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Prof. Xiang-Lan Piao
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Research Focus & Metrics
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Academic Career Length
9Years (2018-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications1 May 2021 in Journal of Ethnopharmacology
Journal Article
HLHui Liu
Hui Liu
XLXiuming Li
Xiuming Li
YDYu Duan
Yu Duan
JXJin-Bo Xie
Jin-Bo Xie
XPXiang-Lan Piao
Xiang-Lan Piao16 September 2023 in Journal of Ethnopharmacology
Journal Article
PXPeng Xie
Peng Xie
HLHao-Tian Luo
Hao-Tian Luo
WPWen-Jing Pei
Wen-Jing Pei
MXMan-Yu Xiao
Man-Yu Xiao
FLFang-Fang Li
Fang-Fang Li
XPXiang-Lan Piao
Xiang-Lan Piao +1
1 December 2021 in Journal of Ethnopharmacology
Journal Article
YQYan-Shuang Qi
Yan-Shuang Qi
JXJin-Bo Xie
Jin-Bo Xie
PXPeng Xie
Peng Xie
YDYu Duan
Yu Duan
YLYa-Qin Ling
Ya-Qin LingXPXiang-Lan Piao
Xiang-Lan Piao +1
17 April 2023 in Phytomedicine
Journal Article
PXPeng Xie
Peng Xie
JXJin-Bo Xie
Jin-Bo Xie
MXMan-Yu Xiao
Man-Yu Xiao
MGMei Guo
Mei Guo
YQYan-Shuang Qi
Yan-Shuang Qi
XPXiang-Lan Piao
Xiang-Lan Piao +1
2 May 2022 in Journal of Ethnopharmacology
Journal Article
PXPeng Xie
Peng Xie
MGMei Guo
Mei Guo
JXJin-Bo Xie
Jin-Bo Xie
MXMan-Yu Xiao
Man-Yu Xiao
YQYan-Shuang Qi
Yan-Shuang Qi
XPXiang-Lan Piao
Xiang-Lan Piao +2
1 January 2021 in Bioorganic Chemistry
Journal Article
XZXin-Fang Zhai
Xin-Fang Zhai
MZMa-Li Zu
Ma-Li Zu
YWYu-Rong Wang
Yu-Rong Wang
WCWei-Ye Cui
Wei-Ye Cui
YDYu Duan
Yu Duan
XPXiang-Lan Piao
Xiang-Lan Piao +1
Gynostemma pentaphyllum has been used as a medicine-food homologious health product in China for a long time. This research aimed to isolate and identify its active compounds with protective effects against hydrogen peroxide induced SH-SY5Y cell death. Four new dammarane-type saponins were isolated from G. pentaphyllum using various chromatographic methods. They were identified as gypenoside S1 (1), gypenoside S3 (2), gypenoside S2 (3) and gypenoside S4 (4), respectively by HRESIMS and NMR spectra. Their cytotoxic activity was evaluated against three human cancer cell lines, A549 (lung), HepG2 (liver), SH-SY5Y (nerve), by MTT method. They showed low cytotoxicities with the IC50 values of more than 100 μM on three cancer cell lines. However, they appeared protective effects against hydrogen peroxide induced SH-SY5Y cell death in a dose-dependent manner. They recovered cell viability more than 69% at the concentration of 20 μM from 66%, while as vitamin C to 67%. Compound 3 and 4 recovered more than 79% at 100 μM. The present study suggests that G. pentaphyllum has antioxidative potential and the saponins from G. pentaphyllum are considered as the active compounds with safe and neuroprotecitve effect.
About Me
Xiang-Lan Piao, professor. School of Pharmacy, Minzu University of China.
Education:
1998.08-2004.08, Ph.D. Of College of Pharmacy, Seoul National University, Korea
1996.09-199.8.08, Master of College of Pharmacy, Seoul National University, Korea
1984.09-1988.07, Bachelor of College of Pharmacy, Yanbian University, China
Research Summary
1) Anti-tumor chemical constituents from natural products.
2) Analysis of metabolites of natural products.
3) Mechanism of gypenosides against A549 cells
Major Projects Hosting
1) Studies on anti-NSCLC Constituents from Gocaekmbaw of Zhuang-medicine based on Metabolites Analysis. Natural Science Foundation of China (NSFC) No.81673692.
2) Development of highly bioactive natural products based on convergence and integration technology of biotransformation. NSFC (No.81511140297).
3) Studies on Active Constituents against Non-Small Cell Lung Carcinoma from Heat-processed Zhuang-medicine Gocaekmbaw. NSFC (No.81274186).
4) Chemical Constituents and Biological Activity of Biotransformed Herbal Medicines Belonging genus Panax. NSFC (No.81181240306).
5) Analysis of geographical factor on the origin discrimination of crude drugs between Korea and China by chromatographic and chemical fingerprinting studies. NSFC (No.81011140347).
6) HPLC-Tyrosinase Inhibition Detection and Tyrosinase Inhibitory Constituents from Forsythia suspensa. NSFC (No.30973960).