In the last decades, supramolecular chemists have developed new molecular receptors able to include a wide range of guests. In addition, they have designed synthetic hosts able to form capsules having an internal volume of thousands of ų. This inner space shows different features from the bulk solution. In particular, this environment has recently been employed to perform chemical reactions, obtaining reaction products different from the “normal” conditions. These supramolecular capsules act as nanoreactors, catalyzing many chemical transformations. This review collects the recent developments (since 2015) in this field, focusing on supramolecular capsules based on resorcinarene hexameric capsules and metal-cage capsules.

We report on new Zn–Salen oligomer receptors able to recognize a nerve agent simulant, namely dimethyl methylphosphonate (DMMP), by a supramolecular approach. In particular, three Zn-Salen oligomers (Zn–Oligo–A, –B, and –C), differing by the length distribution, were obtained and characterized by NMR, Gel Permeation Chromatography (GPC), UV-Vis, and fluorescence spectroscopy. Furthermore, we investigated their recognition properties towards DMMP by using fluorescence measurements. We found that the recognition ability depends on the length of the oligomeric chain, and the Zn–Oligo–C shows a binding constant value higher than those already reported in literature for the DMMP detection.