Due to the high proportion of aircraft faults caused by cracks in aircraft structures, crack inspection in aircraft structures has long played an important role in the aviation industry. The existing approaches, however, are time-consuming or have poor accuracy, given the complex background of aircraft structure images. In order to solve these problems, we propose the YOLOv3-Lite method, which combines depthwise separable convolution, feature pyramids, and YOLOv3. Depthwise separable convolution is employed to design the backbone network for reducing parameters and for extracting crack features effectively. Then, the feature pyramid joins together low-resolution, semantically strong features at a high-resolution for obtaining rich semantics. Finally, YOLOv3 is used for the bounding box regression. YOLOv3-Lite is a fast and accurate crack detection method, which can be used on aircraft structure such as fuselage or engine blades. The result shows that, with almost no loss of detection accuracy, the speed of YOLOv3-Lite is 50% more than that of YOLOv3. It can be concluded that YOLOv3-Lite can reach state-of-the-art performance.

Despite the widespread use of ionizable lipid nanoparticles (LNPs) in clinical applications for messenger RNA (mRNA) delivery, the mRNA drug delivery system faces an efficient challenge in the screening of LNPs. Traditional screening methods often require a substantial amount of experimental time and incur high research and development costs. To accelerate the early development stage of LNPs, we propose TransLNP, a transformer-based transfection prediction model designed to aid in the selection of LNPs for mRNA drug delivery systems. TransLNP uses two types of molecular information to perceive the relationship between structure and transfection efficiency: coarse-grained atomic sequence information and fine-grained atomic spatial relationship information. Due to the scarcity of existing LNPs experimental data, we find that pretraining the molecular model is crucial for better understanding the task of predicting LNPs properties, which is achieved through reconstructing atomic 3D coordinates and masking atom predictions. In addition, the issue of data imbalance is particularly prominent in the real-world exploration of LNPs. We introduce the BalMol block to solve this problem by smoothing the distribution of labels and molecular features. Our approach outperforms state-of-the-art works in transfection property prediction under both random and scaffold data splitting. Additionally, we establish a relationship between molecular structural similarity and transfection differences, selecting 4267 pairs of molecular transfection cliffs, which are pairs of molecules that exhibit high structural similarity but significant differences in transfection efficiency, thereby revealing the primary source of prediction errors. The code, model and data are made publicly available at https://github.com/wklix/TransLNP.

Object detection in low-light conditions presents significant challenges due to issues such as weak contrast, high noise, and blurred boundaries. Existing methods often use image enhancement to improve detection, which results in a large amount of computational resource consumption. To address these challenges, this paper proposes a detection method, 3L-YOLO, based on YOLOv8n, which eliminates the need for image enhancement modules. First, we introduce switchable atrous convolution (SAConv) into the C2f module of YOLOv8n, improving the model’s ability to efficiently capture global contextual information. Second, we present a multi-scale neck module that aggregates shallow features and incorporates a channel attention mechanism to prioritize the most relevant features. Third, we introduce a dynamic detection head, which employs a cascade of spatial, scale, and channel attention mechanisms to enhance detection accuracy and robustness. Finally, we replace the original loss function with MPDIoU loss, improving bounding box regression and overall reliability. Additionally, we create a synthetic low-light dataset to evaluate the performance of the proposed method. Extensive experiments on the ExDark, ExDark+, and DARK FACE datasets demonstrate that 3L-YOLO outperforms YOLOv8n in low-light object detection, with improvements in mAP@0.5 of 2.7%, 4.3%, and 1.4%, respectively, across the three datasets. In comparison to the LOL-YOLO low-light object detection algorithm, 3L-YOLO requires 16.9 GFLOPs, representing a reduction of 4 GFLOPs.

As the primary messenger RNA (mRNA) delivery vehicles, ionizable lipid nanoparticles (LNPs) exhibit excellent safety, high transfection efficiency, and strong immune response induction. However, the screening process for LNPs is time-consuming and costly. To expedite the identification of high-transfection-efficiency mRNA drug delivery systems, we propose an explainable LNPs transfection efficiency prediction model, called TransMA. TransMA employs a multimodal molecular structure fusion architecture, wherein the fine-grained atomic spatial relationship extractor named molecule 3D Transformer captures three-dimensional spatial features of the molecule, and the coarse-grained atomic sequence extractor named molecule Mamba captures one-dimensional molecular features. We design the mol-attention mechanism block, enabling it to align coarse and fine-grained atomic features and capture relationships between atomic spatial and sequential structures. TransMA achieves state-of-the-art performance in predicting transfection efficiency using the scaffold and cliff data splitting methods on the current largest LNPs dataset, including Hela and RAW cell lines. Moreover, we find that TransMA captures the relationship between subtle structural changes and significant transfection efficiency variations, providing valuable insights for LNPs design. Additionally, TransMA’s predictions on external transfection efficiency data maintain a consistent order with actual transfection efficiencies, demonstrating its robust generalization capability. We hope that high-accuracy transfection prediction models in the future can aid in LNPs design and initial screening, thereby assisting in accelerating the mRNA design process.

Single-image dehazing technology plays a significant role in video surveillance and intelligent transportation. However, existing dehazing methods using vanilla convolution only extract features in the temporal domain and lack the ability to capture multi-directional information. To address the aforementioned issues, we design a new full spectral attention-based detail enhancement dehazing network, named SAD-Net. SAD-Net adopts a U-Net-like structure and integrates Spectral Detail Enhancement Convolution (SDEC) and Frequency-Guided Attention (FGA). SDEC combines wavelet transform and difference convolution(DC) to enhance high-frequency features while preserving low-frequency information. FGA detects haze-induced discrepancies and fine-tunes feature modulation. Experimental results show that SAD-Net outperforms six other dehazing networks on the Dense-Haze, NH-Haze, RESIDE and I-Haze datasets. Specifically, it increases the peak signal-to-noise ratio (PSNR) to 17.16 dB on the Dense-Haze dataset, surpassing the current state-of-the-art (SOTA) methods. Additionally, SAD-Net achieves excellent dehazing performance on an external dataset without any prior training.