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Giuseppina Sanna
Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042 Cagliari, Italy

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Journal article
Published: 29 June 2021 in Viruses
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Vitis vinifera represents an important and renowned source of compounds with significant biological activity. Wines and winery bioproducts, such as grape pomace, skins, and seeds, are rich in bioactive compounds against a wide range of human pathogens, including bacteria, fungi, and viruses. However, little is known about the biological properties of vine leaves. The aim of this study was the evaluation of phenolic composition and antiviral activity of Vitis vinifera leaf extract against two human viruses: the Herpes simplex virus type 1 (HSV-1) and the pandemic and currently widespread severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). About 40 phenolic compounds were identified in the extract by HPLC-MS/MS analysis: most of them were quercetin derivatives, others included derivatives of luteolin, kaempferol, apigenin, isorhamnetin, myricetin, chrysoeriol, biochanin, isookanin, and scutellarein. Leaf extract was able to inhibit both HSV-1 and SARS-CoV-2 replication in the early stages of infection by directly blocking the proteins enriched on the viral surface, at a very low concentration of 10 μg/mL. These results are very promising and highlight how natural extracts could be used in the design of antiviral drugs and the development of future vaccines.

ACS Style

Carla Zannella; Rosa Giugliano; Annalisa Chianese; Carmine Buonocore; Giovanni Vitale; Giuseppina Sanna; Federica Sarno; Aldo Manzin; Angela Nebbioso; Pasquale Termolino; Lucia Altucci; Massimiliano Galdiero; Donatella de Pascale; Gianluigi Franci. Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1. Viruses 2021, 13, 1263 .

AMA Style

Carla Zannella, Rosa Giugliano, Annalisa Chianese, Carmine Buonocore, Giovanni Vitale, Giuseppina Sanna, Federica Sarno, Aldo Manzin, Angela Nebbioso, Pasquale Termolino, Lucia Altucci, Massimiliano Galdiero, Donatella de Pascale, Gianluigi Franci. Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1. Viruses. 2021; 13 (7):1263.

Chicago/Turabian Style

Carla Zannella; Rosa Giugliano; Annalisa Chianese; Carmine Buonocore; Giovanni Vitale; Giuseppina Sanna; Federica Sarno; Aldo Manzin; Angela Nebbioso; Pasquale Termolino; Lucia Altucci; Massimiliano Galdiero; Donatella de Pascale; Gianluigi Franci. 2021. "Antiviral Activity of Vitis vinifera Leaf Extract against SARS-CoV-2 and HSV-1." Viruses 13, no. 7: 1263.

Communication
Published: 29 March 2021 in Pathogens
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Plant products provide an alternative and successful source of lead compounds for the pharmaceutical industry. The present study was aimed to evaluate, in cell-based assays, the antiviral properties of essential oils obtained from plants that commonly grow in Sardinia, Italy, against a broad spectrum of RNA/DNA viruses. The essential oils of Helichrisumitalicum (Roth) G. Don ssp. microphyllum (Willd.) Nyman, Laurus nobilis L., Mirtuscommunis L., Pistacia lentiscus L., Salvia officinalis L., Saturejathymbra L., Lavandula angustifolia Mill., Foeniculum vulgare Mill., and Eucalyptus globulus Labill. were extracted by hydrodistillation and analyzed by gas chromatography mass spectrometry (GC–MS). Interestingly, the essential oil of Salvia officinalis showed moderate activity against bovine viral diarrhea virus (BVDV), an enveloped RNA virus belonging to the Flaviviridae family. BVDV is responsible for several clinical manifestations in bovines, including respiratory, gastroenteric, and reproductive diseases, with a significant economic impact. With the aim to individuate the constituent of the Salvia officinalis responsible for the biological activity, we tested the major components of the oil: camphene, β-pinene, limonene, 1,8-cineole, cis-thujone, camphor, (E)-caryophyllene, and α-humulene. Here, we describe α-humulene as an active component that is non-cytotoxic and active against BVDV (EC50 = 36 µM). Its antiviral effects were evaluated using virucidal cytopathic effect inhibition and viral yield reduction assays. This is the first scientific report showing the anti BVDV effects of Salvia officinalis essential oil and α-humulene as the main active component.

ACS Style

Silvia Madeddu; Alessandra Marongiu; Giuseppina Sanna; Carla Zannella; Danilo Falconieri; Silvia Porcedda; Aldo Manzin; Alessandra Piras. Bovine Viral Diarrhea Virus (BVDV): A Preliminary Study on Antiviral Properties of Some Aromatic and Medicinal Plants. Pathogens 2021, 10, 403 .

AMA Style

Silvia Madeddu, Alessandra Marongiu, Giuseppina Sanna, Carla Zannella, Danilo Falconieri, Silvia Porcedda, Aldo Manzin, Alessandra Piras. Bovine Viral Diarrhea Virus (BVDV): A Preliminary Study on Antiviral Properties of Some Aromatic and Medicinal Plants. Pathogens. 2021; 10 (4):403.

Chicago/Turabian Style

Silvia Madeddu; Alessandra Marongiu; Giuseppina Sanna; Carla Zannella; Danilo Falconieri; Silvia Porcedda; Aldo Manzin; Alessandra Piras. 2021. "Bovine Viral Diarrhea Virus (BVDV): A Preliminary Study on Antiviral Properties of Some Aromatic and Medicinal Plants." Pathogens 10, no. 4: 403.

Journal article
Published: 04 January 2021 in Viruses
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Enterovirus A71 (EV-A71) infection has emerged as a significant public health concern atthe global level. Epidemic events of EV-A71 have been reported worldwide, and this succession of outbreaks has heightened concern that EV-A71 may become a public health threat. In recent years, widespread A71 enterovirus also occurred in European countries. EV-A71 infection causes hand-foot-mouth disease (HFMD), herpangina, and fever. However, it can sometimes induce a variety of neurological complications, including encephalitis, aseptic meningitis, pulmonary edema, and acute flaccid paralysis. We identified new benzimidazole derivatives and described their in vitro cytotoxicity and broad-spectrum anti-enterovirus activity. Among them, derivative 2b resulted in interesting activity against EV-A71, and therefore it was selected for further investigations. Compound 2b proved to be able to protect cell monolayers from EV-A71-induced cytopathogenicity, with an EC50 of 3 µM. Moreover, Vero-76 cells resulted in being significantly protected from necrosis and apoptosis when treated with 2b at 20 and 80 µM. Compound 2b reduced viral adsorption to Vero-76 cells, and when evaluated in a time-of-addition assay, the derivative had the highest effect when added during the infection period. Moreover, derivative 2b reduced viral penetration into host cells. Besides, 2b did not affect intestinal monolayers permeability, showing no toxic effects. A detailed insight into the efficacy of compound 2b against EV-A71 showed a dose-dependent reduction in the viral titer, also at low concentrations. Mechanism of action investigations suggested that our derivative can inhibit viral endocytosis by reducing viral attachment to and penetration into host cells. Pharmacokinetic and toxicity predictions validated compound 2b as a good candidate for further in vivo assays.

ACS Style

Roberta Ibba; Antonio Carta; Silvia Madeddu; Paola Caria; Gabriele Serreli; Sandra Piras; Simona Sestito; Roberta Loddo; Giuseppina Sanna. Inhibition of Enterovirus A71 by a Novel 2-Phenyl-Benzimidazole Derivative. Viruses 2021, 13, 58 .

AMA Style

Roberta Ibba, Antonio Carta, Silvia Madeddu, Paola Caria, Gabriele Serreli, Sandra Piras, Simona Sestito, Roberta Loddo, Giuseppina Sanna. Inhibition of Enterovirus A71 by a Novel 2-Phenyl-Benzimidazole Derivative. Viruses. 2021; 13 (1):58.

Chicago/Turabian Style

Roberta Ibba; Antonio Carta; Silvia Madeddu; Paola Caria; Gabriele Serreli; Sandra Piras; Simona Sestito; Roberta Loddo; Giuseppina Sanna. 2021. "Inhibition of Enterovirus A71 by a Novel 2-Phenyl-Benzimidazole Derivative." Viruses 13, no. 1: 58.

Journal article
Published: 28 November 2020 in Antibiotics
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Bloodstream infections (BSIs) are among the leading causes of morbidity and mortality worldwide, among infectious diseases. Local knowledge of the main bacteria involved in BSIs and their associated antibiotic susceptibility patterns is essential to rationalize the empiric antimicrobial therapy. The aim of this study was to define the incidence of infection and evaluate the antimicrobial resistance profile of the main pathogens involved in BSIs. This study enrolled patients of all ages and both sexes admitted to the University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno, Italy between January 2015 to December 2019. Bacterial identification and antibiotic susceptibility testing were performed with Vitek 2. A number of 3.949 positive blood cultures were included out of 24,694 total blood cultures from 2015 to 2019. Coagulase-negative staphylococci (CoNS) were identified as the main bacteria that caused BSI (17.4%), followed by Staphylococcus aureus (12.3%), Escherichia coli (10.9%), and Klebsiella pneumoniae (9.4%). Gram-positive bacteria were highly resistant to Penicillin G and Oxacillin, while Gram-negative strains to Ciprofloxacin, Cefotaxime, Ceftazidime, and Amoxicillin-clavulanate. High susceptibility to Vancomycin, Linezolid, and Daptomycin was observed among Gram-positive strains. Fosfomycin showed the best performance to treatment Gram-negative BSIs. Our study found an increase in resistance to the latest generation of antibiotics over the years. This suggests an urgent need to improve antimicrobial management programs to optimize empirical therapy in BSI.

ACS Style

Biagio Santella; Veronica Folliero; Gerarda Maria Pirofalo; Enrica Serretiello; Carla Zannella; Giuseppina Moccia; Emanuela Santoro; Giuseppina Sanna; Oriana Motta; Francesco De Caro; Pasquale Pagliano; Mario Capunzo; Massimiliano Galdiero; Giovanni Boccia; Gianluigi Franci. Sepsis—A Retrospective Cohort Study of Bloodstream Infections. Antibiotics 2020, 9, 851 .

AMA Style

Biagio Santella, Veronica Folliero, Gerarda Maria Pirofalo, Enrica Serretiello, Carla Zannella, Giuseppina Moccia, Emanuela Santoro, Giuseppina Sanna, Oriana Motta, Francesco De Caro, Pasquale Pagliano, Mario Capunzo, Massimiliano Galdiero, Giovanni Boccia, Gianluigi Franci. Sepsis—A Retrospective Cohort Study of Bloodstream Infections. Antibiotics. 2020; 9 (12):851.

Chicago/Turabian Style

Biagio Santella; Veronica Folliero; Gerarda Maria Pirofalo; Enrica Serretiello; Carla Zannella; Giuseppina Moccia; Emanuela Santoro; Giuseppina Sanna; Oriana Motta; Francesco De Caro; Pasquale Pagliano; Mario Capunzo; Massimiliano Galdiero; Giovanni Boccia; Gianluigi Franci. 2020. "Sepsis—A Retrospective Cohort Study of Bloodstream Infections." Antibiotics 9, no. 12: 851.

Journal article
Published: 30 September 2020 in The Journal of Infection in Developing Countries
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Introduction: The present study aimed to determine the chemical compositions and bioactivities of the essential oil of Atalantia sessiflora Guillaumin (A. sessiflora), including antibacterial, antimycotic, antitrichomonas, anti-inflammatory and antiviral effects. Methodology: The essential oil from leaves of A. sessiflora was extracted by hydrodistillation using a Clevenger apparatus. Chemical compositions of oil were identified by GC/MS. Antimicrobial and antitrichomonas activity were determined by the microdilution method; anti-inflammatory and antiviral were determined by the MTT method. Results: The average yield of oil was 0.46 ± 0.01% (v/w, dry leaves). A number of 45 constituents were identified by GC/MS. The essential oil comprised four main components. The oil showed antimicrobial activities against Gram-positive strains as Staphylococcus; Gram-negative bacteria such as Klebsiella pneumoniae and Escherichia coli; and finally four Candida species. Enterococcus faecalis and Pseudomonas aeruginosa were least susceptible to the oil of A. sessiflora, as seen in their MIC and MLC values over 16% (v/v). Activity against Trichomonas vaginalis was also undertaken, showing IC50, IC90 and MLC values of 0.016, 0.03 and 0.06% (v/v) respectively, after 48 hours of incubation. The oil of A. sessiflora displayed activity against the nitric oxide generation with the IC50 of 95.94 ± 6.18 µg/mL. The oil was completely ineffective against tested viruses, ssRNA+, ssRNA-, dsRNA, and dsDNA viruses. Conclusions: This is the first yet comprehensive scientific report about the chemical compositions and pharmacological properties of the essential oil of A. sessiflora. Further studies should be done to evaluate the safety and toxicity of A. sessiflora oil.

ACS Style

Nhan Trong Le; Matthew Gavino Donadu; Duc Viet Ho; Tuan Quoc Doan; Anh Tuan Le; Ain Raal; Donatella Usai; Giuseppina Sanna; Mauro Marchetti; Marianna Usai; Nicia Diaz; Paola Rappelli; Stefania Zanetti; Piero Cappuccinelli; Hoai Thi Nguyen. Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam. The Journal of Infection in Developing Countries 2020, 14, 1054 -1064.

AMA Style

Nhan Trong Le, Matthew Gavino Donadu, Duc Viet Ho, Tuan Quoc Doan, Anh Tuan Le, Ain Raal, Donatella Usai, Giuseppina Sanna, Mauro Marchetti, Marianna Usai, Nicia Diaz, Paola Rappelli, Stefania Zanetti, Piero Cappuccinelli, Hoai Thi Nguyen. Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam. The Journal of Infection in Developing Countries. 2020; 14 (9):1054-1064.

Chicago/Turabian Style

Nhan Trong Le; Matthew Gavino Donadu; Duc Viet Ho; Tuan Quoc Doan; Anh Tuan Le; Ain Raal; Donatella Usai; Giuseppina Sanna; Mauro Marchetti; Marianna Usai; Nicia Diaz; Paola Rappelli; Stefania Zanetti; Piero Cappuccinelli; Hoai Thi Nguyen. 2020. "Biological activities of essential oil extracted from leaves of Atalantia sessiflora Guillauminin Vietnam." The Journal of Infection in Developing Countries 14, no. 9: 1054-1064.

Research article
Published: 25 September 2020 in Natural Product Research
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In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Škorničkis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant strains. Here, we describe for the first time the evaluation of Hb EO against a spectrum of viruses responsible for important human diseases. Hb EO resulted active against Vaccinia virus (VV) (EC50 values 80 μg/mL), closely related to variola virus, causative agent of smallpox. Hb EO was able to strongly reduce the viral VV titer in cell-based assay at not cytotoxic concentration and its potential mode of action was characterised by virucidal activity evaluation followed by time-of-addition assay. Furthermore, Hb EO antiviral activity was implemented in a combination study with the mycophenolic acid. Graphical Abstract

ACS Style

Giuseppina Sanna; Silvia Madeddu; Gabriele Serreli; Hoai Thi Nguyen; Nhan Trong Le; Donatella Usai; Antonio Carta; Piero Cappuccinelli; Stefania Zanetti; Matthew Gavino Donadu. Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV). Natural Product Research 2020, 1 -7.

AMA Style

Giuseppina Sanna, Silvia Madeddu, Gabriele Serreli, Hoai Thi Nguyen, Nhan Trong Le, Donatella Usai, Antonio Carta, Piero Cappuccinelli, Stefania Zanetti, Matthew Gavino Donadu. Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV). Natural Product Research. 2020; ():1-7.

Chicago/Turabian Style

Giuseppina Sanna; Silvia Madeddu; Gabriele Serreli; Hoai Thi Nguyen; Nhan Trong Le; Donatella Usai; Antonio Carta; Piero Cappuccinelli; Stefania Zanetti; Matthew Gavino Donadu. 2020. "Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV)." Natural Product Research , no. : 1-7.

Journal article
Published: 07 August 2020 in Medicinal Chemistry
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Background: Coxsackievirus infections are associated with cases of aseptic meningitis, encephalitis, myocarditis, and some chronic disease. Methods: A series of benzo[d][1,2,3]triazol-1(2)-yl derivatives (here named benzotriazol-1(2)-yl) (4a-i, 5a-h, 6a-e, g, i, j and 7a-f, h-j) were designed, synthesized and in vitro evaluated for cytotoxicity and antiviral activity against two important human enteroviruses (HEVs) members of the Picornaviridae family [Coxsackievirus B 5 (CVB-5) and Poliovirus 1 (Sb-1)]. Results: Compounds 4c (CC50 >100 μM; EC50 = 9 μM), 5g (CC50 >100 μM; EC50 = 8 μM), and 6a (CC50 >100 μM; EC50 = 10 μM) were found active against CVB-5. With the aim of evaluating the selectivity of action of this class of compounds, a wide spectrum of RNA (positive- and negativesense), double-stranded (dsRNA) or DNA viruses were also assayed. For none of them, significant antiviral activity was determined. Conclusion: These results point towards a selective activity against CVB-5, an important human pathogen that causes both acute and chronic diseases in infants, young children, and immunocompromised patients.

ACS Style

Sandra Piras; Paola Corona; Roberta Ibba; Federico Riu; Gabriele Murineddu; Giuseppina Sanna; Silvia Madeddu; Ilenia Delogu; Roberta Loddo; Antonio Carta. Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas. Medicinal Chemistry 2020, 16, 677 -688.

AMA Style

Sandra Piras, Paola Corona, Roberta Ibba, Federico Riu, Gabriele Murineddu, Giuseppina Sanna, Silvia Madeddu, Ilenia Delogu, Roberta Loddo, Antonio Carta. Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas. Medicinal Chemistry. 2020; 16 (5):677-688.

Chicago/Turabian Style

Sandra Piras; Paola Corona; Roberta Ibba; Federico Riu; Gabriele Murineddu; Giuseppina Sanna; Silvia Madeddu; Ilenia Delogu; Roberta Loddo; Antonio Carta. 2020. "Preliminary Anti-Coxsackie Activity of Novel 1-[4-(5,6-dimethyl(H)- 1H(2H)-benzotriazol-1(2)-yl)phenyl]-3-alkyl(aryl)ureas." Medicinal Chemistry 16, no. 5: 677-688.

Journal article
Published: 19 June 2020 in Viruses
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Historically, natural products have been the most successful source of inspiration for the development of new drugs. Members of the Thymelaeaceae family have been of interest owing to their excellent medicinal value. Given the successful history of natural product-based drug discovery, extracts from the aerial parts of Thymelaea hirsuta were evaluated for their potential anti-human immunodeficiency virus type 1 (HIV-1) activity. Ethyl acetate extracts from leaves (71B) and branches (72B) of Thymelaea hirsuta showed potent and selective activity against HIV-1 wt (EC50 = 0.8 µg/mL) at non-cytotoxic concentrations (CC50 > 100 µg/mL). They proved to be active against HIV-1 variants carrying clinically relevant NNRTI and NRTI mutations at low concentration (0.3–4 µg/mL range) and against the M-tropic strain HIV-1 BaL. The 72B extract, chosen as a lead, was not able to inhibit the RT and protease enzymatic functions. Furthermore, it was not virucidal, since exposure of HIV to high concentration did not affect virus infectivity. The pre-clinical safety profile of this extract showed no adverse effect on the growth of Lactobacilli, and non-toxic concentration of the extract did not influence the Caco-2 epithelial cells monolayer integrity. Additionally, extract 72B prevented syncytia formation at low concentration (0.4 µg/mL). The potent inhibitory effect on the syncytia formation in co-cultures showed that 72B inhibits an early event in the replication cycle of HIV. All of these findings prompt us to carry on new studies on Thymelaea hirsuta extracts.

ACS Style

Giuseppina Sanna; Silvia Madeddu; Giuseppe Murgia; Gabriele Serreli; Michela Begala; Pierluigi Caboni; Alessandra Incani; Gianluigi Franci; Marilena Galdiero; Gabriele Giliberti. Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts. Viruses 2020, 12, 664 .

AMA Style

Giuseppina Sanna, Silvia Madeddu, Giuseppe Murgia, Gabriele Serreli, Michela Begala, Pierluigi Caboni, Alessandra Incani, Gianluigi Franci, Marilena Galdiero, Gabriele Giliberti. Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts. Viruses. 2020; 12 (6):664.

Chicago/Turabian Style

Giuseppina Sanna; Silvia Madeddu; Giuseppe Murgia; Gabriele Serreli; Michela Begala; Pierluigi Caboni; Alessandra Incani; Gianluigi Franci; Marilena Galdiero; Gabriele Giliberti. 2020. "Potent and Selective Activity against Human Immunodeficiency Virus 1 (HIV-1) of Thymelaea hirsuta Extracts." Viruses 12, no. 6: 664.

Journal article
Published: 18 June 2020 in Antibiotics
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The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, the chemical compositions and cytotoxicity, as well as the antibacterial, antifungal, antitrichomonas, and antiviral activities of essential oils from the leaves, rhizomes, and whole plant of Hornstedtia bella were investigated. The GC/MS analysis showed that β-pinene, E-β-caryophyllene, and α-humulene were found at high concentrations in the essential oils. The essential oils exhibited (i) inhibition against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis with minimum inhibitory concentrations (MIC) and minimum lethal concentration (MLC) values from 1 to 4% (v/v); (ii) MIC and MLC values from 2 to 16% (v/v) in Candida tropicalis and Candida parapsilosis; (iii) MIC and MLC values from 4 to 16% in Enterococcus faecalis; and (iv) MIC and MLC values from 8 to greater than or equal to 16% (v/v) in the remaining strains, including Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans, and Candida glabrata. In antitrichomonas activity, the leaves and whole-plant oils of Hornstedtia bella possessed IC50, IC90, and MLC values of 0.008%, 0.016%, and 0.03% (v/v), respectively, whilst those of rhizomes oil had in turn, 0.004%, 0.008%, and 0.016% (v/v).Besides, the leaf oil showed a weak cytotoxicity against Vero 76 and MRC-5; meanwhile, rhizomes and whole-plant oils did not exert any toxic effects on cell monolayers. Finally, these oils were not active against EV-A71.

ACS Style

Matthew Gavino Donadu; Nhan Trong Le; Duc Viet Ho; Tuan Quoc Doan; Anh Tuan Le; Ain Raal; Marianna Usai; Mauro Marchetti; Giuseppina Sanna; Silvia Madeddu; Paola Rappelli; Nicia Diaz; Paola Molicotti; Antonio Carta; Sandra Piras; Donatella Usai; Hoai Thi Nguyen; Piero Cappuccinelli; Stefania Zanetti. Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk. Antibiotics 2020, 9, 334 .

AMA Style

Matthew Gavino Donadu, Nhan Trong Le, Duc Viet Ho, Tuan Quoc Doan, Anh Tuan Le, Ain Raal, Marianna Usai, Mauro Marchetti, Giuseppina Sanna, Silvia Madeddu, Paola Rappelli, Nicia Diaz, Paola Molicotti, Antonio Carta, Sandra Piras, Donatella Usai, Hoai Thi Nguyen, Piero Cappuccinelli, Stefania Zanetti. Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk. Antibiotics. 2020; 9 (6):334.

Chicago/Turabian Style

Matthew Gavino Donadu; Nhan Trong Le; Duc Viet Ho; Tuan Quoc Doan; Anh Tuan Le; Ain Raal; Marianna Usai; Mauro Marchetti; Giuseppina Sanna; Silvia Madeddu; Paola Rappelli; Nicia Diaz; Paola Molicotti; Antonio Carta; Sandra Piras; Donatella Usai; Hoai Thi Nguyen; Piero Cappuccinelli; Stefania Zanetti. 2020. "Phytochemical Compositions and Biological Activities of Essential Oils from the Leaves, Rhizomes and Whole Plant of Hornstedtia bella Škorničk." Antibiotics 9, no. 6: 334.

Journal article
Published: 24 April 2020 in Antibiotics
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The present study aimed to determine the bioactivities of essential oils extracted from the leaves of Paramignya trimera and Limnocitrus littoralis, including cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas effects. Herein, it was indicated that P. trimera and L. littoralis oils showed no cytotoxicity on normal cells, namely MT-4, BHK-21, MDBK, and Vero-76. P. trimera oil (i) exhibited the strongest inhibition against Staphylococcus aureus with MIC and MLC values of 2% (v/v); (ii) showed MIC and MLC values of 8% (v/v) in Candida parapsilosis; and (iii) in the remaining strains, showed MIC and MLC values greater than or equal to 16% (v/v). On the other hand, L. littoralis oil (i) displayed the strongest inhibition against Candida tropicalis and Candida parapsilosis with 2% (v/v) of MIC and MLC; and (ii) in the remaining strains, possessed MIC and MLC greater than or equal to 16% (v/v). In addition, antitrichomonas activities of the oils were undertaken, showing IC50, IC90, MLC values, respectively, at 0.016%, 0.03%, and 0.06% (v/v) from P. trimera, and 0.03%, 0.06%, 0.12% (v/v) from L. littoralis, after 48 h of incubation. The oils were completely ineffective against ssRNA+ (HIV-1, YFV, BVDV, Sb-1, CV-B4), ssRNA- (RSV, VSV), dsRNA (Reo-1), and dsDNA (HSV-1, VV) viruses. This is the first report describing the cytotoxicity, antiviral, antibacterial, antimycotic, and antitrichomonas activities of the essential oils of P. trimera and L. littoralis.

ACS Style

Nhan Trong Le; Duc Viet Ho; Tuan Quoc Doan; Anh Tuan Le; Ain Raal; Donatella Usai; Giuseppina Sanna; Antonio Carta; Paola Rappelli; Nicia Diaz; Piero Cappuccinelli; Stefania Zanetti; Hoai Thi Nguyen; Matthew Gavino Donadu. Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle. Antibiotics 2020, 9, 207 .

AMA Style

Nhan Trong Le, Duc Viet Ho, Tuan Quoc Doan, Anh Tuan Le, Ain Raal, Donatella Usai, Giuseppina Sanna, Antonio Carta, Paola Rappelli, Nicia Diaz, Piero Cappuccinelli, Stefania Zanetti, Hoai Thi Nguyen, Matthew Gavino Donadu. Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle. Antibiotics. 2020; 9 (4):207.

Chicago/Turabian Style

Nhan Trong Le; Duc Viet Ho; Tuan Quoc Doan; Anh Tuan Le; Ain Raal; Donatella Usai; Giuseppina Sanna; Antonio Carta; Paola Rappelli; Nicia Diaz; Piero Cappuccinelli; Stefania Zanetti; Hoai Thi Nguyen; Matthew Gavino Donadu. 2020. "Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle." Antibiotics 9, no. 4: 207.

Communication
Published: 20 January 2020 in Viruses
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Orthohantaviruses, previously known as hantaviruses (family Hantaviridae, order Bunyavirales), are emerging zoonoses hosted by different rodent and insectivore species. Orthohantaviruses are transmitted by aerosolized excreta (urine, saliva and feces) of their reservoir hosts. When transmitted to humans, they cause hemorrhagic fever with renal syndrome (HFRS) in Asia and Europe and hantavirus (cardio) pulmonary syndrome (HPS) in the Americas. Clinical studies have shown that early treatments of HFRS patients with ribavirin (RBV) improve prognosis. Nevertheless, there is the need for urgent development of specific antiviral drugs. In the search for new RNA virus inhibitors, we recently identified a series of variously substituted 5,6-dichloro-1(2)-phenyl-1(2)H-benzo[d][1,2,3]triazole derivatives active against the human respiratory syncytial virus (HRSV). Interestingly, several 2-phenyl-benzotriazoles resulted in fairly potent inhibitors of the Hantaan virus in a chemiluminescence focus reduction assay (C-FRA) showing an EC50 = 4–5 µM, ten-fold more active than ribavirin. Currently, there are no FDA approved drugs for the treatment of orthohantavirus infections. Antiviral activities and cytotoxicity profiles suggest that 5,6-dichloro-1(2)-phenyl-1(2)H-benzo[d][1,2,3]triazoles could be promising candidates for further investigation as a potential treatment of hantaviral diseases.

ACS Style

Giuseppina Sanna; Sandra Piras; Silvia Madeddu; Bernardetta Busonera; Boris Klempa; Paola Corona; Roberta Ibba; Gabriele Murineddu; Antonio Carta; Roberta Loddo. 5,6-Dichloro-2-Phenyl-Benzotriazoles: New Potent Inhibitors of Orthohantavirus. Viruses 2020, 12, 122 .

AMA Style

Giuseppina Sanna, Sandra Piras, Silvia Madeddu, Bernardetta Busonera, Boris Klempa, Paola Corona, Roberta Ibba, Gabriele Murineddu, Antonio Carta, Roberta Loddo. 5,6-Dichloro-2-Phenyl-Benzotriazoles: New Potent Inhibitors of Orthohantavirus. Viruses. 2020; 12 (1):122.

Chicago/Turabian Style

Giuseppina Sanna; Sandra Piras; Silvia Madeddu; Bernardetta Busonera; Boris Klempa; Paola Corona; Roberta Ibba; Gabriele Murineddu; Antonio Carta; Roberta Loddo. 2020. "5,6-Dichloro-2-Phenyl-Benzotriazoles: New Potent Inhibitors of Orthohantavirus." Viruses 12, no. 1: 122.

Short communication
Published: 25 March 2019 in Natural Product Research
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Nerium oleander (NO), a member of the Apocynaceae family, is an ornamental plant. In this study, we evaluated the antiviral activity of hot and cold extract of NO against six different viruses such as herpes simplex virus type 1 (HSV-1), polio virus type 1 (Sb-1), vesicular stomatitis virus (VSV), reovirus type-1 (Reo-1), human immunodeficiency virus type-1 (HIV-1), and yellow fever virus (YFV). Interestingly the results of plaque reduction assay demonstrated that both, hot extract and cold extract (breastin) of NO inhibited Sb-1 viral infection. In order to identify the mechanism by which NO exerts its antiviral activity, the virucidal effect, the time of addition and the adsorption assay were carried out. Results demonstrated that NO exerts its effect after infection period, particularly during the first two hours post infection.

ACS Style

Giuseppina Sanna; Silvia Madeddu; Alessandra Serra; David Collu; Thomas Efferth; F. Lukmanul Hakkim; Luay Rashan. Anti-poliovirus activity of Nerium oleander aqueous extract. Natural Product Research 2019, 35, 633 -636.

AMA Style

Giuseppina Sanna, Silvia Madeddu, Alessandra Serra, David Collu, Thomas Efferth, F. Lukmanul Hakkim, Luay Rashan. Anti-poliovirus activity of Nerium oleander aqueous extract. Natural Product Research. 2019; 35 (4):633-636.

Chicago/Turabian Style

Giuseppina Sanna; Silvia Madeddu; Alessandra Serra; David Collu; Thomas Efferth; F. Lukmanul Hakkim; Luay Rashan. 2019. "Anti-poliovirus activity of Nerium oleander aqueous extract." Natural Product Research 35, no. 4: 633-636.

Journal article
Published: 07 October 2018 in Molecules
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A series of 2-(1H-indol-3-yl)ethylthiourea derivatives were prepared by condensation of 2-(1H-indol-3-yl)ethanamine with appropriate aryl/alkylisothiocyanates in anhydrous media. The structures of the newly synthesized compounds were confirmed by spectroscopic analysis and the molecular structures of 8 and 28 were confirmed by X-ray crystallography. All obtained compounds were tested for antimicrobial activity against Gram-positive cocci, Gram-negative rods and for antifungal activity. Microbiological evaluation was carried out over 20 standard strains and 30 hospital strains. Compound 6 showed significant inhibition against Gram-positive cocci and had inhibitory effect on the S. aureus topoisomerase IV decatenation activity and S. aureus DNA gyrase supercoiling activity. Compounds were tested for cytotoxicity and antiviral activity against a large panel of DNA and RNA viruses, including HIV-1 and other several important human pathogens. Interestingly, derivative 8 showed potent activity against HIV-1 wild type and variants bearing clinically relevant mutations. Newly synthesized tryptamine derivatives showed also a wide spectrum activity, proving to be active against positive- and negative-sense RNA viruses.

ACS Style

Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Sandra Piras; Marta Struga; Małgorzata Wrzosek; Grażyna Kubiak-Tomaszewska; Anna E. Koziol; Oleksandra Savchenko; Tadeusz Lis; Joanna Stefanska; Piotr Tomaszewski; Michał Skrzycki; Daniel Szulczyk. Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas. Molecules 2018, 23, 2554 .

AMA Style

Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Sandra Piras, Marta Struga, Małgorzata Wrzosek, Grażyna Kubiak-Tomaszewska, Anna E. Koziol, Oleksandra Savchenko, Tadeusz Lis, Joanna Stefanska, Piotr Tomaszewski, Michał Skrzycki, Daniel Szulczyk. Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas. Molecules. 2018; 23 (10):2554.

Chicago/Turabian Style

Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Sandra Piras; Marta Struga; Małgorzata Wrzosek; Grażyna Kubiak-Tomaszewska; Anna E. Koziol; Oleksandra Savchenko; Tadeusz Lis; Joanna Stefanska; Piotr Tomaszewski; Michał Skrzycki; Daniel Szulczyk. 2018. "Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas." Molecules 23, no. 10: 2554.

Journal article
Published: 07 October 2018 in Molecules
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ACS Style

Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Sandra Piras; Marta Struga; Małgorzata Wrzosek; Grażyna Kubiak-Tomaszewska; Anna E. Koziol; Oleksandra Savchenko; Tadeusz Lis; Joanna Stefanska; Piotr Tomaszewski; Michał Skrzycki; Daniel Szulczyk. Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas. Molecules 2018, 23, 1 .

AMA Style

Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Sandra Piras, Marta Struga, Małgorzata Wrzosek, Grażyna Kubiak-Tomaszewska, Anna E. Koziol, Oleksandra Savchenko, Tadeusz Lis, Joanna Stefanska, Piotr Tomaszewski, Michał Skrzycki, Daniel Szulczyk. Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas. Molecules. 2018; 23 (10):1.

Chicago/Turabian Style

Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Sandra Piras; Marta Struga; Małgorzata Wrzosek; Grażyna Kubiak-Tomaszewska; Anna E. Koziol; Oleksandra Savchenko; Tadeusz Lis; Joanna Stefanska; Piotr Tomaszewski; Michał Skrzycki; Daniel Szulczyk. 2018. "Synthesis and Biological Evaluation of Novel Indole-Derived Thioureas." Molecules 23, no. 10: 1.

Journal article
Published: 21 September 2018 in Molecules
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4-Chloro-3-nitrophenylthioureas 1–30 were synthesized and tested for their antimicrobial and cytotoxic activities. Compounds exhibited high to moderate antistaphylococcal activity against both standard and clinical strains (MIC values 2–64 μg/mL). Among them derivatives with electron-donating alkyl substituents at the phenyl ring were the most promising. Moreover, compounds 1–6 and 8–19 were cytotoxic against MT-4 cells and various other cell lines derived from human hematological tumors (CC50 ≤ 10 μM). The influence of derivatives 11, 13 and 25 on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed.

ACS Style

Anna Bielenica; Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Joanna Stefańska; Anna E. Kozioł; Oleksandra Savchenko; Paulina Strzyga-Łach; Alicja Chrzanowska; Grażyna Kubiak-Tomaszewska; Marta Struga. Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies. Molecules 2018, 23, 2428 .

AMA Style

Anna Bielenica, Giuseppina Sanna, Silvia Madeddu, Gabriele Giliberti, Joanna Stefańska, Anna E. Kozioł, Oleksandra Savchenko, Paulina Strzyga-Łach, Alicja Chrzanowska, Grażyna Kubiak-Tomaszewska, Marta Struga. Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies. Molecules. 2018; 23 (10):2428.

Chicago/Turabian Style

Anna Bielenica; Giuseppina Sanna; Silvia Madeddu; Gabriele Giliberti; Joanna Stefańska; Anna E. Kozioł; Oleksandra Savchenko; Paulina Strzyga-Łach; Alicja Chrzanowska; Grażyna Kubiak-Tomaszewska; Marta Struga. 2018. "Disubstituted 4-Chloro-3-nitrophenylthiourea Derivatives: Antimicrobial and Cytotoxic Studies." Molecules 23, no. 10: 2428.

Original paper
Published: 09 June 2018 in Monatshefte für Chemie - Chemical Monthly
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In this study, we designed and synthesized a series of new 5-chlorobenzotriazole derivatives. Compounds were tested for cytotoxicity and antiviral activity in cell-based assays against several positive single-stranded RNA viruses: BVDV, YFV, CVB-5, and Sb-1; two negative single-stranded RNA viruses: RSV and VSV; a double-stranded RNA virus (Reo-1); and two DNA viruses: VV and HSV-1. N-[4-(5-Chloro-2H-benzo[d][1,2,3]triazol-2-yl)phenyl]-3,4,5-trimethoxybenzamide turned out to be the most potent compound against bovine viral diarrhea virus (BVDV). Its activity was shown to be comparable to the activity of the reference drug NM 107 (EC50 3.0 vs. 1.7 μM). It is going to be used as a lead compound for future antiviral drug developments.

ACS Style

Roberta Ibba; Paola Corona; Antonio Carta; Paolo Giunchedi; Roberta Loddo; Giuseppina Sanna; Ilenia Delogu; Sandra Piras. Antiviral activities of 5-chlorobenzotriazole derivatives. Monatshefte für Chemie - Chemical Monthly 2018, 149, 1247 -1256.

AMA Style

Roberta Ibba, Paola Corona, Antonio Carta, Paolo Giunchedi, Roberta Loddo, Giuseppina Sanna, Ilenia Delogu, Sandra Piras. Antiviral activities of 5-chlorobenzotriazole derivatives. Monatshefte für Chemie - Chemical Monthly. 2018; 149 (7):1247-1256.

Chicago/Turabian Style

Roberta Ibba; Paola Corona; Antonio Carta; Paolo Giunchedi; Roberta Loddo; Giuseppina Sanna; Ilenia Delogu; Sandra Piras. 2018. "Antiviral activities of 5-chlorobenzotriazole derivatives." Monatshefte für Chemie - Chemical Monthly 149, no. 7: 1247-1256.

Journal article
Published: 01 February 2018 in European Journal of Medicinal Chemistry
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Enteroviruses are among the most common and important human pathogens for which there are no specific antiviral agents approved by the US Food and Drug Administration so far. Particularly, coxsackievirus infections have a worldwide distribution and can cause many important diseases. We here report the synthesis of new 14 quinoxaline derivatives and the evaluation of their cytotoxicity and antiviral activity against representatives of ssRNA, dsRNA and dsDNA viruses. Promisingly, three compounds showed a very potent and selective antiviral activity against coxsackievirus B5, with EC50 in the sub-micromolar range (0.3–0.06 μM). A combination of experimental techniques (i.e. virucidal activity, time of drug addition and adsorption assays) and in silico modeling studies were further performed, aiming to understand the mode of action of the most active, selective and not cytotoxic compound, the ethyl 4-[(2,3-dimethoxyquinoxalin-6-yl)methylthio]benzoate (6).

ACS Style

Antonio Carta; Giuseppina Sanna; Irene Briguglio; Silvia Madeddu; Gabriella Vitale; Sandra Piras; Paola Corona; Alessandra Tiziana Peana; Erik Laurini; Maurizio Fermeglia; Sabrina Pricl; Alessandra Serra; Elisa Carta; Roberta Loddo; Gabriele Giliberti. Quinoxaline derivatives as new inhibitors of coxsackievirus B5. European Journal of Medicinal Chemistry 2018, 145, 559 -569.

AMA Style

Antonio Carta, Giuseppina Sanna, Irene Briguglio, Silvia Madeddu, Gabriella Vitale, Sandra Piras, Paola Corona, Alessandra Tiziana Peana, Erik Laurini, Maurizio Fermeglia, Sabrina Pricl, Alessandra Serra, Elisa Carta, Roberta Loddo, Gabriele Giliberti. Quinoxaline derivatives as new inhibitors of coxsackievirus B5. European Journal of Medicinal Chemistry. 2018; 145 ():559-569.

Chicago/Turabian Style

Antonio Carta; Giuseppina Sanna; Irene Briguglio; Silvia Madeddu; Gabriella Vitale; Sandra Piras; Paola Corona; Alessandra Tiziana Peana; Erik Laurini; Maurizio Fermeglia; Sabrina Pricl; Alessandra Serra; Elisa Carta; Roberta Loddo; Gabriele Giliberti. 2018. "Quinoxaline derivatives as new inhibitors of coxsackievirus B5." European Journal of Medicinal Chemistry 145, no. : 559-569.

Journal article
Published: 01 November 2017 in Journal of Inorganic Biochemistry
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The new Cu(II) complexes of 1/2/3-(bromophenyl)-3-(1,7,8,9-tetramethyl-3,5-dioxo-4-azatricyclo[5.2.1.0]dec-8-en-4-yl)thiourea derivatives have been synthesized. The spectroscopic studies together with density functional theory calculations of Cu(II) complexes revealed that two parent ligands coordinate to the copper cation in bidentate fashion via thiocarbonyl S and deprotonated N atoms forming rarely observed four-membered chelate ring, with nearly planar [CuNS] moiety. In solid state, the mononuclear complex is formed for thiourea derivative with 3-bromophenyl, whereas for Cu(II) connection with 2- and 4-bromophenyl-thioureas the formation of dinuclear complexes is observed, the latter formed by the stacking of mononuclear complexes. The microbiological activity of novel compounds has been evaluated. The Cu(II) complex with 4-bromophenyl ring connected to the thiourea moiety showed significant inhibition against standard strains of S. aureus and S. epidermidis. The range of minimal inhibitory concentration values is 2-4μg/mL. That compound exhibited antibiofilm potency and effectively inhibited the formation of biofilm of methicillin-susceptive strain of S. epidermidis ATCC 12228. Moreover, the cytotoxicity against the MT-4 cells of all obtained complexes has been evaluated. The complexes turned out to be non-cytotoxic for exponentially growing MT-4.

ACS Style

Aleksandra Drzewiecka-Antonik; Paweł Rejmak; Marcin Klepka; Anna Wolska; Piotr Pietrzyk; Karolina Stępień; Giuseppina Sanna; Marta Struga. Synthesis, structural studies and biological activity of novel Cu(II) complexes with thiourea derivatives of 4-azatricyclo[5.2.1.0 2,6 ]dec-8-ene-3,5-dione. Journal of Inorganic Biochemistry 2017, 176, 8 -16.

AMA Style

Aleksandra Drzewiecka-Antonik, Paweł Rejmak, Marcin Klepka, Anna Wolska, Piotr Pietrzyk, Karolina Stępień, Giuseppina Sanna, Marta Struga. Synthesis, structural studies and biological activity of novel Cu(II) complexes with thiourea derivatives of 4-azatricyclo[5.2.1.0 2,6 ]dec-8-ene-3,5-dione. Journal of Inorganic Biochemistry. 2017; 176 ():8-16.

Chicago/Turabian Style

Aleksandra Drzewiecka-Antonik; Paweł Rejmak; Marcin Klepka; Anna Wolska; Piotr Pietrzyk; Karolina Stępień; Giuseppina Sanna; Marta Struga. 2017. "Synthesis, structural studies and biological activity of novel Cu(II) complexes with thiourea derivatives of 4-azatricyclo[5.2.1.0 2,6 ]dec-8-ene-3,5-dione." Journal of Inorganic Biochemistry 176, no. : 8-16.

Journal article
Published: 07 June 2017 in Chemical Biology & Drug Design
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Thiourea derivatives have been reported to possess many biological activities, among them antiviral and antitumoral properties. As part of our continuing effort to develop new active compounds, we report the synthesis and the evaluation of new fifteen thiourea derivatives with 1,3-benzothiazol-2-yl moiety, among them a group of biologically active (1-7) also underwent cyclisation to 1,3-thiazolidin-4-ones. Molecular structure of four compounds (4, 13, 15 and 3a) was determined by an X-ray crystallography. We here report the evaluation of their cytotoxicity against human leukaemia/lymphoma- and solid tumour-derived cell lines and of their antiviral activity against HIV-1 and representatives of ssRNA and dsDNA viruses. Derivative 5 showed an interesting activity against HIV-1 wild type and against variants carrying clinically relevant mutations. A colorimetric enzyme immunoassay clarified its mode of action as a non-nucleoside inhibitor of the reverse transcriptase.This article is protected by copyright. All rights reserved.

ACS Style

Anna Bielenica; Giuseppina Sanna; Silvia Madeddu; Marta Struga; Michał Jóźwiak; Anna E. Kozioł; Aleksandra Sawczenko; Ilona B. Materek; Alessandra Serra; Gabriele Giliberti. New thiourea and 1,3-thiazolidin-4-one derivatives effective on the HIV-1 virus. Chemical Biology & Drug Design 2017, 90, 883 -891.

AMA Style

Anna Bielenica, Giuseppina Sanna, Silvia Madeddu, Marta Struga, Michał Jóźwiak, Anna E. Kozioł, Aleksandra Sawczenko, Ilona B. Materek, Alessandra Serra, Gabriele Giliberti. New thiourea and 1,3-thiazolidin-4-one derivatives effective on the HIV-1 virus. Chemical Biology & Drug Design. 2017; 90 (5):883-891.

Chicago/Turabian Style

Anna Bielenica; Giuseppina Sanna; Silvia Madeddu; Marta Struga; Michał Jóźwiak; Anna E. Kozioł; Aleksandra Sawczenko; Ilona B. Materek; Alessandra Serra; Gabriele Giliberti. 2017. "New thiourea and 1,3-thiazolidin-4-one derivatives effective on the HIV-1 virus." Chemical Biology & Drug Design 90, no. 5: 883-891.

Journal article
Published: 01 October 2016 in Antiviral Research
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Some Mannich bases of 7-hydroxycoumarins (3–6) with piperazine or other amines bearing two secondary amine groups were prepared and tested against viruses representative of RNA families. All compounds were symmetrical, possessing two identical coumarin moieties with respect to one diamine. Then, some of these double Mannich bases were alkylated and acylated. The 7-hydroxy derivative 3a was endowed with significant activity against Bovine Viral Diarrhoea Virus (BVDV). On the other hand, the propyloxy derivatives 3e and 3f showed modest antiviral activity. The most potent activity was shown by the p-nitrobenzoyl derivative 3i. On the whole, the behaviour of the compounds presented here is quite different, in terms of SAR, from that of similar Mannich bases of 7-hydroxycoumarin already published.

ACS Style

Munjed M. Ibrahim; Mauro Mazzei; Ilenia Delogu; Róbert Szabó; Giuseppina Sanna; Roberta Loddo. Activity of bis(7-hydroxycoumarin) Mannich bases against bovine viral diarrhoea virus. Antiviral Research 2016, 134, 153 -160.

AMA Style

Munjed M. Ibrahim, Mauro Mazzei, Ilenia Delogu, Róbert Szabó, Giuseppina Sanna, Roberta Loddo. Activity of bis(7-hydroxycoumarin) Mannich bases against bovine viral diarrhoea virus. Antiviral Research. 2016; 134 ():153-160.

Chicago/Turabian Style

Munjed M. Ibrahim; Mauro Mazzei; Ilenia Delogu; Róbert Szabó; Giuseppina Sanna; Roberta Loddo. 2016. "Activity of bis(7-hydroxycoumarin) Mannich bases against bovine viral diarrhoea virus." Antiviral Research 134, no. : 153-160.