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Despite the pandemic, 34,154 migrants, refugees or asylum-seekers landed in Sicily (Italy) in 2020, representing the main point of entry by sea into Europe. The SARS-CoV-2 surveillance program among migrants arriving to Sicily via the Mediterranean Sea, made by the combination of clinical examination and molecular testing, has been integrated by full-genome sequencing strains using the NGS technology from the last week of February. To date, more than one hundred full-genome strains have been sequenced and 8 different lineages have been identified mostly belonging to the lineages B.1.1.7 and B.1.525. As global access to COVID-19 vaccines should be ensured, the need to provide more detailed information to inform policies and to drive the possible re-engineering of vaccines needed to deal with the challenge of new and future variants should be highlighted.
Claudia Marotta; Paola Stefanelli; Fabio Tramuto; Ulrico Angeloni; Carmelo Massimo Maida; Achille Cernigliaro; Teresa Barone; Francesco Vitale; Giovanni Rezza; Walter Mazzucco; Sami-Surv Collaboration. The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes. Annals of Global Health 2021, 87, 71 .
AMA StyleClaudia Marotta, Paola Stefanelli, Fabio Tramuto, Ulrico Angeloni, Carmelo Massimo Maida, Achille Cernigliaro, Teresa Barone, Francesco Vitale, Giovanni Rezza, Walter Mazzucco, Sami-Surv Collaboration. The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes. Annals of Global Health. 2021; 87 (1):71.
Chicago/Turabian StyleClaudia Marotta; Paola Stefanelli; Fabio Tramuto; Ulrico Angeloni; Carmelo Massimo Maida; Achille Cernigliaro; Teresa Barone; Francesco Vitale; Giovanni Rezza; Walter Mazzucco; Sami-Surv Collaboration. 2021. "The Dual/Global Value of SARS-CoV-2 Genome Surveillance on Migrants Arriving to Europe via the Mediterranean Routes." Annals of Global Health 87, no. 1: 71.
Background Occurrence of HCV infection is reduced by effective risk management procedures, but patient-to-patient transmission continues to be reported in healthcare settings. Aim To report the use of phylogenetic analysis in the clinical risk management of an HCV outbreak among 128 thalassemia outpatients followed at a thalassemia unit of an Italian hospital. Methods Epidemiological investigation and root-cause analysis were performed. All patients with acute hepatitis and known chronic infection were tested for HCV-RNA, HCV genotyping, and NS3, NS5A and NS5B HCV-genomic regions sequencing. To identify transmission clusters we built phylogenetic trees for each gene employing Bayesian methods. Findings All patients with acute hepatitis were infected with HCV genotype 1b. Root-cause analysis, including a lookback procedure excluded blood donors as the source of HCV transmission. The phylogenetic analysis, conducted on seven patients with acute infection and eight patients with chronic infection, highlighted four transmission clusters including at least one patient with chronic and one patient with acute HCV infection. All patients in the same cluster received a blood transfusion during the same day. Two patients with acute hepatitis spontaneously cleared HCV within four weeks and nine patients received ledipasvir plus sofosbuvir for six weeks, all achieving a sustained virological response. Conclusions Combined use of root cause analysis and molecular epidemiology was effective in ascertaining the origin of the HCV outbreak. Antiviral therapy avoided the chronic progression of the infection and further spread in care units and in the family environment.
Walter Mazzucco; Velia Chiara di Maio; Fabrizio Bronte; Lavinia Fabeni; Rosaria Maria Pipitone; Stefania Grimaudo; Donatella Ferraro; Claudia Marotta; Marianna Aragri; Maurizio Macaluso; Francesco Vitale; Francesco Di Raimondo; Francesca Ceccherini-Silberstein; Vito Di Marco. Phylogenetic analysis in the clinical risk management of an outbreak of hepatitis C virus infection among transfused thalassaemia patients in Italy. Journal of Hospital Infection 2021, 115, 51 -58.
AMA StyleWalter Mazzucco, Velia Chiara di Maio, Fabrizio Bronte, Lavinia Fabeni, Rosaria Maria Pipitone, Stefania Grimaudo, Donatella Ferraro, Claudia Marotta, Marianna Aragri, Maurizio Macaluso, Francesco Vitale, Francesco Di Raimondo, Francesca Ceccherini-Silberstein, Vito Di Marco. Phylogenetic analysis in the clinical risk management of an outbreak of hepatitis C virus infection among transfused thalassaemia patients in Italy. Journal of Hospital Infection. 2021; 115 ():51-58.
Chicago/Turabian StyleWalter Mazzucco; Velia Chiara di Maio; Fabrizio Bronte; Lavinia Fabeni; Rosaria Maria Pipitone; Stefania Grimaudo; Donatella Ferraro; Claudia Marotta; Marianna Aragri; Maurizio Macaluso; Francesco Vitale; Francesco Di Raimondo; Francesca Ceccherini-Silberstein; Vito Di Marco. 2021. "Phylogenetic analysis in the clinical risk management of an outbreak of hepatitis C virus infection among transfused thalassaemia patients in Italy." Journal of Hospital Infection 115, no. : 51-58.
Many African countries, representing the origin of the majority of refugees, asylum-seekers, and other migrants, toward regions bordering on the Mediterranean area, are experiencing sustained local transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Sicily is one of the main entry gates of migrants crossing into Europe. We conducted a pilot study, based on the full-genome sequencing of SARS-CoV-2 strains isolated from migrants coming to Sicily by crossing the Mediterranean Sea, with the aim to investigate the viral genome polymorphism and to describe their genetic variations and the phylogenetic relationships. On June 21, a nongovernmental organization vessel rescued 210 migrants crossing the Mediterranean Sea from Libya to Sicily. Of them, 13.4% tested positive for SARS-CoV-2. Eighteen whole genome sequences were obtained to explore viral genetic variability. All but one of the sequences clustered with other viral African strains within the lineage A, whereas only one intermixed among B.1 lineage genomes. Our findings documented that most of the investigated migrants acquired SARS-CoV-2 infection before landing in Sicily. However, SARS-CoV-2 transmission during travel or in overcrowded Libyan immigrant camps and/or illegal transport boats could not be ruled out. SARS-CoV-2 molecular surveillance on migrants arriving in Europe through the Sicilian gate may improve the knowledge of global SARS-CoV-2 transmission dynamic also in light of the emergence of new variants.
Fabio Tramuto; Stefano Reale; Alessandra Lo Presti; Francesco Vitale; Claudio Pulvirenti; Giovanni Rezza; Fabrizio Vitale; Giuseppa Purpari; Carmelo Massimo Maida; Salvatore Zichichi; Silvia Scibetta; Walter Mazzucco; Paola Stefanelli. Genomic Analysis and Lineage Identification of SARS-CoV-2 Strains in Migrants Accessing Europe Through the Libyan Route. Frontiers in Public Health 2021, 9, 632645 .
AMA StyleFabio Tramuto, Stefano Reale, Alessandra Lo Presti, Francesco Vitale, Claudio Pulvirenti, Giovanni Rezza, Fabrizio Vitale, Giuseppa Purpari, Carmelo Massimo Maida, Salvatore Zichichi, Silvia Scibetta, Walter Mazzucco, Paola Stefanelli. Genomic Analysis and Lineage Identification of SARS-CoV-2 Strains in Migrants Accessing Europe Through the Libyan Route. Frontiers in Public Health. 2021; 9 ():632645.
Chicago/Turabian StyleFabio Tramuto; Stefano Reale; Alessandra Lo Presti; Francesco Vitale; Claudio Pulvirenti; Giovanni Rezza; Fabrizio Vitale; Giuseppa Purpari; Carmelo Massimo Maida; Salvatore Zichichi; Silvia Scibetta; Walter Mazzucco; Paola Stefanelli. 2021. "Genomic Analysis and Lineage Identification of SARS-CoV-2 Strains in Migrants Accessing Europe Through the Libyan Route." Frontiers in Public Health 9, no. : 632645.
Exposure to atmospheric particulate matter and nitrogen dioxide has been linked to SARS-CoV-2 infection and death. We hypothesized that an interaction between SARS-CoV-2 infection and exposure to farming-related atmospheric pollutants worsens the effect of SARS-CoV-2 on mortality. Our objective was investigate this hypothesis by performing an ecological study in five Italian Regions (Piedmont, Lombardy, Veneto, Emilia-Romagna and Sicily) linking all-cause mortality, by province (administrative entities within regions), to atmospheric particulate matter (PM2.5 and PM10) nitrous oxide (N2O), ammonia (NH3) and methane (CH4) mainly produced by agricultural activities. Study outcome was change in all-cause mortality during March-April 2020, compared to March-April 2015-2019 (period) as assessed by mortality rate ratios (MRRs) estimated using multivariate negative binomial regression models that adjusted for air temperature, humidity and population density. The MRR for the interaction of period with NH3 exposure, considering all pollutants together was 1.133, equivalent to a 13.3% increase in mortality over and above that due to period (proxy for COVID-19 mortality) for each ton/km2 increase in NH3 emissions. Although the study was ecological, and did not provide evidence of a causal link between SARS-CoV-2 and farming-related pollutants, in accord with the precautionary principle we recommend application of measures to limit NH3 exposure particularly while the COVID-19 pandemic continues.
Paolo Contiero; Alessandro Borgini; Martina Bertoldi; Anna Abita; Giuseppe Cuffari; Paola Tomao; Maria Concetta D’Ovidio; Stefano Reale; Silvia Scibetta; Giovanna Tagliabue; Roberto Boffi; Vittorio Krogh; Fabio Tramuto; Carmelo Massimo Maida; Walter Mazzucco. An Ecological Study to Investigate Links Between Atmospheric Pollutants From Farming and SARS-CoV-2 Mortality. 2021, 1 .
AMA StylePaolo Contiero, Alessandro Borgini, Martina Bertoldi, Anna Abita, Giuseppe Cuffari, Paola Tomao, Maria Concetta D’Ovidio, Stefano Reale, Silvia Scibetta, Giovanna Tagliabue, Roberto Boffi, Vittorio Krogh, Fabio Tramuto, Carmelo Massimo Maida, Walter Mazzucco. An Ecological Study to Investigate Links Between Atmospheric Pollutants From Farming and SARS-CoV-2 Mortality. . 2021; ():1.
Chicago/Turabian StylePaolo Contiero; Alessandro Borgini; Martina Bertoldi; Anna Abita; Giuseppe Cuffari; Paola Tomao; Maria Concetta D’Ovidio; Stefano Reale; Silvia Scibetta; Giovanna Tagliabue; Roberto Boffi; Vittorio Krogh; Fabio Tramuto; Carmelo Massimo Maida; Walter Mazzucco. 2021. "An Ecological Study to Investigate Links Between Atmospheric Pollutants From Farming and SARS-CoV-2 Mortality." , no. : 1.
In December 2019, several cases of atypical pneumonia were detected in Wuhan city, Hubei province, inland China. The initial outbreak was of considerable size first in China subsequently spread to the rest of the world. Immediately after the epidemic (which according to the World Health Organization had risen to pandemic status), the problem of whether or not to update the occupational risk assessment arose, also considering how the biological risk from SARS CoV-2 should be understood: specific or generic. To this end, we conducted a literature review to identify national health legislation and policies, examining how Italy has addressed the COVID-19 emergency in occupational health planning, in order to develop considerations on the need to update the Risk Assessment Document following the pandemic status. The data that emerged from the review of current legislation allowed us to conclude that the risk from SARS-CoV-2 is in most work activities to be understood as a generic or aggravated generic risk, requiring the employer to apply and control the preventive measures suggested by health authorities to contain the spread of the virus.
Luigi Cirrincione; Venerando Rapisarda; Walter Mazzucco; Rosanna Provenzano; Emanuele Cannizzaro. SARS-CoV-2 and the Risk Assessment Document in Italian Work; Specific or Generic Risk Even If Aggravated? International Journal of Environmental Research and Public Health 2021, 18, 3729 .
AMA StyleLuigi Cirrincione, Venerando Rapisarda, Walter Mazzucco, Rosanna Provenzano, Emanuele Cannizzaro. SARS-CoV-2 and the Risk Assessment Document in Italian Work; Specific or Generic Risk Even If Aggravated? International Journal of Environmental Research and Public Health. 2021; 18 (7):3729.
Chicago/Turabian StyleLuigi Cirrincione; Venerando Rapisarda; Walter Mazzucco; Rosanna Provenzano; Emanuele Cannizzaro. 2021. "SARS-CoV-2 and the Risk Assessment Document in Italian Work; Specific or Generic Risk Even If Aggravated?" International Journal of Environmental Research and Public Health 18, no. 7: 3729.
Background Hepatocellular carcinoma (HCC) is the most frequent primary invasive cancer of the liver. During the last decade, the epidemiology of HCC has been continuously changing in developed countries, due to more effective primary prevention and to successful treatment of virus-related liver diseases. The study aims to examine survival by level of access to care in patients with HCC, for all patients combined and by age. Methods We included 2018 adult patients (15–99 years) diagnosed with a primary liver tumour, registered in the Palermo Province Cancer Registry during 2006–2015, and followed-up to 30 October 2019. We obtained a proxy measure of access to care by linking each record to the Hospital Discharge Records and the Ambulatory Discharge Records. We estimated net survival up to 5 years after diagnosis by access to care (“easy access to care” versus “poor access to care”), using the Pohar-Perme estimator. Estimates were age-standardised using International Cancer Survival Standard (ICSS) weights. We also examined survival by access to care and age (15–64, 65–74 and ≥ 75 years). Results Among the 2018 patients, 62.4% were morphologically verified and 37.6% clinically diagnosed. Morphologically verified tumours were more frequent in patients aged 65–74 years (41.6%), while tumours diagnosed clinically were more frequent in patients aged 75 years or over (50.2%). During 2006–2015, age-standardised net survival was higher among HCC patients with “easy access to care” than in those with “poor access to care” (68% vs. 48% at 1 year, 29% vs. 11% at 5 years; p < 0.0001). Net survival up to 5 years was higher for patients with “easy access to care” in each age group (p < 0.0001). Moreover, survival increased slightly for patients with easier access to care, while it remained relatively stable for patients with poor access to care. Conclusions During 2006–2015, 5-year survival was higher for HCC patients with easier access to care, probably reflecting progressive improvement in the effectiveness of health care services offered to these patients. Our linkage algorithm could provide valuable evidence to support healthcare decision-making in the context of the evolving epidemiology of hepatocellular carcinoma.
Walter Mazzucco; Francesco Vitale; Sergio Mazzola; Rosalba Amodio; Maurizio Zarcone; Davide Alba; Claudia Marotta; Rosanna Cusimano; Claudia Allemani. Does access to care play a role in liver cancer survival? The ten-year (2006–2015) experience from a population-based cancer registry in Southern Italy. BMC Cancer 2021, 21, 1 -8.
AMA StyleWalter Mazzucco, Francesco Vitale, Sergio Mazzola, Rosalba Amodio, Maurizio Zarcone, Davide Alba, Claudia Marotta, Rosanna Cusimano, Claudia Allemani. Does access to care play a role in liver cancer survival? The ten-year (2006–2015) experience from a population-based cancer registry in Southern Italy. BMC Cancer. 2021; 21 (1):1-8.
Chicago/Turabian StyleWalter Mazzucco; Francesco Vitale; Sergio Mazzola; Rosalba Amodio; Maurizio Zarcone; Davide Alba; Claudia Marotta; Rosanna Cusimano; Claudia Allemani. 2021. "Does access to care play a role in liver cancer survival? The ten-year (2006–2015) experience from a population-based cancer registry in Southern Italy." BMC Cancer 21, no. 1: 1-8.
Costs of cancer care are increasing worldwide, and sustainability of cancer burden is critical. In this study, the economic impact of rectal cancer on the Italian healthcare system, measured as public healthcare expenditure related to investigation and treatment of rectal cancer patients is estimated. A cross-sectional cohort of 9358 rectal cancer patients is linked, on an individual basis, to claims associated to rectal cancer diagnosis and treatments. Costs refer mainly to years 2010–2011 and are estimated by phase of care, as healthcare needs vary along the care pathway: diagnostic procedures are mainly provided in the first year, surveillance procedures are addressed to chronically ill patients, and end-of-life procedures are given in the terminal status. Clinical approaches and corresponding costs are specific by cancer type and vary by phase of care, stage at diagnosis, and age. Surgery is undertaken by the great majority of patients. Thus, hospitalization is the main cost driver. The evidence produced can be used to improve planning and allocation of healthcare resources. In particular, early diagnosis of rectal cancer is a gain in healthcare budget. Policies raising spreading of and adherence to screening plans, above all when addressed to people living in Southern Italy, should be strongly encouraged.
Anna Gigli; Silvia Francisci; Giulia Capodaglio; Daniela Pierannunzio; Sandra Mallone; Andrea Tavilla; Tania Lopez; Manuel Zorzi; Fabrizio Stracci; Susanna Busco; Walter Mazzucco; Sara Lonardi; Fortunato Bianconi; Antonio Giampiero Russo; Silvia Iacovacci; Diego Serraino; Gianfranco Manneschi; Mario Fusco; Rosanna Cusimano; Massimo Rugge; Stefano Guzzinati. The Economic Impact of Rectal Cancer: A Population-Based Study in Italy List of Authors. International Journal of Environmental Research and Public Health 2021, 18, 474 .
AMA StyleAnna Gigli, Silvia Francisci, Giulia Capodaglio, Daniela Pierannunzio, Sandra Mallone, Andrea Tavilla, Tania Lopez, Manuel Zorzi, Fabrizio Stracci, Susanna Busco, Walter Mazzucco, Sara Lonardi, Fortunato Bianconi, Antonio Giampiero Russo, Silvia Iacovacci, Diego Serraino, Gianfranco Manneschi, Mario Fusco, Rosanna Cusimano, Massimo Rugge, Stefano Guzzinati. The Economic Impact of Rectal Cancer: A Population-Based Study in Italy List of Authors. International Journal of Environmental Research and Public Health. 2021; 18 (2):474.
Chicago/Turabian StyleAnna Gigli; Silvia Francisci; Giulia Capodaglio; Daniela Pierannunzio; Sandra Mallone; Andrea Tavilla; Tania Lopez; Manuel Zorzi; Fabrizio Stracci; Susanna Busco; Walter Mazzucco; Sara Lonardi; Fortunato Bianconi; Antonio Giampiero Russo; Silvia Iacovacci; Diego Serraino; Gianfranco Manneschi; Mario Fusco; Rosanna Cusimano; Massimo Rugge; Stefano Guzzinati. 2021. "The Economic Impact of Rectal Cancer: A Population-Based Study in Italy List of Authors." International Journal of Environmental Research and Public Health 18, no. 2: 474.
BackgroundIn consideration of the increasing prevalence of COVID-19 cases in several countries and the resulting demand for unbiased sequencing approaches, we performed a direct RNA sequencing experiment using critical oropharyngeal swab samples collected from Italian patients infected with SARS-CoV-2 from the Palermo region in Sicily.MethodsHere, we identified the sequences SARS-CoV-2 directly in RNA extracted from critical samples using the Oxford Nanopore MinION technology without prior cDNA retro-transcription.ResultsUsing an appropriate bioinformatics pipeline, we could identify mutations in the nucleocapisid (N) gene, which have been reported previously in studies conducted in other countries.ConclusionTo the best of our knowledge, the technique used in this study has not been used for SARS-CoV-2 detection previously owing to the difficulties in the extraction of RNA of sufficient quantity and quality from routine oropharyngeal swabs.Despite these limitations, this approach provides the advantages of true native RNA sequencing, and does not include amplification steps that could introduce systematic errors.This study can provide novel information relevant to the current strategies adopted in SARS-CoV-2 next-generation sequencing.We deposited the gene sequence in the NCBI database under the following URL:https://www.ncbi.nlm.nih.gov/nuccore/MT457389
Davide Vacca; Antonino Fiannaca; Fabio Tramuto; Valeria Cancila; Laura La Paglia; Walter Mazzucco; Alessandro Gulino; Massimo La Rosa; Carmelo Massimo Maida; Gaia Morello; Beatrice Belmonte; Alessandra Casuccio; Rosario Maugeri; Gerardo Iacopino; Francesco Vitale; Claudio Tripodo; Alfonso Urso. Direct RNA nanopore sequencing of SARS-CoV-2 extracted from critical material from swabs. 2020, 1 .
AMA StyleDavide Vacca, Antonino Fiannaca, Fabio Tramuto, Valeria Cancila, Laura La Paglia, Walter Mazzucco, Alessandro Gulino, Massimo La Rosa, Carmelo Massimo Maida, Gaia Morello, Beatrice Belmonte, Alessandra Casuccio, Rosario Maugeri, Gerardo Iacopino, Francesco Vitale, Claudio Tripodo, Alfonso Urso. Direct RNA nanopore sequencing of SARS-CoV-2 extracted from critical material from swabs. . 2020; ():1.
Chicago/Turabian StyleDavide Vacca; Antonino Fiannaca; Fabio Tramuto; Valeria Cancila; Laura La Paglia; Walter Mazzucco; Alessandro Gulino; Massimo La Rosa; Carmelo Massimo Maida; Gaia Morello; Beatrice Belmonte; Alessandra Casuccio; Rosario Maugeri; Gerardo Iacopino; Francesco Vitale; Claudio Tripodo; Alfonso Urso. 2020. "Direct RNA nanopore sequencing of SARS-CoV-2 extracted from critical material from swabs." , no. : 1.
Cancer represents one of the most common causes of death worldwide. Among women, breast cancer is the most diagnosed cancer and the principal cause of death due to malignant disease, while cervical cancer ranks fourth for both incidence and mortality. The present review aims to analyze the epidemiology of cervical and breast cancer (incidence, mortality, survival rates, and trends). Moreover, the most important primary and secondary preventive strategies (reduction of risk factors, exposure, vaccination, cancer screening) intended to reduce the future burden of cervical and breast cancer, that should be adopted actively and free of charge, were discussed in accordance to more recent and evidence-based findings.
Claudio Costantino; Davide Alba; Livia Cimino; Arianna Conforto; Walter Mazzucco. The Role of Vaccination and Screening in Limiting the Worldwide Disease Burden of Preventable Female Cancers: A Review. Women 2020, 1, 16 -28.
AMA StyleClaudio Costantino, Davide Alba, Livia Cimino, Arianna Conforto, Walter Mazzucco. The Role of Vaccination and Screening in Limiting the Worldwide Disease Burden of Preventable Female Cancers: A Review. Women. 2020; 1 (1):16-28.
Chicago/Turabian StyleClaudio Costantino; Davide Alba; Livia Cimino; Arianna Conforto; Walter Mazzucco. 2020. "The Role of Vaccination and Screening in Limiting the Worldwide Disease Burden of Preventable Female Cancers: A Review." Women 1, no. 1: 16-28.
Landfilling should be the last option in an integrated Municipal Solid Waste (MSW) management approach. In the European Union (EU), the policy framework to protect the environment and the public health against the impact of health hazards related to urban solid waste management has been consistently implemented in recent decades. A growing interest in the negative impact of fires in waste landfills on the environment and people’s health was reported in some European countries. In Italy, an increasing occurrence of arsons in MSW and landfills has been reported in recent years. During the summer of 2012, a multi-site arson occurred in the Palermo Municipal solid waste landfill of Bellolampo (western Sicily), giving rise to an environmental emergency of public health concern. Local health authorities reacted by creating an inter-institutional multidisciplinary task force with the aim to implement measures to prevent and control the risk of exposure by delimiting a protection area to be taken under strict monitoring. Environmental and epidemiological investigations were put in place by air, soil, and farm product sampling. A syndromic surveillance of the exposed population was conducted as well. The air monitoring stations system in place detected an increase in the concentrations of dioxins and dioxin-like substances with the PM10 highest emission pick documented within the first 24 h and estimated at about 60 μg/m3. Levels of heavy metals above the limits permitted by law were detected in the top- and sub-soil samples collected within the two landfill sampling sites and also in other nearby sites. Non-conforming concentration values of dioxins and dioxin-like substances were detected in samples taken from farms, milk, and water. The health syndromic surveillance did not document any daily increase in the notification of emergency admissions related to acute respiratory diseases or any other health effect potentially related to the waste arson, but these findings were limited by the non-systematic collection of data. The experience reported in the present case report, as declined within the European Union policy framework and in the view of environmental justice, documented the need to structure a permanent collaboration between the different institutional actors involved in environmental and public health protection activities in order to develop specific protocols to manage events related to the occurrence of waste-related environmental emergencies or disasters.
Walter Mazzucco; Claudio Costantino; Vincenzo Restivo; Davide Alba; Claudia Marotta; Elisa Tavormina; Achille Cernigliaro; Maurizio Macaluso; Rosanna Cusimano; Rosario Grammauta; Fabio Tramuto; Salvatore Scondotto; Francesco Vitale. The Management of Health Hazards Related to Municipal Solid Waste on Fire in Europe: An Environmental Justice Issue? International Journal of Environmental Research and Public Health 2020, 17, 6617 .
AMA StyleWalter Mazzucco, Claudio Costantino, Vincenzo Restivo, Davide Alba, Claudia Marotta, Elisa Tavormina, Achille Cernigliaro, Maurizio Macaluso, Rosanna Cusimano, Rosario Grammauta, Fabio Tramuto, Salvatore Scondotto, Francesco Vitale. The Management of Health Hazards Related to Municipal Solid Waste on Fire in Europe: An Environmental Justice Issue? International Journal of Environmental Research and Public Health. 2020; 17 (18):6617.
Chicago/Turabian StyleWalter Mazzucco; Claudio Costantino; Vincenzo Restivo; Davide Alba; Claudia Marotta; Elisa Tavormina; Achille Cernigliaro; Maurizio Macaluso; Rosanna Cusimano; Rosario Grammauta; Fabio Tramuto; Salvatore Scondotto; Francesco Vitale. 2020. "The Management of Health Hazards Related to Municipal Solid Waste on Fire in Europe: An Environmental Justice Issue?" International Journal of Environmental Research and Public Health 17, no. 18: 6617.
(1) Aim: To assess the attitude toward Lifestyle Medicine and healthy behaviours among students in the healthcare area and to demonstrate its association to psychological well-being; (2) Methods: A cross-sectional study is conducted among 508 undergraduates of the University of Palermo (140 (27.6%) in the healthcare area and 368 (72.4%) in the non-healthcare area), during the academic year 2018–2019. Psychological well-being is measured through two dimensions of eudaimonia and hedonia, using the 10-item Hedonic and Eudaimonic Motives for Activities-Revised (HEMA-R) scale, with answers coded on a 7-point scale. The association between demographic and modifiable behavioural risk factors for chronic diseases is assessed through crude and adjusted Odds ratios with 95% confidence intervals; (3) Results: Orientation to both hedonia and eudaimonia is significantly associated to the Mediterranean diet (ORAdj = 2.28; 95% CI = (1.42–3.70)) and drinking spirits less than once a week (ORAdj = 1.89; 95% CI = (1.10–3.27)) and once a week or more (ORAdj = 6.02; 95% CI = (1.05–34.52)), while these conditions occur together less frequently for current smokers (ORAdj = 0.38; 95% CI = (0.18–0.81)). Students inclined to well-being consider healthcare professionals as models for their patients and all people in general (OR = 1.96, 95% CI = (1.28–3.00)); (4) Conclusions: The positive relation found between a virtuous lifestyle and psychological well-being suggests the construction, development and cultivation of individual skills are a means to succeed in counteracting at risk behaviours for health.
Domenica Matranga; Vincenzo Restivo; Laura Maniscalco; Filippa Bono; Giuseppe Pizzo; Giuseppe Lanza; Valerio Gaglio; Walter Mazzucco; Silvana Miceli. Lifestyle Medicine and Psychological Well-Being Toward Health Promotion: A Cross-Sectional Study on Palermo (Southern Italy) Undergraduates. International Journal of Environmental Research and Public Health 2020, 17, 5444 .
AMA StyleDomenica Matranga, Vincenzo Restivo, Laura Maniscalco, Filippa Bono, Giuseppe Pizzo, Giuseppe Lanza, Valerio Gaglio, Walter Mazzucco, Silvana Miceli. Lifestyle Medicine and Psychological Well-Being Toward Health Promotion: A Cross-Sectional Study on Palermo (Southern Italy) Undergraduates. International Journal of Environmental Research and Public Health. 2020; 17 (15):5444.
Chicago/Turabian StyleDomenica Matranga; Vincenzo Restivo; Laura Maniscalco; Filippa Bono; Giuseppe Pizzo; Giuseppe Lanza; Valerio Gaglio; Walter Mazzucco; Silvana Miceli. 2020. "Lifestyle Medicine and Psychological Well-Being Toward Health Promotion: A Cross-Sectional Study on Palermo (Southern Italy) Undergraduates." International Journal of Environmental Research and Public Health 17, no. 15: 5444.
Following the implementation of the new Italian legislation on responsibility of healthcare workers, a multi-professional framework, involving representatives of the Italian public health professionals and legal professionals expert in the field, drafted a proposal of the actionable recommendations to be implemented in the management of civil and penal disputes arising from the practice of public health interventions. In order to prevent legal disputes concerning some public health fields such as vaccinations, cancer screening, environmental health surveillance, and hospital management, it should be primary taken into account to update guidelines in supporting decision-making processes, in accordance with the “best scientific evidence available.” Furthermore, a multidisciplinary alliance between public health and legal area professionals should be encouraged and should be promoted both at national and European level.
Claudio Costantino; Walter Mazzucco; Vincenzo Restivo; Ida Iolanda Mura; Gaetano Maria Fara; Giuseppe Giammanco; Sabrina Vecchio Verderame; Giuseppe Alessio Messano; Carmelo Massimo Maida; Alessandra Casuccio; Francesco Vitale. Proposal for an Alliance Between Healthcare and Legal Area Professionals for Shared Public Health and Preventive Strategies in Italy and Europe. Frontiers in Public Health 2020, 8, 324 .
AMA StyleClaudio Costantino, Walter Mazzucco, Vincenzo Restivo, Ida Iolanda Mura, Gaetano Maria Fara, Giuseppe Giammanco, Sabrina Vecchio Verderame, Giuseppe Alessio Messano, Carmelo Massimo Maida, Alessandra Casuccio, Francesco Vitale. Proposal for an Alliance Between Healthcare and Legal Area Professionals for Shared Public Health and Preventive Strategies in Italy and Europe. Frontiers in Public Health. 2020; 8 ():324.
Chicago/Turabian StyleClaudio Costantino; Walter Mazzucco; Vincenzo Restivo; Ida Iolanda Mura; Gaetano Maria Fara; Giuseppe Giammanco; Sabrina Vecchio Verderame; Giuseppe Alessio Messano; Carmelo Massimo Maida; Alessandra Casuccio; Francesco Vitale. 2020. "Proposal for an Alliance Between Healthcare and Legal Area Professionals for Shared Public Health and Preventive Strategies in Italy and Europe." Frontiers in Public Health 8, no. : 324.
Work-related stress can induce a break in homeostasis by placing demands on the body that are met by the activation of two different systems, the hypothalamic–pituitary–adrenal axis and the sympathetic nervous system. Night-shift work alters the body’s exposure to the natural light–dark schedule and disrupts circadian (daily) rhythms. The greatest effect of night-shift work is the disruption of circadian rhythms. The impact that these disruptions may have on the pathogenesis of many diseases, including cancer, is unknown. This study aims to discover the relationship among three different job activities of security guards and their stress-related responses by evaluating salivary cortisol levels and blood pressure. Methods: Ninety security guards, including night-time workers and night-time and daily-shift workers, were recruited for this study. Each security guard provided two saliva samples before and after three scheduled time points: (i) at 22:00, (ii) at 06:30, and (iii) at 14:00. Results: The results of the study showed a significant alteration in cortisol levels. Night-time shift cortisol levels significantly increased before and after the work shifts. A physiological prevalence of the vagal tone on the cardiocirculatory activity was found during night-shift work. Conclusions: This study indicates that cortisol levels and blood pressure are sensitive markers of biological responses to severe work stress. Shift-change consequences may occur at the end of the night shift when there is a significant increase in the cortisol level and a significant variation in cardiovascular parameters.
Emanuele Cannizzaro; Luigi Cirrincione; Walter Mazzucco; Alessandro Scorciapino; Cesare Catalano; Tiziana Ramaci; Caterina Ledda; Fulvio Plescia. Night-Time Shift Work and Related Stress Responses: A Study on Security Guards. International Journal of Environmental Research and Public Health 2020, 17, 562 .
AMA StyleEmanuele Cannizzaro, Luigi Cirrincione, Walter Mazzucco, Alessandro Scorciapino, Cesare Catalano, Tiziana Ramaci, Caterina Ledda, Fulvio Plescia. Night-Time Shift Work and Related Stress Responses: A Study on Security Guards. International Journal of Environmental Research and Public Health. 2020; 17 (2):562.
Chicago/Turabian StyleEmanuele Cannizzaro; Luigi Cirrincione; Walter Mazzucco; Alessandro Scorciapino; Cesare Catalano; Tiziana Ramaci; Caterina Ledda; Fulvio Plescia. 2020. "Night-Time Shift Work and Related Stress Responses: A Study on Security Guards." International Journal of Environmental Research and Public Health 17, no. 2: 562.
In June 2017, University and Health Ministries jointly enacted a decree implementing a new accreditation system for the Italian post-graduate medical schools (residency programs). We report the innovations introduced through the reform. Universities were called to submit post-graduate medical school projects to the National Observatory on medical residency programs, the inter-institutional committee responsible for the entire accreditation process, through an interactive web platform. The adherence to minimum standards, requirements and the performances were measured. After this first assessment, universities were asked to provide programs of improvement for critical schools. At the end of the evaluation, residency schools were proposed for a full or a partial accreditation. Of the 1,431 post-graduate medical school projects submitted to the National Observatory by 37 public and 4 private Universities, 672 (47.0%) obtained a full accreditation, 629 (43.9%) a partial accreditation, with a gap to be filled within a two-year period according to a specific improvement programme, while 130 (9.1%) were not accredited. Further, 1,254 out of the 1,301 schools with a full or partial accreditation were activated according to the available public financial resources, excluding those performing the lowest. Annual surveys were in place to investigate the residents' level of satisfaction concerning the quality of the training programs. The National Observatory further developed an experimental methodology to conduct on-site visits to support quality improvement. This reform can be considered an important initiative to guarantee high standards in the quality of care and to face the challenge of sustainability for the National Health System.
Mazzucco Walter; Silenzi Andrea; Gray Muir; Vettor Roberto; Walter Mazzucco; Andrea Silenzi; Muir Gray; Robert Vettor. The accreditation system of Italian medical residency programs: fostering quality and sustainability of the National Health Service. 2019, 90, 15 -20.
AMA StyleMazzucco Walter, Silenzi Andrea, Gray Muir, Vettor Roberto, Walter Mazzucco, Andrea Silenzi, Muir Gray, Robert Vettor. The accreditation system of Italian medical residency programs: fostering quality and sustainability of the National Health Service. . 2019; 90 ():15-20.
Chicago/Turabian StyleMazzucco Walter; Silenzi Andrea; Gray Muir; Vettor Roberto; Walter Mazzucco; Andrea Silenzi; Muir Gray; Robert Vettor. 2019. "The accreditation system of Italian medical residency programs: fostering quality and sustainability of the National Health Service." 90, no. : 15-20.
ObjectivesTo assess the trends concerning utilisation of maternal and child health (MCH) services before, during and after the Ebola outbreak, quantifying the contribution of a reorganised referral system (RS).DesignA prospective observational study of MCH services.SettingPujehun district in Sierra Leone, 77 community health facilities and 1 hospital from 2012 to 2017.Main outcome measuresMCH utililization was evaluated by assessing: (1) institutional deliveries, Cesarean-sections, paediatric and maternity admissions and deaths, and major direct obstetric complications (MDOCs), at hospital level; (2) antenatal care (ANC) 1 and 4, institutional delivery and family planning, at community level. Contribution of a strengthened RS was also measured.ResultsAt hospital level, there is a significant difference between trends Ebola versus pre-Ebola for maternal admissions (7, 95% CI 4 to 11, pConclusionsA stronger health system compared with other districts in Sierra Leone and a strengthened RS enabled health facilities in Pujehun to maintain service provision and uptake during and after the Ebola epidemic.
Gianluca Quaglio; Francesca Tognon; Livio Finos; David Bome; Santigie Sesay; Atiba Kebbie; Francesco Di Gennaro; Bienvenu Salim Camara; Claudia Marotta; Vincenzo Pisani; Zainab Bangura; Damiano Pizzol; Annalisa Saracino; Walter Mazzucco; Susan Jones; Giovanni Putoto. Impact of Ebola outbreak on reproductive health services in a rural district of Sierra Leone: a prospective observational study. BMJ Open 2019, 9, e029093 .
AMA StyleGianluca Quaglio, Francesca Tognon, Livio Finos, David Bome, Santigie Sesay, Atiba Kebbie, Francesco Di Gennaro, Bienvenu Salim Camara, Claudia Marotta, Vincenzo Pisani, Zainab Bangura, Damiano Pizzol, Annalisa Saracino, Walter Mazzucco, Susan Jones, Giovanni Putoto. Impact of Ebola outbreak on reproductive health services in a rural district of Sierra Leone: a prospective observational study. BMJ Open. 2019; 9 (9):e029093.
Chicago/Turabian StyleGianluca Quaglio; Francesca Tognon; Livio Finos; David Bome; Santigie Sesay; Atiba Kebbie; Francesco Di Gennaro; Bienvenu Salim Camara; Claudia Marotta; Vincenzo Pisani; Zainab Bangura; Damiano Pizzol; Annalisa Saracino; Walter Mazzucco; Susan Jones; Giovanni Putoto. 2019. "Impact of Ebola outbreak on reproductive health services in a rural district of Sierra Leone: a prospective observational study." BMJ Open 9, no. 9: e029093.
ObjectivesIn response to public health concern about effects of arson at solid waste management plants in July 2012, we analysed vital statistics data to evaluate any potential effect on pregnancies at different gestational ages of pollutants emitted from the landfill on fire.SettingA community living near the largest landfill plant in Sicily.ParticipantsThe study group comprised 551 births, live births and stillbirths from pregnancies of mothers residing in the extra-urban exposed area, conceived during a 40 week period during which the highest fire’s peak might have influenced pregnancy.Primary and secondary outcome measuresBirth outcomes (gestational age ResultsAmong singleton live births we observed a three-fold increase in risk of very preterm birth between the extra-urban area and the remaining low inhabitants density and unindustrialised areas for births whose pregnancies were in the third trimester (OR adjusted for maternal age and infant gender=3.41; 95% CI 1.04 to 11.16). There was an excess of very low birth weight singleton infants in the study group as compared with the reference group, which was limited to births to mothers exposed during periconception period (OR adjusted for maternal age and infant gender=4.64; 95% CI 1.04 to 20.6) and first trimester (OR adjusted for maternal age and infant gender=3.66; 95% CI 1.11 to 12.1). The association estimates were imprecise due to the small number of outcomes recorded.ConclusionsThe study documented an excess of very preterm and very low birth weight among infants born to mothers exposed to the landfill fire emissions during conception or early pregnancy.
Walter Mazzucco; Elisa Tavormina; Maurizio Macaluso; Claudia Marotta; Rosanna Cusimano; Davide Alba; Claudio Costantino; Rosario Grammauta; Achille Cernigliaro; Salvatore Scondotto; Francesco Vitale. Do emissions from landfill fires affect pregnancy outcomes? A retrospective study after arson at a solid waste facility in Sicily. BMJ Open 2019, 9, e027912 .
AMA StyleWalter Mazzucco, Elisa Tavormina, Maurizio Macaluso, Claudia Marotta, Rosanna Cusimano, Davide Alba, Claudio Costantino, Rosario Grammauta, Achille Cernigliaro, Salvatore Scondotto, Francesco Vitale. Do emissions from landfill fires affect pregnancy outcomes? A retrospective study after arson at a solid waste facility in Sicily. BMJ Open. 2019; 9 (7):e027912.
Chicago/Turabian StyleWalter Mazzucco; Elisa Tavormina; Maurizio Macaluso; Claudia Marotta; Rosanna Cusimano; Davide Alba; Claudio Costantino; Rosario Grammauta; Achille Cernigliaro; Salvatore Scondotto; Francesco Vitale. 2019. "Do emissions from landfill fires affect pregnancy outcomes? A retrospective study after arson at a solid waste facility in Sicily." BMJ Open 9, no. 7: e027912.
Background: The aim of the study was to investigate the intra-host variability through next-generation-sequencing (NGS) of the NS5A-gene in nosocomial transmission-clusters observed in two Italian hospitals among hepatitis C virus (HCV)-genotype-1b infected patients. Methods: HCV-sequencing was performed by Sanger-sequencing (NS3 + NS5A + NS5B) and by NGS (NS5A, MiSeq-Illumina) in 15 HCV-1b infected patients [five acute with onco-hematologic-disease and 10 (4/6 acute/chronic) with β-thalassemia]. Resistance-associated-substitutions (RAS) were analysed by Geno2pheno-algorithm. Nucleotide-sequence-variability (NSV, at 1%, 2%, 5%, 10% and 15% NGS-cutoffs) and Shannon entropy were estimated. Phylogenetic analysis was performed by Mega6-software and Bayesian-analysis. Results: Phylogenetic analysis showed five transmission-clusters: one involving four HCV-acute onco-hematologic-patients; one involving three HCV-chronic β-thalassemia-patients and three involving both HCV-acute and chronic β-thalassemia-patients. The NS5A-RAS Y93H was found in seven patients, distributed differently among chronic/acute patients involved in the same transmission-clusters, independently from the host-genetic IL-28-polymorphism. The intra-host NSV was higher in chronic-patients versus acute-patients, at all cutoffs analyzed (p < 0.05). Even though Shannon-entropy was higher in chronic-patients, significantly higher values were observed only in chronic β-thalassemia-patients versus acute β-thalassemia-patients (p = 0.01). Conclusions: In nosocomial HCV transmission-clusters, the intra-host HCV quasispecies divergence in patients with acute-infection was very low in comparison to that in chronic-infection. The NS5A-RAS Y93H was often transmitted and distributed differently within the same transmission-clusters, independently from the IL-28-polymorphism.
Maria Concetta Bellocchi; Marianna Aragri; Luca Carioti; Lavinia Fabeni; Rosaria Maria Pipitone; Giuseppina Brancaccio; Maria Chiara Sorbo; Silvia Barbaliscia; Velia Chiara Di Maio; Fabrizio Bronte; Stefania Grimaudo; Walter Mazzucco; Ferdinando Frigeri; Marco Cantone; Antonio Pinto; Carlo Federico Perno; Antonio Craxì; Giovanni Battista Gaeta; Vito Di Marco; Francesca Ceccherini-Silberstein. NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients. Cells 2019, 8, 666 .
AMA StyleMaria Concetta Bellocchi, Marianna Aragri, Luca Carioti, Lavinia Fabeni, Rosaria Maria Pipitone, Giuseppina Brancaccio, Maria Chiara Sorbo, Silvia Barbaliscia, Velia Chiara Di Maio, Fabrizio Bronte, Stefania Grimaudo, Walter Mazzucco, Ferdinando Frigeri, Marco Cantone, Antonio Pinto, Carlo Federico Perno, Antonio Craxì, Giovanni Battista Gaeta, Vito Di Marco, Francesca Ceccherini-Silberstein. NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients. Cells. 2019; 8 (7):666.
Chicago/Turabian StyleMaria Concetta Bellocchi; Marianna Aragri; Luca Carioti; Lavinia Fabeni; Rosaria Maria Pipitone; Giuseppina Brancaccio; Maria Chiara Sorbo; Silvia Barbaliscia; Velia Chiara Di Maio; Fabrizio Bronte; Stefania Grimaudo; Walter Mazzucco; Ferdinando Frigeri; Marco Cantone; Antonio Pinto; Carlo Federico Perno; Antonio Craxì; Giovanni Battista Gaeta; Vito Di Marco; Francesca Ceccherini-Silberstein. 2019. "NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients." Cells 8, no. 7: 666.
Bullying is one of the most common expressions of violence in the peer context during school years. This study investigates the prevalence of bullying and the short-term effects on students' bullying perceptions of a preventive intervention conducted among teachers of first-grade secondary schools in Palermo, Sicily (Italy). Between the 2017/2018 and 2018/2019 school years, a pre-post intervention study was conducted among nine school institutions, sampled and categorized by neighbourhood socioeconomic index. A questionnaire investigating physical, verbal, and indirect bullying, the role of observers, prosociality, and resiliency in bullying was administered before and after intervention with formative cascade training of the teachers of the selected classes. Three different methods (sentinel questions, the five-question method, the 'score of seven' method) were used to detect the baseline level of bullying. A total of 402 students participated in the study (72.7% response rate). A decrease in the number of bullying episodes after the intervention was reported by the students in all types of bullying explored (physical, verbal, and indirect bullying, observers, resiliency, and prosociality), with all three methods. In particular, a statistically significant decrease in all the bullying areas investigated (except for resiliency) was reported for students attending schools of an intermediate socioeconomic level. Even if many school-based interventions have been implemented to reduce school bullying throughout the world, this is one of the first conducted in Europe and it assesses the effectiveness among students of an anti-bullying intervention tailored for teachers. The encouraging results in reducing the number of bullying episodes together with the low cost in terms of human and economic resources could suggest an extension of this research on a regional/national scale.
Claudio Costantino; and the BIAS Study Working Group; Alessandra Casuccio; Claudia Marotta; Stefania Enza Bono; Gianmarco Ventura; Walter Mazzucco; Francesco Vitale; Vincenzo Restivo; Evelina Arcidiacono. Effects of an intervention to prevent the bullying in first-grade secondary schools of Palermo, Italy: the BIAS study. Italian Journal of Pediatrics 2019, 45, 65 .
AMA StyleClaudio Costantino, and the BIAS Study Working Group, Alessandra Casuccio, Claudia Marotta, Stefania Enza Bono, Gianmarco Ventura, Walter Mazzucco, Francesco Vitale, Vincenzo Restivo, Evelina Arcidiacono. Effects of an intervention to prevent the bullying in first-grade secondary schools of Palermo, Italy: the BIAS study. Italian Journal of Pediatrics. 2019; 45 (1):65.
Chicago/Turabian StyleClaudio Costantino; and the BIAS Study Working Group; Alessandra Casuccio; Claudia Marotta; Stefania Enza Bono; Gianmarco Ventura; Walter Mazzucco; Francesco Vitale; Vincenzo Restivo; Evelina Arcidiacono. 2019. "Effects of an intervention to prevent the bullying in first-grade secondary schools of Palermo, Italy: the BIAS study." Italian Journal of Pediatrics 45, no. 1: 65.
ObjectiveOur cross-sectional study aimed at evaluating the diagnostic performance of Focused Assessment with Sonography for HIV-associated tuberculosis (FASH) to detect extrapulmonary tuberculosis in extremely resource-limited settings, with visceral leishmaniasis as a differential diagnosis with overlapping sonographic feature.DesignCross-sectional study.SettingVoluntary Counselling and Testing Centre (VCT) of Yirol Hospital, South Sudan.ParticipantsFrom May to November 2017, 252 HIV-positive patients out of 624 newly admitted to VCT Centre were registered for antiretroviral treatment. According to the number of trained doctors available to practise ultrasound (US) scan, a sample of 100 patients were screened using the FASH protocol.InterventionsFollowing a full clinical examination, each patient was scanned with a portable US scanner in six different positions for pleural, pericardial, ascitic effusion, abdominal lymphadenopathy and hepatic/splenic microabscesses, according to the FASH protocol. A k39 antigen test for visceral leishmaniasis was also performed on patients with lymphadenopathy and/or splenomegaly. All demographic, clinical and HIV data, as well as FASH results and therapy adjustments, were recorded following the examination.ResultsThe FASH protocol allowed the detection of pathological US findings suggestive of tuberculosis in 27 out of the 100 patients tested. Overall, FASH results supported tuberculosis treatment indication for 16 of 21 patients, with the treatment being based exclusively on FASH findings in half of them (8 patients). The group of FASH-positive patients had a significantly higher proportion of patients with CD4 count below 0.2 x109/L (n=22, 81%) as compared with FASH-negative patients (n=35, 48%) (p=0.003). Moreover, 48% (n=13) of FASH-positive patients had CD4 below 100 cells/mm3. All patients tested had a negative result on k39 antigen test.ConclusionFASH was found to be a relevant diagnostic tool to detect signs of tuberculosis. Further research is needed to better define a patient profile suitable for investigation and also considering diagnostic accuracy.
Flavio Bobbio; Francesco Di Gennaro; Claudia Marotta; John Kok; Gabriel Akec; Luca Norbis; Laura Monno; Annalisa Saracino; Walter Mazzucco; Marta Lunardi. Focused ultrasound to diagnose HIV-associated tuberculosis (FASH) in the extremely resource-limited setting of South Sudan: a cross-sectional study. BMJ Open 2019, 9, e027179 .
AMA StyleFlavio Bobbio, Francesco Di Gennaro, Claudia Marotta, John Kok, Gabriel Akec, Luca Norbis, Laura Monno, Annalisa Saracino, Walter Mazzucco, Marta Lunardi. Focused ultrasound to diagnose HIV-associated tuberculosis (FASH) in the extremely resource-limited setting of South Sudan: a cross-sectional study. BMJ Open. 2019; 9 (4):e027179.
Chicago/Turabian StyleFlavio Bobbio; Francesco Di Gennaro; Claudia Marotta; John Kok; Gabriel Akec; Luca Norbis; Laura Monno; Annalisa Saracino; Walter Mazzucco; Marta Lunardi. 2019. "Focused ultrasound to diagnose HIV-associated tuberculosis (FASH) in the extremely resource-limited setting of South Sudan: a cross-sectional study." BMJ Open 9, no. 4: e027179.
Co-infection between malaria and HIV has major public health implications. The aims of this study were to assess the malaria prevalence and to identify predictors of positivity to malaria Test in HIV positive patients admitted to the health center São Lucas of Beira, Mozambique. A retrospective cross-sectional study was performed from January 2016 to December 2016. Overall, 701 adult HIV patients were enrolled, positivity to malaria test was found in 232 (33.0%). These patients were found to be more frequently unemployed (76.3%), aged under 40 (72.0%), with a HIV positive partner (22.4%) and with a CD4 cell count <200 (59.9%). The following variables were predictors of malaria: age under 40 (O.R. = 1.56; 95%CI: 1.22–2.08), being unemployed (O.R. = 1.74; 95%CI: 1.24–2.21), irregularity of cotrimoxazole prophylaxis’s (O.R. = 1.42; 95%CI: 1.10–1.78), CD4 cell count <200 (O.R. = 2.01; 95%CI: 1.42–2.32) and tuberculosis comorbidity (O.R. = 1.58; 95%CI: 1.17–2.79). In conclusion, high malaria prevalence was found in HIV patients accessing the out-patients centre of São Lucas of Beira. Our findings allowed us to identify the profile of HIV patients needing more medical attention: young adults, unemployed, with a low CD4 cell count and irregularly accessing to ART and cotrimoxazole prophylaxis.
Francesco Di Gennaro; Claudia Marotta; Damiano Pizzol; Kajal Chhaganlal; Laura Monno; Giovanni Putoto; Annalisa Saracino; Alessandra Casuccio; Walter Mazzucco. Prevalence and Predictors of Malaria in Human Immunodeficiency Virus Infected Patients in Beira, Mozambique. International Journal of Environmental Research and Public Health 2018, 15, 2032 .
AMA StyleFrancesco Di Gennaro, Claudia Marotta, Damiano Pizzol, Kajal Chhaganlal, Laura Monno, Giovanni Putoto, Annalisa Saracino, Alessandra Casuccio, Walter Mazzucco. Prevalence and Predictors of Malaria in Human Immunodeficiency Virus Infected Patients in Beira, Mozambique. International Journal of Environmental Research and Public Health. 2018; 15 (9):2032.
Chicago/Turabian StyleFrancesco Di Gennaro; Claudia Marotta; Damiano Pizzol; Kajal Chhaganlal; Laura Monno; Giovanni Putoto; Annalisa Saracino; Alessandra Casuccio; Walter Mazzucco. 2018. "Prevalence and Predictors of Malaria in Human Immunodeficiency Virus Infected Patients in Beira, Mozambique." International Journal of Environmental Research and Public Health 15, no. 9: 2032.