Dr. Jamal Ibdah
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Academic Career Length
39Years (1988-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 May 2010 in Journal of Hepatology
Journal Article
RRR. Scott Rector
R. Scott RectorJTJohn P. Thyfault
John P. ThyfaultGUGrace M. Uptergrove
Grace M. Uptergrove
EME. Matthew Morris
E. Matthew MorrisSNScott P. Naples
Scott P. Naples
Jamal Ibdah +5
3 June 1999 in New England Journal of Medicine
Journal Article
Jamal IbdahMBMichael J. Bennett
Michael J. Bennett
PRPiero Rinaldo
Piero Rinaldo
YZYiwen Zhao
Yiwen Zhao
BGBeverly Gibson
Beverly Gibson
ASArnold W. Strauss
Arnold W. Strauss +1
Acute fatty liver of pregnancy and the HELLP syndrome (hemolysis, elevated liver-enzyme levels, and a low platelet count) are serious hepatic disorders that may occur during pregnancy in women whose fetuses are later found to have a deficiency of long-chain 3-hydroxyacyl-coenzyme A (CoA) dehydrogenase. This enzyme resides in the mitochondrial trifunctional protein, which also contains the active site of long-chain 2,3-enoyl-CoA hydratase and long-chain 3-ketoacyl-CoA thiolase. We undertook this study to determine the relation between mutations in the trifunctional protein in infants with defects in fatty-acid oxidation and acute liver disease during pregnancy in their mothers.
1 January 2014 in World Journal of Gastroenterology
Journal Article
Gastric cancer (GC) is the fourth most common cancer in the world with more than 70% of cases occur in the developing world. More than 50% of cases occur in Eastern Asia. GC is the second leading cause of cancer death in both sexes worldwide. In Asia, GC is the third most common cancer after breast and lung and is the second most common cause of cancer death after lung cancer. Although the incidence and mortality rates are slowly declining in many countries of Asia, GC still remains a significant public health problem. The incidence and mortality varies according to the geographic area in Asia. These variations are closely related to the prevalence of GC risk factors; especially Helicobacter pylori (H. pylori) and its molecular virulent characteristics. The gradual and consistent improvements in socioeconomic conditions in Asia have lowered the H. pylori seroprevalence rates leading to a reduction in the GC incidence. However, GC remains a significant public health and an economic burden in Asia. There has been no recent systemic review of GC incidence, mortality, and H. pylori molecular epidemiology in Asia. The aim of this report is to review the GC incidence, mortality, and linkage to H. pylori in Asia.
Journal Article
Fatiha NassirJamal IbdahNonalcoholic fatty liver disease (NAFLD) affects about 30% of the general population in the United States and includes a spectrum of disease that includes simple steatosis, non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Significant insight has been gained into our understanding of the pathogenesis of NALFD; however the key metabolic aberrations underlying lipid accumulation in hepatocytes and the progression of NAFLD remain to be elucidated. Accumulating and emerging evidence indicate that hepatic mitochondria play a critical role in the development and pathogenesis of steatosis and NAFLD. Here, we review studies that document a link between the pathogenesis of NAFLD and hepatic mitochondrial dysfunction with particular focus on new insights into the role of impaired fatty acid oxidation, the transcription factor peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α), and sirtuins in development and progression of NAFLD.
1 January 2008 in World Journal of Gastroenterology
Journal Article
SPSrinivas R Puli
Srinivas R Puli
JRJyotsna Bk Reddy
Jyotsna Bk Reddy
MBMatthew L Bechtold
Matthew L Bechtold
DADaphne Antillon
Daphne Antillon
Jamal IbdahMAMainor R Antillon
Mainor R AntillonStaging accuracy of esophageal cancer by endoscopic ultrasound: A meta-analysis and systematic review
1 January 2008 in World Journal of Gastroenterology
Journal Article
YWYongzhong Wei
Yongzhong Wei
RRR Scott Rector
R Scott RectorJTJohn P Thyfault
John P ThyfaultJamal IbdahNonalcoholic fatty liver disease and mitochondrial dysfunction
About Me
Jamal A Ibdah received his MD degree from the University of
Jordan and a Ph.D. degree in Biochemistry from the Medical College of
Pennsylvania, followed by postdoctoral research training. He is currently a
Professor of Internal Medicine, Medical Pharmacology, and Physiology, and
Raymond E. and Vaona H. Peck Endowed Research Chair at the University of
Missouri. He was the Director of the Division of Gastroenterology and
Hepatology and Director of the Missouri Digestive Health Center at the
University of Missouri-Columbia from 2005 to 2019. He is a fellow of the American
Gastroenterological Association, the American College of Gastroenterology, and
the American Association for the Study of Liver Diseases. His current studies
are focused on understanding the role of mitochondria in non-alcoholic fatty
liver disease utilizing studies in mouse models and human subjects. His work
has led to seminal contributions in the field. His work has beenpublished in more
than 140 peer-reviewed articles, including publications in the New England
Journal of Medicine, JAMA, Journal of Clinical Investigation, Gastroenterology,
and Hepatology, in addition to more than 15 book chapters. He is the editor of
the book "Maternal Liver Disease", has served on multiple editorial
boards and NIH study sections, and his work is continuously supported by NIH grants,
VA Merit Review awards, the American Diabetes Foundation, March of Dimes, and
Digestive Health Foundation.