-Min Yon; Sin-Soo Jeun; Hyun Kook Lim; Sung Won Kim. Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer’s disease. Stem Cell Research & Therapy 2021, 12, 1 -18.

AMA Style

Jung Yeon Lim, Sang In Park, Soon A. Park, Jung Ho Jeon, Ho Yong Jung, Jung-Min Yon, Sin-Soo Jeun, Hyun Kook Lim, Sung Won Kim. Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer’s disease. Stem Cell Research & Therapy. 2021; 12 (1):1-18.

Chicago/Turabian Style

Jung Yeon Lim; Sang In Park; Soon A. Park; Jung Ho Jeon; Ho Yong Jung; Jung-Min Yon; Sin-Soo Jeun; Hyun Kook Lim; Sung Won Kim. 2021. "Potential application of human neural crest-derived nasal turbinate stem cells for the treatment of neuropathology and impaired cognition in models of Alzheimer’s disease." Stem Cell Research & Therapy 12, no. 1: 1-18.

Research article
Published: 28 June 2021 in Ear, Nose & Throat Journal
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Objective: We investigated the anatomical and dental factors associated with unilateral maxillary sinus fungal ball (MSFB). Also, we evaluated the effect of combinations of those factors on the incidence of MSFB. Methods: Three hundred patients were divided into MSFB, normal, and chronic rhinosinusitis (CRS) groups. We reviewed paranasal computed tomography scans for the presence of deviated nasal septum, concha bullosa (CB), Haller cells, and various dental factors. Also, we measured the ethmoid infundibulum, maxillary natural ostium, and CB. Results: Maxillary sinus fungal ball showed a more significant association with CB compared to the other 2 groups (37%, P < .05). The MSFB group had a lower rate of Haller cells than the normal group (10% vs 22%, respectively; P < .05). Also, the MSFB group had a wider maxillary sinus ostium than the normal group (7.07 ± 1.8 vs 5.48 ± 1.3 mm; P < .01). Moreover, the combination of CB and Haller cells was significantly associated with a decreased rate of the fungal ball ( P = .047, odds ratio = 0.694). The dental factors were more prevalent in the MSFB and CRS groups (73% and 75%, respectively) than in the normal group (32%, P < .001). Conclusions: Maxillary sinus fungal ball is significantly associated with CB, Haller cells, an increased maxillary sinus ostium size, and dental factors.

ACS Style

Mohammed Basurrah; Il Hwan Lee; Do Hyun Kim; Sung Won Kim; Soo Whan Kim. Anatomical Variations Associated With Maxillary Sinus Fungal Ball. Ear, Nose & Throat Journal 2021, 1 .

AMA Style

Mohammed Basurrah, Il Hwan Lee, Do Hyun Kim, Sung Won Kim, Soo Whan Kim. Anatomical Variations Associated With Maxillary Sinus Fungal Ball. Ear, Nose & Throat Journal. 2021; ():1.

Chicago/Turabian Style

Mohammed Basurrah; Il Hwan Lee; Do Hyun Kim; Sung Won Kim; Soo Whan Kim. 2021. "Anatomical Variations Associated With Maxillary Sinus Fungal Ball." Ear, Nose & Throat Journal , no. : 1.

Journal article
Published: 01 May 2021 in Clinical and Experimental Otorhinolaryngology
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Objectives. A systematic review of the literature was conducted to evaluate hypotensive agents in terms of their adverse effects and associations with perioperative morbidity in patients undergoing nasal surgery.Methods. Two authors independently searched databases (Medline, Scopus, and Cochrane databases) up to February 2020 for randomized controlled trials comparing the perioperative administration of a hypotensive agent with a placebo or other agent. The outcomes of interest for this analysis were intraoperative morbidity, operative time, intraoperative bleeding, hypotension, postoperative nausea/vomiting, and postoperative pain. Both a standard pairwise meta-analysis and network meta-analysis were conducted.Results. Our analysis was based on 37 trials. Treatment networks consisting of six interventions (placebo, clonidine, dexmedetomidine, beta-blockers, opioids, and nitroglycerine) were defined for the network meta-analysis. Dexmedetomidine resulted in the greatest differences in intraoperative bleeding (−0.971; 95% confidence interval [CI], −1.161 to −0.781), intraoperative fentanyl administration (−3.683; 95% CI, −4.848 to −2.518), and postoperative pain (−2.065; 95% CI, −3.170 to −0.960) compared with placebo. The greatest difference in operative time compared with placebo was achieved with clonidine (−0.699; 95% CI, −0.977 to −0.421). All other agents also had beneficial effects on the measured outcomes. Dexmedetomidine was less likely than other agents to cause adverse effects.Conclusion. This study demonstrated the superiority of the systemic use of dexmedetomidine as a perioperative hypotensive agent compared with the other five tested agents. However, the other agents were also superior to placebo in improving operative time, intraoperative bleeding, and postoperative pain.

ACS Style

Do Hyun Kim; Junuk Lee; Sung Won Kim; Se Hwan Hwang. The Efficacy of Hypotensive Agents on Intraoperative Bleeding and Recovery Following General Anesthesia for Nasal Surgery: A Network Meta-Analysis. Clinical and Experimental Otorhinolaryngology 2021, 14, 200 -209.

AMA Style

Do Hyun Kim, Junuk Lee, Sung Won Kim, Se Hwan Hwang. The Efficacy of Hypotensive Agents on Intraoperative Bleeding and Recovery Following General Anesthesia for Nasal Surgery: A Network Meta-Analysis. Clinical and Experimental Otorhinolaryngology. 2021; 14 (2):200-209.

Chicago/Turabian Style

Do Hyun Kim; Junuk Lee; Sung Won Kim; Se Hwan Hwang. 2021. "The Efficacy of Hypotensive Agents on Intraoperative Bleeding and Recovery Following General Anesthesia for Nasal Surgery: A Network Meta-Analysis." Clinical and Experimental Otorhinolaryngology 14, no. 2: 200-209.

Journal article
Published: 20 April 2021 in Journal of Clinical Medicine
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The sources of mesenchymal stromal cells (MSCs) for cell therapy trials are expanding, increasing the need for their characterization. Here, we characterized multi-donor, turbinate-derived MSCs (TB-MSCs) that develop from the neural crest, and compared them to bone marrow-derived MSCs (BM-MSCs). TB-MSCs had higher proliferation potential and higher self-renewal of colony forming cells, but lower potential for multi-lineage differentiation than BM-MSCs. TB-MSCs expressed higher levels of neural crest markers and lower levels of pericyte-specific markers. These neural crest-like properties of TB-MSCs were reflected by their propensity to differentiate into neuronal cells and proliferative response to nerve growth factors. Proteomics (LC–MS/MS) analysis revealed a distinct secretome profile of TB-MSCs compared to BM and adipose tissue-derived MSCs, exhibiting enrichments of factors for cell-extracellular matrix interaction and neurogenic signaling. However, TB-MSCs and BM-MSCs exhibited comparable suppressive effects on the allo-immune response and comparable stimulatory effects on hematopoietic stem cell self-renewal. In contrast, TB-MSCs stimulated growth and metastasis of breast cancer cells more than BM-MSCs. Altogether, our multi-donor characterization of TB-MSCs reveals distinct cell autonomous and paracrine properties, reflecting their unique developmental origin. These findings support using TB-MSCs as an alternative source of MSCs with distinct biological characteristics for optimal applications in cell therapy.

ACS Style

Hyun-Jee Kim; Sungho Shin; Seon-Yeong Jeong; Sun-Ung Lim; Dae-Won Lee; Yunhee-Kim Kwon; Jiyeon Kang; Sung-Won Kim; Chan-Kwon Jung; Cheolju Lee; Il-Hoan Oh. Nasal Turbinate Mesenchymal Stromal Cells Preserve Characteristics of Their Neural Crest Origin and Exert Distinct Paracrine Activity. Journal of Clinical Medicine 2021, 10, 1792 .

AMA Style

Hyun-Jee Kim, Sungho Shin, Seon-Yeong Jeong, Sun-Ung Lim, Dae-Won Lee, Yunhee-Kim Kwon, Jiyeon Kang, Sung-Won Kim, Chan-Kwon Jung, Cheolju Lee, Il-Hoan Oh. Nasal Turbinate Mesenchymal Stromal Cells Preserve Characteristics of Their Neural Crest Origin and Exert Distinct Paracrine Activity. Journal of Clinical Medicine. 2021; 10 (8):1792.

Chicago/Turabian Style

Hyun-Jee Kim; Sungho Shin; Seon-Yeong Jeong; Sun-Ung Lim; Dae-Won Lee; Yunhee-Kim Kwon; Jiyeon Kang; Sung-Won Kim; Chan-Kwon Jung; Cheolju Lee; Il-Hoan Oh. 2021. "Nasal Turbinate Mesenchymal Stromal Cells Preserve Characteristics of Their Neural Crest Origin and Exert Distinct Paracrine Activity." Journal of Clinical Medicine 10, no. 8: 1792.

Research article
Published: 26 March 2021 in PLOS ONE
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Objectives We describe the strategy used to repair intraoperative leaks of various grades and define factors for preventing postoperative cerebrospinal fluid leakage (CSF) after surgery via the endoscopic endonasal transsphenoidal approach (EETA). Study design Retrospective chart review at a tertiary referral center. Methods Patients who underwent surgery via EETA from January 2009 to May 2020 were retrospectively reviewed. Intraoperative CSF leakage was graded 0–3 in terms of the dural defect size; various repairs were used depending on the grade. Results A total of 777 patients underwent 869 operations via EETA; 609 (70.1%) experienced no intraoperative CSF leakage (grade 0) but 260 (29.9%) did. Leakage was of grade 1 in 135 cases (15.5%), grade 2 in 83 (9.6%), and grade 3 in 42 (4.8%). In 260 patients with intraoperative CSF leakage, a buttress was wedged into the sellar defect site in 178 cases (68.5%) and a pedicled flap was placed in 105 cases (40.4%). Autologous fat (108 cases, 41.5%) and a synthetic dural substitute (91 cases, 35%) were used to fill the dead space of the sellar resection cavity. Postoperative CSF leakage developed in 21 patients: 6 of grade 1, 7 of grade 2, and 8 of grade 3. Buttress placement significantly decreased postoperative leakage in grade 1 patients (p = 0.041). In patients of perioperative leakage grades 2 and 3, postoperative CSF leakage was significantly reduced only when both fat and a buttress were applied (p = 0.042 and p = 0.043, respectively). Conclusion A buttress prevented postoperative CSF leakage in grade 1 patients; both fat and buttress were required by patients with intraoperative leakage of grades 2 and 3.

ACS Style

Il Hwan Lee; Do Hyun Kim; Jae-Sung Park; Sin-Soo Jeun; Yong-Kil Hong; Sung Won Kim. Cerebrospinal fluid leakage repair of various grades developing during endoscopic transnasal transsphenoidal surgery. PLOS ONE 2021, 16, e0248229 .

AMA Style

Il Hwan Lee, Do Hyun Kim, Jae-Sung Park, Sin-Soo Jeun, Yong-Kil Hong, Sung Won Kim. Cerebrospinal fluid leakage repair of various grades developing during endoscopic transnasal transsphenoidal surgery. PLOS ONE. 2021; 16 (3):e0248229.

Chicago/Turabian Style

Il Hwan Lee; Do Hyun Kim; Jae-Sung Park; Sin-Soo Jeun; Yong-Kil Hong; Sung Won Kim. 2021. "Cerebrospinal fluid leakage repair of various grades developing during endoscopic transnasal transsphenoidal surgery." PLOS ONE 16, no. 3: e0248229.

Journal article
Published: 18 February 2021 in Toxics
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Background: Eupatilin is an active flavon extracted from the Artemisia species and has properties such as antioxidant, anti-inflammatory, and anti-cancer. We examined the effect of eupatilin using fine particulate matter (FPM) and human bronchial epithelial cell line (BEAS-2B) to confirm the potential of eupatilin as a therapeutic agent for respiratory diseases caused by FPM. Methods: Reactive oxygen species (ROS) levels were checked by flow cytometry to identify if FPM and eupatilin affect ROS production. Western blotting was performed to identify the mechanism of action of eupatilin in FPM-exposed BEAS-2B cells. Results: When cells were exposed to FPM above 12.5 μg/mL concentration for 24 h, ROS production increased significantly compared to the control. When eupatilin was added to cells exposed to FPM, the ROS level decreased proportionally with the eupatilin dose. The phosphorylation of Akt, NF-κB p65, and p38 MAPK induced by FPM was significantly reduced by eupatilin, respectively. Conclusion: FPM cause respiratory disease by producing ROS in bronchial epithelial cells. Eupatilin has been shown to inhibit ROS production through altering signaling pathways. The ROS inhibiting property of eupatilin can be exploited in FPM induced respiratory disorders.

ACS Style

Dong Lee; Jeong-Min Oh; Hyunsu Choi; Sung Kim; Soo Kim; Byung Kim; Jin Cho; Joohyung Lee; Ji-Sun Kim. Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells. Toxics 2021, 9, 38 .

AMA Style

Dong Lee, Jeong-Min Oh, Hyunsu Choi, Sung Kim, Soo Kim, Byung Kim, Jin Cho, Joohyung Lee, Ji-Sun Kim. Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells. Toxics. 2021; 9 (2):38.

Chicago/Turabian Style

Dong Lee; Jeong-Min Oh; Hyunsu Choi; Sung Kim; Soo Kim; Byung Kim; Jin Cho; Joohyung Lee; Ji-Sun Kim. 2021. "Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells." Toxics 9, no. 2: 38.

Journal article
Published: 13 February 2021 in Brazilian Journal of Otorhinolaryngology
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Traditional meta-analyses on the diagnostic accuracy of oral lesions have been conducted, but they were inherently limited to direct pairwise comparisons between a single method and a single alternative, while multiple diagnostic options and the ranking thereof were methodologically not possible. To evaluate the diagnostic values of various methods in patients with oral potential malignant disease by performing a network meta-analysis. Two authors independently searched the databases (MEDLINE, SCOPUS, the Cochrane Register of Controlled Trials, and Google scholar) up to June 2020 for studies comparing the diagnostic accuracy of various tools (autofluorescence, chemiluminescence, cytology, narrow band imaging, and toluidine blue) with visual examination or other tools. The outcomes of interest for this analysis were sensitivity, specificity, negative predictive value, positive predictive value and accuracy. Both a standard pairwise meta-analysis and network meta-analysis were conducted. Treatment networks consisting of six interventions were defined for the network meta-analysis. The results of traditional meta-analysis showed that, among six methods, narrow band imaging showed higher sensitivity, specificity, negative predictive value, positive predictive value, and accuracy compared to visual examination. The results of network meta-analysis showed that autofluorescence, chemiluminescence, and narrow band imaging had higher sensitivity compared with visual examination, and that chemiluminescence and narrow band imaging had higher negative predictive value compared with visual examination. However, autofluorescence and chemiluminescence had lower specificity compared with visual examination. There were no significant differences in positive predictive value and accuracy among the six interventions. This study demonstrated that narrow banding imaging has superiority in terms of sensitivity and negative predictive value compared with the other five tested agents.

ACS Style

Do Hyun Kim; Sun Won Kim; Se Hwan Hwang. Efficacy of non-invasive diagnostic methods in the diagnosis and screening of oral cancer and precancer. Brazilian Journal of Otorhinolaryngology 2021, 1 .

AMA Style

Do Hyun Kim, Sun Won Kim, Se Hwan Hwang. Efficacy of non-invasive diagnostic methods in the diagnosis and screening of oral cancer and precancer. Brazilian Journal of Otorhinolaryngology. 2021; ():1.

Chicago/Turabian Style

Do Hyun Kim; Sun Won Kim; Se Hwan Hwang. 2021. "Efficacy of non-invasive diagnostic methods in the diagnosis and screening of oral cancer and precancer." Brazilian Journal of Otorhinolaryngology , no. : 1.

Review
Published: 27 January 2021 in Clinical Otolaryngology
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Background It remains unclear whether the use of adjunctive diagnostic screening methods improves the diagnostic efficacies of oral premalignant and cancerous lesions. Objective of review We evaluated the diagnostic accuracy of narrow‐band imaging used to detect oral cancer and precancerous lesions defined employing different narrow‐band imaging criteria. Type of review Systematic review and meta‐analyses. Search strategy We searched PubMed, Scopus, the Web of Science, Embase, Google Scholar and the Cochrane Central Register of Controlled Trials to May 2020. Evaluation methods Three different criteria for oral mucosal vascular changes using narrow‐band imaging were compared: class I: well‐demarcated brownish areas with thick dark spots and/or winding vessels; class II: intraepithelial papillary capillary looping of grades 2, 3 and 4; and class III: intraepithelial papillary capillary looping of grades 3 and 4. Methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies (ver. 2) tool. We compared narrow‐band imaging to conventional white‐light imaging. Results We included 10 prospective or retrospective studies (1374 patients). To detect all dysplastic and cancerous lesions, the class I criteria afforded the optimal specificity and sensitivity; the area under the summary receiver operating characteristic curve was 0.918. To detect highly dysplastic and advanced cancerous lesions, the class III criteria afforded appropriate specificity and sensitivity. The summary receiver operating characteristic curve was 0.905. When using the class III criteria, narrow‐band imaging afforded better specificity (0.941 [range 0.920, 0.9572], P < .0001) compared to white‐light imaging (0.520 [range 0.409, 0.629]). However, the white‐light imaging data were inconsistent and the ranges were broad; narrow‐band imaging may be considerably more accurate than white‐light imaging when using the class III criteria. Conclusion Narrow‐band imaging diagnosed oral premalignant or cancerous lesions much more reliably than white‐light imaging.

ACS Style

Do Hyun Kim; Sung Won Kim; Jaeyoon Lee; Se Hwan Hwang. Narrow‐band imaging for screening of oral premalignant or cancerous lesions: A systematic review and meta‐analysis. Clinical Otolaryngology 2021, 46, 501 -507.

AMA Style

Do Hyun Kim, Sung Won Kim, Jaeyoon Lee, Se Hwan Hwang. Narrow‐band imaging for screening of oral premalignant or cancerous lesions: A systematic review and meta‐analysis. Clinical Otolaryngology. 2021; 46 (3):501-507.

Chicago/Turabian Style

Do Hyun Kim; Sung Won Kim; Jaeyoon Lee; Se Hwan Hwang. 2021. "Narrow‐band imaging for screening of oral premalignant or cancerous lesions: A systematic review and meta‐analysis." Clinical Otolaryngology 46, no. 3: 501-507.

Systematic review
Published: 25 January 2021 in The Laryngoscope
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Objective/Hypothesis To evaluate the diagnostic accuracy of Delphian lymph node (DLN) metastasis for the prediction of central lymph node (CLN) metastasis and lateral lymph node (LLN) metastasis. Methods Two authors independently reviewed the six databases (Cochrane database, Embase, Google Scholar, PubMed, SCOPUS, and Web of Science). Four parameters were extracted from each study: true positive, true negative, false positive, and false negative. The quality of the methodology was evaluated using the Quality Assessment of Diagnostic Accuracy Studies ver. 2 tool. Results The diagnostic odds ratio of DLN in CLN metastasis was 8.859 (95% confidence interval [CI], 4.419; 16.578). The area under the summary receiver operating characteristic curve was 0.748. The diagnostic odds ratio of DLN in LLN metastasis was 7.61 (95% CI, 4.48; 12.94). The area under the summary receiver operating characteristic curve was 0.837. DLN metastasis was moderately predictive of CLN metastasis (sensitivity = 32%, specificity = 95%), LLN metastasis (sensitivity = 52%, specificity = 89%), and contralateral CLN metastasis (sensitivity = 46%, specificity = 85%). DLN metastasis had statistically significant correlation with specific clinicopathological characteristics, including younger age (< 45 years old), bilaterality, capsule invasion, extrathyroidal extension, lymphovascular invasion, male sex, multifocality, and tumor size (> 1 cm). Conclusions The higher specificities of DLN pathology may help predict central and lateral compartment involvement in patients with thyroid cancer. Level of Evidence N/A Laryngoscope, 2021

ACS Style

Do Hyun Kim; Sung Won Kim; Se Hwan Hwang. Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer. The Laryngoscope 2021, 131, 1990 -1996.

AMA Style

Do Hyun Kim, Sung Won Kim, Se Hwan Hwang. Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer. The Laryngoscope. 2021; 131 (9):1990-1996.

Chicago/Turabian Style

Do Hyun Kim; Sung Won Kim; Se Hwan Hwang. 2021. "Predictive Value of Delphian Lymph Node Metastasis in the Thyroid Cancer." The Laryngoscope 131, no. 9: 1990-1996.

Journal article
Published: 14 September 2020 in Medicina
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Background and objectives: The average rate of chronic sinusitis after maxillary implantation was approximately 5.1%. However, the evidence of predictive risk factors for sinusitis after implantation is lacking. The aim of this study was to perform an anatomic study on the maxillary sinus mucosal thickness (MSMT), the distance between the maxillary sinus ostium and sinus floor (MOD), and the MSMT/MOD ratio as a preoperative risk indicator for sinusitis after maxillary dental implantation. Materials and Methods: Between October 2008 and October 2019, all patients referred to the otolaryngology department were included in this study. A total of 120 patients were enrolled. The 95 patients who received no treatment prior to implantation were classified into Group A, the 16 patients who used antibiotics before implantation were classified into Group B, and the patients who had implants inserted after functional endoscopic sinus surgery were classified into Group C. The MSMT, MOD, MSMT/MOD ratio, anatomical factors associated with ostial obstruction, and the occurrence of postoperative sinusitis were reviewed. Results: There were significant group differences in MSMT (Group A vs. Group B, p = 0.001; Group B vs. Group C, p = 0.003; Group C vs. Group A, p < 0.0001). The MOD showed no significant difference among the three groups. The MSMT/MOD ratio showed significant differences between Groups A and B (p = 0.001), B and C (p < 0.0001), and C and A (p < 0.0001). Conclusions: It is important to check not only the proportion of the maxillary sinus occupying lesion, but also the status of the maxillary sinus osteomeatal complex when making therapeutic decisions. In addition, collaboration between dentists and otolaryngologists could improve outcomes in patients with maxillary sinus lesions.

ACS Style

Il Lee; Do Kim; Soo Kim; Jun-Beom Park; Sung Kim. An Anatomic Study on the Maxillary Sinus Mucosal Thickness and the Distance between the Maxillary Sinus Ostium and Sinus Floor for the Maxillary Sinus Augmentation. Medicina 2020, 56, 470 .

AMA Style

Il Lee, Do Kim, Soo Kim, Jun-Beom Park, Sung Kim. An Anatomic Study on the Maxillary Sinus Mucosal Thickness and the Distance between the Maxillary Sinus Ostium and Sinus Floor for the Maxillary Sinus Augmentation. Medicina. 2020; 56 (9):470.

Chicago/Turabian Style

Il Lee; Do Kim; Soo Kim; Jun-Beom Park; Sung Kim. 2020. "An Anatomic Study on the Maxillary Sinus Mucosal Thickness and the Distance between the Maxillary Sinus Ostium and Sinus Floor for the Maxillary Sinus Augmentation." Medicina 56, no. 9: 470.

Original article
Published: 27 August 2020 in BioChip Journal
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The airway mucosa is the first point of exposure to all inhalant materials. It is possible to produce microenvironments functionally similar to airway by using different types of extracellular matrices around mucosal cells, such as an extracellular matrix decellularized from trachea. In this study, we introduced a novel human respiratory mucosa-on-a-chip model that uses decellularized tracheal extracellular matrix to assess functional similarities. We also evaluated the effects of respiratory toxicant based on changes in cell viability, tight junction function, oxidative stress, expression of cell adhesion proteins in the vascular network, mucous secretion, and inflammatory cytokine secretion after treatment. This novel human respiratory mucosa-on-a-chip model is expected to be useful for assessing respiratory mucosa reactions to external bacteria or viruses and inhaled drugs.

ACS Style

Mi Hyun Lim; Min Jae Lim; Won-Soo Yun; Songwan Jin; Donghyun Lee; Do Hyun Kim; Sung Won Kim. Development of a Human Respiratory Mucosa-on-a-chip using Decellularized Extracellular Matrix. BioChip Journal 2020, 14, 279 -289.

AMA Style

Mi Hyun Lim, Min Jae Lim, Won-Soo Yun, Songwan Jin, Donghyun Lee, Do Hyun Kim, Sung Won Kim. Development of a Human Respiratory Mucosa-on-a-chip using Decellularized Extracellular Matrix. BioChip Journal. 2020; 14 (3):279-289.

Chicago/Turabian Style

Mi Hyun Lim; Min Jae Lim; Won-Soo Yun; Songwan Jin; Donghyun Lee; Do Hyun Kim; Sung Won Kim. 2020. "Development of a Human Respiratory Mucosa-on-a-chip using Decellularized Extracellular Matrix." BioChip Journal 14, no. 3: 279-289.

Review
Published: 01 August 2020 in Clinical Otolaryngology
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Aims The accuracy of toluidine blue (TB) and chemiluminescence for diagnosing oral cancer and precancer was evaluated. Methods Two authors (working independently) comprehensively reviewed six databases (PubMed, Cochrane database, Embase, Web of Science, SCOPUS, and Google Scholar) from their dates of inception until March 2020. Oral mucosal disorder, as detected by TB, was compared with that detected by chemiluminescence. True‐positive, true‐negative, false‐positive, and false‐negative data were extracted for each study. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool (ver. 2). The extent of interrater agreement was also assessed. Results Twenty‐nine prospective and retrospective studies were included. The diagnostic odds ratio (DOR) of TB was 7.017 (95% confidence interval [CI], 4.544; 10.836). The area under the summary receiver operating characteristic curve was 0.766. The correlation between the sensitivity and the false‐positive rate was 0.196, indicating the absence of heterogeneity. TB exhibited moderate interrater reliability (0.6777; 95% CI, 0.43; 0.7455). Compared with chemiluminescence, as used in nine studies, TB had a lower sensitivity (0.659 vs. 0.841), but a higher specificity (0.809 vs. 0.345), negative predictive value (0.766 vs. 0.690), and DOR (10.565 vs. 5.203). Compared with clinical examination, as used in four studies, TB method had a higher sensitivity (0.891 vs. 0.891), specificity (0.739 vs. 0.634), negative predictive value (0.920 vs. 0.714), and DOR (28.491 vs. 8.526). Subgroup analysis showed that screening for severe dysplasia or more severe disease was significantly more sensitive, but less specific, than screening for all dysplasias. Conclusions Although the diagnostic accuracy of TB in the diagnostic work‐up of oral cancer and precancer was higher than that of clinical examination, it was not high enough for TB to reliably be used alone. Instead, it should be combined with chemiluminescence or other diagnostic tools.

ACS Style

Do Hyun Kim; Eun A. Song; Sung Won Kim; Se Hwan Hwang. Efficacy of toluidine blue in the diagnosis and screening of oral cancer and pre‐cancer: A systematic review and meta‐analysis. Clinical Otolaryngology 2020, 46, 23 -30.

AMA Style

Do Hyun Kim, Eun A. Song, Sung Won Kim, Se Hwan Hwang. Efficacy of toluidine blue in the diagnosis and screening of oral cancer and pre‐cancer: A systematic review and meta‐analysis. Clinical Otolaryngology. 2020; 46 (1):23-30.

Chicago/Turabian Style

Do Hyun Kim; Eun A. Song; Sung Won Kim; Se Hwan Hwang. 2020. "Efficacy of toluidine blue in the diagnosis and screening of oral cancer and pre‐cancer: A systematic review and meta‐analysis." Clinical Otolaryngology 46, no. 1: 23-30.

Review
Published: 29 July 2020 in Brazilian Journal of Otorhinolaryngology
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Early detection of potentially malignant oral cavity disorders is critical for a good prognosis, and it is unclear whether the use of chemiluminescence as an adjunctive diagnostic screening method improves diagnostic accuracy. This systematic review and meta-analysis was performed to assess the accuracy of chemiluminescence for diagnosis of oral cancer and precancerous lesions. Sixteen prospective and retrospective studies from PubMed, Cochrane database, SCOPUS, Web of Science, Embase, and Google Scholar were reviewed. Oral mucosal disorder, as detected by chemiluminescence, was compared with oral mucosal disorder detected by toluidine blue or visual examination. True-positive, true-negative, false-positive, and false-negative rates were extracted for each study. Methodological quality was evaluated using the Quality Assessment of Diagnostic Accuracy Studies tool (ver. 2). Sensitivity, specificity, negative predictive value, and diagnostic odds ratio (DOR) of the use of toluidine blue were 0.832 (95% confidence interval [CI] 0.692–0.917), 0.429 (95% CI 0.217–0.672), 0.747 (95% CI 0.607–0.849), and 4.061 (95% CI 1.528–10.796; I2 = 9.128%), respectively. The area under the summary receiver operating characteristic (SROC) curve was 0.743. Compared with toluidine blue, as used in 12 studies, chemiluminescence had a higher sensitivity (0.831 vs. 0.694); it had a lower specificity (0.415 vs. 0.734), negative predictive value (0.674 vs. 0.729), and DOR (3.891 vs. 7.705). Compared with clinical examination, as used in three studies, chemiluminescence had lower DOR (4.576 vs. 5.499) and area under the curve (0.818 vs. 0.91). Although chemiluminescence itself has good sensitivity for diagnostic work-up of oral cancer and precancer, the diagnostic accuracy of chemiluminescence is comparable to or worse than toluidine blue and clinical examination. Diagnostic accuracy was therefore insufficient for reliable use of chemiluminescence alone. A detecção precoce de distúrbios orais potencialmente malignos é fundamental para um bom prognóstico, e não está claro se o uso da quimiluminescência como método auxiliar de triagem diagnóstica melhora a eficácia do diagnóstico. Esta revisão sistemática e meta-análise foi realizada para avaliar a precisão da quimiluminescência para o diagnóstico de câncer oral e pré-câncer. Foram revisados dezesseis estudos prospectivos e retrospectivos dos bancos de dados PubMed, Cochrane, SCOPUS, Web of Science, Embase e Google Scholar. Os distúrbios da mucosa oral detectados por quimiluminescência foram comparados com os distúrbios da mucosa oral detectados pelo azul de toluidina ou pelo exame visual. Taxas de resultados verdadeiro-positivos, verdadeiro-negativos, falso-positivos e falso-negativos foram extraídas de cada estudo. A qualidade metodológica foi avaliada utilizando a ferramenta Quality Assessment of Diagnostic Accuracy Studies-versão 2 (QUADAS-2). Sensibilidade, especificidade, valor preditivo negativo e odds ratio diagnóstico do uso do azul de toluidina foram 0,832 (intervalo de confiança de 95%: 0,692-0,917), 0,429 (IC95%: 0,217-0,672), 0,747 (IC95%: 0,607-0,849) e 4,061 (intervalo de confiança 95%: 1,528-10,796; I2 = 9,128%), respectivamente. A área sob a curva SROC do inglês summary receiver operating characteristic, foi de 0,743. Comparado ao azul de toluidina, como utilizado em 12 estudos, a quimiluminescência apresentou uma sensibilidade mais alta (0,831 vs. 0,694) e especificidade (0,415 vs. 0,734), valor preditivo negativo (0,674 vs. 0,729) e odds ratio diagnóstico (3,889 vs. 7,705) mais baixos. Comparado com o exame clínico, como utilizado em três estudos, a quimiluminescência apresentou menor odds ratio diagnóstico (4.576 vs. 5.499) e área sob a curva (0,818 vs. 0,91). Embora a quimiluminescência em si tenha boa sensibilidade para o diagnóstico de câncer oral e pré-câncer, sua precisão diagnóstica é comparável ou pior do que o azul de toluidina e o exame clínico. A precisão do diagnóstico foi, portanto, insuficiente para o uso isolado confiável da quimiluminescência.

ACS Style

Do Hyun Kim; Jaeyoon Lee; Min Hyeong Lee; Sung Won Kim; Se Hwan Hwang. Efficacy of chemiluminescence in the diagnosis and screening of oral cancer and precancer: a systematic review and meta-analysis. Brazilian Journal of Otorhinolaryngology 2020, 1 .

AMA Style

Do Hyun Kim, Jaeyoon Lee, Min Hyeong Lee, Sung Won Kim, Se Hwan Hwang. Efficacy of chemiluminescence in the diagnosis and screening of oral cancer and precancer: a systematic review and meta-analysis. Brazilian Journal of Otorhinolaryngology. 2020; ():1.

Chicago/Turabian Style

Do Hyun Kim; Jaeyoon Lee; Min Hyeong Lee; Sung Won Kim; Se Hwan Hwang. 2020. "Efficacy of chemiluminescence in the diagnosis and screening of oral cancer and precancer: a systematic review and meta-analysis." Brazilian Journal of Otorhinolaryngology , no. : 1.

Novus imago
Published: 03 June 2020 in Applied Microscopy
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The human turbinate-derived mesenchymal stem cells (hTMSCs), which were DiI-labeled and transplanted into the subretinal space in degenerating mouse retina, were observed in retinal vertical sections processed for rhodopsin (a marker for rod photoreceptor) by confocal microscope with differential interference contrast (DIC) filters. The images clearly demonstrated that DiI-labeled hTMSCs have rhodopsin-immunoreactive appendages, indicating differentiation of transplanted hTMSC into rod photoreceptor. Conclusively, the finding suggests therapeutic potential of hTMSCs in retinal degeneration.

ACS Style

Yong Soo Park; Yeonji Kim; Sung Won Kim; In-Beom Kim. Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse. Applied Microscopy 2020, 50, 1 -3.

AMA Style

Yong Soo Park, Yeonji Kim, Sung Won Kim, In-Beom Kim. Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse. Applied Microscopy. 2020; 50 (1):1-3.

Chicago/Turabian Style

Yong Soo Park; Yeonji Kim; Sung Won Kim; In-Beom Kim. 2020. "Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse." Applied Microscopy 50, no. 1: 1-3.

Review
Published: 13 May 2020 in The Laryngoscope
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Objective We assessed the diagnostic accuracy of sentinel lymph node biopsy (SLNB) for detecting neck nodal metastasis in early oral squamous cell carcinoma (OSCC) as an alternative to elective neck dissection. Study Design A systematic search for relevant literature was conducted in the PubMed, SCOPUS, Embase, Web of Science, and Cochrane databases. Methods Two reviewers individually searched the five databases up to November 2019. For studies that met inclusion criteria, data on patient diagnoses were pooled, including true positives, true negatives, false positives, and false negatives. Methodological quality was checked with the Quality Assessment of Diagnostic Accuracy Studies (version 2) tool. Results In total, 98 observational or retrospective studies were included. The diagnostic odds ratio of SLNB was 326.165 (95% confidence interval [CI]: 231.477–459.587; I2 = 0%). The area under the summary receiver operating characteristic curve was 0.982. Sensitivity was 0.827 (95% CI: 0.804–0.848), and specificity was 0.981 (95% CI: 0.975–0.986). The correlation between sensitivity and the false positive rate was −0.076, which indicates that heterogeneity did not exist. Subgroup analyses were performed with the subgroups reference test type, publication year, and study type. No significant difference was found within the reference test type subgroup. However, differences within the publication year and study type subgroups were significant, where the retrospective study subgroup was significantly more sensitive and specific than the prospective study subgroup. Conclusion Results of this meta‐analysis imply that the high specificity of SLNB supports its role as a diagnostic tool for patients with clinical tumor stage (CT)1‐2 clinically negative (N0) OSCC. More studies should be done to further verify the results of this study. Level of Evidence 2a Laryngoscope, 2020

ACS Style

Do Hyun Kim; Yeonji Kim; Sung Won Kim; Se Hwan Hwang. Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis. The Laryngoscope 2020, 131, 1 .

AMA Style

Do Hyun Kim, Yeonji Kim, Sung Won Kim, Se Hwan Hwang. Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis. The Laryngoscope. 2020; 131 (2):1.

Chicago/Turabian Style

Do Hyun Kim; Yeonji Kim; Sung Won Kim; Se Hwan Hwang. 2020. "Usefulness of Sentinel Lymph Node Biopsy for Oral Cancer: A Systematic Review and Meta‐Analysis." The Laryngoscope 131, no. 2: 1.

Original article
Published: 12 May 2020 in Tissue Engineering and Regenerative Medicine
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Articular cartilage injury has a poor repair ability and limited regeneration capacity with therapy based on articular chondrocytes (ACs) implantation. Here, we validated the hypothesis that human nasal septum-derived chondrocytes (hNCs) are potent therapeutic agents for clinical use in cartilage tissue engineering using an injectable hydrogel, type I collagen (COL1). We manufactured hNCs incorporated in clinical-grade soluble COL1 and investigated their clinical potential as agents in an articular defect model. The hNCs encapsulated in COL1 (hNC-collagen) were uniformly distributed throughout the collagen and showed much greater growth rate than hACs encapsulated in collagen for the 14 days of culture. Fluorescent staining of hNC-collagen showed high expression levels of chondrocyte-specific proteins under clinical conditions. Moreover, a negative mycoplasma screening result were obtained in culture of hNC-collagen. Notably, implantation of hNC-collagen increased the repair of osteochondral defects in rats compared with implantation of collagen only. Many human cells were detected within the cartilage defects. These results provide reliable evidences supporting for clinical applications of hNC-collagen in regenerative medicine for cartilage repair.

ACS Style

Mi Hyun Lim; Jung Ho Jeun; Do Hyun Kim; Sun Hwa Park; Seok-Jung Kim; Weon Sun Lee; Se Hwan Hwang; Jung Yeon Lim; Sung Won Kim. Evaluation of Collagen Gel-Associated Human Nasal Septum-Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair. Tissue Engineering and Regenerative Medicine 2020, 17, 387 -399.

AMA Style

Mi Hyun Lim, Jung Ho Jeun, Do Hyun Kim, Sun Hwa Park, Seok-Jung Kim, Weon Sun Lee, Se Hwan Hwang, Jung Yeon Lim, Sung Won Kim. Evaluation of Collagen Gel-Associated Human Nasal Septum-Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair. Tissue Engineering and Regenerative Medicine. 2020; 17 (3):387-399.

Chicago/Turabian Style

Mi Hyun Lim; Jung Ho Jeun; Do Hyun Kim; Sun Hwa Park; Seok-Jung Kim; Weon Sun Lee; Se Hwan Hwang; Jung Yeon Lim; Sung Won Kim. 2020. "Evaluation of Collagen Gel-Associated Human Nasal Septum-Derived Chondrocytes As a Clinically Applicable Injectable Therapeutic Agent for Cartilage Repair." Tissue Engineering and Regenerative Medicine 17, no. 3: 387-399.

Journal article
Published: 30 March 2020 in BMC Complementary Medicine and Therapies
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Background Particulate matter (PM) can cause various negative acute and chronic diseases of the respiratory system, including the upper airways. Curcumin has been reported to have anti-inflammatory and anti-oxidative effects; therefore, we investigated the effects of curcumin on nasal fibroblasts exposed to urban PM (UPM). Methods Samples of inferior turbinate tissue were obtained from six patients. Flow cytometry was used to assess the levels of reactive oxygen species (ROS) following the treatment of nasal fibroblasts with UPM and/or curcumin. We evaluated the effects of UPM and/or curcumin on the expression of phosphorylated ERK, Nrf2, HO-1, and SOD2 in fibroblasts by Western blotting. Results When UPM was applied to nasal fibroblasts, ROS production was significantly increased in a dose-dependent manner. UPM-exposed fibroblasts caused the activation of ERK to increase HO-1 expression and decrease SOD2 expression. Treatment with curcumin reduced the UPM-mediated increase in ROS; this decrease in ROS occurred in a dose-dependent manner. The UPM-induced activation of ERK was inhibited by curcumin. Nrf2 production was also promoted to increase the expression of HO-1 and SOD2 by curcumin. Conclusion Curcumin reduced ROS production caused by UPM in human nasal fibroblasts in a dose-dependent manner, suggesting that curcumin has anti-oxidative effects and may be useful in the treatment of nasal diseases caused by UPM, such as allergic and chronic rhinitis.

ACS Style

Ji-Sun Kim; Jeong-Min Oh; Hyunsu Choi; Sung Won Kim; Soo Whan Kim; Byung Guk Kim; Jin Hee Cho; Joohyung Lee; Dong Chang Lee. Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter. BMC Complementary Medicine and Therapies 2020, 20, 101 -8.

AMA Style

Ji-Sun Kim, Jeong-Min Oh, Hyunsu Choi, Sung Won Kim, Soo Whan Kim, Byung Guk Kim, Jin Hee Cho, Joohyung Lee, Dong Chang Lee. Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter. BMC Complementary Medicine and Therapies. 2020; 20 (1):101-8.

Chicago/Turabian Style

Ji-Sun Kim; Jeong-Min Oh; Hyunsu Choi; Sung Won Kim; Soo Whan Kim; Byung Guk Kim; Jin Hee Cho; Joohyung Lee; Dong Chang Lee. 2020. "Activation of the Nrf2/HO-1 pathway by curcumin inhibits oxidative stress in human nasal fibroblasts exposed to urban particulate matter." BMC Complementary Medicine and Therapies 20, no. 1: 101-8.

Original research
Published: 26 February 2020 in The Laryngoscope
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ACS Style

Do Hyun Kim; Min Hyeong Lee; Jaeyoon Lee; Sung Won Kim. Effect of endoscopic endonasal skull base surgery on snoring. The Laryngoscope 2020, 5, 344 -347.

AMA Style

Do Hyun Kim, Min Hyeong Lee, Jaeyoon Lee, Sung Won Kim. Effect of endoscopic endonasal skull base surgery on snoring. The Laryngoscope. 2020; 5 (3):344-347.

Chicago/Turabian Style

Do Hyun Kim; Min Hyeong Lee; Jaeyoon Lee; Sung Won Kim. 2020. "Effect of endoscopic endonasal skull base surgery on snoring." The Laryngoscope 5, no. 3: 344-347.