Endometrial cancer is one of the most common cancers in developing and developed countries. Although the detection of this cancer is high at the early stages, there is still a lack of markers to monitor the disease, its recurrence, and metastasis. MiRNAs are in charge of the post-transcriptional regulation of genes responsible for the most important biological processes, which is why they are increasingly used as biomarkers in many types of cancer. Many studies have demonstrated the influence of miRNAs on the processes related to carcinogenesis. The characteristics of miRNA expression profiles in endometrial cancer will allow their use as diagnostic and prognostic biomarkers. This paper focuses on the discussion of selected miRNAs based on the literature and their role in the development of endometrial cancer.

Surgical treatment is the most important part of therapy for endometrial cancer. The aim of the study was to define factors having the most significant impact on surgical treatment of endometrial cancer when using traditional and laparoscopic methods. In the study, we evaluated 75 females who were treated for endometrial cancer via laparoscopic surgery in 2019 and used a historical control of 70 patients treated by laparotomy in 2011. The evaluated risk factors included the method of surgery, type of lymphadenectomy, patient’s age, various obesity parameters, histological grading, cancer clinical staging, pelvic dimensions, previous abdominal surgeries, comorbidities, and number of deliveries. The duration of hospitalization, operation time, loss of hemoglobin, and procedure-related complications were used as parameters of perioperative outcomes. Multivariable linear regression analysis confirmed the following factors as being predictors of worse perioperative outcomes: laparotomy, abdominal obesity (waist circumstance and waist-to-hip ratio), range of lymphadenectomy, prior abdominal surgeries, and larger pelvic dimensions. Abdominal obesity is a significant risk factor in the treatment of endometrial cancer. Laparotomy continues to be utilized frequently in the management of endometrial cancer in Poland as well as elsewhere, and adopting a minimally invasive approach is likely to be beneficial for patient outcome.

Objectives: The metabolic pathway of cancerous tissue differs from healthy tissue, leading to the unique isotopic composition of stable isotopes at their natural abundance. We have studied if these changes can be developed into diagnostic or prognostic tools in the case of endometrial cancer. Methods: Measurements of stable isotope ratios were performed using isotope ratio mass spectrometry for nitrogen, carbon, and sulfur isotopic assessment. Uterine tissue and serum samples were collected from patients and the control group. Results: At a natural abundance, the isotopic compositions of all three of the studied elements of uterus cancerous and healthy tissues are different. However, no correlation of the isotopic composition of the tissues with that of serum was found. Conclusions: Differences in the isotopic composition of the tissues might be a potential prognostic tool. However, the lack of a correlation between the differences in the isotopic composition of the tissues and serum seems to exclude their application as diagnostic biomarkers, which, however, might be possible if a position-specific isotopic analysis is performed.

Introduction. The problem of health care affects every country. The structure and quality of hospitalization in Poland have changed over recent years. The state’s management of a balanced policy is possible prior to the collection of reports allowing to obtain data enabling assessment of changes in the health structure of the population, development of statistical data, as well as implementation and supervision of the National Health Program. Aim. The aim of the study was to evaluate the quality of hospitalization basing on the patients’ assessment of the availability, conditions, course of treatment and contact with hospital staff in the city of Lublin. Material and methods. The material for analysis was data collected from 254 patients. Respondents represented departments of diabetology, rehabilitation and internal diseases. The group consisted of 159 women and 95 men aged 19-84. The interview questionnaire was a research tool. Respondents were asked to assess: accessibility to hospital, efficiency of completing formalities when admitted to the hospital, cleanliness in the room, quality of the gastronomic services and contact with nursing and medical staff. Likert’s 5-point scale was used. Statistical analysis was performed using the software “STATISTICA 10.0”. Results. Most respondents assessed the quality of hospitalization as satisfactory. As many as 99% of respondents assessed contact with doctors as good or very good. Contact with nursing staff was rated as good by 88% of respondents. Conclusions. This study demonstrated good quality of health care in the examined hospital in Lublin. However, it is important to emphasize the need for further research aimed at collecting data on the presented problem.

Background: Endometrial cancer is one of the most common cancers in women. In recent years, minimally invasive methods such as laparoscopy and robotic surgery have become very popular. Robotic surgery is a rapidly evolving and continuously improving modality. Methods: The main goal of our study was to compare patients operated on with the da Vinci robot with laparoscopy. The study included 300 patients with endometrial cancer who underwent surgery using the da Vinci robotic system and 80 patients with endometrial cancer who underwent laparoscopic surgery. Results: We have demonstrated that robot-assisted surgery is associated with significantly lower blood loss and a reduced risk of complications, whereas operative time remains shorter with laparoscopy. At the same time, we have observed that prolonged robotic operative time occurs particularly in older patients and those with a higher BMI, which should be taken into account when planning surgical procedures. Conclusions: Further research is needed to better define the groups of patients who benefit most and to optimize surgical strategies.