Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying, and changes in stool consistency. We compared the effectiveness of three different dietary treatment plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, the G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. A total of seventy-three female patients diagnosed with a mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in Group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with a dietitian. Patients from Group 3 (G3-K) received nutrition advice from a gastroenterologist. Significant differences in the reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group (idiopathic abdominal pain, p < 0.001; abdominal pain after a meal, p < 0.001; abdominal pain during defecation, p = 0.008), while in the G1-FM group, some of the IBS symptoms significantly improved (mucus in stool, p = 0.031; bloating, p < 0.001). In group G3-K no significant improvement was seen. Based on the results of this open-label study, it was concluded that various dietary interventions in the treatment of IBS-M patients do not uniformly affect the course and outcomes of disease management. Rotation diets based on IgG show significantly better results compared to other diets.

Background Irritable bowel syndrome (IBS) is a chronic disease with recurrent abdominal pain, disturbed bowel emptying and change in stool consistency. We compared the effectiveness of dietary treatment of three different diet plans (G1-FM-low FODMAP diet, G2-IP IgG based elimination-rotation-diet, and as control group, G3-K control diet recommended by an attending gastroenterologist) in treating patients diagnosed with mixed irritable bowel syndrome. Methods 73 female patients diagnosed with mixed form of irritable bowel syndrome (IBS-M) were enrolled in the study. The diet of each patient in group 1 (G1-FM) and 2 (G2-IP) was determined individually during a meeting with dietitian. Patients from group 3 (G3-K) received nutrition advice from a gastroenterologist. Results Significant differences in reduction of IBS symptoms were found between the groups. IBS symptoms as well as comorbid symptoms significantly improved or disappeared completely in the G2-IP group, while in the G1-FM group, some of the IBS symptoms significantly improved. In group G3-K no significant improvement was seen.Conclusion Based on the results of this open study it was found that the different dietary intervention in the treatment of patients with IBS-M was unlikely effective. The G2-IP IgG based elimination-rotation-diet demonstrating a significant overall superior result compared to the others. Trial registration The clinical trial was retrospective registered at ClinicalTrials.gov, March 12, 2020, ClinicalTrials.gov ID: NCT04307368.

Introduction: Psoriasis is a chronic inflammatory systemic disorder. It has been suggested that dietary factors may influence the course and severity of the disease. Aim : To assess nutritive values of daily food rations (DFRs) of patients with psoriasis vulgaris and to correlate them with...