For the cases of spontaneous respiration and paced respiration with a fixed frequency and linearly increasing frequency, we investigate synchronization between three main rhythmic processes governing the cardiovascular dynamics in humans, namely, the main heart rhythm, respiration, and the process whose fundamental frequency is close to 0.1 Hz. The analysis of the experimental records reveals synchronous regimes of different orders between all the three main rhythms. The influence of the regime of breathing and the magnitude of heart rate variability on the degree of synchronization is considered.
27 July 2009 in Chaos: An Interdisciplinary Journal of Nonlinear Science
We investigate synchronization between the low-frequency oscillations of heart rate and blood pressure having in humans a basic frequency close to 0.1 Hz. A method is proposed for quantitative estimation of synchronization between these oscillating processes based on calculation of relative time of phase synchronization of oscillations. It is shown that healthy subjects exhibit on average substantially longer epochs of internal synchronization between the low-frequency oscillations in heart rate and blood pressure than patients after acute myocardial infarction.
1 September 2012 in Journal of the American Society of Hypertension
A mathematical model is proposed for the autonomic control of cardiovascular system, which takes into account two separated self-exciting sympathetic control loops of heart rate and peripheral vascular tone. The control loops are represented by self-exciting time-delay systems and their tone depends on activity of the aortic, carotid, and lower-body baroreceptors. The model is used to study the dynamics of the adaptive processes that manifest in a healthy cardiovascular system during the passive head-up tilt test. Computer simulation provides continuous observation of the dynamics of the indexes and variables that cannot be measured in the direct experiment, including the noradrenaline concentration in vessel wall and heart muscle, tone of the sympathetic and parasympathetic control, peripheral vascular resistance, and blood pressure. In the supine and upright positions, we estimated the spectral characteristics of the model variables, especially in the low-frequency band, and the original index of total percent of phase synchronization between the low-frequency oscillations in heart rate and blood pressure signals. The model demonstrates good quantitative agreement with the dynamics of the experimentally observed indexes of cardiovascular system that were averaged for 50 healthy subjects.
1 March 2016 in Journal of the American Society of Hypertension